Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines.

abstract：BACKGROUND:A positive association was previously reported between angiotensin-converting enzyme (ACE) gene polymorphism and several cardiovascular diseases, such as myocardial infarction, left ventricular hypertrophy, and restenosis after percutaneous transluminal coronary angioplasty. Plasma ACE activity and carotid-w...

journal_title：Circulation

authors： Ishigami T,Umemura S,Iwamoto T,Tamura K,Hibi K,Yamaguchi S,Nyuui N,Kimura K,Miyazaki N,Ishii M

更新日期：1995-02-15 00:00:00

abstract：:Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or ruptu...

journal_title：Circulation

authors： Fletcher AJ,Syed MBJ,Aitman TJ,Newby DE,Walker NL

更新日期：2020-05-12 00:00:00

abstract：:The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 +/- 0.3 mm to 8.1 +/- 0.3 mm (P less than 0.001);...

journal_title：Circulation

authors： Gaasch WH,Bernard SA

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition wit...

journal_title：Circulation

authors： Lang CC,Rayos GH,Chomsky DB,Wood AJ,Wilson JR

更新日期：1997-07-01 00:00:00

abstract：:Cardiac events of early diastole were studied in 50 normal subjects and 46 patients with mitral stenosis (MS) by simultaneous recordings of the mitral valve echogram (MVE), phonocardiogram, and apexcardiogram (ACG). Left ventricular isovolumic relaxation time (IRT), measured between A2 and onset of the MVE opening mot...

journal_title：Circulation

authors： Toutouzas P,Velimezis A,Castellanos S,Avgoustakis D

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Cardiac hypertrophy is a common response to circulatory or neurohumoral stressors as a mechanism to augment contractility. When the heart is under sustained stress, the hypertrophic response can evolve into decompensated heart failure, although the mechanism(s) underlying this transition remain largely unkno...

journal_title：Circulation

authors： Warren SA,Briggs LE,Zeng H,Chuang J,Chang EI,Terada R,Li M,Swanson MS,Lecker SH,Willis MS,Spinale FG,Maupin-Furlowe J,McMullen JR,Moss RL,Kasahara H

更新日期：2012-11-27 00:00:00

abstract：BACKGROUND:The management of asymptomatic severe mitral regurgitation remains controversial. The aim of this study was to evaluate the outcome of a watchful waiting strategy in which patients are referred to surgery when symptoms occur or when asymptomatic patients develop left ventricular (LV) enlargement, LV dysfunct...

journal_title：Circulation

authors： Rosenhek R,Rader F,Klaar U,Gabriel H,Krejc M,Kalbeck D,Schemper M,Maurer G,Baumgartner H

更新日期：2006-05-09 00:00:00

abstract：BACKGROUND:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Downstream of gp130, two signal-transducing pathways have been recognized, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway and the Ras-mitogen-activated protein kinase (MAPK) pathway. To d...

journal_title：Circulation

authors： Kunisada K,Hirota H,Fujio Y,Matsui H,Tani Y,Yamauchi-Takihara K,Kishimoto T

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...

journal_title：Circulation

authors： Li WG,Gavrila D,Liu X,Wang L,Gunnlaugsson S,Stoll LL,McCormick ML,Sigmund CD,Tang C,Weintraub NL

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:Previous evidence has shown that increased sympathetic tone enhances the cesium chloride (Cs)-induced early afterdepolarizations (EADs) and ventricular tachycardias (VTs). METHODS AND RESULTS:We assessed the effects of vagal stimulation on Cs-induced EADs and ventricular arrhythmias in the rabbit heart. Mon...

journal_title：Circulation

authors： Takahashi N,Ito M,Ishida S,Fujino T,Saikawa T,Arita M

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Vasodilator drugs have variable effects on veins and arteries. However, direct measurements of their effects on the splanchnic veins, perhaps the most important volume reservoir, have not been reported. We assessed the effect of acute heart failure and the subsequent administration of hydralazine, enalaprila...

