Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.

abstract：:Misregulation of NF-kappaB signaling leads to infectious, inflammatory, or autoimmune disorders. IkappaB kinase beta (IKKbeta) is an essential activator of NF-kappaB and is known to phosphorylate the NF-kappaB inhibitor, IkappaBalpha, allowing it to undergo ubiquitin-mediated proteasomal degradation. However, beyond I...

journal_title：Molecular and cellular biology

authors： Hutti JE,Turk BE,Asara JM,Ma A,Cantley LC,Abbott DW

更新日期：2007-11-01 00:00:00

abstract：:Neurite outgrowth is an essential process during neuronal differentiation as well as neuroregeneration. Thus, understanding the molecular and cellular control of neurite outgrowth will benefit patients with neurological diseases. We have previously shown that overexpression of the signaling adaptor protein SH2B1β prom...

journal_title：Molecular and cellular biology

authors： Chang YJ,Chen KW,Chen CJ,Lin MH,Sun YJ,Lee JL,Chiu IM,Chen L

更新日期：2014-03-01 00:00:00

abstract：:Studies were undertaken to determine the effect of the Ras suppressor Rsu-1 on Ras signal transduction pathways in two different cell backgrounds. An expression vector containing the mouse rsu-1 cDNA under the control of a mouse mammary tumor virus promoter was introduced into NIH 3T3 cells and the pheochromocytoma ce...

journal_title：Molecular and cellular biology

authors： Masuelli L,Cutler ML

更新日期：1996-10-01 00:00:00

abstract：:The gastrointestinal glutathione peroxidase (GI-GPx, GPx2) is a selenoprotein that was suggested to act as barrier against hydroperoxide absorption but has also been implicated in the control of inflammation and malignant growth. In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN)...

journal_title：Molecular and cellular biology

authors： Banning A,Deubel S,Kluth D,Zhou Z,Brigelius-Flohé R

更新日期：2005-06-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 by degradation is a mechanism utilized by cells to adapt to endoplasmic reticulum (ER) stress. However, the mechanisms of p53 destabilization by ER stress are not known. We demonstrate here that the E3 ubiquitin-ligase Hdm2 is essential for the nucleocytoplasmic transport and p...

journal_title：Molecular and cellular biology

authors： Pluquet O,Qu LK,Baltzis D,Koromilas AE

更新日期：2005-11-01 00:00:00

abstract：:The selective expression of a unique copy gene in several mammalian tissues has been approached by studying the regulatory sequences needed to control expression of the rat phosphoenolpyruvate carboxykinase (PEPCK) gene in transgenic mice. A transgene containing the entire PEPCK gene, including 2.2 kb of the 5'-flanki...

journal_title：Molecular and cellular biology

authors： Eisenberger CL,Nechushtan H,Cohen H,Shani M,Reshef L

更新日期：1992-03-01 00:00:00

abstract：:Histone acetylation provides a switch between transcriptionally repressive and permissive chromatin. By regulating the chromatin structure at specific promoters, histone acetyltransferases (HATs) carry out important functions during differentiation and development of higher eukaryotes. HAT complexes are present in org...

journal_title：Molecular and cellular biology

authors： Guelman S,Suganuma T,Florens L,Weake V,Swanson SK,Washburn MP,Abmayr SM,Workman JL

更新日期：2006-10-01 00:00:00

abstract：:Interleukin-5 (IL-5) and IL-6 have both been reported to act as B-cell differentiation factors by stimulating activated B cells to secrete antibody. However, it has not been possible to directly compare the effects of these two lymphokines because of the lack of a suitable B-cell line capable of responding to both. We...

journal_title：Molecular and cellular biology

authors： Randall TD,Lund FE,Brewer JW,Aldridge C,Wall R,Corley RB

更新日期：1993-07-01 00:00:00

abstract：:IMP dehydrogenase (IMPDH) is the rate-limiting enzyme in the de novo synthesis of guanine nucleotides. It is a target of therapeutically useful drugs and is implicated in the regulation of cell growth rate. In the yeast Saccharomyces cerevisiae, mutations in components of the RNA polymerase II (Pol II) transcription e...

journal_title：Molecular and cellular biology

authors： Shaw RJ,Reines D

更新日期：2000-10-01 00:00:00

abstract：:Transcription of Xenopus laevis mitochondrial DNA (xl-mtDNA) by the mitochondrial RNA polymerase requires a dissociable factor. This factor was purified to near homogeneity and identified as a 40-kDa protein. A second protein implicated in the transcription of mtDNA, the Xenopus homolog of the HMG box protein mtTFA, w...

