Glucose metabolism and insulin resistance in sepsis.

Abstract:

:Hyperglycemia is a common feature of the critically ill in general and of patients with sepsis in particular. Even a moderate degree of hyperglycemia appears detrimental for the outcome of critically ill patients, since maintenance of normoglycemia (blood glucose levels

journal_name

Curr Pharm Des

authors

Van Cromphaut SJ,Vanhorebeek I,Van den Berghe G

doi

10.2174/138161208784980563

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

1887-99

issue

19

eissn

1381-6128

issn

1873-4286

journal_volume

14

pub_type

杂志文章,评审
  • Fluoroquinolones as chemotherapeutics against mycobacterial infections.

    abstract::The antimicrobial agents used in the treatment of mycobacterial infections have remained largely unchanged for several decades. Primary treatment of tuberculosis relies on four drugs, isoniazid, a rifamycin, pyrazinamide, and ethambutol (or streptomycin), and generally results in >95% cure in uncomplicated tuberculosi...

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    doi:10.2174/1381612043383296

    authors: Jacobs MR

    更新日期:2004-01-01 00:00:00

  • Superparamagnetic iron oxide nanoparticles (SPIONs): synthesis and surface modification techniques for use with MRI and other biomedical applications.

    abstract::Superparamagnetic iron oxide nanoparticles (SPIONs) comprise a fundamental technology class within the emerging field of nanomedicine, and have been extensively researched for cancer imaging and therapy. This review article will discuss the chemistry and design considerations associated with the synthesis of SPIONs an...

    journal_title:Current pharmaceutical design

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    authors: Yoffe S,Leshuk T,Everett P,Gu F

    更新日期:2013-01-01 00:00:00

  • Novel and Practical Approaches to Manage Diet-induced Metabolic Disorders: Part-I.

    abstract::Metabolic syndrome (MetS) which is caused by poor dietary habits and sedentary behavior is a serious global health problem. MetS is a cluster of risk factors, represented by central obesity, hyperglycemia, dyslipidemia, and hypertension. In the 21st century, MetS and associated comorbidities, including obesity, diabet...

    journal_title:Current pharmaceutical design

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    doi:10.2174/138161282639201110165712

    authors: Korivi M,Liu BR

    更新日期:2020-01-01 00:00:00

  • Perinatal gene transfer to the liver.

    abstract::The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first weeks or months of life is inevitable. Some diseases ca...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211797247541

    authors: McKay TR,Rahim AA,Buckley SM,Ward NJ,Chan JK,Howe SJ,Waddington SN

    更新日期:2011-01-01 00:00:00

  • Role of free radicals in sepsis: antioxidant therapy.

    abstract::Severe sepsis leading to shock is the principal cause of death in intensive care units. It is a systemic inflammatory response caused by excessive secretion of pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNFalpha) and reactive oxygen species (ROS), mainly induced by endotoxin (a major component of...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612054864894

    authors: Victor VM,Rocha M,Esplugues JV,De la Fuente M

    更新日期:2005-01-01 00:00:00

  • Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy.

    abstract::Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319130015

    authors: de Girolamo L,Lucarelli E,Alessandri G,Avanzini MA,Bernardo ME,Biagi E,Brini AT,D'Amico G,Fagioli F,Ferrero I,Locatelli F,Maccario R,Marazzi M,Parolini O,Pessina A,Torre ML,Italian Mesenchymal Stem Cell Group

    更新日期:2013-01-01 00:00:00

  • B cells compartment in centenarian offspring and old people.

    abstract::Immunosenescence is considered a major contributory factor to the increased frequency of morbidity and mortality among elderly. On the other hand centenarians are considered the best example of successful ageing. To gain insight into mechanisms of immunosenescence and its clinical relevance, a possible model is repres...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161210790883750

    authors: Colonna-Romano G,Buffa S,Bulati M,Candore G,Lio D,Pellicanò M,Vasto S,Caruso C

    更新日期:2010-01-01 00:00:00

  • New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection.

    abstract::Mitochondria fulfill a number of essential cellular functions, being recognized that the strict regulation of the structure, function and turnover of these organelles is an immutable control node for the maintenance of neuronal integrity and homeostasis. Many lines of evidence posit that mitochondria constitute a conv...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211798072490

    authors: Correia SC,Cardoso S,Santos RX,Carvalho C,Santos MS,Perry G,Smith MA,Moreira PI

    更新日期:2011-01-01 00:00:00

  • Integrins: a method of early intervention in the treatment of colorectal liver metastases.

    abstract::The integrin family of cell surface receptors were principally thought to be involved in cell adhesion. Intense study has shown that these glycoproteins also regulate a diverse range of physiological processes. Inappropriate activation of integrins has been implicated in many pathological processes. Recent studies hav...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208783413284

    authors: Robertson JH,Iga AM,Sales KM,Winslet MC,Seifalian AM

    更新日期:2008-01-01 00:00:00

  • Treatment of hypertensive complications in pregnancy.

