Adipobiology of disease: adipokines and adipokine-targeted pharmacology.

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disease and a leading cause of coronary artery disease, peripheral vascular disease and stroke. Lipid-laden macrophages are derived from circulating monocytes and form fatty streaks as the first step of atherogenesis. METHODS:An electronic search in major databases ...

journal_title：Current pharmaceutical design

authors： Taghizadeh E,Taheri F,Renani PG,Reiner Ž,Navashenaq JG,Sahebkar A

更新日期：2019-01-01 00:00:00

abstract：:These are exciting times for bioinformaticians, computational biologists and drug designers with the genome and proteome sequences and related structural databases growing at an accelerated pace. The post-genomic era has triggered high expectations for a rapid and successful treatment of diseases. However, in this bio...

journal_title：Current pharmaceutical design

authors： Soni A,Pandey KM,Ray P,Jayaram B

更新日期：2013-01-01 00:00:00

abstract：:Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated tryptase as a mediator in the pathology of numerous allergic and inflammatory conditions including rhinitis, conjunctivitis, and most notably asthma. A growing...

journal_title：Current pharmaceutical design

authors： Rice KD,Tanaka RD,Katz BA,Numerof RP,Moore WR

更新日期：1998-10-01 00:00:00

abstract：:Introduction of flow cytometric technique to the research on basophil activation has led to significant achievements in allergy diagnosis in vitro. Most of the studies employing the flow cytometry used CD63 as a marker of basophil activation and only some of them used CD203c. Recently discovered basophil activation ma...

journal_title：Current pharmaceutical design

authors： Wolanczyk-Medrala A,Barg W,Medrala W

更新日期：2011-11-01 00:00:00

abstract：:In this review, the antimicrobial properties of a number of peptides are described. We first deal with helical linear peptides such as the well-known gramicidin, magainins, melittin, and other less well-known or more recently discovered peptides. Then, beta-sheet peptides (defensins isolated from insects and also from...

journal_title：Current pharmaceutical design

authors： Duclohier H

更新日期：2010-01-01 00:00:00

abstract：:Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate...

journal_title：Current pharmaceutical design

authors： Ishii M,Kurachi Y

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the elderly. The increase of life-expectancy is transforming AD into a major health-care problem. AD is characterized by a progressive impairment of memory and other cognitive skills leading to dementia. The major pathogenic factor ass...

journal_title：Current pharmaceutical design

authors： Agostinho P,Cunha RA,Oliveira C

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Compounds and extracts derived from natural sources continue to stand in the spotlight of drug design owing to their versatile interaction with enzymes, receptors and metabolic pathways. Nanomedicine offers an operative tool for the efficient delivery of natural products, in terms of increased bioavailabilit...

journal_title：Current pharmaceutical design

authors： Simona AD,Florina A,Rodica CA,Evelyne O,Maria-Corina S

更新日期：2017-01-01 00:00:00

abstract：:Since the 1950's, herpes simplex viruses (HSV) have played prominent roles in the development of antivirals. The first efficacious antivirals, as well as the first safe for systemic use, were developed against HSV. It was only in 1995 when the first antiviral against a target not validated first with HSV was approved ...

journal_title：Current pharmaceutical design

authors： Schang LM

更新日期：2006-01-01 00:00:00

abstract：:The apoptosis inducing factor (AIF) was first discovered as a caspase-independent apoptosis effector that promoted cell death upon release from the mitochondria (triggered by pro-apoptotic stimuli) and relocalization into the nucleus, where it promotes chromatin condensation and DNA fragmentation. AIF is a mammalian m...

journal_title：Current pharmaceutical design

authors： Ferreira P,Villanueva R,Cabon L,Susín SA,Medina M

更新日期：2013-01-01 00:00:00

abstract：:Extracellular matrix (ECM) is composed of large collagen fibrils. Glycoproteins, such as fibronectin, can bind to collagen or form their own networks. Collagen fibrils are also decorated by proteoglycans, proteins that have large glycosaminoglycan sidechains. In addition, extracellular space often contains hyaluronan,...

journal_title：Current pharmaceutical design

authors： Heino J,Käpylä J

更新日期：2009-01-01 00:00:00

abstract：:Depression is one of the leading causes of disability in the world. Current pharmaceutical treatment for depression remains unsatisfactory due to its limited therapeutic efficacy and undesirable side effects. There is increasing interest in looking for alternative strategies from diet for the treatment of depressive d...

journal_title：Current pharmaceutical design

authors： Wang X,Zhao F,Wang X,Niu Y,Niu L,Wang C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The integrin family receptors stimulate the cellular proliferation and migration through the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was to investigate the integrin-ligated motifs through the activation of focal adhesion pathway. METHODS:A chimeric...

journal_title：Current pharmaceutical design

authors： Khosravi M,Kakavandi N,Rezaee S,Shabani M,Najafi M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To investigate if low-dose lithium may counteract the microstructural and metabolic brain changes proposed to occur in individuals at ultra-high risk (UHR) for psychosis. METHODS:Hippocampal T2 relaxation time (HT2RT) and proton magnetic resonance spectroscopy ((1)H-MRS) measurements were performed prior to...

journal_title：Current pharmaceutical design

authors： Berger GE,Wood SJ,Ross M,Hamer CA,Wellard RM,Pell G,Phillips L,Nelson B,Amminger GP,Yung AR,Jackson G,Velakoulis D,Pantelis C,Manji H,McGorry PD

更新日期：2012-01-01 00:00:00

abstract：:Gene therapy, currently, represents one of the new therapies that have emerged for the treatment of different diseases. Between the different approaches that can be chosen concerning this therapy, gene delivery with non-viral systems has focused the attention during the past decades, because of the reduced toxicity co...

