Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2AAdenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors.

abstract：:The rise of multi-drug resistant and extensively drug resistant M. tuberculosis around the world poses a great threat to human health, and necessitates development of new, effective and inexpensive anti-tubercular agents. The availability of knowledge on molecular biology of M. tuberculosis infection coupled with whol...

journal_title：Current pharmaceutical design

authors： Chauhan RS,Chanumolu SK,Rout C,Shrivastava R

更新日期：2014-01-01 00:00:00

abstract：:MNPs find numerous important biomedical applications owing to their high biocompatibility and unique magnetic properties at the bottom level. Among several other biomedical applications, MNPs are gaining importance in treating various kinds of cancer either as a hyperthermia agent alone or as a drug/gene carrier for s...

journal_title：Current pharmaceutical design

authors： T S A,Shalumon KT,Chen JP

更新日期：2019-01-01 00:00:00

abstract：:The pivotal therapeutic role of myocardial metabolic modulation in ischemic heart disease (IHD) is increasingly recognized. Among the others, inhibitors of free fatty acids (FFA) oxidation have been consistently shown to play an important role in the therapeutic strategy of IHD patients. Additionally, abnormalities of...

journal_title：Current pharmaceutical design

authors： Fragasso G,Salerno A,Spoladore R,Cera M,Montanaro C,Margonato A

更新日期：2009-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research focused on identifying compounds that restore cognition and memory in AD patients is a very active investigational pursuit, but unfortunately, it has been only successful in terms of developing symptomatic treatments. Aβ deposition a...

journal_title：Current pharmaceutical design

authors： Solas M,Puerta E,Ramirez MJ

更新日期：2015-01-01 00:00:00

abstract：:Stroke is a leading cause of death and disability worldwide. Conventional treatment has a limitation of very narrow therapeutic time window and its devastating nature necessitate a novel regenerative approach. Transplanted stem cells resulted in functional recovery through multiple mechanisms including neuroprotection...

journal_title：Current pharmaceutical design

authors： Kwak KA,Kwon HB,Lee JW,Park YS

更新日期：2018-01-01 00:00:00

abstract：:We set up two models of gastric bleeding in rats using low-dose aspirin (ASA) and the antiplatelet drug clopidogrel, a P2Y₁₂ receptor antagonist, and examined the effect of antiulcer drugs on gastric bleeding and ulcerogenic responses under such conditions. Under urethane anesthesia, two catheters were inserted into t...

journal_title：Current pharmaceutical design

authors： Takeuchi K,Izuhara C,Takayama S,Momode T,Kojo M,Hara D,Amagase K

更新日期：2014-01-01 00:00:00

abstract：:Non-enzymatic modification of proteins by reducing sugars, a process that is also known as Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo. There is a growing body of evidence that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerat...

journal_title：Current pharmaceutical design

authors： Unoki H,Yamagishi S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM)-induced airway injuries and chronic obstructive pulmonary disease (COPD) are characterized by chronic inflammation of the respiratory tract and share some similarities regarding the cellular and molecular mechanisms orchestrating airway destruction. Since available data regarding the immu...

journal_title：Current pharmaceutical design

authors： Panahi Y,Jadidi-Niaragh F,Jamalkandi SA,Ghanei M,Pedone C,Nikravanfard N,Nikravesh F,Sahebkar A

更新日期：2016-01-01 00:00:00

abstract：:Hyperglycemia is a common feature of the critically ill in general and of patients with sepsis in particular. Even a moderate degree of hyperglycemia appears detrimental for the outcome of critically ill patients, since maintenance of normoglycemia (blood glucose levels

journal_title：Current pharmaceutical design

authors： Van Cromphaut SJ,Vanhorebeek I,Van den Berghe G

更新日期：2008-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) remains the single biggest challenge in infectious disease in the civilized world. Moreover, vancomycin resistance is also spreading, leading to fears of untreatable infections as were common in ancient times. Molecular microbiology and bioinformatics have revealed ma...

