Cancer chemotherapy chemosensitivity testing is useful in evaluating the appropriate adjuvant cancer chemotherapy for stages III/IV gastric cancers without peritoneal dissemination.

abstract：BACKGROUND:The aim of this study was to investigate whether tributyrin, a natural butyrate pro-drug, as well as butyrate itself could affect growth, differentiation and apoptosis in two human pancreatic cancer cell lines in culture. MATERIALS AND METHODS:Proliferation was studied by cell counting using crystal violet ...

journal_title：Anticancer research

authors： Gaschott T,Maassen CU,Stein J

更新日期：2001-07-01 00:00:00

abstract：:Intracellular accumulation of adriamycin (ADR) has been reported to be influenced by cell membrane potential. We first evaluated intracellular accumulation of ADR and 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, and found a good correlation between ADR and NK-2280 i...

journal_title：Anticancer research

authors： Asaumi JI,Kawasaki S,Gao XS,Kuroda M,Hiraki Y

更新日期：1996-03-01 00:00:00

abstract：:Menogaril is an antitumor agent active after oral administration, and unlike other anthracyclines, extravasation cannot occur. When the IC90 values of menogaril were plotted versus exposure time on a double-logarithmic scale, the regression lines had slopes between -0.64 and -0.80. These results showed that the mode o...

journal_title：Anticancer research

authors： Yoshida M,Kobunai T,Nakano K,Saito H,Toko T,Takeda S,Unemi N

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Lung cancer tissues are often infiltrated by B lymphocytes, but it is not clear whether these infiltrations represent tumor-specific immune response or a nonspecific reaction. MATERIALS AND METHODS:The serological analysis of recombinant cDNA expression libraries (SEREX) were previously modified using a sev...

journal_title：Anticancer research

authors： Yasuda M,Mizukami M,Hanagiri T,Shigematsu Y,Fukuyama T,Nagata Y,So T,Ichiki Y,Sugaya M,Takenoyama M,Sugio K,Yasumoto K

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Basic fibroblast growth factor (bFGF) is a potent angiogenetic factor which may influence breast cancer evolution. MATERIALS AND METHODS:Serum bFGF, (cut-off 10 pg/ml), was assayed in 166 breast cancer patients at all stages and compared with CA 15.3. RESULTS:In 99 pre-treatment (PT) sera, 39/99 (39.4%) we...

journal_title：Anticancer research

authors： Pichon MF,Moulin G,Pallud C,Pecking A,Floiras JL

更新日期：2000-03-01 00:00:00

abstract：:Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

journal_title：Anticancer research

authors： Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND/AIM:The hormonally-active form of vitamin D, 1,25(OH)2D3, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia....

journal_title：Anticancer research

authors： Oak ASW,Bocheva G,Kim TK,Brożyna AA,Janjetovic Z,Athar M,Tuckey RC,Slominski AT

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND/AIM:We undertook a case-control and a case-case study to examine the possible association of p53 codon72 polymorphism with the breast cancer risk and resistance to anthracycline-based chemotherapy. PATIENTS AND METHODS:Case-control study: This study enrolled 175 patients with breast cancer treated at the Sa...

journal_title：Anticancer research

authors： Arfaoui A,Douik H,Kablouti G,Chaaben AB,Handiri N,Zid Z,Ouni N,Zouiouch F,Ayari F,Mamoughli T,Bouassida J,Abazza H,Harzallaha L,Guemira F

更新日期：2015-03-01 00:00:00

abstract：:We assessed the effect of granulocyte apheresis in patients exhibiting increased granulocyte-to-lymphocyte ratio in order to overcome granulocytosis occurring in the terminal stages of malignancies. 17 patients with post-operative recurrent metastatic tumors including 6 gastric, 3 colonic, 2 rectal, 1 esophageal and 5...

journal_title：Anticancer research

authors： Tabuchi T,Ubukata H,Sato S,Nakata I,Goto Y,Watanabe Y,Hashimoto T,Mizuta T,Adachi M,Soma T

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Transient hypocalcaemia is a frequent complication after total knee arthroplasty (TKA). In this study, we investigated the factors associated with the development of hypocalcaemia after TKA in order to explore its clinical significance and treatment. PATIENTS AND METHODS:A retrospective analysis of the chan...