    abstract::Hypertension is the most common medical disorder during pregnancy. Approximately 70 percent of women diagnosed with hypertension during pregnancy will have gestational hypertension-preeclampsia. The term gestational hypertension-preeclampsia is used to describe a wide spectrum of patients who may have only mild elevat...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612053381864

    authors: Coppage KH,Sibai BM

    更新日期:2005-01-01 00:00:00

  • Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules.

    abstract::Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct cell-cell contact and indirect paracrine signaling among osteoblasts, endothelial cells, and other cell types. The vasculature provides a source of nutrients, oxygen,...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319190007

    authors: Segar CE,Ogle ME,Botchwey EA

    更新日期:2013-01-01 00:00:00

  • Drug eluting stents and beyond.

    abstract::The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the proper usage of different treatments available for atherosclerosis. In light of the latest developments, a plethora of new stents have been and continue to be de...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208785294573

    authors: Rastogi A,Stavchansky S

    更新日期:2008-01-01 00:00:00

  • Phosphodiesterase 5 inhibitors in the treatment of erectile dysfunction.

    abstract::Erectile dysfunction (ED) has multifactor pathogenesis, with neurological, vascular, endocrinological and psychogenic components described. However, about 50-85% of ED population report the presence of one or more comorbidities i.e. hypertension, diabetes, cardiovascular disease, dyslipidemia which all impair endothel...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206778343046

    authors: Aversa A,Bruzziches R,Pili M,Spera G

    更新日期:2006-01-01 00:00:00

  • Targeting Functional Biomarkers in Schizophrenia with Neuroimaging.

    abstract::Many of the most debilitating symptoms for psychiatric disorders such as schizophrenia remain poorly treated. As such, the development of novel treatments is urgently needed. Unfortunately, the costs associated with high failure rates for investigational compounds as they enter clinical trials has led to pharmaceutica...

    journal_title:Current pharmaceutical design

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    doi:10.2174/1381612822666160127113912

    authors: Wylie KP,Smucny J,Legget KT,Tregellas JR

    更新日期:2016-01-01 00:00:00

  • The role of hyperglycaemia and the hypercoagulable state in the pathogenesis of cardiovascular events in diabetes mellitus: implications for hypertension management.

    abstract::Population studies have identified diabetes mellitus as a risk factor for cardiac and vascular events, with a common association with hypertension. Observational studies have consistently demonstrated blood glucose as a continuous cardiovascular risk factor. Experimental studies suggest that elevated blood glucose, th...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206776843322

    authors: Lim HS,MacFadyen RJ,Bakris G,Lip GY

    更新日期:2006-01-01 00:00:00

  • Targeting Mitochondrial Dysfunction in Chronic Heart Failure: Current Evidence and Potential Approaches.

    abstract:BACKGROUND:Mitochondria are cellular organelles responsible for energy production, calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of apoptosis. All these functions are crucial for cardiac homeostasis, and may be impaired in chronic heart failure (CHF). Therefore, mitochondrial d...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666160701075027

    authors: Aimo A,Borrelli C,Vergaro G,Piepoli MF,Caterina AR,Mirizzi G,Valleggi A,Raglianti V,Passino C,Emdin M,Giannoni A

    更新日期:2016-01-01 00:00:00

  • Genetic and Molecular Approaches to Drug Target Discovery for Treatment of the most Dangerous Diseases that are Rapidly Increasing Globally. Part I.

    abstract:: ...

    journal_title:Current pharmaceutical design

    pub_type: 社论

    doi:10.2174/138161282503190514123728

    authors: Sukhorukov VN,Orekhov AN

    更新日期:2019-01-01 00:00:00

  • Applications of Magnetic Liposomes in Cancer Therapies.

    abstract::MNPs find numerous important biomedical applications owing to their high biocompatibility and unique magnetic properties at the bottom level. Among several other biomedical applications, MNPs are gaining importance in treating various kinds of cancer either as a hyperthermia agent alone or as a drug/gene carrier for s...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1389203720666190521114936

    authors: T S A,Shalumon KT,Chen JP

    更新日期:2019-01-01 00:00:00

  • Decreased expression and altered methylation of syncytin-1 gene in human placentas associated with preeclampsia.

    abstract::Syncytin-1 is a protein coded by a human endogenous retrovirus (HERV) gene of the HERV-W family (HERVWE1). Syncytin- 1 mediates formation of syncytiotrophoblasts through fusion of cytotrophoblasts, a hallmark of terminal differentiation of placental trophoblast linage. Syncytin-1 also possesses nonfusogenic functions ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/13816128113199990541

    authors: Zhuang XW,Li J,Brost BC,Xia XY,Chen HB,Wang CX,Jiang SW

    更新日期:2014-01-01 00:00:00

  • GnRH in the treatment of Hypogonadotropic hypogonadism.

    abstract::Gonadotropin Releasing Hormone (GnRH) is at the centre of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Cli...

    journal_title:Current pharmaceutical design

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    doi:10.2174/1381612826666201125113319

    authors: Bettocchi C,Rinaldi M,Sebastiani F

    更新日期:2020-11-24 00:00:00

  • Oxidative stress and antioxidants in carcinogenesis and integrative therapy of cancer.