journal_title：Current pharmaceutical design

authors： Magana M,Ioannidis A,Magiorkinis E,Ursu O,Bologa CG,Chatzipanagiotou S,Hamblin MR,Tegos GP

更新日期：2015-01-01 00:00:00

abstract：:Immunotoxins (ITs) are protein-based drugs combining a target-specific binding domain (usually derived from an antibody) and a cytotoxic domain to kill target cells. They are among the most promising new therapeutic tools to fight cancer, and several clinical trials have been completed with encouraging results. Althou...

journal_title：Current pharmaceutical design

authors： Hetzel C,Bachran C,Tur MK,Fuchs H,Stöcker M

更新日期：2009-01-01 00:00:00

abstract：:Naoxintong (NXT), a Chinese Materia Medica standardized product, extracted from 16 various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica sinennsis, Astragali Radix, is clinically effective in treating atherosclerosisrelated diseases. Here, we tested the hypothesis that the anti-...

journal_title：Current pharmaceutical design

authors： Zhao J,Zhu H,Wang S,Ma X,Liu X,Wang C,Zhao H,Fan S,Jin X,Zhao B,Zhao T,Jia L,Wang K,Zou Y,Hu K,Sun A,Ge J

更新日期：2013-01-01 00:00:00

abstract：:Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated tryptase as a mediator in the pathology of numerous allergic and inflammatory conditions including rhinitis, conjunctivitis, and most notably asthma. A growing...

journal_title：Current pharmaceutical design

authors： Rice KD,Tanaka RD,Katz BA,Numerof RP,Moore WR

更新日期：1998-10-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) are components of most current antiretroviral (ARV) regimens. Side effects arising from mitochondrial toxicity (MtT) induced by these drugs is a common reason why patients treated with NRTI change or discontinue therapy. These toxicities can be difficult to reverse, ...

journal_title：Current pharmaceutical design

authors： Feeney ER,Mallon PW

更新日期：2010-10-01 00:00:00

abstract：:Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activatio...

journal_title：Current pharmaceutical design

authors： Dimakopoulou A,Foran D,Jayasena CN,Minhas S

更新日期：2020-02-12 00:00:00

abstract：:Recent progresses in the development of fluorescent technologies become a reliable device for drug discovery research. The fluorescence tools offer attractive options for an opportunity to visualize the effects of drug candidates in the cells. The fluorescent tools, such as fluorescent protein, are regularly used in a...

journal_title：Current pharmaceutical design

authors： Chakraborty C,Hsu CH,Wen ZH,Lin CS

更新日期：2009-01-01 00:00:00

abstract：:Despite the significant progresses made in antiretroviral therapy, current drugs still cannot cure or prevent HIV infection. And all drugs continue to select for drug-resistant HIV strains. Consequently, new antiretroviral drugs are constantly being developed. To ensure safety, these drugs are usually designed to inhi...

journal_title：Current pharmaceutical design

authors： Provencher VM,Coccaro E,Lacasse JJ,Schang LM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials. OBJECTIVE:The aim ...

journal_title：Current pharmaceutical design

authors： Guo Y,Chen B,Pei X,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:There is an increasing need to rapidly determine the specificity of proteases that potentially play a role in human and animal disease. Substrates for novel proteases can be discovered by testing standard protease substrates such as oxidized insulin B-chain, by screening commercially available substrates for other pro...

journal_title：Current pharmaceutical design

authors： Richardson PL

更新日期：2002-01-01 00:00:00

abstract：:Among pediatric patients, preterm neonates and newborns are the most vulnerable subpopulation. Rapid developmental changes of physiological factors affecting the pharmacokinetics of drug substances in newborns require extreme care in dose and dose regimen decisions. These decisions could be supported by in silico meth...

journal_title：Current pharmaceutical design

authors： Claassen K,Thelen K,Coboeken K,Gaub T,Lippert J,Allegaert K,Willmann S

更新日期：2015-01-01 00:00:00

abstract：:The substantial morbidity and mortality associated with invasive fungal infections constitute undisputed tokens of their severity. The continued expansion of susceptible population groups (such as immunocompromised individuals, patients undergoing extensive surgery, and those hospitalized with serious underlying disea...

