CD164 as a Basophil Activation Marker.

abstract：:The skin is often introduced as the largest organ of the human body which - being uniquely exposed to external stress - faces several types of challenges, from physical, chemical, biological, and immunological origin. Therefore, the skin is also a site where inflammation, oxidative stress and cellular damage occurs re...

journal_title：Current pharmaceutical design

authors： Szabo IL,Kenyeres A,Szegedi A,Szollosi AG

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The integrin family receptors stimulate the cellular proliferation and migration through the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was to investigate the integrin-ligated motifs through the activation of focal adhesion pathway. METHODS:A chimeric...

journal_title：Current pharmaceutical design

authors： Khosravi M,Kakavandi N,Rezaee S,Shabani M,Najafi M

更新日期：2020-01-01 00:00:00

abstract：:The typical way of judging about either the efficacy of a new treatment or, on the contrary, the damage of a pollutant agent is through a test of hypothesis having its ineffectiveness as null hypothesis. This is the typical operational field of Kolmogorov's statistical framework where wastes of data (for instance non ...

journal_title：Current pharmaceutical design

authors： Apolloni B,Bassis S,Gaito S,Malchiodi D

更新日期：2007-01-01 00:00:00

abstract：:Type 2 diabetes is associated with substantially increased cardiovascular mortality. The need to reduce the progression of atherosclerosis alongside lowering blood glucose levels is now well established. Ideally, pharmaceutical treatment should address both of these needs. This review summarises current evidence of th...

journal_title：Current pharmaceutical design

authors： Papanas N,Maltezos E

更新日期：2009-01-01 00:00:00

abstract：:Infections are the most common inflammatory triggers and acute and chronic infections have been associated with the development and progression of atherosclerotic disease raising interest in the infectious hypothesis of atherosclerosis. Pathogens have been identified in atherosclerotic plaques and large epidemiologica...

journal_title：Current pharmaceutical design

authors： Charakida M,Tousoulis D

更新日期：2013-01-01 00:00:00

abstract：:Estrogens are known as important modulators of development, growth and maintenance of primary sexual physiology. The medical field has also grown increasingly appreciative of the effects of estrogens on non-traditional target tissues such as bone, cardiovascular tissue and the CNS. Postmenopausal women have been the b...

journal_title：Current pharmaceutical design

authors： Miller CP

更新日期：2002-01-01 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles (SPIONs) comprise a fundamental technology class within the emerging field of nanomedicine, and have been extensively researched for cancer imaging and therapy. This review article will discuss the chemistry and design considerations associated with the synthesis of SPIONs an...

journal_title：Current pharmaceutical design

authors： Yoffe S,Leshuk T,Everett P,Gu F

更新日期：2013-01-01 00:00:00

abstract：:Glioblastoma (GBM) is a deadly tumor, which in spite of surgery and radio/chemotherapy frequently undergoes relapses related to the infiltration of the normal parenchyma and to resistance to cytotoxic and radiation therapy. Immunotherapy may represent a promising approach, which may complement existing therapies with ...

journal_title：Current pharmaceutical design

authors： Daga A,Bottino C,Castriconi R,Gangemi R,Ferrini S

更新日期：2011-01-01 00:00:00

abstract：:Glucocorticoids are the first line medication used in the therapy of many severe inflammatory disorders. They exert their activity through binding to the glucocorticoid receptor, a ligand-dependent transcription factor, and result in either activation or repression of a large set of glucocorticoid responsive genes. Th...

journal_title：Current pharmaceutical design

authors： Schulz M,Eggert M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal li...

journal_title：Current pharmaceutical design

authors： Su H,Liu D,Shao J,Li Y,Wang X,Gao Q

更新日期：2020-01-01 00:00:00

abstract：:The clinical presentation of heart disease is different between men and women and this distinction is pivotal for a correct diagnosis and an adequate treatment. However, the definition of symptoms classically associated with heart disease is mainly based on the characteristics of those reported in men. Chest pain or c...

journal_title：Current pharmaceutical design

authors： Collins P,Vitale C,Spoletini I,Barbaro G

更新日期：2011-01-01 00:00:00

abstract：:Inflammatory Bowel Diseases (IBD) are now widely receiving attention. There are many reasons why people get IBD; for example, environment, smoking, family heredity, intestinal microbiota and so on. Antibiotics have not been proven effective and those suffering from IBD have begun to look for other effective drugs to t...

journal_title：Current pharmaceutical design

authors： Ma Y,Yan W,Ding S,Fei Y,Liu G,Fang J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Vitamin D exerts multiple pleiotropic effects beyond its role in calcium-phosphate metabolism. Growing evidence suggests an association between hypovitaminosis D and sleep disorders, thus increasing the interest in the role of this vitamin in the regulatory mechanisms of the sleep-wake cycle. OBJECTIVE:The ...

journal_title：Current pharmaceutical design

authors： Romano F,Muscogiuri G,Di Benedetto E,Zhukouskaya VV,Barrea L,Savastano S,Colao A,Di Somma C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with a number of severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. METHODS:We summarized the literature focu...

journal_title：Current pharmaceutical design

authors： Ruan X,Li M,Mueck AO

更新日期：2018-01-01 00:00:00

abstract：:Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-infectious; and by anatomical localization of inflammation as anterior, posterior and panuveitis. Non-infectious uveitis is believed...