journal_title：Anticancer research

authors： Gai P,Sun H,Sui L,Wang G

更新日期：2016-03-01 00:00:00

abstract：:Decreased expression of VDUP1, which is an interesting stress response gene, has been shown in rat mammary tumors and has been discussed in relation to the development of the tumor. However, VDUP1 expression in clinical specimens of human cancer remains unclear. We employed TaqMan RT-PCR assay to investigate VDUP1 exp...

journal_title：Anticancer research

authors： Ikarashi M,Takahashi Y,Ishii Y,Nagata T,Asai S,Ishikawa K

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIM:Recent progress with BRAF and immune checkpoint inhibitors has dramatically changed the treatment landscape of metastatic melanoma (MM). The limited duration of responses to new agents, however, justifies the, still important, role of chemotherapy in the management of MM. This study prospectively explore...

journal_title：Anticancer research

authors： Linardou H,Pentheroudakis G,Varthalitis I,Gogas H,Pectasides D,Makatsoris T,Fountzilas G,Bafaloukos D,Hellenic Cooperative Oncology Group.

更新日期：2015-02-01 00:00:00

abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...

journal_title：Anticancer research

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) remains the most aggressive and frequently occurring brain neoplasm. Members of the Rho family of small GTP-binding proteins, including Rho, Rac, and Cdc42, have been shown to participate in cell growth differentiation and motility. The mitogen-activated protein kinase (MAPK) pa...

journal_title：Anticancer research

authors： Zohrabian VM,Forzani B,Chau Z,Murali R,Jhanwar-Uniyal M

更新日期：2009-01-01 00:00:00

abstract：:In the present study, we have investigated the effect of cytotropic heterogeneous molecular lipid (CHML), a new anticancer agent, on growth suppression in a variety of human tumor cell lines. At a non-toxic concentration (a range from 25 micrograms/ml to 100 micrograms/ml), CHML has shown to strongly inhibit tumor cel...

journal_title：Anticancer research

authors： Zhan Q,Xu Z

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The recent prevalence of ultrasonography and fine-needle aspiration biopsy (FNAB) has facilitated the detection and diagnosis of papillary thyroid carcinoma. However, there are still cases that are preoperatively misdiagnosed and treated as benign nodules because ultrasonographic and FNAB findings do not pro...

journal_title：Anticancer research

authors： Ito Y,Higashiyama T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2007-03-01 00:00:00

abstract：UNLABELLED:AIM/ BACKGROUND: To determine the feasibility and safety of intratumoral α-gal glycolipids injection for conversion of human tumors into autologous Tumor Associated Antigens (TAA) vaccine. α-Gal glycolipids bind anti-Gal--the most abundant antibody in humans. Pre-clinical studies indicated that injected α-ga...

journal_title：Anticancer research

authors： Whalen GF,Sullivan M,Piperdi B,Wasseff W,Galili U

更新日期：2012-09-01 00:00:00

abstract：:Treatment of advanced prostatic cancer is currently based on hormonal manipulation. In 1982 Labrié supported a new concept of hormonal treatment based on complete androgen blockade. The objective of this study was to evaluate the effects of total androgen suppression, achieved by the combination of a LHRH agonist (bus...

journal_title：Anticancer research

authors： Neri B,Bartalucci S,Pieri A,Gemelli MT,Rizzo M,Bartoletti R,Trippitelli A,Paoletti MC

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) have provided backbone structure for the chemical synthesis of potent anticancer drugs. In this study, the cytotoxicity of fifteen 2-(N-cyclicamino)chromone derivatives was investigated and subjected to quantitative structure-activity relationship (QSAR) analysis. MATE...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Sakagami H,Tomomura M,Tomomura A,Uesawa Y,Takao K,Sugita Y

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Late developing breast cancer metastases are common and lethal despite treatment with adjuvant chemotherapy at the time of primary tumor excision. Stimulation of an antitumor immune response is an alternative strategy for preventing this devastating development. MATERIALS AND METHODS:A mouse model of the hu...

