Abstract:
:One of the prominent biological phenomena controlled by Wnt signaling is the expansion of cells with predefined fates. In the November 27, 2002, issue of Cell, Rosenfeld and colleagues describe an example of Wnt-controlled proliferation during genesis of the cardiac outflow tract and the pituitary gland. As a downstream target gene of the Wnt cascade, the bicoid-related transcription factor Pitx2 directly drives proliferation in these tissues.
journal_name
Mol Celljournal_title
Molecular cellauthors
Clevers Hdoi
10.1016/s1097-2765(02)00801-8subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1260-1issue
6eissn
1097-2765issn
1097-4164pii
S1097-2765(02)00801-8journal_volume
10pub_type
杂志文章相关文献
MOLECULAR CELL文献大全abstract::The heat shock protein 90 (Hsp90) family of heat shock proteins is an abundantly expressed and highly conserved family of ATP-dependent molecular chaperones. Hsp90 facilitates remodeling and activation of hundreds of proteins. In this study, we developed a screen to identify Hsp90-defective mutants in E. coli. The mut...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.11.017
更新日期:2013-02-07 00:00:00
abstract::Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are largely unknown. We have carried out whole-genome bisulfite sequencing (BS-Seq) and RNA-Seq across key stages from E6.5 epiblast to E16.5 PGCs. Global...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.11.001
更新日期:2012-12-28 00:00:00
abstract::We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new componen...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)00059-9
更新日期:2000-09-01 00:00:00
abstract::Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil domain that disrupt ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00274-0
更新日期:2003-07-01 00:00:00
abstract::The RNA-binding protein HuR, while known to stabilize cytoplasmic mRNAs, is largely nuclear. In this issue of Molecular Cell, Mukherjee et al. (2011) and Lebedeva et al. (2011) identify transcriptome-wide HuR-RNA interactions using PAR-CLIP, unveiling HuR's nuclear role in pre-mRNA processing. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2011.07.016
更新日期:2011-08-05 00:00:00
abstract::In the current issue of Molecular Cell, Liu et al. (2020) show that the secretion of cancer-linked forms of mutant calreticulin allow cancer cells to escape protective immune responses induced by chemotherapeutic and immunotherapeutic drugs, thereby promoting tumor growth. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2020.01.024
更新日期:2020-02-20 00:00:00
abstract::The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like beta-grasp folds that interact with e...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2006.08.002
更新日期:2006-09-01 00:00:00
abstract::Genome stability depends upon the RecQ helicases, which are conserved from bacteria to man, but little is known about how their myriad activities are regulated. Fission yeast lacking the telomere protein Taz1 (mammalian TRF1/TRF2 ortholog) lose many hallmarks of telomeres, including accurate replication and local prot...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.01.027
更新日期:2009-03-13 00:00:00
abstract::The accurate propagation of histone marks during chromosomal replication is proposed to rely on the tight coupling of replication with the recycling of parental histones to the daughter strands. Here, we show in the avian cell line DT40 that REV1, a key regulator of DNA translesion synthesis at the replication fork, i...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.11.009
更新日期:2010-12-10 00:00:00
abstract::Transcription is repressed if a DNA double-strand break (DSB) is introduced in close proximity to a transcriptional activation site at least in part by H2A-ubiquitination. While ATM signaling is involved, how it controls H2A-ubiquitination remains unclear. Here, we identify that, in response to DSBs, a transcriptional...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.03.023
更新日期:2015-05-07 00:00:00
abstract::The Mre11-Rad50-Xrs2 (MRX) complex is related to SMC complexes that form rings capable of holding two distinct DNA strands together. MRX functions at stalled replication forks and double-strand breaks (DSBs). A mutation in the N-terminal OB fold of the 70 kDa subunit of yeast replication protein A, rfa1-t11, abrogates...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.10.032
更新日期:2016-12-01 00:00:00
abstract::Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(01)00298-2
更新日期:2001-07-01 00:00:00
abstract::RING ubiquitin ligases (E3) recruit ubiquitin-conjugate enzymes (E2) charged with ubiquitin (Ub) to catalyze ubiquitination. Non-covalent Ub binding to the backside of certain E2s promotes processive polyUb formation, but the mechanism remains elusive. Here, we show that backside bound Ub (Ub(B)) enhances both RING-in...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.02.017
更新日期:2015-04-16 00:00:00
abstract::Two publications in the current issue of Cell introduce novel methods for high-throughput single-cell transcriptomics by using droplet microfluidics and sophisticated barcoding schemes for transcriptional profiling of thousands of individual cells. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2015.05.019
更新日期:2015-05-21 00:00:00
abstract::In a recent paper in Cell Metabolism, Altman et al. (2015) report that MYC disrupts the molecular clock in cancer cells and describe a link between oncogenesis, circadian rhythms, and metabolism. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2015.11.008
更新日期:2015-11-19 00:00:00
