Endothelial Progenitor Cells as a Therapeutic Approach for Intracerebral Hemorrhage.

abstract：:Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeated injury, such as hypertension and atherosclerosis. In contrast, fully differentiated, quiescent VSMC allow arterial vasodil...

journal_title：Current pharmaceutical design

authors： Isenović ER,Soskić S,Trpković A,Dobutović B,Popović M,Gluvić Z,Putniković B,Marche P

更新日期：2010-01-01 00:00:00

abstract：:Severe sepsis leading to shock is the principal cause of death in intensive care units. It is a systemic inflammatory response caused by excessive secretion of pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNFalpha) and reactive oxygen species (ROS), mainly induced by endotoxin (a major component of...

journal_title：Current pharmaceutical design

authors： Victor VM,Rocha M,Esplugues JV,De la Fuente M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The integrin family receptors stimulate the cellular proliferation and migration through the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was to investigate the integrin-ligated motifs through the activation of focal adhesion pathway. METHODS:A chimeric...

journal_title：Current pharmaceutical design

authors： Khosravi M,Kakavandi N,Rezaee S,Shabani M,Najafi M

更新日期：2020-01-01 00:00:00

abstract：:Since the discovery of human immunodeficiency virus (HIV) as a causative agent of acquired immune deficiency syndrome (AIDS) various strategies were employed to counter its devastating actions. One such concept relies on the prevention of HIV entry into host's "competent" cells by means of compounds known as entry inh...

journal_title：Current pharmaceutical design

authors： Micewicz ED,Ruchala P

更新日期：2013-01-01 00:00:00

abstract：:Fusion proteins have been well-studied and widely applied in biopharmaceutics. Albumin fusion proteins are simple to construct, easy to purify, and stable to formulate. One main application of fusion protein is to extend the plasma half-life of therapeutic proteins and peptides. Albiglutide for diabetes treatment is t...

journal_title：Current pharmaceutical design

authors： Rogers B,Dong D,Li Z,Li Z

更新日期：2015-01-01 00:00:00

abstract：:Mechanical loading provides an anabolic stimulus for bone. More importantly, the mechanosensing apparatus in bone directs osteogenesis to where it is most needed for improving bone strength. The biological processes involved in bone mechanotransduction are poorly understood and further investigation of the molecular m...

journal_title：Current pharmaceutical design

authors： Turner CH,Robling AG

更新日期：2004-01-01 00:00:00

abstract：:1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol) (DSPE- PEG) is a widely used phospholipids-polymer conjugate in drug delivery applications. It is a biocompatible, biodegradable and amphiphilic material which can also be functionalized with various biomolecules for specific functions. With the em...

journal_title：Current pharmaceutical design

authors： Che J,Okeke CI,Hu ZB,Xu J

更新日期：2015-01-01 00:00:00

abstract：:Neuroinflammation is a common characteristic of several mental health conditions such as major depression, bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia (SCHZ). Inflammatory processes trigger and/or further deteriorate mental functions and are regarded as targets for therapeutic drug develo...

journal_title：Current pharmaceutical design

authors： Echeverria V,Grizzell JA,Barreto GE

更新日期：2016-01-01 00:00:00

abstract：:Oxidative processes exert a fundamental regulatory function during pregnancy. It depends on the influence of oxygen, nitric oxide, reactive oxygen species and reactive nitrogen species metabolic pathways upon the vascular changes in the maternal organism, as well as on the regulation of uterine and cervical tone throu...

journal_title：Current pharmaceutical design

authors： Biondi C,Pavan B,Lunghi L,Fiorini S,Vesce F

更新日期：2005-01-01 00:00:00

abstract：:Deubiquitinating enzymes (DUBs) remove ubiquitin and ubiquitin-like modifications from proteins and they have been known to contribute to processes relevant in microbial infection, such as immune responses pathways. Numerous viral and bacterial DUBs have been identified, and activities of several host DUBs are known t...

journal_title：Current pharmaceutical design

authors： Nanduri B,Suvarnapunya AE,Venkatesan M,Edelmann MJ

更新日期：2013-01-01 00:00:00

abstract：:Obesity, a chronic low-grade inflammation disorder characterized by an expansion in adipose tissue mass, is rapidly expanding worldwide leading to an increase in the incidence of comorbidities such as insulin resistance, type 2 diabetes and cardiovascular diseases. This has led to a renewed interest in the adipose tis...

journal_title：Current pharmaceutical design

authors： Landini L,Honka MJ,Ferrannini E,Nuutila P

更新日期：2016-01-01 00:00:00

abstract：:Subjects affected by ischemic heart disease with non-obstructive coronary arteries constitute a population that has received increasing attention over the past two decades. Since the first studies with coronary angiography, female patients have been reported to have non-obstructive coronary artery disease more frequen...

journal_title：Current pharmaceutical design

authors： Bergami M,Scarpone M,Cenko E,Varotti E,Amaduzzi PL,Manfrini O

更新日期：2020-10-12 00:00:00

abstract：:In the last two decades a tremendous development has been noticed in our understanding of the purinergic system, consisting of heterogeneously expressed purinoceptor subtypes and its classical agonists: e.g., adenosine triphosphate, uridine triphosphate or complex dinucleoside polyphosphates. These agonists exert mult...

journal_title：Current pharmaceutical design

authors： Schuchardt M,Tölle M,van der Giet M

更新日期：2012-01-01 00:00:00

abstract：:The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The fir...

journal_title：Current pharmaceutical design

authors： Tsoucalas G,Papaioannou T,Panayiotakopoulos G,Saridaki Z,Vrachatis DA,Karamanou M

