Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.

abstract：:The highly conserved SR family contains a growing number of phosphoproteins acting as both essential and alternative splicing factors. In this study, we have cloned human genomic and cDNA sequences encoding a novel SR protein designated SRp46. Nucleotide sequence analyses have revealed that the SRp46 gene corresponds ...

journal_title：Molecular and cellular biology

authors： Soret J,Gattoni R,Guyon C,Sureau A,Popielarz M,Le Rouzic E,Dumon S,Apiou F,Dutrillaux B,Voss H,Ansorge W,Stévenin J,Perbal B

更新日期：1998-08-01 00:00:00

abstract：:tRNAs in eukaryotic nuclei and organelles are synthesized as precursors lacking the 3'-terminal CCA sequence and possessing 5' (leader) and 3' (trailer) extensions. Nucleolytic cleavage of the 3' trailer and addition of CCA are therefore required for formation of functional tRNA 3' termini. Many chloroplast tRNA genes...

journal_title：Molecular and cellular biology

authors： Oommen A,Li XQ,Gegenheimer P

更新日期：1992-02-01 00:00:00

abstract：:GATA1 is a master regulator of erythropoiesis, expression of which is regulated by multiple discrete cis-acting elements. In this study, we examine the activity of a promoter-proximal double GATA (dbGATA) motif, using a Gata1 bacterial artificial chromosome (BAC)-transgenic green fluorescent protein (GFP) reporter (G1...

journal_title：Molecular and cellular biology

authors： Moriguchi T,Suzuki M,Yu L,Takai J,Ohneda K,Yamamoto M

更新日期：2015-03-01 00:00:00

abstract：:MicroRNA 155 (miR-155) is an oncomir, generated as a noncoding RNA from the BIC gene whose promoter activity is mainly controlled via activation protein 1 (AP-1) and NF-κB transcription factors. We found that the expression levels of miR-155 and programmed cell death 4 (Pdcd4) exhibit inverse relationships in tongue c...

journal_title：Molecular and cellular biology

authors： Zargar S,Tomar V,Shyamsundar V,Vijayalakshmi R,Somasundaram K,Karunagaran D

更新日期：2019-03-01 00:00:00

abstract：:The synthesis of 60S ribosomal subunits in Saccharomyces cerevisiae requires Tif6p, the yeast homologue of mammalian eukaryotic translation initiation factor 6 (eIF6). In the present work, we have isolated a protein kinase from rabbit reticulocyte lysates on the basis of its ability to phosphorylate recombinant human ...

journal_title：Molecular and cellular biology

authors： Basu U,Si K,Deng H,Maitra U

更新日期：2003-09-01 00:00:00

abstract：:Transcriptional insulators are cis regulatory elements that organize chromatin into independently regulated domains. At the imprinted murine Igf2/H19 locus, the H19-ICR insulator prevents the activation of the Igf2 promoter on the maternal allele by enhancers that activate H19 on the same chromosome. Given the well-de...

journal_title：Molecular and cellular biology

authors： Singh V,Srivastava M

更新日期：2008-06-01 00:00:00

abstract：:Although mitogenic and differentiating factors often activate a number of common signaling pathways, the mechanisms leading to their distinct cellular outcomes have not been elucidated. In a previous report, we demonstrated that mitogen-activated protein (MAP) kinase (ERK) activation by the neurogenic agents fibroblas...

journal_title：Molecular and cellular biology

authors： Corbit KC,Soh JW,Yoshida K,Eves EM,Weinstein IB,Rosner MR

更新日期：2000-08-01 00:00:00

abstract：:Studies ex vivo have shown that phosphoinositide 3-kinase (PI3K) activity is necessary but not sufficient for insulin-stimulated glucose uptake. Unexpectedly, mice lacking either of the PI3K regulatory subunits p85alpha or p85beta exhibit increased insulin sensitivity. The insulin hypersensitivity is particularly unex...

journal_title：Molecular and cellular biology

authors： Brachmann SM,Ueki K,Engelman JA,Kahn RC,Cantley LC

更新日期：2005-03-01 00:00:00

abstract：:Very little is known about the mechanisms mediating longevities of mRNAs. As a means of identifying potential cis- and trans-acting elements which stabilize an individual mRNA, naturally occurring mutations that decreased stability of the normally long-lived globin mRNA were analyzed. Our previous studies demonstrated...

journal_title：Molecular and cellular biology

authors： Weiss IM,Liebhaber SA

更新日期：1995-05-01 00:00:00

abstract：:The genetic effects of the mitotic inhibitor methyl benzimidazole-2-yl-carbamate (MBC) have been studied in Saccharomyces cerevisiae. MBC had little or no effect on the frequency of mutation. In some experiments MBC caused an increase in the frequency of mitotic recombination; however, this effect was small and not re...