journal_title：Molecular and cellular biology

authors： Antoshechkin I,Bogenhagen DF

更新日期：1995-12-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK) facilitates cell cycle progression in most mammalian cells, but in certain cell types prolonged signaling through this pathway promotes differentiation and lineage-specific gene expression through mechanisms that are poorly understood. Here, we characterize the transcription...

journal_title：Molecular and cellular biology

authors： Sevinsky JR,Whalen AM,Ahn NG

更新日期：2004-05-01 00:00:00

abstract：:Ribosomal DNA (rDNA) genes in eukaryotes are organized into multicopy tandem arrays and transcribed by RNA polymerase I. During cell proliferation, ∼50% of these genes are active and have a relatively open chromatin structure characterized by elevated accessibility to psoralen cross-linking. In Saccharomyces cerevisia...

journal_title：Molecular and cellular biology

authors： Johnson JM,French SL,Osheim YN,Li M,Hall L,Beyer AL,Smith JS

更新日期：2013-07-01 00:00:00

abstract：:In the accompanying report (C. F. Webb, C. Das, S. Eaton, K. Calame, and P. Tucker, Mol. Cell. Biol. 11:5197-5205, 1991), we characterize B-cell-specific protein-DNA interactions at -500 and -200 bp upstream of the mu immunoglobulin heavy chain promoter whose abundances were increased by interleukin-5 plus antigen. Be...

journal_title：Molecular and cellular biology

authors： Webb CF,Das C,Eneff KL,Tucker PW

更新日期：1991-10-01 00:00:00

abstract：:Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the pathway for repair of UV-induced DNA damage. The global genomic repair (GGR) subpathway of NER, but not transcription-coupled repair (TCR), is mainly affected by p53 loss or inactivation. We have utilized mouse emb...

journal_title：Molecular and cellular biology

authors： Smith ML,Ford JM,Hollander MC,Bortnick RA,Amundson SA,Seo YR,Deng CX,Hanawalt PC,Fornace AJ Jr

更新日期：2000-05-01 00:00:00

abstract：:The simian virus 40 core origin of replication consists of nucleotides 5211 through 31. These 64 base pairs contain three functional domains with strict sequence requirements and two spacer regions with relaxed sequence specificity but precise positional constraints. The early domain extends for 10 contiguous base pai...

journal_title：Molecular and cellular biology

authors： Deb S,DeLucia AL,Baur CP,Koff A,Tegtmeyer P

更新日期：1986-05-01 00:00:00

abstract：:Eight strains of Chinese hamster ovary (CHO) cells having an assembly-defective beta-tubulin were found among revertants of strain Cmd 4, a mutant with a conditional lethal mutation in a beta-tubulin gene (F. Cabral, M. E. Sobel, and M. M. Gottesman, Cell 20:29-36, 1980). The altered beta-tubulins in these strains hav...

journal_title：Molecular and cellular biology

authors： Boggs B,Cabral F

更新日期：1987-08-01 00:00:00

abstract：:A point mutation, Gly380Arg, in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) leads to achondroplasia, the most common form of genetic dwarfism in humans. This substitution was suggested to enhance mutant receptor dimerization, leading to constitutive, ligand-independent activation. We found ...

journal_title：Molecular and cellular biology

authors： Monsonego-Ornan E,Adar R,Feferman T,Segev O,Yayon A

更新日期：2000-01-01 00:00:00

abstract：:In Schizosaccharomyces pombe, MBF is a DNA-binding complex suspected to activate the transcription of genes necessary for entry into S phase. The MBF complex contains both p85cdc10 and p72res1/sct1. To obtain a better understanding of how the MBF complex regulates gene expression at the G1/S transition, we have perfor...

journal_title：Molecular and cellular biology

authors： Ayté J,Leis JF,Herrera A,Tang E,Yang H,DeCaprio JA

更新日期：1995-05-01 00:00:00

abstract：:The uptake of various nucleosides by S49 mouse T-lymphoma cells and that by a single-step nucleoside transport-defective mutant thereof (AE1) were compared. Residual nucleoside entry into AE1 cells occurred via two routes, nonmediated permeation and saturable, non-concentrative transport with broad substrate specifici...

journal_title：Molecular and cellular biology

authors： Plagemann PG,Woffendin C

更新日期：1987-01-01 00:00:00

abstract：:The translocation (6;9)(p23;q34) in acute nonlymphocytic leukemia results in the formation of a highly consistent dek-can fusion gene. Translocation breakpoints invariably occur in single introns of dek and can, which were named icb-6 and icb-9, respectively. In a case of acute undifferentiated leukemia, a breakpoint ...