更新日期：2018-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical design

authors： Isenovic ER

更新日期：2019-01-01 00:00:00

abstract：:Hypertension and insomnia are very common and often coexist. There is evidence to suggest that the increasing prevalence of arterial hypertension in the past decade might be related both to an increased prevalence of insomnia and to the decline of sleep duration due to modern lifestyle. The aim of this paper is to rec...

journal_title：Current pharmaceutical design

authors： Palagini L,Bruno RM,Gemignani A,Baglioni C,Ghiadoni L,Riemann D

更新日期：2013-01-01 00:00:00

abstract：:Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. Th...

journal_title：Current pharmaceutical design

authors： Capuron L,Geisler S,Kurz K,Leblhuber F,Sperner-Unterweger B,Fuchs D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Antiepileptic treatment strategy plays an important role in the management of intracranial vascular malformations. The intracranial vascular malformations can be divided into cavernous hemangiomas, arteriovenous malformations, developmental venous anomalies and capillary telangiectasias. Seizures and hemorrh...

journal_title：Current pharmaceutical design

authors： Giakoumettis D,Margetis K,Stranjalis G,Haliasos N,Papaioannou TG,Themistocleous MS

更新日期：2017-01-01 00:00:00

abstract：:Aneuploidy is a pathological condition that affects 35% of human spontaneous abortions and 0.3% of livebirths. In spite of the increasing knowledge about molecular mechanisms of meiosis and chromosome segregation, maternal age remains the only ascertained aetiological factor. Genetically modified mouse models have bee...

journal_title：Current pharmaceutical design

authors： Pacchierotti F,Ranaldi R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a global epidemic involving 20-40% of the general population. NAFLD is rapidly becoming the leading cause of hepatocellular carcinoma (HCC) worldwide. Knowledge about NAFLD-HCC peculiar features is needed to understand this emerging disease better. OBJECTIVE:To r...

journal_title：Current pharmaceutical design

authors： Tovoli F,Ferri S,Piscaglia F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:A mobile health application is an exciting, fast-paced domain that is likely to improve prenatal care. METHODS:In this narrative review, we summarise the use of mobile health applications in this setting with a special emphasis on both the benefits of remote monitoring devices and the potential pitfalls of ...

journal_title：Current pharmaceutical design

authors： Gyselaers W,Lanssens D,Perry H,Khalil A

更新日期：2019-01-01 00:00:00

abstract：:Although the obesity epidemic is constantly expanding at very high costs for health care systems, the currently available options for the pharmacotherapy of obesity are very limited. This is not due to lack of interest or research on the subject but rather to the poor efficacy and/or safety profile of the majority of ...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Brüning JC,Berthold HK

更新日期：2013-01-01 00:00:00

abstract：:From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics face a considerably higher risk of developing cardiovascular and cerebrovascular diseases. Both large and small blood vessels are susceptible to alterations from diabetes. Endothelial cell dysfunction associated with small ve...

journal_title：Current pharmaceutical design

authors： Huber JD

更新日期：2008-01-01 00:00:00

abstract：:ATP-binding cassette (ABC) transporters are a huge family of ATP-dependent transmembrane proteins whose main function is exporting or importing substances or molecules through the cell membranes, plasma cell membrane, or inner membranes in organelles. They fulfill these functions by maintaining cell integrity, metabol...

journal_title：Current pharmaceutical design

authors： Benadiba M,Maor Y

更新日期：2016-01-01 00:00:00

abstract：:DNA methyltransferase (DNMT) and histone deacetylase are key enzymes mediating the epigenetic regulation of gene expression. DNA hypermethylation and/or histone deacetylation in promoter regions is often associated with downregulation or silencing of transcription. Epigenetic silencing of tumor suppressor genes plays ...

journal_title：Current pharmaceutical design

authors： Xu S,Ren J,Chen HB,Wang Y,Liu Q,Zhang R,Jiang SW,Li J

更新日期：2014-01-01 00:00:00

abstract：:The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment ...

journal_title：Current pharmaceutical design

authors： Slyepchenko A,Maes M,Machado-Vieira R,Anderson G,Solmi M,Sanz Y,Berk M,Köhler CA,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cel...

journal_title：Current pharmaceutical design

authors： Ferrín G,Linares CI,Muntané J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:There is a strong rationale for usage of anti-angiogenic agents in epithelial ovarian cancer. Bevacizumab is the most widely investigated anti-VEGF agent and has shown promising results in recent clinical trials. OBJECTIVE:To review the rationale and usage of bevacizumab in advanced epithelial ovarian cance...

journal_title：Current pharmaceutical design

authors： Kroep JR,Nortier JW

更新日期：2012-01-01 00:00:00

abstract：:The prevalence of obesity is increasing globally. Rational perioperative anesthetic drug selection and administration require knowledge of how obesity interacts with those drugs. In this review, we summarize different aspects of the anesthetic agents, including pharmacokinetics (PK), pharmacodynamics (PD) and clinical...

journal_title：Current pharmaceutical design

authors： Dos Reis Falcão LF,Mc Loughlin S,Alvarez A

更新日期：2019-01-01 00:00:00

abstract：:Natural products remain the best resources of drugs and drug leads. Recently, there is growing recognition that identifying new small molecules to promote bone regeneration is a laudable translational goal. In fact, new approaches for bone repair and regeneration that involve inexpensive naturally-derived compounds wo...

journal_title：Current pharmaceutical design

authors： Awale G,Wong E,Rajpura K,W-H Lo K

更新日期：2017-01-01 00:00:00