The impact of diabetes mellitus on coronary artery disease: new therapeutic approaches.

abstract：:Virtual screening, especially the structure-based virtual screening, has emerged as a reliable, cost-effective and time-saving technique for the discovery of lead compounds. Here, the basic ideas and computational tools for virtual screening have been briefly introduced, and emphasis is placed on aspects of recent dev...

journal_title：Current pharmaceutical design

authors： Hou T,Xu X

更新日期：2004-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is one of the main endogenous pro-angiogenic cytokines. Inhibition of the VEGF signaling pathways is an effective treatment for cancer patients. In addition, local anti- VEGF therapy was developed and established to treat proliferative diabetic retinopathy, age-related macular...

journal_title：Current pharmaceutical design

authors： van der Giet M,Henkel C,Schuchardt M,Tolle M

更新日期：2015-01-01 00:00:00

abstract：:The incidence of diabetes has increased globally in recent years and figures of diabetic patients were estimated to rise up to 642 million by 2040. The disorder is accompanied with various complications if not managed at the early stages, and interlinked high mortality rate and morbidity with time. Different classes o...

journal_title：Current pharmaceutical design

authors： Usman B,Sharma N,Satija S,Mehta M,Vyas M,Khatik GL,Khurana N,Hansbro PM,Williams K,Dua K

更新日期：2019-01-01 00:00:00

abstract：:Fibrates are widely prescribed lipid-lowering drug in the treatment of dyslipidemia. Their main clinical effects, mediated by peroxisome proliferative activated receptor (PPAR) alpha activation, are a moderate reduction in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, a marked reduction in ...

journal_title：Current pharmaceutical design

authors： Ansquer JC,Foucher C,Aubonnet P,Le Malicot K

更新日期：2009-01-01 00:00:00

abstract：:This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photos...

journal_title：Current pharmaceutical design

authors： Da Ros T,Spalluto G,Boutorine AS,Bensasson RV,Prato M

更新日期：2001-11-01 00:00:00

abstract：:Mediation of antinociception via opioid receptors located in the periphery is a viable strategy to produce analgesia without the occurrence of side effects associated with stimulation of opioid receptors located in the central nervous system. Peripheral opioid receptors are particularly important in inflammatory pain ...

journal_title：Current pharmaceutical design

authors： DeHaven-Hudkins DL,Dolle RE

更新日期：2004-01-01 00:00:00

abstract：:Malignant tumors aberrantly overexpress various embryonic genes and proto-oncogenes, including a variety of cancer-testis antigens (CTAs). CTAs belong to a class of testis-derived proteins which are only expressed in germ cells in the male testis, and the expression of CTA genes is entirely silenced in the adult somat...

journal_title：Current pharmaceutical design

authors： Yang P,Huo Z,Liao H,Zhou Q

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Despite the limited evidence about the effect of micronutrient supplementation on the semen quality, many micronutrient supplements have been used to improve male fertility. Approximately, 40%-50% of male infertility cases in general and up to 80% in men with idiopathic infertility cases are caused by oxidat...

journal_title：Current pharmaceutical design

authors： Dimitriadis F,Tsounapi P,Zachariou A,Kaltsas A,Sokolakis I,Hatzichristodoulou G,Symeonidis EN,Kotsiris D,Gabales MR,Vlachopoulou E,Takenaka A,Sofikitis N

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Vagal nerve plays an important role in the stomach function. The cholinergic nerves are the most abundantly distributed nerves in the gastric tissue. It has recently been reported that the vagal nerve is significantly related to both gastric cancer development and progression. However, its relation to the me...

journal_title：Current pharmaceutical design

authors： Kodama Y,Sasaki K,Murasato F,Overby A,Takahashi S,Murayama SY,Matsui H,Nakamura M

更新日期：2018-01-01 00:00:00

abstract：:Peroxynitrite, the product of the reaction between nitric oxide and superoxide, is spontaneouly formed within most mammalian cells under physiological conditions. Initial work addressing the pathophysiology of peroxynitrite afforded the generally accepted notion that this compound would be the long-term neurotoxic nit...

