Importance of ABC Transporters in Drug Development.

abstract：:Retinoids (vitamin A and its analogs) exert profound effects on a wide variety of life processes, including morphogenesis and embryonic development. Several retinoids are also effective drugs for therapy of skin diseases and some types of cancer. However, the applicability of this class of compounds is limited by thei...

journal_title：Current pharmaceutical design

authors： Tzimas G,Nau H

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:In spite of considerable efforts of researchers the cancer deseases remain to be incurable and a percentage of cancer deseases in the structure of mortality increases every year. At that, high systemic toxicity of antitumor drugs hampers their effective use. Because of this fact, the development of nanosyste...

journal_title：Current pharmaceutical design

authors： Grushevskaya HV,Krylova NG

更新日期：2018-01-01 00:00:00

abstract：:In recent years, nanosuspensions have been accepted as a valuable drug delivery system for poorly water-soluble drugs. Topdown and bottom-up technologies are the two main approaches for generating nanosuspensions. Several products manufactured by the top-down technologies have been successfully commercialized demonstr...

journal_title：Current pharmaceutical design

authors： Zhang X,Li LC,Mao S

更新日期：2014-01-01 00:00:00

abstract：:The last decade, the number of health economic evaluations has increased substantially in the field of child psychiatry. The objective of the present paper is to offer an overview of economic evaluations of child psychiatric drug treatment. Major electronic databases, as well as abstract booklets from international cl...

journal_title：Current pharmaceutical design

authors： Schlander M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Heat shock proteins are powerful endogenous cytoprotective proteins which help cells to survive recurrent cellular stress events. Identifying the underlying molecular mechanisms and molecular targets is especially interesting since it may help to develop new therapeutic strategies for the treatment of diseas...

journal_title：Current pharmaceutical design

authors： Golenhofen N,Bartelt-Kirbach B

更新日期：2016-01-01 00:00:00

abstract：:The gut microbiota plays significant roles in the human body during all spheres' of life and influences innate immunity, promotes granulocyte signaling and provides resistance during pathogenic colonization of the gut; crucial for a healthy life. Antibiotics directly affect the gut microbiota that consequently alters ...

journal_title：Current pharmaceutical design

authors： Paul D,Manna S,Mandal SM

更新日期：2018-01-01 00:00:00

abstract：:An important goal of biomedical research is to translate basic research findings into practical clinical implementation. Despite the advances in the technology used in drug discovery, the development of drugs for central nervous system diseases remains challenging. The failure rate for new drugs targeting important ce...

journal_title：Current pharmaceutical design

authors： Morofuji Y,Nakagawa S

更新日期：2020-01-01 00:00:00

abstract：:The mechanisms of beneficial preventive and therapeutic effects achieved by traditional and complementary medicine are currently being deciphered in molecular medicine. Curcumin, a yellow-colored polyphenol derived from the rhizome of turmeric (Curcuma longa), influences a wide variety of cellular processes through th...

journal_title：Current pharmaceutical design

authors： Troselj KG,Kujundzic RN

更新日期：2014-01-01 00:00:00

abstract：:There is a plausible role for cytokines, brain-derived neurotrophic factor (BDNF), and their interaction in major depressive disorder's (MDD) etiology. This review includes (i) briefly defining cytokines, (ii) a discussion of theories for why they may affect brain function, (iii) cross-sectional associations between c...

journal_title：Current pharmaceutical design

authors： Lotrich F

更新日期：2012-01-01 00:00:00

abstract：:Naoxintong (NXT), a Chinese Materia Medica standardized product, extracted from 16 various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica sinennsis, Astragali Radix, is clinically effective in treating atherosclerosisrelated diseases. Here, we tested the hypothesis that the anti-...

journal_title：Current pharmaceutical design

authors： Zhao J,Zhu H,Wang S,Ma X,Liu X,Wang C,Zhao H,Fan S,Jin X,Zhao B,Zhao T,Jia L,Wang K,Zou Y,Hu K,Sun A,Ge J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Mitochondria are cellular organelles responsible for energy production, calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of apoptosis. All these functions are crucial for cardiac homeostasis, and may be impaired in chronic heart failure (CHF). Therefore, mitochondrial d...

