The Role of Solid State Characterization in Predicting Stability of Solid Dosage Forms.

abstract：:Arrhythmias in left ventricular hypertrabeculation/noncompaction (LVHT) comprise sustained or non-sustained ventricular tachycardia (VT) (n=135), atrial fibrillation (AF) (n=96) AV block (n=55) and QT prolongation (n=47). The prevalence differs between children and adults. In children most frequent are WPW-syndrome (n...

journal_title：Current pharmaceutical design

authors： Stöllberger C,Finsterer J

更新日期：2010-01-01 00:00:00

abstract：:Androgen receptor (AR) is a steroid hormone receptor that is activated by endogenous androgens, mainly testosterone and 5alpha-dihydrotestosterone (5alpha-DHT). AR is also an important drug target, and AR antagonists (antiandrogens) have been widely used for prostate cancer therapy. Antiandrogens currently available o...

journal_title：Current pharmaceutical design

authors： Gao W

更新日期：2010-01-01 00:00:00

abstract：:Rapid increase in the emergence and spread of microbes resistant to conventionally used antibiotics has become a major threat to global health care. Antimicrobial peptides (AMPs) are considered as a potential source of novel antibiotics because of their numerous advantages such as broad-spectrum activity, lower tenden...

journal_title：Current pharmaceutical design

authors： Lohan S,Bisht GS

更新日期：2013-01-01 00:00:00

abstract：:Benzodiazepines (BZs) have been widely investigated in terms of clinical efficacy, factors underlying dependence, associated cognitive impairments, and interactions with psychotherapy for anxiety control. However, few studies have systematically considered manner of BZ administration in relation to these variables. St...

journal_title：Current pharmaceutical design

authors： Westra HA,Stewart SH

更新日期：2002-01-01 00:00:00

abstract：:The discovery of the delicate role of endogenous nitric oxide in the homeostasis of various cellular functions and the dynamic behaviour of the airways, has led to a new, rapidly progressing area of physiological science, that has direct bearing for our understanding of multiple airway diseases. The potentially protec...

journal_title：Current pharmaceutical design

authors： Folkerts G,Nijkamp FP

更新日期：2006-01-01 00:00:00

abstract：:Development of effective drug delivery systems is important for medicine and healthcare. Polymer particulates (micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming various limitations of conventional delivery methods. The properties of polymeric particles can be readily t...

journal_title：Current pharmaceutical design

authors： Kaur H,Kumar V,Kumar K,Rathor S,Kumari P,Singh J

更新日期：2016-01-01 00:00:00

abstract：:Ablation has become an important treatment for many pediatric patients with common supraventricular tachycardias (SVTs). Many multicenter studies have documented that radiofrequency (RF) catheter ablation is a safe and effective procedure for treatment of a large variety of SVTs in children and adults with a high succ...

journal_title：Current pharmaceutical design

authors： De Santis A,Fazio G,Silvetti MS,Drago F

更新日期：2008-01-01 00:00:00

abstract：:Unhealthy diet and alcohol are serious health problems, especially in adolescents and young adults. "Binge" is defined as the excessive and uncontrolled consumption of food (binge eating) and alcohol (binge drinking). Both behaviors are frequent among young people and have a highly negative impact on health and qualit...

journal_title：Current pharmaceutical design

authors： Escrivá-Martínez T,Herrero R,Molinari G,Rodríguez-Arias M,Verdejo-García A,Baños RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Loss of olfaction can cause noticeable reduction in general quality of life. Only a small portion of patients with olfactory loss respond to current medications. Thus, development of novel therapeutic strategies seems to be necessary. Looking into traditional medical knowledge can be of great value in addres...

journal_title：Current pharmaceutical design

authors： Sinaei F,Emami SA,Sahebkar A,Javadi B

更新日期：2017-01-01 00:00:00

abstract：:This review will focus on the construction, refinement, and validation of G Protein-coupled receptor models for the purpose of structure-based virtual screening. Practical tips and tricks derived from concrete modeling and virtual screening exercises to overcome the problems and pitfalls associated with the different ...

