Chemical Senses in Cancer Patients.

abstract：:There is a high rate of benzodiazepine use in the population. Benzodiazepines are used for multiple indications (anxiety, seizures, alcohol withdrawal, muscular relaxation and anesthesia). Benzodiazepines are also addictive substances and a non-negligible fraction of regular users will develop dependence. There is cur...

journal_title：Current pharmaceutical design

authors： Sabioni P,Bertram J,Le Foll B

更新日期：2015-01-01 00:00:00

abstract：:MNPs find numerous important biomedical applications owing to their high biocompatibility and unique magnetic properties at the bottom level. Among several other biomedical applications, MNPs are gaining importance in treating various kinds of cancer either as a hyperthermia agent alone or as a drug/gene carrier for s...

journal_title：Current pharmaceutical design

authors： T S A,Shalumon KT,Chen JP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:A substantial part of literature has been centered on sex differences in the clinical aspects of ischemic heart disease (IHD). Many reports have documented differences in the presentation and risk profile between women and men. Such differences drive sex-related inequalities in the referral and treatment of ...

journal_title：Current pharmaceutical design

authors： Cenko E,Bugiardini R

更新日期：2016-01-01 00:00:00

abstract：:In recent years, new strategies in cancer therapy have been developed targeting key signaling molecules in the receptor tyrosine kinase signal transduction pathway. In contrast, most therapeutical concepts to manipulate G protein-coupled receptors (GPCR)-mediated disorders are still limited to the use of receptor-spec...

journal_title：Current pharmaceutical design

authors： Liebmann C

更新日期：2004-01-01 00:00:00

abstract：:Abnormal regulation of the ubiquitin-proteasome system (UPS) has been known to be involved in the pathogenesis of a variety of human diseases. A number of studies have focused on the identification of small modifiers for the UPS. Even though the proteasome inhibitor Bortezomib (Velcade®) has been approved for the ther...

journal_title：Current pharmaceutical design

authors： Lim KH,Baek KH

更新日期：2013-01-01 00:00:00

abstract：:Marine fungi with their successful pharmacological effects were considered to be the treasure of ocean medicines concerning the striking ability of their secondary metabolites. Literature over literature has been published on fungi derived bioactive molecules to probe its therapeutic potential. Marine fungi have an im...

journal_title：Current pharmaceutical design

authors： Shams Ul Hassan S,Ishaq M,Zhang WD,Jin HZ

更新日期：2020-07-28 00:00:00

abstract：:Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. Th...

journal_title：Current pharmaceutical design

authors： Capuron L,Geisler S,Kurz K,Leblhuber F,Sperner-Unterweger B,Fuchs D

更新日期：2014-01-01 00:00:00

abstract：:The nanodelivery of therapeutics into the brain will require a step-change in thinking; overcoming the blood brain barrier is one of the major challenges to any neural therapy. The promise of nanotechnology is that the selective delivery of therapeutics can be delivered through to the brain without causing secondary d...

journal_title：Current pharmaceutical design

authors： Ellis-Behnke RG,Teather LA,Schneider GE,So KF

更新日期：2007-01-01 00:00:00

abstract：:Inhaled glucocorticoids, also know as corticosteroids (ICS), revolutionized the treatment of asthma by suppressing airways inflammation and ICS therapy now forms the basis of treatment of asthma of all severities. More recently and usually in combination with a long-acting β-agonist (LABA), ICS use has been establishe...

journal_title：Current pharmaceutical design

authors： Adcock IM,Marwick J,Casolari P,Contoli M,Chung KF,Kirkham P,Papi A,Caramori G

更新日期：2010-01-01 00:00:00

abstract：:Several lines of evidence support a mutual relationship between the nervous system and the immune system. Therefore, it is not surprising that some neuropsychiatric disorders are also characterized by immune abnormalities. In patients with phobic disorders and in patients with migraine without aura some common immune ...

journal_title：Current pharmaceutical design

authors： Covelli V,Pellegrino NM,Jirillo E

更新日期：2003-01-01 00:00:00

abstract：:Following injury, as part of the wound-healing process, cell proliferation occurs mostly to replace damaged cells and to reconstitute the tissue back to normal condition/function. In the spinal cord some of the dividing cells following injury interfere with the repair processes. This interference occurs at the later s...

journal_title：Current pharmaceutical design

authors： Kalderon N

更新日期：2005-01-01 00:00:00

abstract：:The analysis of enantiorecognition processes involves the detection of enantiomeric species as well as the study of chiral discrimination mechanisms. In both fields Nuclear Magnetic Resonance (NMR) spectroscopy plays a fundamental role, providing several tools, based on the use of suitable chiral auxiliaries, for obse...

journal_title：Current pharmaceutical design

authors： Uccello-Barretta G,Balzano F,Salvadori P

更新日期：2006-01-01 00:00:00

abstract：:Rapid increase in the emergence and spread of microbes resistant to conventionally used antibiotics has become a major threat to global health care. Antimicrobial peptides (AMPs) are considered as a potential source of novel antibiotics because of their numerous advantages such as broad-spectrum activity, lower tenden...

journal_title：Current pharmaceutical design

authors： Lohan S,Bisht GS

更新日期：2013-01-01 00:00:00

abstract：:DNA methylation is an important regulatory component which influences phenotypes by modulating gene expression. Changes in DNA methylation may lead to altered phenotypes and ability of an organism to respond to stress leading to subsequent manifestation of life style diseases, cancer, etc. The human X chromosome repre...

journal_title：Current pharmaceutical design

authors： Rajpathak SN,Deobagkar DD

更新日期：2014-01-01 00:00:00

abstract：:Apoptosis is a regulated process leading to cell death, which is implicated both in normal development and in various pathologies including heart failure, stroke and neurodegenerative diseases. Caspase-3, a key enzyme of the apoptotic pathway, is considered as a major target for the treatment of abnormal cell death. M...

