AMPA receptor antagonists with additional mechanisms of action: new opportunities for neuroprotective drugs?

abstract：:Over the last several years, it has become increasingly clear that dendritic cells (DC) are not only critical for the initiation of T cell immunity, but these cells also determine the course of the subsequent immune response (i.e. tolerance vs. immunity, Th1 vs. Th2). However, the mechanisms by which DC can influence ...

journal_title：Current pharmaceutical design

authors： Wan Y,Bramson J

更新日期：2001-07-01 00:00:00

abstract：:Human heart has endogenous regenerative capability; however, the intrinsic repair mechanism is not sufficient to overcome the impact placed by adverse pathological conditions, such as myocardial infarction (MI). In such circumstances, the damaged tissue initiates a series of remodeling process which results in the det...

journal_title：Current pharmaceutical design

authors： Joshi J,Kothapalli CR

更新日期：2015-01-01 00:00:00

abstract：:The most important glycoproteins of trypanosomatids are anchored by glycoinositolphospholipids (GIPLs) to their plasma membrane. In addition, free GIPLs have been described, for instance the lipopeptidophosphoglycan (LPPG) which is a major component of the surface of T. cruzi epimastigotes. An inositolphosphoceramide ...

journal_title：Current pharmaceutical design

authors： Lederkremer RM,Bertello LE

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a promising therapeutic target in cancer. Recent studies have revealed an important role for CK2 in tumorigenesis. High levels of CK2 are noted in many malignancies including leukemia. Use of CK2 inhibitors in various malignancies includ...

journal_title：Current pharmaceutical design

authors： Gowda C,Sachdev M,Muthusami S,Kapadia M,Petrovic-Dovat L,Hartman M,Ding Y,Song C,Payne JL,Tan BH,Dovat S

更新日期：2017-01-01 00:00:00

abstract：:Packaging small-molecule drugs into nanoparticles improves their bio-availability, bio-compatibility and safety profiles. Multifunctional particles carrying large drug payloads for targeted transport, immune evasion and favourable drug release kinetics at the target site, require a certain minimum size usually 30-300 ...

journal_title：Current pharmaceutical design

authors： Debbage P

更新日期：2009-01-01 00:00:00

abstract：:Growth and metastasis of lung cancer requires a sequence of events, which alter the ability of neoplastic cells to adhere to themselves, to normal surrounding cells, or to the extracellular matrix. Interactions between cells are primarily mediated by four types of structures in the plasma membrane: gap junctions, tigh...

journal_title：Current pharmaceutical design

authors： Syrigos KN,Katirtzoglou N,Kotteas E,Harrington K

更新日期：2008-01-01 00:00:00

abstract：:LIM (Lin-11, Isl-1, Mec-3), RING (Really interesting new gene), PHD (Plant homology domain) and MYND (myeloid, Nervy, DEAF-1) domains are all zinc-binding domains that ligate two zinc ions. Unlike the better known classical zinc fingers, these domains do not bind DNA, but instead mediate interactions with other protei...

journal_title：Current pharmaceutical design

authors： Matthews JM,Bhati M,Lehtomaki E,Mansfield RE,Cubeddu L,Mackay JP

更新日期：2009-01-01 00:00:00

abstract：:Phytoestrogens are plant-derived compounds with estrogen-like activities. Certain foods such as soy-derived products are known to have high levels of phytoestrogens, and about 25% of commercial infant formulas used in the United States are soy-based. One of the most important phytoestrogens is the isoflavone genistein...

journal_title：Current pharmaceutical design

authors： You L

更新日期：2004-01-01 00:00:00

abstract：:This review will focus on the construction, refinement, and validation of G Protein-coupled receptor models for the purpose of structure-based virtual screening. Practical tips and tricks derived from concrete modeling and virtual screening exercises to overcome the problems and pitfalls associated with the different ...

journal_title：Current pharmaceutical design

authors： de Graaf C,Rognan D

更新日期：2009-01-01 00:00:00

abstract：:In recent years, nanosuspensions have been accepted as a valuable drug delivery system for poorly water-soluble drugs. Topdown and bottom-up technologies are the two main approaches for generating nanosuspensions. Several products manufactured by the top-down technologies have been successfully commercialized demonstr...

