Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis.

Abstract:

BACKGROUND:Calcipotriene and betamethasone dipropionate are topical treatments for psoriasis vulgaris. Their mode of action is different. Improved risk/benefit may result with concomitant use of the two compounds together. A new vehicle has been created with the objective of obtaining optimal stability of both calcipotriene and betamethasone dipropionate in the combination product. OBJECTIVE:We compared the clinical efficacy of a fixed combination of calcipotriene and betamethasone dipropionate in a new vehicle to calcipotriene in the new vehicle, betamethasone in the new vehicle, and the new vehicle alone. METHODS:This was an international, multicenter, prospective, randomized, double-blind, parallel-group, 4-week study in patients with psoriasis vulgaris amenable to topical treatment. RESULTS:The mean percentage reduction in PASI from baseline to end of treatment was 73.2% in the combination group (n = 301), 48.8% in the calcipotriene group (n = 308), 63.1% in the betamethasone dipropionate group (n = 312) and 28.8% in the new vehicle group (n = 107), (P < .001). The mean percentage reduction in PASI during the first week was 48.1%, 28.4%, 41.4%, and 21.5%, respectively (P < .001). CONCLUSION:A combination product of calcipotriene 50 microg/g and betamethasone dipropionate 0.5 mg/g in the new vehicle shows superior efficacy with a more rapid onset of action than the new vehicle containing either constituent alone in the treatment of psoriasis vulgaris.

journal_name

J Am Acad Dermatol

authors

Papp KA,Guenther L,Boyden B,Larsen FG,Harvima RJ,Guilhou JJ,Kaufmann R,Rogers S,van de Kerkhof PC,Hanssen LI,Tegner E,Burg G,Talbot D,Chu A

doi

10.1067/mjd.2003.130

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

48-54

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(03)50010-X

journal_volume

48

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Survey of sterile technique used by dermatologic surgeons.

    abstract::A survey was made of the sterile technique practices of dermatologists interested in dermatologic surgery. The steam autoclave is the most popular method for sterilizing surgical instruments. Dry heat sterilization is often used, as is cold, chemical sterilization. The most popular agent for chemical sterilization con...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(88)70114-0

    authors: Sebben JE

    更新日期:1988-05-01 00:00:00

  • Cutaneous extramedullary hemopoiesis in chronic myeloproliferative and myelodysplastic disorders.

    abstract::Cutaneous extramedullary hemopoiesis (EMH) is a rare complication of chronic myeloproliferative and myelodysplastic disorders. Chronic idiopathic myelofibrosis (CIMF) is the most common underlying condition. To date, fewer than 30 cases have been reported in the literature and there has been significant confusion with...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2005.11.1038

    authors: Haniffa MA,Wilkins BS,Blasdale C,Simpson NB

    更新日期:2006-08-01 00:00:00

  • Cellular and immunologic mechanisms in atopic dermatitis.

    abstract::Atopic dermatitis is a chronic inflammatory skin disease that is frequently associated with respiratory allergies. Atopic dermatitis develops as a result of a complex interrelationship of environmental, immunologic, genetic, and pharmacologic factors. Efforts to understand the relative contributions of these factors h...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1067/mjd.2001.109815

    authors: Leung DY,Soter NA

    更新日期:2001-01-01 00:00:00

  • Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas.

    abstract:BACKGROUND:We have used a schedule for soft x-ray therapy of epithelial malignancies that takes into account the clinically diagnosed tumor involution under treatment. OBJECTIVE:We sought to evaluate the effectiveness of this schedule in terms of cure rate and late ulcerations. METHODS:Patients with 1267 consecutivel...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2005.07.045

    authors: Schulte KW,Lippold A,Auras C,Bramkamp G,Breitkopf C,Elsmann HJ,Habenicht EM,Jasnoch V,Müller-Pannes H,Rupprecht R,Suter L

    更新日期:2005-12-01 00:00:00

  • Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis.

    abstract::For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(85)70004-7

    authors: Pestana A,Halprin KM,Taylor JR,Schiff ER,Esquenazi V,Comerford M,Gomez C

    更新日期:1985-01-01 00:00:00

  • Eosinophilic pustular folliculitis.