journal_title：Current pharmaceutical design

authors： Seaborn T,Masmoudi-Kouli O,Fournier A,Vaudry H,Vaudry D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:There is a strong rationale for usage of anti-angiogenic agents in epithelial ovarian cancer. Bevacizumab is the most widely investigated anti-VEGF agent and has shown promising results in recent clinical trials. OBJECTIVE:To review the rationale and usage of bevacizumab in advanced epithelial ovarian cance...

journal_title：Current pharmaceutical design

authors： Kroep JR,Nortier JW

更新日期：2012-01-01 00:00:00

abstract：:The development of radioligands to image beta-amyloid (A beta) plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and active area of radiopharmaceutical design. When used in combination with positron emission tomography (Pet) or single photon emission computed tomography (spect...

journal_title：Current pharmaceutical design

authors： Mathis CA,Wang Y,Klunk WE

更新日期：2004-01-01 00:00:00

abstract：:New biopharmaceutical molecules, potentially able to provide more personalized and effective treatments, are being identified through the advent of advanced synthetic biology strategies, sophisticated chemical synthesis approaches, and new analytical methods to assess biological potency. However, translation of many o...

journal_title：Current pharmaceutical design

authors： Munsell EV,Ross NL,Sullivan MO

更新日期：2016-01-01 00:00:00

abstract：:The state-of-the-art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for e...

journal_title：Current pharmaceutical design

authors： Doadrio AL,Salinas AJ,Sánchez-Montero JM,Vallet-Regí M

更新日期：2015-01-01 00:00:00

abstract：:Neuregulin1 proteins (NRG1s) are epidermal growth factor (EGF) family members which are ligands for the ErbB receptor tyrosine kinases (RTKs). A decade of research has revealed that the NRG1-ErbB signaling is essential for the cardiac development and pivotal for maintaining the physiological function of the adult hear...

journal_title：Current pharmaceutical design

authors： Yan X,Morgan JP

更新日期：2011-01-01 00:00:00

abstract：:Hyperuricemia, has been traditionally related to nephrolithiasis and gout. However, it has also been associated with the development of type 2 diabetes mellitus (T2DM) and cardiometabolic and cardiovascular diseases. Pathophysiologically, elevated serum uric acid (SUA) levels may be associated with abnormal lipid and ...

journal_title：Current pharmaceutical design

authors： Katsiki N,Dimitriadis GD,Mikhailidis DP

更新日期：2021-01-04 00:00:00

abstract：:Protein palmitoylation is a fundamental and reversible post-translational lipid modification that involves a series of biological processes. Although a large number of experimental studies have explored the molecular mechanism behind the palmitoylation process, the computational methods has attracted much attention fo...

journal_title：Current pharmaceutical design

authors： Li Y,Pu F,Wang J,Zhou Z,Zhang C,He F,Ma Z,Zhang J

更新日期：2020-11-12 00:00:00

abstract：:Monoclonal antibodies have undergone a radical evolutionary journey over the last 25 years, with advances in molecular biology, process development and drug formulation underpinning their rise to becoming one of the most efficacious and economically important class of drug today. The success of antibodies for the trea...

journal_title：Current pharmaceutical design

authors： Lowe DC,Vaughan TJ

更新日期：2015-01-01 00:00:00

abstract：:In the last two decades the development of efficient plant-based expression strategies and new concepts for the purification of recombinant proteins prompted the application of plant-derived vaccines for veterinary purposes. The expression of recombinant proteins in plants possesses advantages over conventional eukary...

journal_title：Current pharmaceutical design

authors： Phan HT,Floss DM,Conrad U

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Glioma is the most common human central nervous system tumour with a high degree of malignancy. Some Rab GTPases have significant effects on glioma. OBJECTIVE:This study aimed to investigate the effect of Rab3b (Rab GTPase3b) on human glioma cell proliferation and apoptosis by silencing Rab3b and to initial...

journal_title：Current pharmaceutical design

authors： Luo Q,Liu Y,Yuan Z,Huang L,Diao B

更新日期：2020-09-17 00:00:00

abstract：:Obesity was first described as a low-grade inflammatory condition more than a decade ago. However, it is only relatively recently that obese individuals have been described with increased macrophage infiltration of adipose tissue, as well as an increase in the number of "M1" or "classically activated" macrophages. Fur...

journal_title：Current pharmaceutical design

authors： Heilbronn LK,Campbell LV

更新日期：2008-01-01 00:00:00

abstract：:In recent years, Aβ aggregation prevention, one of the most concerned strategies in drug development has been carefully assessed to treat Alzheimer's disease. Aβ peptides can transform structurally from random coil monomer into β-stranded protofibril via multiple oligomeric states. Among the various Aβ species, the id...

journal_title：Current pharmaceutical design

authors： Tran L

更新日期：2018-01-01 00:00:00

abstract：:Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first st...

journal_title：Current pharmaceutical design

authors： Prieto JM,Silveira D

更新日期：2018-01-01 00:00:00

abstract：:The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. Ang II activates Ang II type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transm...

journal_title：Current pharmaceutical design

authors： Akazawa H,Yano M,Yabumoto C,Kudo-Sakamoto Y,Komuro I

更新日期：2013-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is one of the main endogenous pro-angiogenic cytokines. Inhibition of the VEGF signaling pathways is an effective treatment for cancer patients. In addition, local anti- VEGF therapy was developed and established to treat proliferative diabetic retinopathy, age-related macular...

journal_title：Current pharmaceutical design

authors： van der Giet M,Henkel C,Schuchardt M,Tolle M

更新日期：2015-01-01 00:00:00