journal_title：Anticancer research

authors： Gao Y,Bergman I

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:AZD8055 is an inhibitor of mammalian target of rapamycin (mTOR) that can suppress both mTOR complex 1 (mTORC1) and mTORC2. This study investigated the antitumor effects of AZD8055 on colon cancer. MATERIALS AND METHODS:The effects of AZD8055 on proliferation, apoptosis, and cell cycle of colon cancer ce...

journal_title：Anticancer research

authors： Chen Y,Lee CH,Tseng BY,Tsai YH,Tsai HW,Yao CL,Tseng SH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIM:Accumulating evidence shows that various types of cancers induce a specific immune response resulting in the production of antibodies against self-components (autoantibodies). The aim of the present study was to identify antigens for autoantibodies in sera from patients with ovarian cancer, especially cl...

journal_title：Anticancer research

authors： Yoneyama K,Kojima S,Kodani Y,Yamaguchi N,Igarashi A,Kurose K,Kawase R,Takeshita T,Hattori S,Nagata K

更新日期：2015-02-01 00:00:00

abstract：:Many retrospective trials have demonstrated a survival benefit for elective lymph node dissection (ELND) in the treatment of clinical stage I malignant melanoma, but two randomized trials have found none. The relevant medical literature was reviewed with special attention devoted to the tumor burden of nodal disease. ...

journal_title：Anticancer research

authors： Evans RA

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:The rat model of breast cancer induced by the administration of N-methyl-nitrosourea (NMU) constitutes a useful tool for dissecting the initiation, promotion and progression process of carcinogenesis. Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. Tum...

journal_title：Anticancer research

authors： Carrera MP,Ramírez-Expósito MJ,Valenzuela MT,García MJ,Mayas MD,Martínez-Martos JM

更新日期：2004-03-01 00:00:00

abstract：:The antibacterial agent taurolidine (TRD) has been used as a lavage antibiotic to prevent development of peritonitis in patients after surgery. We recently showed that TRD induced growth arrest and apoptosis of a variety of cultured cell lines derived from human solid tumors and also significantly inhibited the growth...

journal_title：Anticancer research

authors： Han Z,Ribbizi I,Pantazis P,Wyche J,Darnowski J,Calabresi P

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Altered retinoblastoma gene expression has been found in various types of cancers including non-small cell lung cancer (NSCLC) and some reports have shown it also to be associated with a poor clinical prognosis in NSCLC. MATERIALS AND METHODS:We evaluated the expression of Rb protein by immunohistochemistry...

journal_title：Anticancer research

authors： Sugio K,Tsukamoto S,Ushijima C,Yamazaki K,Kase S,Yamaguchi M,Ondo K,Yano T,Sugimachi K

更新日期：2001-05-01 00:00:00

abstract：:The interaction between sodium 5,6-benzylidene-L-ascorbate (SBA) and dopamine was investigated by three different parameters: radical intensity, prooxidant action and cytotoxic activity. Under alkaline conditions, SBA and dopamine produced doublet and quartet ESR signals, respectively. The addition of increasing conce...

journal_title：Anticancer research

authors： Satoh K,Ida Y,Kochi M,Sakagami H

更新日期：1998-09-01 00:00:00

abstract：AIM:To estimate the clinical outcomes of induction chemotherapy (IC) followed by standard chemoradiotherapy (CRT) and CRT alone in patients with locally advanced human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinoma. PATIENTS AND METHODS:Consecutive patients with histologically-proven HPV-negative...

journal_title：Anticancer research

authors： DE Felice F,Abate G,Galdieri A,Bulzonetti N,Musio D,Tombolini V

更新日期：2016-12-01 00:00:00

abstract：:K-ras-NIH3T3 cells were more invasive than NIH3T3 cells in a chemotactic invasion assay. Conophylline, a new vinca alkaloid isolated as a ras function inhibitor, inhibited the invasion of K-ras-NIH3T3 cells, while it showed no effect on NIH3T3 cells. Conophylline did not increase expression of fibronectin but induced ...

journal_title：Anticancer research

authors： Amino N,Ohse T,Koyano T,Umezawa K

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...

journal_title：Anticancer research

authors： Igawa S,Takahashi T,Nakamura Y,Tsuya A,Ono A,Shukuya T,Murakami H,Endo M,Yamamoto N

更新日期：2008-11-01 00:00:00