p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes.

abstract：:Inactivation of DNA mismatch repair by mutation or by transcriptional silencing of the MLH1 gene results in genome instability and cancer predisposition. We recently found (P. V. Shcherbakova and T. A. Kunkel, Mol. Cell. Biol. 19:3177-3183, 1999) that an elevated spontaneous mutation rate can also result from increase...

journal_title：Molecular and cellular biology

authors： Shcherbakova PV,Hall MC,Lewis MS,Bennett SE,Martin KJ,Bushel PR,Afshari CA,Kunkel TA

更新日期：2001-02-01 00:00:00

abstract：:The retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s (RC-L1s) can generate new heritable L1 insertions in the early embryo, primordial germ line, and germ cells. L1 retrotransposition can also occur in the neurona...

journal_title：Molecular and cellular biology

authors： Salvador-Palomeque C,Sanchez-Luque FJ,Fortuna PRJ,Ewing AD,Wolvetang EJ,Richardson SR,Faulkner GJ

更新日期：2019-03-19 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a key regulatory cytokine whose expression is controlled by a complex set of stimuli in a variety of cell types. Previously, we found that the monocyte/macrophage-enriched nuclear transcription factor C/EBPbeta played an important role in the regulation of the TNF alpha gene ...

journal_title：Molecular and cellular biology

authors： Zagariya A,Mungre S,Lovis R,Birrer M,Ness S,Thimmapaya B,Pope R

更新日期：1998-05-01 00:00:00

abstract：:Swi4 and Swi6 form a complex which is required for Start-dependent activation of HO and for high-level expression of G1 cyclin genes CLN1 and CLN2. To identify other regulators of this pathway, we screened for dominant, recessive, conditional, and allele-specific suppressors of swi4 mutants. We isolated 16 recessive s...

journal_title：Molecular and cellular biology

authors： Lycan D,Mikesell G,Bunger M,Breeden L

更新日期：1994-11-01 00:00:00

abstract：:The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress. However, the mechanism underlying both SIRT2 activation and regulation of the G2-to-...

journal_title：Molecular and cellular biology

authors： Movahedi Naini S,Sheridan AM,Force T,Shah JV,Bonventre JV

更新日期：2015-11-01 00:00:00

abstract：:Leukemia results from the expansion of self-renewing hematopoietic cells that are thought to contain mutations that contribute to disease initiation and progression. Studies of the gene expression profiles of human acute myeloid leukemia samples has allowed their classification based on the presence of translocations ...

journal_title：Molecular and cellular biology

authors： Walter MJ,Park JS,Lau SK,Li X,Lane AA,Nagarajan R,Shannon WD,Ley TJ

更新日期：2004-12-01 00:00:00

abstract：:Three ras homologs have been identified in Drosophila melanogaster. Here we describe the tissue distribution of their transcripts as analyzed by in situ hybridization. The RNAs of the three genes show a similar distribution at every developmental stage examined. In embryos, the transcripts are uniformly distributed. I...

journal_title：Molecular and cellular biology

authors： Segal D,Shilo BZ

更新日期：1986-06-01 00:00:00

abstract：:The murine Igh locus has a 3' regulatory region (3' RR) containing four enhancers (hs3A, hs1,2, hs3B, and hs4) at DNase I-hypersensitive sites. The 3' RR exerts long-range effects on class switch recombination (CSR) to several isotypes through its control of germ line transcription. By measuring levels of acetylated h...

journal_title：Molecular and cellular biology

authors： Garrett FE,Emelyanov AV,Sepulveda MA,Flanagan P,Volpi S,Li F,Loukinov D,Eckhardt LA,Lobanenkov VV,Birshtein BK

更新日期：2005-02-01 00:00:00

abstract：:The mouse myosin light-chain 1A (MLC1A) gene, expressed in the atria of the adult heart, is one of the first muscle genes to be activated when skeletal as well as cardiac muscles form in the embryo. It is also transcribed in skeletal muscle cell lines at the onset of differentiation. Transient transfection assays of m...

journal_title：Molecular and cellular biology

authors： Catala F,Wanner R,Barton P,Cohen A,Wright W,Buckingham M

更新日期：1995-08-01 00:00:00

abstract：:SUMO conjugation has emerged as a dynamic process in regulating protein function. Here we identify estrogen receptor β (ERβ) to be a new target of SUMO-1. ERβ SUMO-1 modification occurs on a unique nonconsensus sumoylation motif which becomes fully competent upon phosphorylation of its contained serine residue, which ...