journal_title：Current pharmaceutical design

authors： de Graaf C,Rognan D

更新日期：2009-01-01 00:00:00

abstract：:All common contributing factors to epilepsy such as trauma, malignancies and infections are accompanied by different levels of central nervous system inflammation that in turn have been associated with the occurrence of seizure. Emerging data from human brain tissue and experimental models of epilepsy support the prop...

journal_title：Current pharmaceutical design

authors： Lorigados Pedre L,Morales Chacón LM,Orozco Suárez S,Pavón Fuentes N,Estupiñán Díaz B,Serrano Sánchez T,García Maeso I,Rocha Arrieta L

更新日期：2013-01-01 00:00:00

abstract：:In recent years several new drugs (oxcarbazepine, lamotrigine, topiramate, gabapentin, zonisamide, tiagabine, fosphenytoin, vigabatrin and felbamate) have been added to the therapeutic armamentarium against epilepsy. Some of these represent structural modifications of pre-existing compounds, others were developed with...

journal_title：Current pharmaceutical design

authors： Gatti G,Bonomi I,Jannuzzi G,Perucca E

更新日期：2000-05-01 00:00:00

abstract：:Atherosclerosis is an inflammatory vascular disease that is characterized by progressive accumulation of cholesterol in the arterial walls and it is a major cause of cardiovascular disease. Issues related to the side effects of synthetic drugs have in recent times, led to the misuse of drugs, a lack of patient consult...

journal_title：Current pharmaceutical design

authors： Gholipour S,Sewell RDE,Lorigooini Z,Rafieian-Kopaei M

更新日期：2018-01-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors represent one of the most commonly used categories of drugs in canine and feline medicine. ACE inhibitors currently approved for use in veterinary medicine are benazepril, enalapril, imidapril and ramipril. They are all pro-drugs administered by oral route. A physiologica...

journal_title：Current pharmaceutical design

authors： Lefebvre HP,Brown SA,Chetboul V,King JN,Pouchelon JL,Toutain PL

更新日期：2007-01-01 00:00:00

abstract：:Cyclooxygenase-1 (COX-1) derived eicosanoids promote gastroprotective mucosal defenses and induce platelet aggregation. By sparing COX-1, COX-2 specific inhibitors provide effective anti-inflammatory and analgesic activity while substantially reducing the risk of peptic ulcer disease and GI bleeding compared to dual C...

journal_title：Current pharmaceutical design

authors： Scheiman JM

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:A wide class of human diseases and neurodegenerative disorders, such as Alzheimer's disease, is due to the failure of a specific peptide or protein to keep its native functional conformational state and to undergo a conformational change into a misfolded state, triggering the formation of fibrillar cross-β s...

journal_title：Current pharmaceutical design

authors： Ruggeri FS,Habchi J,Cerreta A,Dietler G

更新日期：2016-01-01 00:00:00

abstract：:G protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-...

journal_title：Current pharmaceutical design

authors： Ciccarelli M,Cipolletta E,Iaccarino G

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal li...

journal_title：Current pharmaceutical design

authors： Su H,Liu D,Shao J,Li Y,Wang X,Gao Q

更新日期：2020-01-01 00:00:00

abstract：:Psoriasis is an immune-mediated, chronic and recurrent inflammatory skin disease, prevalent worldwide, and represents an important burden in life quality of patients. The most common clinical variant is termed as psoriasis vulgaris or plaque psoriasis, which with an individualized and carefully monitored therapy can d...

journal_title：Current pharmaceutical design

authors： Bruschi ML,da Silva JB,Rosseto HC

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is marked by cognitive dysfunctions and existence of neuropathological hallmarks such as amyloid plaques, and neurofibrillary tangles. It has been observed that a persistent immune response in the brain has appeared as another neuropathological hall...

journal_title：Current pharmaceutical design

authors： Uddin MS,Kabir MT,Al Mamun A,Behl T,Mansouri RA,Aloqbi AA,Perveen A,Hafeez A,Ashraf GM

