A Calreticulin Tail: C-terminal Mutants of Calreticulin Allow Cancer Cells to Evade Phagocytosis.

Abstract:

:In the current issue of Molecular Cell, Liu et al. (2020) show that the secretion of cancer-linked forms of mutant calreticulin allow cancer cells to escape protective immune responses induced by chemotherapeutic and immunotherapeutic drugs, thereby promoting tumor growth.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Kaur A,Raghavan M

doi

10.1016/j.molcel.2020.01.024

subject

Has Abstract

pub_date

2020-02-20 00:00:00

pages

683-685

issue

4

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(20)30045-9

journal_volume

77

pub_type

评论,杂志文章
  • A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies.

    abstract::The transcriptional coactivators CBP and p300 are critical regulators of metazoan gene expression. They associate with many different DNA-bound transcription factors through small, conserved domains. We have identified a compactly folded 46 residue domain in CBP and p300, the IRF-3 binding domain (IBiD), and we have d...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)00333-1

    authors: Lin CH,Hare BJ,Wagner G,Harrison SC,Maniatis T,Fraenkel E

    更新日期:2001-09-01 00:00:00

  • CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.

    abstract::Growth factors such as epidermal growth factor (EGF) and insulin regulate development and metabolism via genes containing both POU homeodomain (Pit-1) and phorbol ester (AP-1) response elements. Although CREB binding protein (CBP) functions as a coactivator on these elements, the mechanism of transactivation was previ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(01)00202-7

    authors: Zanger K,Radovick S,Wondisford FE

    更新日期:2001-03-01 00:00:00

  • Prolyl cis-trans Isomerization as a molecular timer in Crk signaling.

    abstract::In a recent issue of Molecular Cell, use NMR to identify peptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, suggesting a new mechanism for controlling the rate of formation of signaling complexes. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2007.02.005

    authors: Nicholson LK,Lu KP

    更新日期:2007-02-23 00:00:00

  • Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.

    abstract::Histone H3K4 demethylase LSD1 plays an important role in stem cell biology, especially in the maintenance of the silencing of differentiation genes. However, how the function of LSD1 is regulated and the differentiation genes are derepressed are not understood. Here, we report that elimination of LSD1 promotes embryon...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2014.06.006

    authors: Han X,Gui B,Xiong C,Zhao L,Liang J,Sun L,Yang X,Yu W,Si W,Yan R,Yi X,Zhang D,Li W,Li L,Yang J,Wang Y,Sun YE,Zhang D,Meng A,Shang Y

    更新日期:2014-08-07 00:00:00

  • Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation.

    abstract::By using single-molecule fluorescence resonance energy transfer (smFRET), we observe the real-time dynamic coupling between the ribosome, labeled at the L1 stalk, and transfer RNA (tRNA). We find that an interaction between the ribosomal L1 stalk and the newly deacylated tRNA is established spontaneously upon peptide ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2008.03.012

    authors: Fei J,Kosuri P,MacDougall DD,Gonzalez RL Jr

    更新日期:2008-05-09 00:00:00

  • miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2.

    abstract::Macroautophagy (autophagy) is a lysosome-dependent degradation process that has been implicated in age-associated diseases. Autophagy is involved in both cell survival and cell death, but little is known about the mechanisms that distinguish its use during these distinct cell fates. Here, we identify the microRNA miR-...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2014.09.011

    authors: Nelson C,Ambros V,Baehrecke EH

    更新日期:2014-11-06 00:00:00

  • A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus.

    abstract::The sliding clamp, PCNA, of the archaeon Sulfolobus solfataricus P2 is a heterotrimer of three distinct subunits (PCNA1, 2, and 3) that assembles in a defined manner. The PCNA heterotrimer, but not individual subunits, stimulates the activities of the DNA polymerase, DNA ligase I, and the flap endonuclease (FEN1) of S...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(02)00824-9

    authors: Dionne I,Nookala RK,Jackson SP,Doherty AJ,Bell SD

    更新日期:2003-01-01 00:00:00

  • Tbf1 or not Tbf1?

    abstract::In this issue of Molecular Cell, Hogues et al. (2008) demonstrate a wholesale shift in the key regulatory protein involved in ribosomal protein (RP) synthesis during the evolution of S. cerevisiae and, en passant, raise interesting questions about the relationship between RP genes and telomeres. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2008.02.008

    authors: Bhattacharya A,Warner JR

    更新日期:2008-03-14 00:00:00

  • Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.

    abstract::In all branches of life, stalled translation intermediates are recognized and processed by ribosome-associated quality control (RQC) pathways. RQC begins with the splitting of stalled ribosomes, leaving an unfinished polypeptide still attached to the large subunit. Ancient and conserved NEMF family RQC proteins target...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2020.11.002

    authors: Crowe-McAuliffe C,Takada H,Murina V,Polte C,Kasvandik S,Tenson T,Ignatova Z,Atkinson GC,Wilson DN,Hauryliuk V

    更新日期:2021-01-07 00:00:00

  • Autoinhibition of Bcr-Abl through its SH3 domain.

