Saccharomyces cerevisiae transcription elongation mutants are defective in PUR5 induction in response to nucleotide depletion.

abstract：:The liver-enriched transcription factor C/EBP alpha has been implicated in the regulation of numerous liver-specific genes. It was previously reported that mice carrying a homozygous null mutation at the c/ebp alpha locus died as neonates due to the absence of hepatic glycogen and the resulting hypoglycemia. However, ...

journal_title：Molecular and cellular biology

authors： Lee YH,Sauer B,Johnson PF,Gonzalez FJ

更新日期：1997-10-01 00:00:00

abstract：:The murine allele temperature-sensitive (ts) p53Val-135 encodes a ts p53 protein that behaves as a mutant polypeptide at 37 degrees C and as a wild-type polypeptide at 32 degrees C. This ts allele was introduced into the p53 nonproducer Friend erythroleukemia cell line DP16-1. The DP16-1 cell line was derived from the...

journal_title：Molecular and cellular biology

authors： Johnson P,Chung S,Benchimol S

更新日期：1993-03-01 00:00:00

abstract：:mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a pathway that is stimulated by removal of the mRNA cap structure. Here we report that a mutation in the SPB8 (YJL124c) gene, initially identified as a suppressor mutation of a poly(A)-binding protein (PAB1) gene deletion, stabilizes the mRNA cap...

journal_title：Molecular and cellular biology

authors： Boeck R,Lapeyre B,Brown CE,Sachs AB

更新日期：1998-09-01 00:00:00

abstract：:Repeat-induced point mutation (RIP) is a process that efficiently detects DNA duplications prior to meiosis in Neurospora crassa and peppers them with G:C to A:T mutations. Cytosine methylation is typically associated with sequences affected by RIP, and methylated cytosines are not limited to CpG dinucleotides. We gen...

journal_title：Molecular and cellular biology

authors： Singer MJ,Marcotte BA,Selker EU

更新日期：1995-10-01 00:00:00

abstract：:The product of the c-myc proto-oncogene is an important positive regulator of cell growth and proliferation. Recently, c-Myc has also been demonstrated to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. To further examine Myc-induced apoptosis, we coexpressed the proto-oncoge...

journal_title：Molecular and cellular biology

authors： Wagner AJ,Small MB,Hay N

更新日期：1993-04-01 00:00:00

abstract：:The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors...

journal_title：Molecular and cellular biology

authors： Wen DX,Xu YF,Mais DE,Goldman ME,McDonnell DP

更新日期：1994-12-01 00:00:00

abstract：:The expression of Id1, a helix-loop-helix protein which inhibits the activity of basic helix-loop-helix transcription factors, is down-regulated during cellular differentiation and cell cycle withdrawal both in tissue culture models and in mouse embryos. In order to study the mechanism of control of Idl expression, we...

journal_title：Molecular and cellular biology

authors： Tournay O,Benezra R

更新日期：1996-05-01 00:00:00

abstract：:The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine protein kinase, termed p50c...

journal_title：Molecular and cellular biology

authors： Gervais FG,Chow LM,Lee JM,Branton PE,Veillette A

更新日期：1993-11-01 00:00:00

abstract：:Resistance to the growth-inhibitory action of retinoic acid (RA), the bioactive derivative of vitamin A, is common in human tumors. One form of RA resistance has been associated with silencing and hypermethylation of the retinoic acid receptor beta2 gene (RARbeta2), an RA-regulated tumor suppressor gene. The presence ...

journal_title：Molecular and cellular biology

authors： Ren M,Pozzi S,Bistulfi G,Somenzi G,Rossetti S,Sacchi N

更新日期：2005-12-01 00:00:00

abstract：:Fusion proteins known to activate transcription in vivo were tested for the ability to stimulate transcription in vitro in a recently developed Saccharomyces cerevisiae RNA polymerase II transcription system. One fusion protein, whose activation domain was derived from the herpesvirus transcriptional activator VP16, g...

journal_title：Molecular and cellular biology

authors： Chasman DI,Leatherwood J,Carey M,Ptashne M,Kornberg RD

更新日期：1989-11-01 00:00:00

abstract：:pp60c-src was localized in the cerebellum of developing chicken embryos by immunoperoxidase staining with antisera raised against bacterially expressed pp60v-src. Immunoreactivity (IR) appeared in the cerebellum of the chicken embryos at the time of neuronal differentiation. pp60c-src IR was detected in regions of the...