    abstract::Oxidative stress is often considered as a causative factor in carcinogenesis. In addition, current knowledge recognizes oxidative stress as a mechanism by which various cancer therapies act against cancer. To ameliorate the side effects of cancer therapy, many of the patients suffering from cancer are subject to adjuv...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666140826152822

    authors: Milkovic L,Siems W,Siems R,Zarkovic N

    更新日期:2014-01-01 00:00:00

  • Role of DAP12 in innate and adaptive immune responses.

    abstract::DAP12 is a novel immunoreceptor tyrosine-based activation motifs (ITAM)-bearing transmembrane adapter molecule. This molecule, together with its partner receptor complex molecules including the killer cell activating receptors (KARs), myeloid DAP12 associating lectin-1 (MDL-1), triggering receptor expressed on myeloid...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033392503

    authors: Aoki N,Kimura S,Xing Z

    更新日期:2003-01-01 00:00:00

  • Harnessing anesthesia and brain imaging for the study of human consciousness.

    abstract::Philosophers have been trying to solve the mind-body problem for hundreds of years. Consciousness is the core of this problem: How do subjective conscious sensations, perceptions, feelings, and thoughts arise out of objective physical brain activities? How is this subjective conscious world in causal interaction with ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:

    authors: Långsjo JW,Revonsuo A,Scheinin H

    更新日期:2014-01-01 00:00:00

  • Peripherally restricted opioid agonists as novel analgesic agents.

    abstract::Mediation of antinociception via opioid receptors located in the periphery is a viable strategy to produce analgesia without the occurrence of side effects associated with stimulation of opioid receptors located in the central nervous system. Peripheral opioid receptors are particularly important in inflammatory pain ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612043453036

    authors: DeHaven-Hudkins DL,Dolle RE

    更新日期:2004-01-01 00:00:00

  • Clinical Usefulness of N-terminal Prohormone of Brain Natriuretic Peptide and High Sensitivity Troponin T in Patients with Heart Failure Undergoing Cardiac Resynchronization Therapy.

    abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) is a valuable intracardiac device--based treatment option for a subgroup of patients with advanced heart failure (HF) and QRS prolongation. However, still a significant proportion of patients do not benefit from CRT implantation, labeled as non-responders. OBJECTIVES:...

    journal_title:Current pharmaceutical design

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    doi:10.2174/1381612825666190621155718

    authors: Debska-Kozlowska A,Ksiazczyk M,Warchol I,Lubinski A

    更新日期:2019-01-01 00:00:00

  • Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors.

    abstract:BACKGROUND AND OBJECTIVE:Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. There...

    journal_title:Current pharmaceutical design

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    doi:10.2174/1381612825666190306164157

    authors: Jiang X,Zhang QL,Liu TG,Zhao WP,Yang M,Wang LN,Sun WL,Pan L,Luo AP,Huang JC,Gu XH

    更新日期:2019-01-01 00:00:00

  • Epigenetic modification in neuropathic pain.

    abstract::Neuropathic pain is characterized by complicated combination of positive (e.g., hyperalgesia and allodynia) and negative (e.g., hypoesthesia and hypoalgesia) symptoms, and is often refractory to conventional pharmacological agents, including morphine. Although the molecular mechanisms for positive symptoms are extensi...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666141027113923

    authors: Ueda H,Uchida H

    更新日期:2015-01-01 00:00:00

  • Inhibition of Long Non-coding RNA CTD-2574D22.4 Alleviates LPS-induced Apoptosis and Inflammatory Injury of Chondrocytes.

    abstract:BACKGROUND:Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration. Long non-coding RNAs (lncRNAs) have been associated with inflammatory diseases, including OA. Here, we investigated the potential molecular role of lncRNAs in OA pathogenesis. METHODS:ATDC5 cells were treated with lipopol...

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    doi:10.2174/1381612825666190801141801

    authors: Li L,Zhang L,Zhang Y,Jiang D,Xu W,Zhao H,Huang L

    更新日期:2019-01-01 00:00:00

  • Frontal lobe synaptic plasticity in development and disease: modulation by the dopamine D1 receptor.

    abstract::Synaptic plasticity is now known to occur at glutamate synapses throughout the brain, including the neocortex, and to play a role in neurodevelopment as well as in a broad spectrum of adult neural functions. Here the hypothesis that synaptic plasticity, specifically long term depression, is the neural substrate that m...

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    doi:10.2174/1381612819666140110122307

    authors: Selemon LD

    更新日期:2014-01-01 00:00:00

  • Pharmacotherapy of Central Serous Chorioretinopathy: A Review of the Current Treatments.

    abstract:BACKGROUND:Central serous chorioretinopathy (CSC) is the fourth most frequent retinal disorder in terms of prevalence. It typically occurs in young subjects and affects men more often than women. CSC is characterized by serous retinal detachment (SRD) involving mainly the macular area. The clinical course is usually se...

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    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666190123165914

    authors: Iacono P,Toto L,Costanzo E,Varano M,Parravano MC

    更新日期:2018-01-01 00:00:00