journal_title：Molecular and cellular biology

authors： Picard N,Caron V,Bilodeau S,Sanchez M,Mascle X,Aubry M,Tremblay A

更新日期：2012-07-01 00:00:00

abstract：:The human and murine MOK2 ortholog genes that are preferentially expressed in brain and testis tissues encode two different Krüppel-like zinc finger proteins. In this paper, we show that the MOK2 proteins are mainly associated with nuclear ribonucleoprotein components, including the nucleoli and extranucleolar structu...

journal_title：Molecular and cellular biology

authors： Arranz V,Harper F,Florentin Y,Puvion E,Kress M,Ernoult-Lange M

更新日期：1997-04-01 00:00:00

abstract：:Endonuclease G (endo G) is one of the most abundant nucleases in eukaryotic cells. It is encoded in the nucleus and imported to the mitochondrial intermembrane space. This nuclease is active on single- and double-stranded DNA. We genetically disrupted the endo G gene in mice without disturbing a conserved, overlapping...

journal_title：Molecular and cellular biology

authors： Irvine RA,Adachi N,Shibata DK,Cassell GD,Yu K,Karanjawala ZE,Hsieh CL,Lieber MR

更新日期：2005-01-01 00:00:00

abstract：:The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer. This element binds two species, myeloid nuclear factors 1 alpha and 1 bet...

journal_title：Molecular and cellular biology

authors： Nuchprayoon I,Meyers S,Scott LM,Suzow J,Hiebert S,Friedman AD

更新日期：1994-08-01 00:00:00

abstract：:Essential for embryonic development, the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in breast and prostate cancers and is implicated in the growth and aggression of the tumors. The tumorigenic mechanism underlying EZH2 overexpression is largely unknown. It is believed that EZH2 exerts i...

journal_title：Molecular and cellular biology

authors： Shi B,Liang J,Yang X,Wang Y,Zhao Y,Wu H,Sun L,Zhang Y,Chen Y,Li R,Zhang Y,Hong M,Shang Y

更新日期：2007-07-01 00:00:00

abstract：:We have shown previously that perturbation of origin firing in chromosome replication causes DNA lesions and triggers DNA damage checkpoint control, which ensures genomic integrity by stopping cell cycle progression until the lesions are repaired or by inducing cell death if they are not properly repaired. This was ba...

journal_title：Molecular and cellular biology

authors： Ide S,Watanabe K,Watanabe H,Shirahige K,Kobayashi T,Maki H

更新日期：2007-01-01 00:00:00

abstract：:The packaging of the eukaryotic genome into chromatin is likely to be important for the maintenance of genomic integrity. Chromatin structures are assembled onto newly synthesized DNA by the action of chromatin assembly factors, including anti-silencing function 1 (ASF1). To investigate the role of chromatin structure...

journal_title：Molecular and cellular biology

authors： Ramey CJ,Howar S,Adkins M,Linger J,Spicer J,Tyler JK

更新日期：2004-12-01 00:00:00

abstract：:The opposing effects on proliferation mediated by G-protein-coupled receptor isoforms differing in their COOH termini could be correlated with the abilities of the receptors to differentially activate p38, implicated in apoptotic events, or phosphatidylinositol 3-kinase (PI 3-K), which provides a source of survival si...

journal_title：Molecular and cellular biology

authors： Sellers LA,Alderton F,Carruthers AM,Schindler M,Humphrey PP

更新日期：2000-08-01 00:00:00

abstract：:We demonstrate that the immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription. The enhancer itself, when placed 5' to the bacterial cat or neo genes, is able to direct transcription by using heterogeneous start sites that are generally the same as those found with bona fide I mu ...

journal_title：Molecular and cellular biology

authors： Su LK,Kadesch T

更新日期：1990-06-01 00:00:00

abstract：:We previously created a knock-in mutant mouse harboring a dominantly negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mouse) that spontaneously develops a follicular thyroid carcinoma similar to human thyroid cancer. We found that beta-catenin, which plays a critical role in oncogenesis, was highly elevate...

journal_title：Molecular and cellular biology

authors： Guigon CJ,Zhao L,Lu C,Willingham MC,Cheng SY

更新日期：2008-07-01 00:00:00

abstract：:Okadaic acid-sensitive serine/threonine phosphatases have been shown to regulate interleukin-2 transcription and T-cell activation. Okadaic acid inhibits protein phosphatase 4 (PP4), a novel PP2A-related serine/threonine phosphatase, at a 50% inhibitory concentration (IC(50)) comparable to that for PP2A. This raises t...

journal_title：Molecular and cellular biology

authors： Shui JW,Hu MC,Tan TH

更新日期：2007-01-01 00:00:00

abstract：:Transgenic mice containing a sheep metallothionein 1a-sheep growth hormone fusion gene exhibited low, tissue-specific basal levels of transgene mRNA expression, resulting in slightly elevated levels of circulating growth hormone that did not lead to a detectable increase in growth. After zinc stimulation, high levels ...