abstract::In this issue of Molecular Cell, Conaway and colleagues (Yao et al., 2008) provide a glimpse into an interesting mechanism to control a deubiquitylating enzyme via interaction of two complexes-the 19S proteasome regulatory particle and an ATP-dependent nucleosome remodeling complex. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.09.005
更新日期:2008-09-26 00:00:00
abstract::Protein synthesis is a major target within the bacterial cell for antibiotics. Investigations into ribosome-targeting antibiotics have provided much needed functional and structural insight into their mechanism of action. However, the increasing prevalence of multi-drug-resistant bacteria has limited the utility of ou...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2015.10.019
更新日期:2016-01-07 00:00:00
abstract::Trimethylation of histone H3 on lysine 4 (H3K4me3) localizes near the 5' region of genes and is tightly associated with active loci. Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumor suppressor family, directly recognize this lysine methyl mark. However, how H3K4me3 recognition participates in active tra...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.11.010
更新日期:2007-11-30 00:00:00
abstract::MicroRNAs have recently emerged as key posttranscriptional regulators of eukaryotic gene expression, yet our understanding of how microRNA expression is itself controlled has remained rudimentary. This review describes recent insights into the mechanisms governing microRNA transcription and processing in vertebrates a...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2004.12.002
更新日期:2004-12-22 00:00:00
abstract::Telomeres protect chromosome ends from fusing to double-stranded breaks (DSBs). Using a quantitative real-time PCR assay, we show that nonhomologous end joining between a telomere and an inducible DSB was undetectable in wild-type cells, but occurred within a few hours of DSB induction in approximately 1/2000 genomes ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00174-6
更新日期:2003-05-01 00:00:00
abstract::Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adaptor protein WDR82 and its assoc...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.09.018
更新日期:2015-11-05 00:00:00
abstract::Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing ribosome footprinting from fly heads, we demonstrate that a group of circRNAs is associated with translating ribosomes. Many of these ribo-ci...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.02.021
更新日期:2017-04-06 00:00:00
abstract::Faithful duplication of the genome in S phase followed by its accurate segregation in mitosis is essential to maintain genomic integrity. Recent studies have suggested that proteins involved in DNA transactions are also required for whole-chromosome stability. Here we demonstrate that the MRN (Mre11, Rad50, and Nbs1) ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.01.023
更新日期:2013-03-28 00:00:00
abstract::Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in multicellular life. Although AS variation has been observed among single cells, little is known about the biological or evolutionary significance of such variation. We developed Expedition, a computational framework consisti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.06.003
更新日期:2017-07-06 00:00:00
abstract::Stress granules (SGs) are condensates of mRNPs that form in response to stress. SGs arise by multivalent protein-protein, protein-RNA, and RNA-RNA interactions. However, the role of RNA-RNA interactions in SG assembly remains understudied. Here, we describe a yeast SG reconstitution system that faithfully recapitulate...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2020.07.017
更新日期:2020-09-17 00:00:00
abstract::AAA+ proteins (ATPases associated with various cellular activities) are oligomeric ATPases that use ATP hydrolysis to remodel their substrates. By similarity with GTPases, a dynamic organization of the nucleotide-binding pockets between ATPase protomers is proposed to regulate functionality. Using the transcription ac...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.06.012
更新日期:2012-08-10 00:00:00
abstract::The Chk2 Ser/Thr kinase plays crucial, evolutionarily conserved roles in cellular responses to DNA damage. Identification of two pro-oncogenic mutations within the Chk2 FHA domain has highlighted its importance for Chk2 function in checkpoint activation. The X-ray structure of the Chk2 FHA domain in complex with an in...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(02)00527-0
更新日期:2002-05-01 00:00:00
abstract::Ten E. coli aminoacyl-tRNAs (aa-tRNAs) were assessed for their ability to decode cognate codons on E. coli ribosomes by using three assays that evaluate the key steps in the decoding pathway. Despite a wide variety of structural features, each aa-tRNA exhibited similar kinetic and thermodynamic properties in each assa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.04.026
更新日期:2008-07-11 00:00:00
abstract::Mismatch repair (MMR) is initiated by MutS family proteins (MSH) that recognize DNA mismatches and recruit downstream repair factors. We used a single-molecule DNA-unzipping assay to probe interactions between S. cerevisiae MSH2-MSH6 and a variety of DNA mismatch substrates. This work revealed a high-specificity bindi...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2005.10.014
更新日期:2005-12-09 00:00:00
abstract::The stimulation of fibroblast growth factor receptors (FGFRs) with distinct FGF ligands generates specific cellular responses. However, the mechanisms underlying this paradigm have remained elusive. Here, we show that FGF-7 stimulation leads to FGFR2b degradation and, ultimately, cell proliferation, whereas FGF-10 pro...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.08.002
更新日期:2013-09-26 00:00:00