更新日期：2020-05-31 00:00:00

abstract：BACKGROUND:Glioma is the most common human central nervous system tumour with a high degree of malignancy. Some Rab GTPases have significant effects on glioma. OBJECTIVE:This study aimed to investigate the effect of Rab3b (Rab GTPase3b) on human glioma cell proliferation and apoptosis by silencing Rab3b and to initial...

journal_title：Current pharmaceutical design

authors： Luo Q,Liu Y,Yuan Z,Huang L,Diao B

更新日期：2020-09-17 00:00:00

abstract：:The development of radioligands to image beta-amyloid (A beta) plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and active area of radiopharmaceutical design. When used in combination with positron emission tomography (Pet) or single photon emission computed tomography (spect...

journal_title：Current pharmaceutical design

authors： Mathis CA,Wang Y,Klunk WE

更新日期：2004-01-01 00:00:00

abstract：:Depression is one of the most common psychiatric conditions affecting numerous individuals in the world. However, the currently available antidepressant medication shows low response and remission rates. Thus, new antidepressants need to be discovered or developed. Aiming to describe the current neurobiological hypoth...

journal_title：Current pharmaceutical design

authors： Kern N,Sheldrick AJ,Schmidt FM,Minkwitz J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cancer and its treatment therapies, such as chemotherapy and radiotherapy, have negative effects on taste and smell functions. It is easy to explain smell and taste dysfunctions when a cancer involves the peripheric end organs or neurologic pathways of smell and taste. However, it is difficult to understand ...

journal_title：Current pharmaceutical design

authors： Altundag A,Cayonu M

更新日期：2016-01-01 00:00:00

abstract：:The involvement of the central nervous system (CNS) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients and the less understood aspect of the disease. Its recognition and treatment continue to represent a major diagnostic and therapeutic challenge. Due to the lack of co...

journal_title：Current pharmaceutical design

authors： Sanna G,Bertolaccini ML,Khamashta MA

更新日期：2008-01-01 00:00:00

abstract：:DARPins (designed ankyrin repeat proteins), new kinds of binding proteins, have the potential to overcome the defects of monoclonal antibodies, and hence may become the alternatives to antibodies and generate a novel therapeutic approach. DARPins can be selected to bind any given target proteins with high affinity and...

journal_title：Current pharmaceutical design

authors： Wu X,Shi Y,Ren P,Wang D,Li G

更新日期：2013-01-01 00:00:00

abstract：:Although acute renal graft rejection rate has declined in the last years, and because an adequate therapy can improve graft outcome, its therapy remains as one of the most significant challenges for pharmacists and physicians taking care of transplant patients. Due to the lack of evidence highlighted by the available ...

journal_title：Current pharmaceutical design

authors： Rodrigo E,Chedid MF,Segundo DS,Millán JCRS,López-Hoyos M

更新日期：2020-01-01 00:00:00

abstract：:Ischaemic stroke of the brain accounts for about one third of all deaths in industrialized countries. Many of the patients who survive are severily impaired. Thus, there is an enormous need for pharmacotherapy for the treatment of ischaemic stroke. Why is such a treatment not available yet? Are the pathophysiological ...

journal_title：Current pharmaceutical design

authors： Weiser T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Heat shock proteins are powerful endogenous cytoprotective proteins which help cells to survive recurrent cellular stress events. Identifying the underlying molecular mechanisms and molecular targets is especially interesting since it may help to develop new therapeutic strategies for the treatment of diseas...

journal_title：Current pharmaceutical design

authors： Golenhofen N,Bartelt-Kirbach B

更新日期：2016-01-01 00:00:00

abstract：:Immunotoxins (ITs) are protein-based drugs combining a target-specific binding domain (usually derived from an antibody) and a cytotoxic domain to kill target cells. They are among the most promising new therapeutic tools to fight cancer, and several clinical trials have been completed with encouraging results. Althou...

journal_title：Current pharmaceutical design

authors： Hetzel C,Bachran C,Tur MK,Fuchs H,Stöcker M

更新日期：2009-01-01 00:00:00