journal_title：Molecular and cellular biology

authors： Wood JS

更新日期：1982-09-01 00:00:00

abstract：:The peptidyl-prolyl isomerase (PPIase) cyclophilin A (Cpr1p) is conserved from eubacteria to mammals, yet its biological function has resisted elucidation. Unable to identify a phenotype that is suggestive of Cpr1p's function in a cpr1Delta Saccharomyces cerevisiae strain, we screened for CPR1-dependent strains. In al...

journal_title：Molecular and cellular biology

authors： Ansari H,Greco G,Luban J

更新日期：2002-10-01 00:00:00

abstract：:Despite the identification of PBC proteins as cofactors that provide DNA affinity and binding specificity for the HOX homeodomain proteins, HOX proteins do not demonstrate robust activity in transient-transcription assays and few authentic downstream targets have been identified for these putative transcription factor...

journal_title：Molecular and cellular biology

authors： Shen WF,Krishnan K,Lawrence HJ,Largman C

更新日期：2001-11-01 00:00:00

abstract：:We studied the process by which whd, a P-element insertion allele of the Drosophila melanogaster white locus, is replaced by its homolog in the presence of transposase. These events are interpreted as the result of double-strand gap repair following excision of the P transposon in whd. We used a series of alleles deri...

journal_title：Molecular and cellular biology

authors： Johnson-Schlitz DM,Engels WR

更新日期：1993-11-01 00:00:00

abstract：:In contrast to differentiated somatic cells, mouse embryonal carcinoma (EC) cell lines spontaneously express high levels of major members of the heat shock protein (HSP) family. In addition, some EC cell lines (noninducible) are not able to induce HSP gene transcription and HSP synthesis after a stress. However, after...

journal_title：Molecular and cellular biology

authors： Mezger V,Bensaude O,Morange M

更新日期：1989-09-01 00:00:00

abstract：:The immunoglobulin M heavy-chain locus contains two poly(A) sites which are alternatively expressed during B-cell differentiation. Despite its promoter proximal location, the secretory poly(A) site is not expressed in undifferentiated cells. Crucial to the activation of the secretory poly(A) site during B-cell differe...

journal_title：Molecular and cellular biology

authors： Phillips C,Pachikara N,Gunderson SI

更新日期：2004-07-01 00:00:00

abstract：:To interrogate endogenous p21(WAF1/CIP1) (p21) promoter activity under basal conditions and in response to various forms of stress, knock-in imaging reporter mice in which expression of firefly luciferase (FLuc) was placed under the control of the endogenous p21 promoter within the Cdkn1a gene locus were generated. Bi...

journal_title：Molecular and cellular biology

authors： Tinkum KL,Marpegan L,White LS,Sun J,Herzog ED,Piwnica-Worms D,Piwnica-Worms H

更新日期：2011-09-01 00:00:00

abstract：:Osteoclast differentiation factor (ODF)/receptor activator of NF-kappaB ligand is essential for inducing the differentiation of mature osteoclasts. We find that nuclear factor Y (NF-Y) binds to the CCAAT box on the ODF promoter and regulates its basal transcriptional activity. The CCAAT box on the ODF gene is required...

journal_title：Molecular and cellular biology

authors： Kabe Y,Yamada J,Uga H,Yamaguchi Y,Wada T,Handa H

更新日期：2005-01-01 00:00:00

abstract：:Members of the transforming growth factor beta (TGF-beta) family transduce signals through Smad proteins. Smad signaling can be regulated by the Ras/Erk/mitogen-activated protein pathway in response to receptor tyrosine kinase activation and the gamma interferon pathway and also by the functional interaction of Smad2 ...

journal_title：Molecular and cellular biology

authors： Wicks SJ,Lui S,Abdel-Wahab N,Mason RM,Chantry A

更新日期：2000-11-01 00:00:00

abstract：:Syncollin is a small protein that is abundantly expressed in pancreatic acinar cells and that is tightly associated with the lumenal side of the zymogen granule membrane. To shed light on the hitherto unknown function of syncollin, we have generated syncollin-deficient mice. The mice are viable and show a normal pancr...

journal_title：Molecular and cellular biology

authors： Antonin W,Wagner M,Riedel D,Brose N,Jahn R

更新日期：2002-03-01 00:00:00

abstract：:DHCR24/seladin-1, a crucial enzyme in sterol synthesis, is of lower abundance in brain areas affected by Alzheimer's disease. While high levels of DHCR24/seladin-1 exert antiapoptotic function by conferring resistance against oxidative stress, the molecular mechanism for this protective effect is not fully understood....