journal_title：Molecular and cellular biology

authors： Fults DW,Towle AC,Lauder JM,Maness PF

更新日期：1985-01-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p21/WAF1/CIP1 is an important regulator of cell cycle progression, senescence, and differentiation. Genotoxic stress leads to activation of the tumor suppressor p53 and subsequently to induction of p21 expression. Here we show that the tumor suppressor p53 cooperates with the tran...

journal_title：Molecular and cellular biology

authors： Lagger G,Doetzlhofer A,Schuettengruber B,Haidweger E,Simboeck E,Tischler J,Chiocca S,Suske G,Rotheneder H,Wintersberger E,Seiser C

更新日期：2003-04-01 00:00:00

abstract：:In self-fertile strains of the fission yeast Schizosaccharomyces pombe, nitrogen starvation initiates a program of sexual development in which cells express mating pheromones and receptors, arrest cell cycle progression in G1, and conjugate. This process is dependent on Rum1, an inhibitor of the Cdc2-Cdc13 and Cdc2-Ci...

journal_title：Molecular and cellular biology

authors： Wu L,Russell P

更新日期：1997-01-01 00:00:00

abstract：:Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA replication and repair. Eukaryotic ribonucleotide reductases (RNRs) are Fe-dependent enzymes that catalyze deoxyribonucleoside diphosphate (dNDP) synthesis. We ...

journal_title：Molecular and cellular biology

authors： Sanvisens N,Romero AM,An X,Zhang C,de Llanos R,Martínez-Pastor MT,Bañó MC,Huang M,Puig S

更新日期：2014-09-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) induce a variety of biological effects on different cell types. They activate a number of genes, including immediate-early genes, such as the transcription factors Fos and Jun, which are also common targets for other tyrosine kinase receptor-activating growth factors. Here we describe ...

journal_title：Molecular and cellular biology

authors： Jaakkola P,Vihinen T,Määttä A,Jalkanen M

更新日期：1997-06-01 00:00:00

abstract：:We previously purified and characterized functionally the Escherichia coli-expressed product of the human subgroup C adenovirus E1A 13S mRNA (B. Ferguson, N. Jones, J. Richter, and M. Rosenberg, Science 224:1343-1346, 1984; B. Krippl, B. Ferguson, M. Rosenberg, and H. Westphal, Proc. Natl. Acad. Sci. USA 81:6988-6992,...

journal_title：Molecular and cellular biology

authors： Ferguson B,Krippl B,Andrisani O,Jones N,Westphal H,Rosenberg M

更新日期：1985-10-01 00:00:00

abstract：:Defects in mismatch repair (MMR) genes result in a mutator phenotype by inducing microsatellite instability (MI), a characteristic of hereditary nonpolyposis colorectal cancers (HNPCC) and a subset of sporadic colon tumors. Present models describing the mechanism by which germ line mutations in MMR genes predispose ki...

journal_title：Molecular and cellular biology

authors： Nicolaides NC,Littman SJ,Modrich P,Kinzler KW,Vogelstein B

更新日期：1998-03-01 00:00:00

abstract：:Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signalin...

journal_title：Molecular and cellular biology

authors： Cristóbal I,Rojo F,Madoz-Gúrpide J,García-Foncillas J

更新日期：2016-05-31 00:00:00

abstract：:The genes of the trithorax group (trxG) in Drosophila melanogaster are required to maintain the pattern of homeotic gene expression that is established early in embryogenesis by the transient expression of the segmentation genes. The precise role of each of the diverse trxG members and the functional relationships amo...

journal_title：Molecular and cellular biology

authors： Crosby MA,Miller C,Alon T,Watson KL,Verrijzer CP,Goldman-Levi R,Zak NB

更新日期：1999-02-01 00:00:00

abstract：:Liver regeneration is a rapid and concerted response to injury, in which growth factor-generated intracellular signals result in activation of transcription factors, DNA synthesis, and hepatocyte proliferation. However, the link between cytoplasmic signals resulting in proliferative response to liver injury remains to...

journal_title：Molecular and cellular biology

authors： Bard-Chapeau EA,Yuan J,Droin N,Long S,Zhang EE,Nguyen TV,Feng GS

更新日期：2006-06-01 00:00:00

abstract：:The Rb protein is known to exert its activity at decision points in the G1 phase of the cell cycle. To investigate whether it may also play some role(s) at later points in the cell cycle, we used a system of rapid inducible gene amplification to conditionally overexpress Rb protein during G2 phase. A cell line express...