journal_title：Current pharmaceutical design

authors： Zhang X,Li LC,Mao S

更新日期：2014-01-01 00:00:00

abstract：:During the last decade immunomodulatory treatments have been shown to influence the natural course of multiple sclerosis (MS). However, demyelination in the central nervous system (CNS) still occurs and repair mechanisms are incomplete leading to neurological deficits. Currently, there is no therapy available to promo...

journal_title：Current pharmaceutical design

authors： Trebst C,Stangel M

更新日期：2006-01-01 00:00:00

abstract：:In the early 1980s, an "atypical" beta-adrenergic receptor was discovered and subsequently called the beta (3)-adrenoceptor (beta(3)-AR). Agonists of the beta(3)-AR were observed to simultaneously increase lipolysis, fat oxidation, energy expenditure and insulin action leading to the belief that this receptor might se...

journal_title：Current pharmaceutical design

authors： de Souza CJ,Burkey BF

更新日期：2001-09-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a group of aquired hematopoietic disorders characterized by ineffective hematopoiesis, and increased risk of progression of acute myeloid leukemia. For a long period of time, the standard therapy for MDS was hematopoietic stem cell transplantation, however DNA methyltransferase inhi...

journal_title：Current pharmaceutical design

authors： Tsujioka T,Matsuoka A,Tohyama Y,Tohyama K

更新日期：2012-01-01 00:00:00

abstract：:Although the obesity epidemic is constantly expanding at very high costs for health care systems, the currently available options for the pharmacotherapy of obesity are very limited. This is not due to lack of interest or research on the subject but rather to the poor efficacy and/or safety profile of the majority of ...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Brüning JC,Berthold HK

更新日期：2013-01-01 00:00:00

abstract：:Schizophrenia is a severe and frequent neuropsychiatric disorder. Despite antipsychotic medications, up to 30% of patients with schizophrenia still report disabling treatment-resistant symptoms. Transcranial direct current stimulation (tDCS) has been proposed as a novel method to alleviate such symptoms. Here, we revi...

journal_title：Current pharmaceutical design

authors： Mondino M,Brunelin J,Palm U,Brunoni AR,Poulet E,Fecteau S

更新日期：2015-01-01 00:00:00

abstract：:Over the last decade, much was learned about the biology of several types of stem and progenitor cells. It has become apparent that various cell sources may have the capacity to promote cardiomyogenesis and new blood vessel formation through different mechanisms, forming the rationale for cell-based therapy in patient...

journal_title：Current pharmaceutical design

authors： Rodrigo SF,Ramshorst Jv,Beeres SL,Bax JJ,Schalij MJ,Atsma DE

更新日期：2011-10-01 00:00:00

abstract：:Biochemical biomarkers are important candidates for the diagnosis and prognosis of neurological diseases of autoimmune etiology, since they may reflect the presence, nature and intensity of certain immune responses caused by both genetic and environmental processes. Different body fluids such as cerebrospinal fluid (C...

journal_title：Current pharmaceutical design

authors： Tumani H,Brettschneider J

更新日期：2012-01-01 00:00:00

abstract：:Humans have always lived with tubercle bacilli. Host susceptibility both inherited and acquired determines whether an individual infected with Mycobacterium tuberculosis will eventually fall ill and develop tuberculosis (TB). After infection with M. tuberculosis, a latent TB infection may ensue reflected by immune r...

journal_title：Current pharmaceutical design

authors： van Altena R,Duggirala S,Gröschel MI,van der Werf TS

更新日期：2011-01-01 00:00:00

abstract：:Lysine acetylation plays an essential role in metabolism. Five individual studies have identified that a large number of cellular proteins are potentially acetylated. Notably, almost every enzyme involved in central metabolic pathways such as glycolysis, the TCA cycle, fat acid metabolism, urea cycle and glycogen meta...

journal_title：Current pharmaceutical design

authors： Lin R,Zhou X,Huang W,Zhao D,Lv L,Xiong Y,Guan KL,Lei QY

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Breast cancer is the most frequently diagnosed malignancy in women worldwide. Breast cancer tends to metastasize to bone. Around 70% of the breast cancer patients eventually develop bone metastasis. After the bone invasion, metastatic cells disrupt the balance between osteoblastic and osteoclastic activities...