    abstract::We present the case of an American adult patient with eosinophilic pustular folliculitis. The majority of previously reported patients have been Japanese. Eosinophilic pustular folliculitis is a rare condition characterized by recurrent, peripherally expanding, sterile papulopustules and plaques. Hair-bearing areas su...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70061-3

    authors: Jaliman HD,Phelps RG,Fleischmajer R

    更新日期:1986-03-01 00:00:00

  • Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage.

    abstract::We studied the effects of two retinoids, naturally occurring all-trans-retinoic acid (retinoic acid) and the synthetic 4-hydroxyphenylretinamide (4-OH-PRT) on monolayer cultures of rabbit synovial fibroblasts and on explants of rabbit articular cartilage. Treatment of fibroblasts with phorbol myristate acetate (PMA; 1...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(82)70048-9

    authors: Brinckerhoff CE,Nagase H,Nagel JE,Harris ED Jr

    更新日期:1982-04-01 00:00:00

  • Apoeccrine sweat duct obstruction as a cause for Fox-Fordyce disease.

    abstract::The pathogenesis of Fox-Fordyce disease has been reported to be hyperkeratosis and obstruction of the upper hair follicle, where the duct of the apocrine sweat gland opens. We report a case of Fox-Fordyce disease with full clinical manifestation. It appeared to be caused by the obstruction of intraepidermal apoeccrine...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2003.93

    authors: Kamada A,Saga K,Jimbow K

    更新日期:2003-03-01 00:00:00

  • Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee.

    abstract::In 2002, the National Rosacea Society assembled an expert committee to develop the first standard classification of rosacea. This original classification was intended to be updated as scientific knowledge and clinical experience increased. Over the last 15 years, significant new insights into rosacea's pathogenesis an...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2017.08.037

    authors: Gallo RL,Granstein RD,Kang S,Mannis M,Steinhoff M,Tan J,Thiboutot D

    更新日期:2018-01-01 00:00:00

  • The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis: A retrospective chart review.

    abstract:BACKGROUND:It is unclear whether the type 2 T helper cell-specific immunosuppressive action of dupilumab interferes with patch testing. OBJECTIVES:We sought to evaluate the reliability of patch testing on dupilumab and the contribution of allergic contact dermatitis (ACD) to complex dermatitis in patients with residua...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.09.028

    authors: Raffi J,Suresh R,Botto N,Murase JE

    更新日期:2020-01-01 00:00:00

  • Hepatonecrosis resulting from parenteral gold therapy in pemphigus vulgaris.

    abstract::A patient who had pemphigus vulgaris received therapy with gold thiomalate in addition to dexamethasone. Three weeks after the initiation of parenteral gold the patient developed acute hepatitis. Causes other than gold toxicity were ruled out, and the patient recovered completely after discontinuation of gold therapy....

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(93)70019-p

    authors: Rye B,Krusinski PA

    更新日期:1993-01-01 00:00:00

  • Forensics in dermatology: part II.

    abstract::The evaluation of skin findings is critical in identifying many types of injury, whether self- inflicted or accidentally or intentionally inflicted. Specific causes of injury include homicide, abuse, neglect, assault, self-inflicted injury, suicide, torture, poisoning, and bioterrorism. Forensic findings in hair and n...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2010.06.066

    authors: Reddy K,Lowenstein EJ

    更新日期:2011-05-01 00:00:00

  • Photoprotection: part II. Sunscreen: development, efficacy, and controversies.

    abstract::In addition to the naturally occurring, physical, and systemic photoprotective agents reviewed in part I, topical ultraviolet radiation filters are an important cornerstone of photoprotection. Sunscreen development, efficacy, testing, and controversies are reviewed in part II of this continuing medical education artic...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2013.08.022

    authors: Jansen R,Osterwalder U,Wang SQ,Burnett M,Lim HW

    更新日期:2013-12-01 00:00:00

  • Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies.

    abstract:BACKGROUND:Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported. OBJECTIVES:To assess the prevalence and incidence of PsA in patients with psoriasis. METHODS:Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of P...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jaad.2018.06.027

    authors: Alinaghi F,Calov M,Kristensen LE,Gladman DD,Coates LC,Jullien D,Gottlieb AB,Gisondi P,Wu JJ,Thyssen JP,Egeberg A