journal_title：Molecular and cellular biology

authors： Shanahan CM,Rigby NW,Murray JD,Marshall JT,Townrow CA,Nancarrow CD,Ward KA

更新日期：1989-12-01 00:00:00

abstract：:Protein acetylation has emerged as a means of controlling levels of mRNA synthesis in eukaryotic cells. Here we report that acetyl coenzyme A (acetyl-CoA) stimulates RNA polymerase II transcription in vitro in the absence of histones. The effect of acetyl-CoA on basal and activated transcription was studied in a human...

journal_title：Molecular and cellular biology

authors： Galasinski SK,Lively TN,Grebe De Barron A,Goodrich JA

更新日期：2000-03-01 00:00:00

abstract：:Kinase-negative mutants of S49 mouse lymphoma cells, which lack detectable catalytic (C) subunit of cyclic AMP-dependent protein kinase, nevertheless contain cytoplasmic mRNAs for the two major forms of C subunit, C alpha and C beta. Investigation of the metabolism of C subunits in wild-type and mutant cells was under...

journal_title：Molecular and cellular biology

authors： Steinberg RA

更新日期：1991-02-01 00:00:00

abstract：:Approximately 30% of human tumors examined for mutations in polymerase beta (pol beta) appear to express pol beta variant proteins (D. Starcevic, S. Dalal, and J. B. Sweasy, Cell Cycle 3:998-1001, 2004). Many of these variants result from a single amino acid substitution. We have previously shown that the K289M and I2...

journal_title：Molecular and cellular biology

authors： Lang T,Dalal S,Chikova A,DiMaio D,Sweasy JB

更新日期：2007-08-01 00:00:00

abstract：:Keratins K5 and K14 form the extensive intermediate filament network of mitotically active basal cells in all stratified epithelia. We have explored the regulatory mechanisms governing cell-type-specific and differentiation stage-specific expression of the human K5 gene in transiently transfected keratinocytes in vitr...

journal_title：Molecular and cellular biology

authors： Byrne C,Fuchs E

更新日期：1993-06-01 00:00:00

abstract：:A mouse homologue of the Drosophila melanogaster germ cell-less (mgcl-1) gene is expressed ubiquitously, and its gene product is localized to the nuclear envelope based on its binding to LAP2 beta (lamina-associated polypeptide 2 beta). To elucidate the role of mgcl-1, we analyzed two mutant mouse lines that lacked mg...

journal_title：Molecular and cellular biology

authors： Kimura T,Ito C,Watanabe S,Takahashi T,Ikawa M,Yomogida K,Fujita Y,Ikeuchi M,Asada N,Matsumiya K,Okuyama A,Okabe M,Toshimori K,Nakano T

更新日期：2003-02-01 00:00:00

abstract：:The expression of chromosomally integrated transgenes usually varies greatly among independent transfectants. This variability in transgene expression has led to the definition of locus control regions (LCRs) as elements which render expression consistent. Analyses of expression in single cells revealed that the expre...

journal_title：Molecular and cellular biology

authors： Ronai D,Berru M,Shulman MJ

更新日期：1999-10-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) play key roles in differentiation, growth, proliferation, and apoptosis. Although MAPKs have been extensively studied, the precise function, specific substrates, and target genes of each MAPK are not known. These issues could be addressed by sole activation of a given MAPK, e....

journal_title：Molecular and cellular biology

authors： Yaakov G,Bell M,Hohmann S,Engelberg D

更新日期：2003-07-01 00:00:00

abstract：:4.5S RNA is a group of RNAs 90 to 94 nucleotides long (length polymorphism due to a varying number of UMP residues at the 3' end) that form hydrogen bonds with poly(A)-terminated RNAs isolated from mouse, hamster, or rat cells (W. R. Jelinek and L. Leinwand, Cell 15:205-214, 1978; F. Harada, N. Kato, and H.-O. Hoshino...

journal_title：Molecular and cellular biology

authors： Schoeniger LO,Jelinek WR

更新日期：1986-05-01 00:00:00

abstract：:Retinoic acid is known to have profound effects on developmental processes. It has been implicated as a putative morphogen in the developing chick limb bud and regenerating amphibian limb blastema and has been demonstrated to have powerful teratogenic effects in mammals, including humans. Recently, three specific reti...

journal_title：Molecular and cellular biology

authors： Giguère V,Shago M,Zirngibl R,Tate P,Rossant J,Varmuza S

更新日期：1990-05-01 00:00:00