journal_title：Current pharmaceutical design

authors： Aimo A,Borrelli C,Vergaro G,Piepoli MF,Caterina AR,Mirizzi G,Valleggi A,Raglianti V,Passino C,Emdin M,Giannoni A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates....

journal_title：Current pharmaceutical design

authors： Smits A,Thewissen L,Dereymaeker A,Dempsey E,Caicedo A,Naulaers G

更新日期：2017-01-01 00:00:00

abstract：:The cardiovascular system exhibits significant daily rhythms in physiologic processes (heart rate, blood pressure, cardiac contractility and function), and molecular gene and protein expression. An increasing number of clinical and experimental studies demonstrate the circadian system is an important underlying mechan...

journal_title：Current pharmaceutical design

authors： Reitz CJ,Martino TA

更新日期：2015-01-01 00:00:00

abstract：:Recent decades mark a great progress in the treatment of HIV infection. What was once a deadly disease is now a chronic infection. However, HIV-infected patients are prone to develop comorbidities, which severely affect their daily functions. For example, a large population of patients develop a variety of neurologica...

journal_title：Current pharmaceutical design

authors： Bertrand L,Nair M,Toborek M

更新日期：2016-01-01 00:00:00

abstract：:Although escape from tumor dormancy has long been recognized as an important problem in the treatment of cancer, the molecular and cellular regulators underlying this transition remain poorly understood. The inability of the cancer cells to induce a complete and successful process of angiogenesis can result in tumor d...

journal_title：Current pharmaceutical design

authors： Shaked Y,McAllister S,Fainaru O,Almog N

更新日期：2014-01-01 00:00:00

abstract：:Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS) play either harmful or beneficial role in biological systems. Beneficial effects of ROS include physiological roles in cellular responses against infectious agents and in several cellular signalling pathways. Harmful effects are due to high conc...

journal_title：Current pharmaceutical design

authors： Balsano C,Alisi A

更新日期：2009-01-01 00:00:00

abstract：:Aim of the presented study was to investigate the role of stromal derived factor 1 (SDF-1α) in mobilizing stem cells in combination with endothelial progenitor cell (EPC) transplantation in a regenerative strategy for myocardial infarction therapy in a murine ischemia/reperfusion model. Initially bone marrow was eradi...

journal_title：Current pharmaceutical design

authors： Schuh A,Konschalla S,Kroh A,Schober A,Marx N,Sonmez TT,Zenke M,Sasse A,Liehn EA

更新日期：2014-01-01 00:00:00

abstract：:Although somewhat controversial, there is good evidence that long-distance travel in general is a risk factor for venous thromboembolism, even in the absence of other risk factors. This is probably due to effects consequent to prolonged sitting but air travel in particular may be associated with risk factors other tha...

journal_title：Current pharmaceutical design

authors： Bradford A

更新日期：2007-01-01 00:00:00

abstract：:Thrombotic events occurring in either arteries or veins are the primary causes of fatal perioperative cardiovascular events. Risk factors for deep vein thrombosis, several of which are evidently associated with specific surgical procedures, are quite different from those for arterial thrombosis (e.g., aging or atheros...

journal_title：Current pharmaceutical design

authors： Azma T,Tuluc F,Ito T,Aoyama-Mani C,Kawahito S,Kinoshita H

更新日期：2014-01-01 00:00:00

abstract：:The study of natural sources such as plants, microorganisms and marine organisms has developed interest among the scientific community in recent years for their extensive and diverse chemical composition and consequent biological potential. The search for antitumor compounds is among the lead causes that justify phyto...

journal_title：Current pharmaceutical design

authors： Garcia C,Teodósio C,Oliveira C,Oliveira C,Díaz-Lanza A,Reis C,Duarte N,Rijo P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Nuts have been an indispensable component of the human diet for hundreds because of their unique nutrient composition and are thought to play a beneficial part in the prevention of cardiovascular diseases. OBJECTIVE:To evaluate the extent, validity and presence of evidence for studies investigating the impa...