journal_title：Current pharmaceutical design

authors： Anastassopoulou CG,Fuchs BB,Mylonakis E

更新日期：2011-01-01 00:00:00

abstract：:The acidic amino acid L-glutamate acts as both a primary excitatory neurotransmitter and a potential neurotoxin within the mammalian central nervous system. Functionally juxtaposed between these neurophysiological and pathological actions are an assorted group of integral membrane transporter proteins that rapidly and...

journal_title：Current pharmaceutical design

authors： Bridges RJ,Kavanaugh MP,Chamberlin AR

更新日期：1999-05-01 00:00:00

abstract：:The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

journal_title：Current pharmaceutical design

authors： Czimmer J,Tache Y

更新日期：2017-01-01 00:00:00

abstract：:Drug-induced photosensitivity of the skin is drawing increasing attention. In past few decades, photosensitivity has been reported with an array of drugs, and is now recognized as a noteworthy medical problem by clinicians, regulatory authorities and pharmaceutical industry. The photosensitivity is of two types i.e., ...

journal_title：Current pharmaceutical design

authors： Zaheer MR,Gupta A,Iqbal J,Zia Q,Ahmad A,Roohi,Owais M,Hashlamon A,Mohd Setapar SH,Ashraf GM,Aliev G

更新日期：2016-01-01 00:00:00

abstract：:The Hereditary Spastic Paraparesis (HSP) or Strumpell-Lorrain disease is a heterogeneous neurodegenerative disease of the spinal cord. It is genetically transmitted and characterized by a progressive muscle weakness, spasticity of the lower limbs and awkward gain. There is no specific pharmacological treatment. The ph...

journal_title：Current pharmaceutical design

authors： Riccardo M,Angela L,Angela D,Vita P,Giulio L,Pietroq F,Giancarlo I,Marisa M

更新日期：2016-01-01 00:00:00

abstract：:Post-translational modification of histones is a primary mechanism through which epigenetic regulation of DNA transcription does occur. Among these modifications, regulation of histone acetylation state is an important tool to influence gene expression. Epigenetic regulation of neurodevelopment contributes to the stru...

journal_title：Current pharmaceutical design

authors： Contestabile A,Sintoni S

更新日期：2013-01-01 00:00:00

abstract：:Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that lead to abnormalities in transepithelial ion transport in the airways of affected patients. Lung disease is the major contributor to morbidity and mortality in patients with cystic fibrosis but recommende...

journal_title：Current pharmaceutical design

authors： Ratjen F,Grasemann H

更新日期：2012-01-01 00:00:00

abstract：:Today, in spite of being older than a century (born in 1911), the Pictet-Spengler two component reaction (PS-2CR) is still one of the most popular reactions, not only for the synthesis of tetrahydroisoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), or more complex structures containing these two privileged moieti...

journal_title：Current pharmaceutical design

authors： Ingallina C,D'Acquarica I,Delle Monache G,Ghirga F,Quaglio D,Ghirga P,Berardozzi S,Markovic V,Botta B

更新日期：2016-01-01 00:00:00

abstract：:Anxiety disorders are common and disabling conditions. Current drug treatment methods have limitations including resistance, delayed efficacy and side effects. The advent of sophisticated imaging techniques and the production of highly selective receptor ligands have increased our knowledge of the biological mechanism...

journal_title：Current pharmaceutical design

authors： Christmas D,Hood S,Nutt D

更新日期：2008-01-01 00:00:00

abstract：:Persistent hyperinsulinemic hypoglycemia (PHH) is caused by solitary benign insulinoma or hyperplasia of pancreatic beta cells. In infants, PHH is caused by functionally defective hyperplastic beta cells, which are either diffusely or focally distributed in the pancreas. In adults, insulinoma is the most common cause ...

journal_title：Current pharmaceutical design

authors： Kauhanen S,Seppänen M,Minn H,Nuutila P

更新日期：2010-05-01 00:00:00