    abstract::Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil domain that disrupt ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(03)00274-0

    authors: Smith KM,Yacobi R,Van Etten RA

    更新日期:2003-07-01 00:00:00

  • Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.

    abstract::Sterol accumulation in membranes blocks the exit of SCAP from the ER, preventing SREBP cleavage and reducing cholesterol synthesis. Sterols act through SCAP's sterol-sensing domain by an obscure mechanism. Here, we show that addition of cholesterol to ER membranes in vitro causes a conformational change in SCAP, detec...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(02)00591-9

    authors: Brown AJ,Sun L,Feramisco JD,Brown MS,Goldstein JL

    更新日期:2002-08-01 00:00:00

  • Retracted: Histone H2B ubquitination regulates retinoic acid signaling through the cooperation of ASXL1 and BAP1.

    abstract::Despite the importance of retinoic acid (RA) signaling and histone monoubiquitination in determining cell fate, the underlying mechanism linking the two processes is poorly explored. We describe that additional sex comb-like 1 (ASXL1) represses RA receptor activity by cooperating with BRCA1-associated protein 1 (BAP1)...

    journal_title:Molecular cell

    pub_type: 杂志文章,收录出版

    doi:10.1016/j.molcel.2013.06.005

    authors: Lee SW,Youn H,Kim EJ,Um SJ

    更新日期:2013-07-25 00:00:00

  • Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

    abstract::Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as a central regulatory mechanism of protein function. However, little is known about the regulation of sumoylation itself. It has been reported that it is increased after exposure to various stresses including strong oxidative str...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2005.12.019

    authors: Bossis G,Melchior F

    更新日期:2006-02-03 00:00:00

  • Angiogenin-induced tRNA fragments inhibit translation initiation.

    abstract::Angiogenin is a stress-activated ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or synthetic tiRNAs inhibits protein synthesis and triggers the phospho-eIF2α-independent assembly of stress granules (SGs), essential components of ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2011.06.022

    authors: Ivanov P,Emara MM,Villen J,Gygi SP,Anderson P

    更新日期:2011-08-19 00:00:00

  • Summon SUMO to wrestle with inflammation.

    abstract::In this issue of Molecular Cell, Lee et al. (2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2009.09.002

    authors: Liu B,Shuai K

    更新日期:2009-09-24 00:00:00

  • Chromatin opening of DNA satellites by targeted sequence-specific drugs.

    abstract::There are few tools available for dissecting and elucidating the functions of DNA satellites and other nongenic DNA. To address this, we have explored the experimental potential of DNA sequence-specific drugs containing pyrrole and imidazole amino acids (polyamides). Compounds were synthesized that target different Dr...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(00)00099-x

    authors: Janssen S,Durussel T,Laemmli UK

    更新日期:2000-11-01 00:00:00

  • A Dicer-Independent Route for Biogenesis of siRNAs that Direct DNA Methylation in Arabidopsis.

    abstract::DNA methylation directed by 24-nucleotide (nt) small interfering RNAs (siRNAs) plays critical roles in gene regulation and transposon silencing in Arabidopsis. 24-nt siRNAs are known to be processed from double-stranded RNAs by Dicer-like 3 (DCL3) and loaded into the effector Argonaute 4 (AGO4). Here we report a disti...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2015.11.015

    authors: Ye R,Chen Z,Lian B,Rowley MJ,Xia N,Chai J,Li Y,He XJ,Wierzbicki AT,Qi Y

    更新日期:2016-01-21 00:00:00

  • Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18.

    abstract::The protein 53BP1 plays a central regulatory role in DNA double-strand break repair. 53BP1 relocates to chromatin by recognizing RNF168-mediated mono-ubiquitylation of histone H2A Lys15 in the nucleosome core particle dimethylated at histone H4 Lys20 (NCP-ubme). 53BP1 relocation is terminated by ubiquitin ligases RNF1...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2017.04.009

    authors: Hu Q,Botuyan MV,Cui G,Zhao D,Mer G

    更新日期:2017-05-18 00:00:00

  • Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).

    abstract::Fidaxomicin is an antibacterial drug in clinical use for treatment of Clostridium difficile diarrhea. The active ingredient of fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting bacterial RNA polymerase (RNAP). Here we report a cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme in complex with Lpm...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2018.02.026

    authors: Lin W,Das K,Degen D,Mazumder A,Duchi D,Wang D,Ebright YW,Ebright RY,Sineva E,Gigliotti M,Srivastava A,Mandal S,Jiang Y,Liu Y,Yin R,Zhang Z,Eng ET,Thomas D,Donadio S,Zhang H,Zhang C,Kapanidis AN,Ebright RH

    更新日期:2018-04-05 00:00:00

  • Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment.

    abstract::Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Several replication-fork-associated "cohesion establishment factors," including the multifunctional Ctf18-RFC complex, aid this process in as yet unknown ways. Here, we show that Ctf18-RFC...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2020.03.017

    authors: Liu HW,Bouchoux C,Panarotto M,Kakui Y,Patel H,Uhlmann F

    更新日期:2020-05-21 00:00:00

  • Growth factor withdrawal and apoptosis: the middle game.