journal_title：Current pharmaceutical design

authors： Bolanos JP,García-Nogales P,Almeida A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Virtual Screening methodologies have emerged as efficient alternatives for the discovery of new drug candidates. At the same time, ensemble methods are nowadays frequently used to overcome the limitations of employing a single model in ligand-based drug design. However, many applications of ensemble methods ...

journal_title：Current pharmaceutical design

authors： Helguera AM,Perez-Castillo Y,D S Cordeiro MN,Tejera E,Paz-Y-Miño C,Sánchez-Rodríguez A,Teijeira M,Ancede-Gallardo E,Cagide F,Borges F,Cruz-Monteagudo M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, a leading cause of death and disability in developed countries. Therapeutic options are notably limited. There is no specific pharmacological treatment, and early surgery has few indications that represent only a small clinically relevant s...

journal_title：Current pharmaceutical design

authors： Pías-Peleteiro J,Campos F,Perez-Mato M,Lopez-Arias E,Rodriguez-Yanez M,Castillo J,Sobrino T

更新日期：2017-01-01 00:00:00

abstract：:There is an increased use of oral anticoagulants for the prevention of venous and arterial thrombosis. Vitamin-K antagonists have been used for decades as the main oral anticoagulants but they have the draback a complex therapeutic management, slow onset of action and by a different oral intake caused by dietary vitam...

journal_title：Current pharmaceutical design

authors： Lamperti M,Khozenko A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：:A large body of evidence has accumulated indicating involvement of oxidative stress (OS) in the mode of action of various bioactive substances, including those of the immune system. The data for anticancer drugs (main and miscellaneous) are summarized herein. Although diverse origins pertain, reactive oxygen species (...

journal_title：Current pharmaceutical design

authors： Kovacic P,Osuna JA Jr

更新日期：2000-02-01 00:00:00

abstract：:The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. Ang II activates Ang II type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transm...

journal_title：Current pharmaceutical design

authors： Akazawa H,Yano M,Yabumoto C,Kudo-Sakamoto Y,Komuro I

更新日期：2013-01-01 00:00:00

abstract：:The last decade, the number of health economic evaluations has increased substantially in the field of child psychiatry. The objective of the present paper is to offer an overview of economic evaluations of child psychiatric drug treatment. Major electronic databases, as well as abstract booklets from international cl...

journal_title：Current pharmaceutical design

authors： Schlander M

更新日期：2010-01-01 00:00:00

abstract：:Curcumin is a natural polyphenol product derived from the rhizome of the Curcuma longa. In vivo and in vitro studies have uncovered many important bioactivities of curcumin, such as antioxidant activity, inducing cell apoptosis, inhibiting cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti...

journal_title：Current pharmaceutical design

authors： Fan X,Zhang C,Liu DB,Yan J,Liang HP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There are controversial results available about using angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) and the development of cancers or improvement of clinical outcomes. Studies reported that using ACEI/ARB may enhance the development of hepatocellular carcinoma (HCC...

journal_title：Current pharmaceutical design

authors： Asgharzadeh F,Jafarzadeh-Esfehani R,Hassanian SM,Ferns GA,Avan A,Khazaei M

更新日期：2020-01-01 00:00:00

abstract：:Reduction strategies of blood pressure, as a modifiable cardiovascular risk, are currently based on office assessment of brachial artery blood pressure. However, antihypertensive treatment based on brachial BP values reduces cardiovascular risk but cannot completely reverse the hypertension-induced risk of morbidity e...

journal_title：Current pharmaceutical design

authors： Rinaldi ER,Yannoutsos A,Borghi C,Safar ME,Blacher J

更新日期：2015-01-01 00:00:00

abstract：:Protein palmitoylation is a fundamental and reversible post-translational lipid modification that involves a series of biological processes. Although a large number of experimental studies have explored the molecular mechanism behind the palmitoylation process, the computational methods has attracted much attention fo...