journal_title：Current pharmaceutical design

authors： Irshad I,Varamini P

更新日期：2018-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of disorders characterized by chronic inflammation within the gastrointestinal tract. It is a multifactorial disease associated with immune-cell mediated oxidative damage to the intestinal mucosa. There is no cure for IBD, but anti-cytokine therapy can limit target inflammat...

journal_title：Current pharmaceutical design

authors： Dostie KE,Thees AV,Lynes MA

更新日期：2018-01-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeated injury, such as hypertension and atherosclerosis. In contrast, fully differentiated, quiescent VSMC allow arterial vasodil...

journal_title：Current pharmaceutical design

authors： Isenović ER,Soskić S,Trpković A,Dobutović B,Popović M,Gluvić Z,Putniković B,Marche P

更新日期：2010-01-01 00:00:00

abstract：:The endocannabinoid system (ECS) is now recognised as an important modulator of various central nervous system processes. More recently, an increasing body of evidence has accumulated to suggest antioxidant, anti-inflammatory and neuroprotective roles of ECS. In this review we discuss the role and therapeutic potentia...

journal_title：Current pharmaceutical design

authors： Velayudhan L,Van Diepen E,Marudkar M,Hands O,Suribhatla S,Prettyman R,Murray J,Baillon S,Bhattacharyya S

更新日期：2014-01-01 00:00:00

abstract：:Management of hypertension has evolved steadily through 25 years of major clinical trials results modifying both the definition of hypertension and clinical management strategies. Trials experience in heart failure is much less extensive given the far smaller therapeutic market and traditionally often followed on the ...

journal_title：Current pharmaceutical design

authors： MacFadyen RJ,Lip GY,Davis R

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials. OBJECTIVE:The aim ...

journal_title：Current pharmaceutical design

authors： Guo Y,Chen B,Pei X,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:Sex-dependent differences are frequently observed in the biological and behavioural effects of substances of abuse, including cannabis. We recently demonstrated a modulating effect of sex and oestrous cycle on cannabinoid-taking and seeking behaviours. Here, we investigated the influence of sex and oestrogen in the re...

journal_title：Current pharmaceutical design

authors： Castelli MP,Fadda P,Casu A,Spano MS,Casti A,Fratta W,Fattore L

更新日期：2014-01-01 00:00:00

abstract：:Despite the significant progresses made in antiretroviral therapy, current drugs still cannot cure or prevent HIV infection. And all drugs continue to select for drug-resistant HIV strains. Consequently, new antiretroviral drugs are constantly being developed. To ensure safety, these drugs are usually designed to inhi...

journal_title：Current pharmaceutical design

authors： Provencher VM,Coccaro E,Lacasse JJ,Schang LM

更新日期：2004-01-01 00:00:00

abstract：:Coronary artery disease (CAD) ranks as the leading cause of death in the Western world. The most widely used therapeutics utilized for the treatment of CAD are the lipid-lowering drugs, which lower plasma cholesterol. However lowering cholesterol alone may not be sufficient to provide benefit to all patient population...

journal_title：Current pharmaceutical design

authors： Arad Y,Saxena U

更新日期：1999-01-01 00:00:00

abstract：:Histone lysine methylation can be modified by various writers and erasers. Different from other epigenetic modifications, mono-, di, and tri- methylation distinctly modulate chromatin structure and thereby contribute to the regulation of DNA-based nuclear processes such as transcription, replication and repair on thei...

journal_title：Current pharmaceutical design

authors： Zheng YC,Ma JL,Liu Y,Liu HM

更新日期：2016-01-01 00:00:00

abstract：:Extracellular matrix (ECM) is composed of large collagen fibrils. Glycoproteins, such as fibronectin, can bind to collagen or form their own networks. Collagen fibrils are also decorated by proteoglycans, proteins that have large glycosaminoglycan sidechains. In addition, extracellular space often contains hyaluronan,...

journal_title：Current pharmaceutical design

authors： Heino J,Käpylä J

更新日期：2009-01-01 00:00:00