journal_title：Current pharmaceutical design

authors： Schwingshackl L,Hoffmann G,Missbach B,Stelmach-Mardas M,Boeing H

更新日期：2017-01-01 00:00:00

abstract：:Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to antibiotics motivated by growing problems with multi-drug resistant pathogens. aPDT uses non-toxic dyes or photosensitizers (PS) in combination with harmless visible of the correct wavelength to be absorbed by the PS. The excited state PS can form...

journal_title：Current pharmaceutical design

authors： Sharma SK,Dai T,Kharkwal GB,Huang YY,Huang L,De Arce VJ,Tegos GP,Hamblin MR

更新日期：2011-01-01 00:00:00

abstract：:Protein palmitoylation is a fundamental and reversible post-translational lipid modification that involves a series of biological processes. Although a large number of experimental studies have explored the molecular mechanism behind the palmitoylation process, the computational methods has attracted much attention fo...

journal_title：Current pharmaceutical design

authors： Li Y,Pu F,Wang J,Zhou Z,Zhang C,He F,Ma Z,Zhang J

更新日期：2020-11-12 00:00:00

abstract：:Natural products have served humankind as drug leads for thousands of years. In the last century natural products have not only served as drugs but have inspired the generation of countless synthetic drugs and drug-leads around natural product pharmacophores. There are no disease targets for which natural products hav...

journal_title：Current pharmaceutical design

authors： Hamann MT

更新日期：2007-01-01 00:00:00

abstract：:Ischaemic stroke of the brain accounts for about one third of all deaths in industrialized countries. Many of the patients who survive are severily impaired. Thus, there is an enormous need for pharmacotherapy for the treatment of ischaemic stroke. Why is such a treatment not available yet? Are the pathophysiological ...

journal_title：Current pharmaceutical design

authors： Weiser T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction is commonly present in estrogen-deficient states, e.g., after menopause. In the search for alternatives to hormone replacement therapy (HRT), treatments based on phytoestrogens or in non-hormonal mechanisms have been under evaluation. OBJECTIVE:Here we aim to present an overview of i...

journal_title：Current pharmaceutical design

authors： Oliveira PWC,Couto MR,de Sousa GJ,Peixoto P,Moraes FSA,de Andrade TU,Bissoli NS

更新日期：2020-01-01 00:00:00

abstract：:The intestinal epithelium forms a barrier against the intestinal contents and the wider environment, allowing entry of selected molecules for nutrition and programming of the mucosal immune system, but excluding toxins and most microorganisms. Many receptors and signalling pathways are coupled and implicated in the ep...

journal_title：Current pharmaceutical design

authors： Talero E,Garcia-Maurino S,Motilva V

更新日期：2014-01-01 00:00:00

abstract：:Carboxylic acids are an important natural component as a final product or intermediates for syntheses. They are produced in plants, animals and also as products from biotechnological processes. This review presents the use of single hydroxide particles and layered double hydroxides as alternative adsorbents to remove ...

journal_title：Current pharmaceutical design

authors： Rodriguez LEG,Bail A,Castillo RO,Arízaga GGC

更新日期：2020-01-01 00:00:00

abstract：:Aspirin is the cornerstone of treatment in patients with coronary artery disease. However, several studies investigating the in vitro response of platelets to the administration of aspirin showed this response to be variable, with some patients exhibiting non-responsiveness or resistance. Aspirin resistance may be cat...

journal_title：Current pharmaceutical design

authors： Papathanasiou A,Goudevenos J,Tselepis AD

更新日期：2009-01-01 00:00:00

abstract：:Growth differentiation factor 5 (GDF5) is a member of the bone morphogenic protein (BMP) family and plays critical roles in organ development processes including bone, cartilage, ligament, and joint formation. GDF5 is expressed in the cartilage primordium in the early limb development, and in the interzone of joint fo...

journal_title：Current pharmaceutical design

authors： Jin L,Li X

更新日期：2013-01-01 00:00:00