journal_title：Circulation

authors： Wang SY,Manyari DE,Scott-Douglas N,Smiseth OA,Smith ER,Tyberg JV

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Cardiac mechanical restitution and relaxation restitution are thought to be physiological correlates of the recovery kinetics of Ca2+ release mechanisms and sequestration capacity of the sarcoplasmic reticulum (SR). Since congestive heart failure is characterized by abnormal intracellular Ca2+ handling, we s...

journal_title：Circulation

authors： Prabhu SD,Freeman GL

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, including cancer and cardiovascular disease. Small-molecule BET protein inhibitors such as JQ1 have demo...

journal_title：Circulation

authors： Kim SY,Zhang X,Schiattarella GG,Altamirano F,Ramos TAR,French KM,Jiang N,Szweda PA,Evers BM,May HI,Luo X,Li H,Szweda LI,Maracaja-Coutinho V,Lavandero S,Gillette TG,Hill JA

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion and myocardial contractility. METHODS AND RESULTS:Twenty-one patients were enrolled...

journal_title：Circulation

authors： Perin EC,Dohmann HF,Borojevic R,Silva SA,Sousa AL,Mesquita CT,Rossi MI,Carvalho AC,Dutra HS,Dohmann HJ,Silva GV,Belém L,Vivacqua R,Rangel FO,Esporcatte R,Geng YJ,Vaughn WK,Assad JA,Mesquita ET,Willerson JT

更新日期：2003-05-13 00:00:00

abstract：:Minoxidil, a potent predominant arterial dilator, improves hemodynamics over the short term in patients with heart failure. In random double-blind fashion 17 patients with chronic left heart failure were given minoxidil (nine patients) or placebo (eight patients) in addition to digoxin and diuretics for 3 months. Card...

journal_title：Circulation

authors： Franciosa JA,Jordan RA,Wilen MM,Leddy CL

更新日期：1984-07-01 00:00:00

abstract：:Experimental studies demonstrate that short-term regional perfusion-contraction matching, in which the energy demands of regional myocardial contraction are reduced to match the diminished myocardial substrate supply, occurs during states of low coronary blood flow under resting conditions and during exercise-induced ...

journal_title：Circulation

authors： Ross J Jr

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Several nonpharmacological interventions, including exercise, are recommended in primary prevention of hypertension and other cardiovascular diseases in which the pathogenetic role of endothelial dysfunction has been suggested. We studied the effects of long-term aerobic exercise on endothelial function in p...

journal_title：Circulation

authors： Higashi Y,Sasaki S,Kurisu S,Yoshimizu A,Sasaki N,Matsuura H,Kajiyama G,Oshima T

更新日期：1999-09-14 00:00:00

abstract：BACKGROUND:In vivo testing of novel antiplatelet agents requires informative biomarkers. By genetically modifying mouse von Willebrand factor (VWF(R1326H)), we have developed a small animal model that supports human but not mouse platelet-mediated thrombosis. Here, we evaluate the use of this biological platform as a p...

journal_title：Circulation

authors： Magallon J,Chen J,Rabbani L,Dangas G,Yang J,Bussel J,Diacovo T

更新日期：2011-01-25 00:00:00

abstract：BACKGROUND:The American Heart Association Cardiovascular Health score (CVH score) is inversely associated with cardiovascular disease (CVD) incidence, but the mechanisms underlying this association warrant exploration. METHODS AND RESULTS:We related the CVH score to circulating biomarkers and prevalent subclinical CVD...

journal_title：Circulation

authors： Xanthakis V,Enserro DM,Murabito JM,Polak JF,Wollert KC,Januzzi JL,Wang TJ,Tofler G,Vasan RS

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...

