Provoking neuroprotection by peroxynitrite.

abstract：BACKGROUND:A substantial part of literature has been centered on sex differences in the clinical aspects of ischemic heart disease (IHD). Many reports have documented differences in the presentation and risk profile between women and men. Such differences drive sex-related inequalities in the referral and treatment of ...

journal_title：Current pharmaceutical design

authors： Cenko E,Bugiardini R

更新日期：2016-01-01 00:00:00

abstract：:Diabetic patients are considered as high risk for development of atherosclerotic disease. Cholesterol treatment is of paramount importance in order to optimise cardiovascular outcomes in this subset of patients. Although statins are regarded as the mainstay of treatment, these may not be tolerated or as efficacious as...

journal_title：Current pharmaceutical design

authors： Felekos I,Karamasis GV,Pavlidis AN

更新日期：2020-06-17 00:00:00

abstract：:In recent years, our understanding of the molecular interaction of collagens with their cognate integrin receptors has remarkably improved. Structural elucidations of both the integrin and the collagenous triple helix have contributed to this achievement. The structures of an entire integrin ectodomain and of an A-dom...

journal_title：Current pharmaceutical design

authors： Eble JA

更新日期：2005-01-01 00:00:00

abstract：:Large doses of omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are used to treat several diseases including hypertriglyceridemia in humans. Modest levels of EPA and DHA may be obtained from food, particularly from fatty fish. This review presents the literature examining the differences ...

journal_title：Current pharmaceutical design

authors： Abete P,Testa G,Galizia G,Della-Morte D,Cacciatore F,Rengo F

更新日期：2009-01-01 00:00:00

abstract：:This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photos...

journal_title：Current pharmaceutical design

authors： Da Ros T,Spalluto G,Boutorine AS,Bensasson RV,Prato M

更新日期：2001-11-01 00:00:00

abstract：:Depression is one of the leading causes of disability in the world. Current pharmaceutical treatment for depression remains unsatisfactory due to its limited therapeutic efficacy and undesirable side effects. There is increasing interest in looking for alternative strategies from diet for the treatment of depressive d...

journal_title：Current pharmaceutical design

authors： Wang X,Zhao F,Wang X,Niu Y,Niu L,Wang C

更新日期：2018-01-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can self-renew indefinitely, while maintaining the capacity to differentiate into useful somatic cell types, including cardiomyocytes. As such, these stem cell types represent an essentially inexhaustible source of committed human cardiomyo...

journal_title：Current pharmaceutical design

authors： Shiba Y,Hauch KD,Laflamme MA

更新日期：2009-01-01 00:00:00

abstract：:The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published data on pharmacologica...

journal_title：Current pharmaceutical design

authors： Tarasov VV,Kudryashov NV,Chubarev VN,Kalinina TS,Barreto GE,Ashraf GM,Aliev G

更新日期：2018-01-01 00:00:00

abstract：:Inflammatory and infectious diseases include many different clinical conditions not often well recognised and characterized with conventional radiology and biochemical tests. Radiological techniques (TC, MRI, US) show anatomical changes that usually occur in chronic stages of the disease leading to a delayed diagnosis...

journal_title：Current pharmaceutical design

authors： Signore A,Lauri C,Galli F

更新日期：2014-01-01 00:00:00

abstract：:Natural product drugs that target the tubulin/microtubule system remain an important component in the therapeutic arsenal to treat many types of malignancies. Agents such as the taxanes and vinca alkaloids bind to beta-tubulin and disrupt microtubule dynamics by inducing a potent mitotic block and subsequent cell deat...

journal_title：Current pharmaceutical design

authors： Verrills NM,Kavallaris M

更新日期：2005-01-01 00:00:00

abstract：:We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective ...

journal_title：Current pharmaceutical design

authors： Tomljenovic L,Spinosa JP,Shaw CA

更新日期：2013-01-01 00:00:00

abstract：:CHD is one of the most common serious chronic conditions in postmenopausal women and leads to extremely high risk for recurrent myocardial infarction and death. On the basis of the currently available randomized clinical-trial results the role of conventional HRT for treatment and prevention of CHD is rapidly evolving...

journal_title：Current pharmaceutical design

authors： Francucci CM,Camilletti A,Boscaro M

更新日期：2005-01-01 00:00:00

abstract：:A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-C...

journal_title：Current pharmaceutical design

authors： Chen S,Luo H,Chen L,Chen J,Shen J,Zhu W,Chen K,Shen X,Jiang H

更新日期：2006-01-01 00:00:00

abstract：:Angiogenic eye disease is among the most common causes of blindness worldwide. Current treatment approaches are insufficiently effective and partially associated with significant adverse effects. From an investigational view, the eye provides an ideal setting to observe real-time and serial observations of angiogenesi...

journal_title：Current pharmaceutical design

authors： Wegewitz U,Göhring I,Spranger J

更新日期：2005-01-01 00:00:00

abstract：:Both high arterial blood pressure (BP) and elevated levels of fine particulate matter (PM2.5) air pollution have been associated with an increased risk for several cardiovascular (CV) diseases, including stroke, heart failure, and myocardial infarction. Given that PM2.5 and high BP are each independently leading risk ...

journal_title：Current pharmaceutical design

authors： Giorgini P,Di Giosia P,Grassi D,Rubenfire M,Brook RD,Ferri C

更新日期：2016-01-01 00:00:00

abstract：:Patients with diabetes mellitus (DM) type 2 have a high prevalence of coronary artery disease (CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Hyperglycemia, elevated free fatty acid, increased amount of circulating end-glucosylated serum products and insulin resistance are the main mechani...