    abstract::In this issue of Molecular Cell, detail molecular events that trigger apoptosis following growth factor withdrawal, linking irreversible mitochondrial permeabilization to activation of GSK-3 and subsequent phosphorylation, ubiquitinylation, and degradation of the antiapoptotic BCL-2 family member MCL-1. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.molcel.2006.03.005

    authors: Letai A

    更新日期:2006-03-17 00:00:00

  • Involvement of actin-related proteins in ATP-dependent chromatin remodeling.

    abstract::Actin-related proteins (Arps) and conventional actin are enigmatic components of many chromatin-remodeling enzyme complexes. The yeast INO80 ATP-dependent chromatin-remodeling complex contains stoichiometric amounts of Arp4, Arp5, Arp8, and actin. Here we have revealed functions of Arp5 and Arp8 by analysis of mutants...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(03)00264-8

    authors: Shen X,Ranallo R,Choi E,Wu C

    更新日期:2003-07-01 00:00:00

  • Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

    abstract::Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic transmission, is a typical case of a human protein that necessitates mammalian systems to obtain functional expression. We developed a computat...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2016.06.012

    authors: Goldenzweig A,Goldsmith M,Hill SE,Gertman O,Laurino P,Ashani Y,Dym O,Unger T,Albeck S,Prilusky J,Lieberman RL,Aharoni A,Silman I,Sussman JL,Tawfik DS,Fleishman SJ

    更新日期:2016-07-21 00:00:00

  • Redox Control of Mitochondrial Calcium Uptake.

    abstract::Dong et al. (2017) establish how the mitochondrial Ca2+ uniporter (MCU) integrates Ca2+ and oxidative stress signals by identifying a cysteine residue that controls MCU channel activity, a mechanism causing mitochondrial Ca2+ overload and cell death during oxidative stress. ...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2017.02.029

    authors: Demaurex N,Rosselin M

    更新日期:2017-03-16 00:00:00

  • The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.

    abstract::During meiosis, the homologous chromosomes pair and recombine. An evolutionarily conserved protein structure, the synaptonemal complex (SC), is located along the paired meiotic chromosomes. We have studied the function of a structural component in the axial/lateral element of the SC, the synaptonemal complex protein 3...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/s1097-2765(00)80404-9

    authors: Yuan L,Liu JG,Zhao J,Brundell E,Daneholt B,Höög C

    更新日期:2000-01-01 00:00:00

  • The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.

    abstract::The phosphatidylinositol 3-kinase (PI3K) signaling pathway is frequently deregulated in cancer. Downstream of PI3K, Akt1 and Akt2 have opposing roles in breast cancer invasive migration, leading to metastatic dissemination. Here, we identify palladin, an actin-associated protein, as an Akt1-specific substrate that mod...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2010.02.031

    authors: Chin YR,Toker A

    更新日期:2010-05-14 00:00:00

  • Liquid Active Zones for Controlling the Phases of Synaptic Transmission.

    abstract::Wu et al. (2019) establish that the active zone proteins RIM and RIM-BP undergo liquid-liquid phase separation to tether Ca2+ channels. This important finding sets a new framework to study assembly and function of the presynaptic nerve terminal. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.molcel.2019.02.020

    authors: Emperador-Melero J,Kaeser PS

    更新日期:2019-03-07 00:00:00

  • Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.

    abstract::Given the intimate link between inflammation and dysregulated cell proliferation in cancer, we investigated cytokine-triggered gene expression in different cell cycle stages. Transcriptome analysis revealed that G1 release through cyclin-dependent kinase 6 (CDK6) and CDK4 primes and cooperates with the cytokine-driven...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2013.12.002

    authors: Handschick K,Beuerlein K,Jurida L,Bartkuhn M,Müller H,Soelch J,Weber A,Dittrich-Breiholz O,Schneider H,Scharfe M,Jarek M,Stellzig J,Schmitz ML,Kracht M

    更新日期:2014-01-23 00:00:00

  • An In Vitro Assembly System Identifies Roles for RNA Nucleation and ATP in Yeast Stress Granule Formation.

    abstract::Stress granules (SGs) are condensates of mRNPs that form in response to stress. SGs arise by multivalent protein-protein, protein-RNA, and RNA-RNA interactions. However, the role of RNA-RNA interactions in SG assembly remains understudied. Here, we describe a yeast SG reconstitution system that faithfully recapitulate...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2020.07.017

    authors: Begovich K,Wilhelm JE

    更新日期:2020-09-17 00:00:00

  • The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.

    abstract::Regulation of gene expression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to high osmolarity results in activation of the SAPK Hog1, which associates with transcription factors bound at target promoters and stimulates transcriptional initiati...

    journal_title:Molecular cell

    pub_type: 杂志文章

    doi:10.1016/j.molcel.2006.05.031

    authors: Proft M,Mas G,de Nadal E,Vendrell A,Noriega N,Struhl K,Posas F

    更新日期:2006-07-21 00:00:00