journal_title：Molecular and cellular biology

authors： Karantza V,Maroo A,Fay D,Sedivy JM

更新日期：1993-11-01 00:00:00

abstract：:Numerous nonribosomal trans-acting factors involved in pre-rRNA processing have been characterized, but few of them are specifically required for the last cytoplasmic steps of 18S rRNA maturation. We have recently demonstrated that Rrp10p/Rio1p is such a factor. By BLAST analysis, we identified the product of a previo...

journal_title：Molecular and cellular biology

authors： Vanrobays E,Gelugne JP,Gleizes PE,Caizergues-Ferrer M

更新日期：2003-03-01 00:00:00

abstract：:Previous analyses defined a proliferating cell nuclear antigen (PCNA) E1A-responsive element (PERE) in the PCNA promoter that is essential for transactivation by the 243-residue product of the adenovirus type 2 E1A 12S mRNA (E1A 243R). In this report, we show that the PERE activates a heterologous basal promoter and c...

journal_title：Molecular and cellular biology

authors： Morris GF,Labrie C,Mathews MB

更新日期：1994-01-01 00:00:00

abstract：:By injecting the appropriately constructed plasmids into one-cell Xenopus embryos, we determined that the 3' region of the maternal Xenopus Eg2 mRNA confers instability on the chimeric mRNA transcribed from these plasmids. This instability, like that of the maternal Eg2 transcript, was abolished by treatment of the em...

journal_title：Molecular and cellular biology

authors： Bouvet P,Paris J,Phillippe M,Osborne HB

更新日期：1991-06-01 00:00:00

abstract：:Two peroxins of the AAA family, PpPex1p and PpPex6p, are required for peroxisome biogenesis in the yeast Pichia pastoris. Cells from the corresponding deletion strains (Pp delta pex1 and Pp delta pex6) contain only small vesicular remnants of peroxisomes, the bulk of peroxisomal matrix proteins is mislocalized to the ...

journal_title：Molecular and cellular biology

authors： Faber KN,Heyman JA,Subramani S

更新日期：1998-02-01 00:00:00

abstract：:The yeast nuclear gene YME1 was one of six genes recently identified in a screen for mutations that elevate the rate at which DNA escapes from mitochondria and migrates to the nucleus. yme1 mutations, including a deletion, cause four known recessive phenotypes: an elevation in the rate at which copies of TRP1 and ARS1...

journal_title：Molecular and cellular biology

authors： Thorsness PE,White KH,Fox TD

更新日期：1993-09-01 00:00:00

abstract：:Studies were performed to verify the physiological significance of attenuation in the life cycle of simian virus 40 and the role of agnoprotein in this process. For these purposes, nuclei were isolated at various times after infection and incubated in vitro in the presence of [alpha-32P]UTP under the standard conditio...

journal_title：Molecular and cellular biology

authors： Hay N,Aloni Y

更新日期：1985-06-01 00:00:00

abstract：:Nucleotide excision repair and the long-patch mismatch repair systems correct abnormal DNA structures arising from DNA damage and replication errors, respectively. DNA synthesis past a damaged base (translesion replication) often causes misincorporation at the lesion site. In addition, mismatches are hot spots for DNA...

journal_title：Molecular and cellular biology

authors： Mu D,Tursun M,Duckett DR,Drummond JT,Modrich P,Sancar A

更新日期：1997-02-01 00:00:00

abstract：:Ligand-induced dimerization and transphosphorylation are thought to be important events by which receptor tyrosine kinases generate cellular signals. We have investigated the ability of signalling-defective, truncated fibroblast growth factor (FGF) receptors (FGFR-1 and FGFR-2) to block the FGF response in cells that ...

journal_title：Molecular and cellular biology

authors： Li Y,Basilico C,Mansukhani A

更新日期：1994-11-01 00:00:00

abstract：:Despite distinct dissimilarities, diverse cancers express several common protumorigenic traits. We present here evidence that the proapoptotic protein Par-4 utilizes one such common tumorigenic trait to become selectively activated and induce apoptosis in cancer cells. Elevated protein kinase A (PKA) activity noted in...

journal_title：Molecular and cellular biology

authors： Gurumurthy S,Goswami A,Vasudevan KM,Rangnekar VM

更新日期：2005-02-01 00:00:00