journal_title：Current pharmaceutical design

authors： Tousoulis D,Kampoli AM,Papageorgiou N,Papaoikonomou S,Antoniades C,Stefanadis C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM)-induced airway injuries and chronic obstructive pulmonary disease (COPD) are characterized by chronic inflammation of the respiratory tract and share some similarities regarding the cellular and molecular mechanisms orchestrating airway destruction. Since available data regarding the immu...

journal_title：Current pharmaceutical design

authors： Panahi Y,Jadidi-Niaragh F,Jamalkandi SA,Ghanei M,Pedone C,Nikravanfard N,Nikravesh F,Sahebkar A

更新日期：2016-01-01 00:00:00

abstract：:Gestational diabetes mellitus is a common metabolic complication of pregnancy. Universal guidelines on gestational diabetes have been impeded by the long-term controversies on its definition and screening strategies. The prevalence of gestational diabetes is rising all over the world, is significantly influenced by et...

journal_title：Current pharmaceutical design

authors： Kousta E,Kontogeorgi A,Robinson S,Johnston DG

更新日期：2020-01-01 00:00:00

abstract：:Serotonin (5-HT) is one of the main transmitters in the nervous system. Serotonergic neurons in the raphe nuclei in the brainstem innervate most parts of the central nervous system including motoneurons in the spinal cord and brainstem. This review will focus on the modulatory role that 5-HT exerts on motoneurons and ...

journal_title：Current pharmaceutical design

authors： Perrier JF,Rasmussen HB,Christensen RK,Petersen AV

更新日期：2013-01-01 00:00:00

abstract：AIM:The effect of endovascular aneurysm repair in patients treated for abdominal aortic aneurysm has not been clearly defined. The objective of the present article was to provide a contemporary literature review and perform an analysis to determine the effect of EVAR on renal function in the early post-operative period...

journal_title：Current pharmaceutical design

authors： Nana P,Kouvelos G,Brotis A,Spanos K,Giannoukas A,Matsagkas M

更新日期：2019-01-01 00:00:00

abstract：:Fetal Alcohol Syndrome (FAS), the most severe manifestation of Fetal Alcohol Spectrum Disorder (FASD) is considered the leading non-hereditary cause of mental retardation and neurological deficit in the Western world. There lie a huge associated human cost to both FASD victims and their families and a considerable fin...

journal_title：Current pharmaceutical design

authors： Brennan D,Giles S

更新日期：2014-01-01 00:00:00

abstract：:Diabetes is an important metabolic disease affecting many organs and systems in the body. The nervous system is one of the body systems affected by diabetes and neuropathic complications are troublesome in diabetic patients with many consequences. As diabetes has deleterious influences almost on bodily systems, an int...

journal_title：Current pharmaceutical design

authors： Öztürk Y,Öztürk N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The use of aromatic plants to relief different illness is not a new therapy. Actually aromatic plants have been used for many centuries by different cultures around the world. Pharmacological studies provide scientific support to the traditional use of aromatic medicinal plants and aromatherapy; nevertheless...

journal_title：Current pharmaceutical design

authors： Maggio A,Rosselli S,Bruno M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a promising therapeutic target in cancer. Recent studies have revealed an important role for CK2 in tumorigenesis. High levels of CK2 are noted in many malignancies including leukemia. Use of CK2 inhibitors in various malignancies includ...

journal_title：Current pharmaceutical design

authors： Gowda C,Sachdev M,Muthusami S,Kapadia M,Petrovic-Dovat L,Hartman M,Ding Y,Song C,Payne JL,Tan BH,Dovat S

更新日期：2017-01-01 00:00:00

abstract：:Transforming growth factor-β family members, which include TGF-βs, activins and bone morphogenetic proteins (BMPs), play important roles in development and maintaining tissue homeostasis. The extracellular TGF-β family members signal across the plasmamembrane by activating type I and type II serine/threonine kinase re...

journal_title：Current pharmaceutical design

authors： de Gorter DJ,Jankipersadsing V,Ten Dijke P

更新日期：2012-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play a vital role in the onset and development of many diseases, including cancers. Emerging evidence shows that numerous miRNAs have the potential to be used as diagnostic biomarkers for cancers, and miRNA-based therapy may be a promising therapy for the treatment of malignant neoplasm. MicroRNA-14...

journal_title：Current pharmaceutical design

authors： Ma Y,Cao X,Shi G,Shi T

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:Heat shock proteins are powerful endogenous cytoprotective proteins which help cells to survive recurrent cellular stress events. Identifying the underlying molecular mechanisms and molecular targets is especially interesting since it may help to develop new therapeutic strategies for the treatment of diseas...

journal_title：Current pharmaceutical design

authors： Golenhofen N,Bartelt-Kirbach B

更新日期：2016-01-01 00:00:00

abstract：:ATP-binding cassette (ABC) transporters are a huge family of ATP-dependent transmembrane proteins whose main function is exporting or importing substances or molecules through the cell membranes, plasma cell membrane, or inner membranes in organelles. They fulfill these functions by maintaining cell integrity, metabol...

journal_title：Current pharmaceutical design

authors： Benadiba M,Maor Y

更新日期：2016-01-01 00:00:00

abstract：:From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics face a considerably higher risk of developing cardiovascular and cerebrovascular diseases. Both large and small blood vessels are susceptible to alterations from diabetes. Endothelial cell dysfunction associated with small ve...

journal_title：Current pharmaceutical design

authors： Huber JD

更新日期：2008-01-01 00:00:00

abstract：:Quinolines are nitrogen heterocyclic compounds ubiquitous in nature and largely used as a structural component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological prop...

journal_title：Current pharmaceutical design

authors： da Gama ANS,de Nazaré Correia Soeiro M

更新日期：2020-10-06 00:00:00