    更新日期:2019-01-01 00:00:00

  • How fingerprints came into use for personal identification.

    abstract::The use of fingerprints for personal identification became widespread early in this century. How the fingerprints slowly became standardized involves many persons, including Nathaniel Grew, Johannes Purkinje, William Herschel, Henry Faulds, Charles Darwin, Francis Galton, Mark Twain, Juan Vucetich, Edward Henry, and J...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/0190-9622(90)70194-m

    authors: Caplan RM

    更新日期:1990-07-01 00:00:00

  • A 12-month treatment of severe psoriasis with acitretin: results of a Canadian open multicenter study.

    abstract::Both etretinate and its principal metabolite, acitretin, are efficacious in the treatment of psoriasis. Because patients with severe psoriasis often require chronic therapy, this study was undertaken to determine the efficacy, tolerability, and safety of acitretin in patients on continuous treatment for 12 months. The...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0190-9622(91)70091-f

    authors: Murray HE,Anhalt AW,Lessard R,Schacter RK,Ross JB,Stewart WD,Geiger JM

    更新日期:1991-04-01 00:00:00

  • Utility of the subcutaneous hinge flap in nasal reconstruction.

    abstract::The subcutaneous pedicle hinge flap provides excellent reconstruction of deep defects of the lateral base and caudal sidewall of the nose that extend into the cheek. The indications, flap design, and operative technique are described. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(94)70056-7

    authors: Johnson TM,Baker S,Brown MD,Nelson BR

    更新日期:1994-03-01 00:00:00

  • Cutaneous carcinoma following psoralen and long-wave ultraviolet radiation (PUVA) therapy for psoriasis.

    abstract::Multiple basal cell epitheliomas developed in two psoriatic patients during treatment with orally administered 8-methoxypsoralen and long-wave ultraviolet radiation (PUVA). Twenty-two basal cell epitheliomas (BCEs) were seen in the two patients, 80% occurring in non-sun-exposed areas. Since neither patient had any his...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(80)80362-8

    authors: Brown FS,Burnett JW,Robinson HM Jr

    更新日期:1980-05-01 00:00:00

  • Transforming growth factor-beta overexpression in cutaneous extramedullary hematopoiesis of a patient with myelodysplastic syndrome associated with myelofibrosis.

    abstract::Extramedullary hematopoiesis (EMH) is a relatively rare, but well-documented, manifestation of chronic myeloproliferative disorders. Microscopically, foci of EMH consist of erythroid and myeloid precursors intermixed with megakaryocytes. It typically occurs in the spleen and liver, but very occasionally manifests as c...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.10.489

    authors: Kawakami T,Kimura S,Kato M,Mizoguchi M,Soma Y

    更新日期:2008-04-01 00:00:00

  • Multiple basal cell carcinomas and HLA frequencies in southern Australia.

    abstract::An association between HLA-DR1 and the development of multiple basal cell carcinomas was detected in southern Australia. A reduction in HLA-DR4 was found in patients with basal cell carcinoma compared with a local control group. The relative risk for HLA-DR1 was 2.1, which was lower than that for persons in farther co...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(91)70082-d

    authors: Czarnecki D,Lewis A,Nicholson I,Tait B

    更新日期:1991-04-01 00:00:00

  • Retinoids and inhibition of ornithine decarboxylase activity.

    abstract::The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a dose-dependent induction (up to 300-fold) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone. Enzyme activity...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(82)80060-1

    authors: Boutwell RK

    更新日期:1982-04-01 00:00:00

  • Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review.