journal_title：Molecular and cellular biology

authors： Kuehnle K,Crameri A,Kälin RE,Luciani P,Benvenuti S,Peri A,Ratti F,Rodolfo M,Kulic L,Heppner FL,Nitsch RM,Mohajeri MH

更新日期：2008-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) receptor (EGFR) has been implicated in tumor development and invasion. Dimerization and autophosphorylation of EGFR are the critical events for EGFR activation. However, the regulation of EGF-dependent and EGF-independent dimerization and phosphorylation of EGFR has not been fully underst...

journal_title：Molecular and cellular biology

authors： Arimoto K,Burkart C,Yan M,Ran D,Weng S,Zhang DE

更新日期：2014-10-01 00:00:00

abstract：:Tumor-promoting phorbol esters affect a variety of cellular functions which may underlie tumor promotion. We isolated from human lymphocytes a cDNA clone whose gene is inducible by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate as well as by the T-cell mitogen phytohemagglutinin. Nuclear transcription experim...

journal_title：Molecular and cellular biology

authors： Arya SK,Wong-Staal F,Gallo RC

更新日期：1984-11-01 00:00:00

abstract：:Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI) provides a reversible means of recruiting proteins to the plasma membrane, with the resultant change in subcellular localization playing a key role in the activation of multiple intracellular signaling pathways. Previously we foun...

journal_title：Molecular and cellular biology

authors： Shan X,Czar MJ,Bunnell SC,Liu P,Liu Y,Schwartzberg PL,Wange RL

更新日期：2000-09-01 00:00:00

abstract：:The first processing event that mouse pre-rRNA undergoes occurs within the external transcribed spacer and is efficiently reproduced in vitro. Analysis with nondenaturing polyacrylamide gels revealed the formation of heparin-resistant complexes of retarded electrophoretic mobility on the substrate rRNA. The specificit...

journal_title：Molecular and cellular biology

authors： Kass S,Sollner-Webb B

更新日期：1990-09-01 00:00:00

abstract：:The 3' AU-rich region of human beta-1 interferon (hu-IFN beta) mRNA was found to act as a translational inhibitory element. The translational regulation of this 3' AU-rich sequence and the effect of its association with the poly(A) tail were studied in cell-free rabbit reticulocyte lysate. A poly(A)-rich hu-IFN beta m...

journal_title：Molecular and cellular biology

authors： Grafi G,Sela I,Galili G

更新日期：1993-06-01 00:00:00

abstract：:As revealed by intracellular pools of nonactive Fas (Apo-1), export of Fas to the cell surface is often impaired in human tumors, thereby inactivating Fas ligand-mediated apoptosis. Here, we demonstrate that association with Fas-associated phosphatase 1 (FAP-1) attenuates Fas export to the cell surface. Forced express...

journal_title：Molecular and cellular biology

authors： Ivanov VN,Lopez Bergami P,Maulit G,Sato TA,Sassoon D,Ronai Z

更新日期：2003-05-01 00:00:00

abstract：:The kidney's vital filtration function depends on the structural integrity of the glomerulus, the proximal portion of the nephron. Within the glomerulus, the architecturally complex podocyte forms the final cellular barrier to filtration. Injury to the podocyte results in a morphological change called foot process eff...

journal_title：Molecular and cellular biology

authors： Yu H,Suleiman H,Kim AH,Miner JH,Dani A,Shaw AS,Akilesh S

更新日期：2013-12-01 00:00:00

abstract：:A key antioxidant pathway, the Keap1-Nrf2 system, is regulated by p62/Sqstm1 via multiple mechanisms, including gene expression, posttranslational modifications (such as ubiquitination and phosphorylation), and autophagic degradation of p62/Sqstm1 and Keap1. Here we demonstrate a novel mode of regulation of the Keap1-...

journal_title：Molecular and cellular biology

authors： Kageyama S,Saito T,Obata M,Koide RH,Ichimura Y,Komatsu M

更新日期：2018-03-15 00:00:00

abstract：:In both tissue sections and cell culture, the endothelial nature of a cell is most commonly determined by demonstration of its expression of von Willebrand factor (vWf) protein and/or mRNA. Thus, the mechanism of cell-type-specific transcriptional regulation of the vWf gene is central to studying the basis of endothel...

journal_title：Molecular and cellular biology

authors： Jahroudi N,Lynch DC

更新日期：1994-02-01 00:00:00

abstract：:Our previous studies of Saccharomyces cerevisiae described a gene repression mechanism where the transcription of intergenic noncoding DNA (ncDNA) (SRG1) assembles nucleosomes across the promoter of the adjacent SER3 gene that interfere with the binding of transcription factors. To investigate the role of histones in ...

journal_title：Molecular and cellular biology

authors： Hainer SJ,Martens JA

更新日期：2011-09-01 00:00:00