journal_title：Current pharmaceutical design

authors： Li Y,Pu F,Wang J,Zhou Z,Zhang C,He F,Ma Z,Zhang J

更新日期：2020-11-12 00:00:00

abstract：:Current antiretroviral therapy has had a significant impact on HIV associated morbidity and mortality. Despite these positive outcomes current antiretroviral regimens have significant deficiencies which include multiple drug-drug interactions, high pill burdens, and considerable financial expense. Perhaps the greatest...

journal_title：Current pharmaceutical design

authors： Romanelli F,Hoven AD

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the elderly. The increase of life-expectancy is transforming AD into a major health-care problem. AD is characterized by a progressive impairment of memory and other cognitive skills leading to dementia. The major pathogenic factor ass...

journal_title：Current pharmaceutical design

authors： Agostinho P,Cunha RA,Oliveira C

更新日期：2010-01-01 00:00:00

abstract：:Lowering low density lipoprotein (LDL) - cholesterol is one of the key issues in modern preventive cardiology by which we are able to interact with the natural course of atherosclerosis. Diet and healthy life style are mandatory for the treatment of CAD high risk patients. Numerous lipid lowering trials confirmed the ...

journal_title：Current pharmaceutical design

authors： Schaefer JR

更新日期：2011-01-01 00:00:00

abstract：:Mechanical loading provides an anabolic stimulus for bone. More importantly, the mechanosensing apparatus in bone directs osteogenesis to where it is most needed for improving bone strength. The biological processes involved in bone mechanotransduction are poorly understood and further investigation of the molecular m...

journal_title：Current pharmaceutical design

authors： Turner CH,Robling AG

更新日期：2004-01-01 00:00:00

abstract：:The typical way of judging about either the efficacy of a new treatment or, on the contrary, the damage of a pollutant agent is through a test of hypothesis having its ineffectiveness as null hypothesis. This is the typical operational field of Kolmogorov's statistical framework where wastes of data (for instance non ...

journal_title：Current pharmaceutical design

authors： Apolloni B,Bassis S,Gaito S,Malchiodi D

更新日期：2007-01-01 00:00:00

abstract：:There is a high rate of benzodiazepine use in the population. Benzodiazepines are used for multiple indications (anxiety, seizures, alcohol withdrawal, muscular relaxation and anesthesia). Benzodiazepines are also addictive substances and a non-negligible fraction of regular users will develop dependence. There is cur...

journal_title：Current pharmaceutical design

authors： Sabioni P,Bertram J,Le Foll B

更新日期：2015-01-01 00:00:00

abstract：:A recent meta-analysis showed that the mean age of onset of psychosis among cannabis users was almost three years earlier than that of non-cannabis users. However, because cannabis users usually smoke tobacco, the use of tobacco might independently contribute to the earlier onset of psychosis. We aimed to use meta-ana...

journal_title：Current pharmaceutical design

authors： Myles N,Newall H,Nielssen O,Large M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hydrogen gas (H2 ) has entered the world of experimental therapeutics approximately four and a half decades ago. Over the years, this simple molecule appears to drive more and more scientific attention perhaps due to a dualism of H2 affirmative features demonstrated in numerous in vitro, animal and human stu...

journal_title：Current pharmaceutical design

authors： Ostojic SM

更新日期：2020-09-22 00:00:00

abstract：:Diabetic patients are considered as high risk for development of atherosclerotic disease. Cholesterol treatment is of paramount importance in order to optimise cardiovascular outcomes in this subset of patients. Although statins are regarded as the mainstay of treatment, these may not be tolerated or as efficacious as...

journal_title：Current pharmaceutical design

authors： Felekos I,Karamasis GV,Pavlidis AN

更新日期：2020-06-17 00:00:00

abstract：:The need to identify and characterize vulnerable atherosclerotic lesions in humans has lead to the development of various animal models of plaque vulnerability. In this review, current concepts of the vulnerable plaque as it leads to an acute coronary event are described, such as plaque rupture, erosion, intraplaque h...

journal_title：Current pharmaceutical design

authors： Schapira K,Heeneman S,Daemen MJ

更新日期：2007-01-01 00:00:00