journal_title：Current pharmaceutical design

authors： Urbiola K,Blanco-Fernandez L,de Ilarduya CT

更新日期：2015-01-01 00:00:00

abstract：:Thrombotic events occurring in either arteries or veins are the primary causes of fatal perioperative cardiovascular events. Risk factors for deep vein thrombosis, several of which are evidently associated with specific surgical procedures, are quite different from those for arterial thrombosis (e.g., aging or atheros...

journal_title：Current pharmaceutical design

authors： Azma T,Tuluc F,Ito T,Aoyama-Mani C,Kawahito S,Kinoshita H

更新日期：2014-01-01 00:00:00

abstract：:Cyclooxygenase-1 (COX-1) derived eicosanoids promote gastroprotective mucosal defenses and induce platelet aggregation. By sparing COX-1, COX-2 specific inhibitors provide effective anti-inflammatory and analgesic activity while substantially reducing the risk of peptic ulcer disease and GI bleeding compared to dual C...

journal_title：Current pharmaceutical design

authors： Scheiman JM

更新日期：2003-01-01 00:00:00

abstract：:The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently ...

journal_title：Current pharmaceutical design

authors： Saljoughian M,Williams PG

更新日期：2000-07-01 00:00:00

abstract：:Peroxynitrite, the product of the reaction between nitric oxide and superoxide, is spontaneouly formed within most mammalian cells under physiological conditions. Initial work addressing the pathophysiology of peroxynitrite afforded the generally accepted notion that this compound would be the long-term neurotoxic nit...

journal_title：Current pharmaceutical design

authors： Bolanos JP,García-Nogales P,Almeida A

更新日期：2004-01-01 00:00:00

abstract：:Obesity was first described as a low-grade inflammatory condition more than a decade ago. However, it is only relatively recently that obese individuals have been described with increased macrophage infiltration of adipose tissue, as well as an increase in the number of "M1" or "classically activated" macrophages. Fur...

journal_title：Current pharmaceutical design

authors： Heilbronn LK,Campbell LV

更新日期：2008-01-01 00:00:00

abstract：:Inflammatory and infectious diseases include many different clinical conditions not often well recognised and characterized with conventional radiology and biochemical tests. Radiological techniques (TC, MRI, US) show anatomical changes that usually occur in chronic stages of the disease leading to a delayed diagnosis...

journal_title：Current pharmaceutical design

authors： Signore A,Lauri C,Galli F

更新日期：2014-01-01 00:00:00

abstract：:Angiogenesis, the development of new capillaries form pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate in response to growth factors to form functional vessels. Therapeutic angiogenesis is proposed to restore tissue integrity and function following damage and...

journal_title：Current pharmaceutical design

authors： Morbidelli L,Donnini S,Ziche M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Medical treatments are used either alone or in combination with assisted reproductive techniques for treatment of infertile patients with hypergonadotropic hypogonadism. A wide range of treatment options such as gonadotropins, aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs) and the...

journal_title：Current pharmaceutical design

authors： Kalkanli A,Akdere H,Cevik G,Salabas E,Cilesiz NC,Kadioglu A

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...

journal_title：Current pharmaceutical design

authors： Zhao Q,Zhang W,Wang R,Wang Y,Ouyang D

更新日期：2017-01-01 00:00:00

abstract：:Metabolic syndrome is an aggregation of conditions and associated with an increased risk of developing diabetes, obesity and cardiovascular diseases (CVD). Edible mushrooms are widely consumed in many countries and are valuable components of the diet because of their attractive taste, aroma, and nutritional value. Med...

journal_title：Current pharmaceutical design

authors： Tung YT,Pan CH,Chien YW,Huang HY

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The prevalence of adrenal hyperandrogenism (AH), as defined by increased circulating dehydroepiandrosterone-sulfate (DHEAS) levels, ranges from 15 to 45% in women with polycystic ovary syndrome (PCOS). METHODS:The aim of this review is to update the pathogenesis and consequences of AH in PCOS, from molecula...

journal_title：Current pharmaceutical design

authors： Luque-Ramírez M,Escobar-Morreale HF

更新日期：2016-01-01 00:00:00

abstract：:Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is induced by co-ordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Fruits and vegetables are a rich source of polyphenolic bioact...

journal_title：Current pharmaceutical design

authors： Nyanhanda T,Gould EM,Hurst RD

更新日期：2014-01-01 00:00:00

abstract：:Stability of a dosage form is its ability to preserve its quality attributes within preset limits. The time span over which these attributes remain within specifications is the shelf-life of the drug product. Stability is a very complex feature and is influenced not only by the stability of the drug substance but also...

journal_title：Current pharmaceutical design

authors： Szabó P,Zelko R,Antal I

更新日期：2016-01-01 00:00:00

abstract：:Nanoparticles have gained ground in several fields. However, it is important to consider their potentially hazardous effects on humans, flora, and fauna. Human exposure to nanomaterials can occur unintentionally in daily life or in industrial settings, and the continuous exposure of the biological components (cells, r...

journal_title：Current pharmaceutical design

authors： Mitarotonda R,Giorgi E,Desimone MF,De Marzi MC

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:At sufficient sun exposure, humans can synthesize vitamin D3 endogenously in their skin, but today's lifestyle makes the secosteroid a true vitamin that needs to be taken up by diet or supplementation with pills. The vitamin D3 metabolite 1α,25-dihydroxyvitamin D3 acts as a nuclear hormone activating the tra...

journal_title：Current pharmaceutical design

authors： Carlberg C

更新日期：2019-01-01 00:00:00