journal_title：Current pharmaceutical design

authors： Klaska IP,Forrester JV

更新日期：2015-01-01 00:00:00

abstract：:Stimulant use disorders are an unrelenting public health concern worldwide. Agonist replacement therapy is among the most effective strategies for managing substance use disorders including nicotine and opioid dependence. The present paper reviewed clinical data from human laboratory self-administration studies and cl...

journal_title：Current pharmaceutical design

authors： Stoops WW,Rush CR

更新日期：2013-01-01 00:00:00

abstract：:Although somewhat controversial, there is good evidence that long-distance travel in general is a risk factor for venous thromboembolism, even in the absence of other risk factors. This is probably due to effects consequent to prolonged sitting but air travel in particular may be associated with risk factors other tha...

journal_title：Current pharmaceutical design

authors： Bradford A

更新日期：2007-01-01 00:00:00

abstract：:Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of au...

journal_title：Current pharmaceutical design

authors： Munn DH,Mellor AL

更新日期：2003-01-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis are the two principal forms of inflammatory bowel disease (IBD). The root causes of these chronic and acute immunological disorders are unclear, but intestinal microorganisms are known to play a key role in the initiation and maintenance of disease. However, at present, there is ...

journal_title：Current pharmaceutical design

authors： Macfarlane GT,Blackett KL,Nakayama T,Steed H,Macfarlane S

更新日期：2009-01-01 00:00:00

abstract：:Psoriasis is an immune-mediated, chronic and recurrent inflammatory skin disease, prevalent worldwide, and represents an important burden in life quality of patients. The most common clinical variant is termed as psoriasis vulgaris or plaque psoriasis, which with an individualized and carefully monitored therapy can d...

journal_title：Current pharmaceutical design

authors： Bruschi ML,da Silva JB,Rosseto HC

更新日期：2019-01-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to generate carbon monoxide, biliverdin and free iron. Increased HO-1 levels constitute an anatomopathological feature of many neurological diseases, such as neurodegenerative disorders and brain infections, which correlate with exacerbated oxidative stress and...

journal_title：Current pharmaceutical design

authors： Cuadrado A,Rojo AI

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Inhibition of hepatic fibrosis is an attainable objective in managing the chronic liver disease. The present study aimed to investigate possible defensive effects of metformin on the activities of antioxidant enzymes, hydroxyproline content, and biochemical factors in bile duct ligation (BDL)-induced cholest...

journal_title：Current pharmaceutical design

authors： Mansourian M,Sadeghi H,Doustimotlagh AH

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI). METHODS:A c...

journal_title：Current pharmaceutical design

authors： Li F,Li H,Xiao Z,Lu R,Zhang Z,Zhu H,Ren L

更新日期：2017-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of disorders characterized by chronic inflammation within the gastrointestinal tract. It is a multifactorial disease associated with immune-cell mediated oxidative damage to the intestinal mucosa. There is no cure for IBD, but anti-cytokine therapy can limit target inflammat...

journal_title：Current pharmaceutical design

authors： Dostie KE,Thees AV,Lynes MA

更新日期：2018-01-01 00:00:00

abstract：:In the early 1980s, an "atypical" beta-adrenergic receptor was discovered and subsequently called the beta (3)-adrenoceptor (beta(3)-AR). Agonists of the beta(3)-AR were observed to simultaneously increase lipolysis, fat oxidation, energy expenditure and insulin action leading to the belief that this receptor might se...

journal_title：Current pharmaceutical design

authors： de Souza CJ,Burkey BF

更新日期：2001-09-01 00:00:00

abstract：:Hypertension and insomnia are very common and often coexist. There is evidence to suggest that the increasing prevalence of arterial hypertension in the past decade might be related both to an increased prevalence of insomnia and to the decline of sleep duration due to modern lifestyle. The aim of this paper is to rec...

journal_title：Current pharmaceutical design

authors： Palagini L,Bruno RM,Gemignani A,Baglioni C,Ghiadoni L,Riemann D

更新日期：2013-01-01 00:00:00

abstract：:There is extensive evidence that changes in immune system activation accompany the pathological changes of Alzheimer's disease (AD), but a mechanistic understanding of how the immune system actually participates in disease pathogenesis is still largely lacking. Because of the complexity of the immunological response, ...

journal_title：Current pharmaceutical design

authors： Nelson RB

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...

journal_title：Current pharmaceutical design

authors： Zhao Q,Zhang W,Wang R,Wang Y,Ouyang D

更新日期：2017-01-01 00:00:00

abstract：:Over the past decade, Lymphocyte Function-Associated Antigen-1 (LFA-1, alphaLbeta2, CD11a/CD18) has emerged as an attractive therapeutic target for the treatment of multiple inflammatory diseases. Its established role in the trafficking and activation of leukocytes coupled with the recent elucidation of the global con...

journal_title：Current pharmaceutical design

authors： Giblin PA,Lemieux RM

更新日期：2006-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained rhythm disturbance, increasing prevalence with age, in particular in patients with cardiovascular disease. On the other hand, a subset of patients with AF being <60 years old and no evidence of underlying cardiovascular disease, and laboratory tests including thyro...

journal_title：Current pharmaceutical design

authors： Tello-Montoliu A,Hernández-Romero D,Sanchez-Martínez M,Valdes M,Marín F

更新日期：2015-01-01 00:00:00