journal_title：Circulation

authors： Wallner K,Li C,Shah PK,Fishbein MC,Forrester JS,Kaul S,Sharifi BG

更新日期：1999-03-16 00:00:00

abstract：:Experience with percutaneous transluminal coronary angioplasty (PTCA) of multiple vessels was reviewed to assess short-term outcome and long-term results. PTCA of multiple vessels was performed in 100 of the initial 500 patients (20%) who underwent PTCA at the Medical College of Virginia between July 1979 and August 1...

journal_title：Circulation

authors： Cowley MJ,Vetrovec GW,DiSciascio G,Lewis SA,Hirsh PD,Wolfgang TC

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Although several prospective cohort studies have found an inverse association between fish consumption and risk of coronary heart disease (CHD) or sudden cardiac death in the general population, limited data are available among diabetic patients. METHODS AND RESULTS:We examined prospectively the association...

journal_title：Circulation

authors： Hu FB,Cho E,Rexrode KM,Albert CM,Manson JE

更新日期：2003-04-15 00:00:00

abstract：:To determine if acute lung rejection after heart-lung transplantation can be detected noninvasively with indium-111-labeled (111In) lymphocytes, we studied 33 allogeneic and 18 isogeneic heterotopic heart-lung transplants in rats. Twenty-four hours after injection of isogeneic splenic 111In-lymphocytes (75 +/- 2 micro...

journal_title：Circulation

authors： Arai H,Yuda T,Goodgold HM,deMello DE,Hendershott L,Pennington DG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that combined cyclooxygenase-1 (COX-1) and prostacyclin synthase (PGIS) gene transfer selectively augments prostacyclin production without a concurrent overproduction of other prostanoids. METHODS AND RESULTS:ECV304 cells were transfected with bicistronic pCOX-1/PGIS versus pCOX-1 o...

journal_title：Circulation

authors： Shyue SK,Tsai MJ,Liou JY,Willerson JT,Wu KK

更新日期：2001-04-24 00:00:00

abstract：BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...

journal_title：Circulation

authors： Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

更新日期：1991-12-01 00:00:00

abstract：:We evaluated the accuracy of the recently reported technique of estimating intraventricular volume by measurement of intracavitary electrical conductance in six isolated, ejecting, canine left ventricles. Left ventricular volumes were measured directly by a previously validated servosystem that employed an electrocond...

journal_title：Circulation

authors： Burkhoff D,van der Velde E,Kass D,Baan J,Maughan WL,Sagawa K

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:A decreased cardiac compliance is a major feature of the cardiomyopathy of diabetes mellitus. Either an increase in the resistance afterload to the LV or an increase in collagen cross-linking induced by the formation of advanced glycosylation end products (AGEs) of collagen may be responsible for the stiff m...

journal_title：Circulation

authors： Norton GR,Candy G,Woodiwiss AJ

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Two hundred eighteen patients were evaluated in a two-phase approach (time to first appropriate discharge, survival after discharge) to identify factors that may be related to maximal benefit derived from use of an automatic implantable cardioverter-defibrillator (AICD). METHODS AND RESULTS:One hundred nine...

journal_title：Circulation

authors： Levine JH,Mellits ED,Baumgardner RA,Veltri EP,Mower M,Grunwald L,Guarnieri T,Aarons D,Griffith LS

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:The majority of infrarenal abdominal aortic aneurysm (AAA) repairs in the United States are performed with endovascular methods. Baseline aortoiliac arterial anatomic characteristics are fundamental criteria for appropriate patient selection for endovascular aortic repair (EVAR) and key determinants of long-...

journal_title：Circulation

authors： Schanzer A,Greenberg RK,Hevelone N,Robinson WP,Eslami MH,Goldberg RJ,Messina L

更新日期：2011-06-21 00:00:00

abstract：:There is strong evidence that revascularization does not prevent myocardial infarction in patients with stable coronary artery disease (CAD). The anatomic basis for this counterintuitive conclusion seems to be that most myocardial infarctions occur at sites that did not previously exhibit an angiographically significa...

journal_title：Circulation

authors： Forrester JS,Shah PK

更新日期：1997-08-19 00:00:00