journal_title：Molecular and cellular biology

authors： von Lindern M,van Baal S,Wiegant J,Raap A,Hagemeijer A,Grosveld G

更新日期：1992-08-01 00:00:00

abstract：:Wnt glycoproteins play essential roles in the development of metazoan organisms. Many Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, which results in accumulation of beta-catenin in the cytosol and nucleus. Other Wnts, such as Wnt5a, activate signaling mechanisms which do not ...

journal_title：Molecular and cellular biology

authors： González-Sancho JM,Brennan KR,Castelo-Soccio LA,Brown AM

更新日期：2004-06-01 00:00:00

abstract：:MOT1 is an essential Saccharomyces cerevisiae protein and a member of the SNF2/SWI2 family of ATPases. MOT1 functions by removing TATA-binding protein (TBP) from DNA, and as a consequence, MOT1 can regulate transcription both in vitro and in vivo. Here we describe the in vivo and in vitro activities of MOT1 deletion a...

journal_title：Molecular and cellular biology

authors： Auble DT,Wang D,Post KW,Hahn S

更新日期：1997-08-01 00:00:00

abstract：:Xenopus in vitro studies have implicated both transforming growth factor beta (TGF-beta) and fibroblast growth factor (FGF) families in mesoderm induction. Although members of both families are present during mouse mesoderm formation, there is little evidence for their functional role in mesoderm induction. We show th...

journal_title：Molecular and cellular biology

authors： Johansson BM,Wiles MV

更新日期：1995-01-01 00:00:00

abstract：:The human vitamin D-binding protein (hDBP) gene exists in a cluster of four liver-expressed genes. A minimal hDBP transgene, containing a defined set of liver-specific DNase I hypersensitive sites (HSs), is robustly expressed in mouse liver in a copy-number-dependent manner. Here we evaluate these HSs for function. De...

journal_title：Molecular and cellular biology

authors： Hiroki T,Liebhaber SA,Cooke NE

更新日期：2007-11-01 00:00:00

abstract：:Defects in mismatch repair (MMR) genes result in a mutator phenotype by inducing microsatellite instability (MI), a characteristic of hereditary nonpolyposis colorectal cancers (HNPCC) and a subset of sporadic colon tumors. Present models describing the mechanism by which germ line mutations in MMR genes predispose ki...

journal_title：Molecular and cellular biology

authors： Nicolaides NC,Littman SJ,Modrich P,Kinzler KW,Vogelstein B

更新日期：1998-03-01 00:00:00

abstract：:Poly(A)-binding protein (PABP) stimulates translation initiation by binding simultaneously to the mRNA poly(A) tail and eukaryotic translation initiation factor 4G (eIF4G). PABP activity is regulated by PABP-interacting (Paip) proteins. Paip1 binds PABP and stimulates translation by an unknown mechanism. Here, we desc...

journal_title：Molecular and cellular biology

authors： Martineau Y,Derry MC,Wang X,Yanagiya A,Berlanga JJ,Shyu AB,Imataka H,Gehring K,Sonenberg N

更新日期：2008-11-01 00:00:00

abstract：:The major cytoskeletal actin gene of Drosophila melanogaster, the actin 5C gene, has two promoters, the distal one of which controls synthesis of actin in a tissue- and developmental stage-specific manner. This very strong promoter has widely been used for expression of heterologous genes in cultured cells. To locate ...

journal_title：Molecular and cellular biology

authors： Chung YT,Keller EB

更新日期：1990-12-01 00:00:00

abstract：:The protein-tyrosine kinases (PTKs) are a burgeoning family of proteins, each of which bears a conserved domain of 250 to 300 amino acids capable of phosphorylating substrate proteins on tyrosine residues. We recently exploited the existence of two highly conserved sequence elements within the catalytic domain to gene...

journal_title：Molecular and cellular biology

authors： Wilks AF,Harpur AG,Kurban RR,Ralph SJ,Zürcher G,Ziemiecki A

更新日期：1991-04-01 00:00:00

abstract：:Intron-encoded U17a and U17b RNAs are members of the H/ACA-box class of small nucleolar RNAs (snoRNAs) participating in rRNA processing and modification. We have investigated the organization and expression of the U17 locus in human cells and found that intronic U17a and U17b sequences are transcribed as part of the t...

journal_title：Molecular and cellular biology

authors： Pelczar P,Filipowicz W

更新日期：1998-08-01 00:00:00

abstract：:The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine protein kinase, termed p50c...

journal_title：Molecular and cellular biology

authors： Gervais FG,Chow LM,Lee JM,Branton PE,Veillette A

更新日期：1993-11-01 00:00:00