    abstract:BACKGROUND:Current knowledge of angiolymphoid hyperplasia with eosinophilia (ALHE) derives from retrospective reports and case series, leading to a nonevidence-based treatment approach. OBJECTIVE:We sought to systematically review the literature relating to cutaneous ALHE to estimate its epidemiology and treatment out...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2015.10.011

    authors: Adler BL,Krausz AE,Minuti A,Silverberg JI,Lev-Tov H

    更新日期:2016-03-01 00:00:00

  • Sweet's syndrome (acute febrile neutrophilic dermatosis)

    abstract::Acute febrile neutrophilic dermatosis, first described in 1964 by Robert Douglas Sweet, has been termed Sweet's syndrome. Classic Sweet's syndrome occurs in middle-aged women after a nonspecific infection of the respiratory or gastrointestinal tract. Raised erythematous plaques with pseudoblistering and occasionally p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(94)70215-2

    authors: von den Driesch P

    更新日期:1994-10-01 00:00:00

  • A prospective observational study evaluating hypothalamic-pituitary-adrenal axis alteration and efficacy of intramuscular triamcinolone acetonide for steroid-responsive dermatologic disease.

    abstract:BACKGROUND:The lack of recommendations regarding dosing and administration, an undetermined risk of hypothalamic-pituitary-adrenal axis alteration, and the unknown effectiveness of intramuscular (IM) corticosteroid injection to treat dermatologic disease may be deterrents to use. OBJECTIVE:We sought to evaluate presen...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2013.02.005

    authors: Reddy S,Ananthakrishnan S,Garg A

    更新日期:2013-08-01 00:00:00

  • Immunology and photocarcinogenesis. New light on an old problem.

    abstract::Renewed interest in experimental photocarcinogenesis was stimulated by the observation that skin cancers induced in mice by ultraviolet radiation are highly antigenic. Most of these cancers are rejected by the immune system on transplantation into a normal, genetically identical animal. This finding raised the questio...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(86)70017-0

    authors: Kripke ML

    更新日期:1986-01-01 00:00:00

  • Topical 5% imiquimod for the therapy of actinic cheilitis.

    abstract:BACKGROUND:Tissue-destructive and more selective cytotoxic therapies are the main methods used to treat actinic cheilitis. A topical immune stimulant, 5% imiquimod cream, has recently been used for treatment of cutaneous epithelial malignancies including squamous cell carcinoma in situ and basal cell carcinoma. OBJECT...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2002.126266

    authors: Smith KJ,Germain M,Yeager J,Skelton H

    更新日期:2002-10-01 00:00:00

  • Cutaneous botryomycosis in a patient with acquired immunodeficiency syndrome.

    abstract::A patient with acquired immunodeficiency syndrome presented with multiple pruritic papules and nodules over the trunk and extremities. Biopsy specimens from two of these lesions contained granules within abscesses of the papillary dermis. There were numerous gram-positive cocci within the granules. Culture of one lesi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)80072-5

    authors: Patterson JW,Kitces EN,Neafie RC

    更新日期:1987-01-01 00:00:00

  • Therapeutic evaluation for intralesional injection of bleomycin sulfate in 143 resistant warts.

    abstract::A 1 U/ml solution of bleomycin sulfate in physiologic saline solution was injected intralesionally in 38 patients, and was compared with physiologic saline solution injection into paired warts in the same patient. No patient received more than 2 ml of bleomycin. Ninety-seven of 143 warts (67.8%) showed complete resolu...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0190-9622(88)70140-1

    authors: Amer M,Diab N,Ramadan A,Galal A,Salem A

    更新日期:1988-06-01 00:00:00

  • Subcutaneous fat necrosis of the newborn with hypercalcemia.

    abstract::A newborn infant with subcutaneous fat necrosis and hypercalcemia is presented. Literature on the association between subcutaneous fat necrosis of the newborn and hypercalcemia is reviewed. Affected infants generally experience severe perinatal difficulties. Both vaginal deliveries and cesarean sections can be associa...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)70056-5

    authors: Norwood-Galloway A,Lebwohl M,Phelps RG,Raucher H

    更新日期:1987-02-01 00:00:00

  • Clinical presentation, immunopathology, and treatment of juvenile-onset mycosis fungoides: a case series of 34 patients.

    abstract:BACKGROUND:Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, typically presents in middle-aged to elderly individuals. OBJECTIVE:We sought to study the demographics, clinicopathologic features, treatment response, and prognosis of patients with biopsy-proven MF diagnosed before 20 years of age...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2014.07.049

    authors: Boulos S,Vaid R,Aladily TN,Ivan DS,Talpur R,Duvic M

    更新日期:2014-12-01 00:00:00