The effects of general anesthetics on norepinephrine release from isolated rat cortical nerve terminals.


UNLABELLED:Intravenous and volatile general anesthetics inhibit norepinephrine (NE) release from sympathetic neurons and other neurosecretory cells. However, the actions of general anesthetics on NE release from central nervous system (CNS) neurons are unclear. We investigated the effects of representative IV and volatile anesthetics on [(3)H]NE release from isolated rat cortical nerve terminals (synaptosomes). Purified synaptosomes prepared from rat cerebral cortex were preloaded with [(3)H]NE and superfused with buffer containing pargyline (a monoamine oxidase inhibitor) and ascorbic acid (an antioxidant). Basal (spontaneous) and stimulus-evoked [(3)H]NE release was evaluated in the superfusate in the absence or presence of various anesthetics. Depolarization with increased concentrations of KCl (15-20 mM) or 4-aminopyridine (0.5-1.0 mM) evoked concentration- and Ca(2+)-dependent increases in [(3)H]NE release from rat cortical synaptosomes. The IV anesthetics etomidate (5-40 microM), ketamine (5-30 microM), or pentobarbital (25-100 microM) did not affect basal or stimulus-evoked [(3)H]NE release. Propofol (5-40 microM) increased basal [(3)H]NE release and, at larger concentrations, reduced stimulus-evoked release. The volatile anesthetic halothane (0.15-0.70 mM) increased basal [(3)H]NE release, but did not affect stimulus-evoked release. These findings demonstrate drug-specific stimulation of basal NE release. Noradrenergic transmission may represent a presynaptic target for selected general anesthetics in the CNS. Given the contrasting effects of general anesthetics on the release of other CNS transmitters, the presynaptic actions of general anesthetics are both drug- and transmitter-specific. IMPLICATIONS:General anesthetics affect synaptic transmission both by altering neurotransmitter release and by modulating postsynaptic responses to transmitter. Anesthetics exert both drug-specific and transmitter-specific effects on transmitter release: therapeutic concentrations of some anesthetics stimulate basal, but not evoked, norepinephrine release, in contrast to evoked glutamate release, which is inhibited.


Anesth Analg


Anesthesia and analgesia


Pashkov VN,Hemmings HC Jr




Has Abstract


2002-11-01 00:00:00


1274-81, table of contents










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    abstract:BACKGROUND:In this study, we evaluated the efficacy of celiac plexus block for the treatment of feeding intolerance in critically ill patients. METHODS:Nineteen mechanically ventilated medical patients intolerant of enteral nutrition and receiving metoclopramide underwent bilateral celiac plexus block. The anterior pr...

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    authors: Memis D,Inal MT,Temizoz O,Genchallac H,Ozdemir H,Sut N

    更新日期:2010-04-01 00:00:00

  • Regression of sensory anesthesia during continuous epidural infusions of bupivacaine and opioid for total knee replacement.

    abstract::The epidural administration of morphine and fentanyl delay the regression of sensory anesthesia in postoperative patients receiving epidural bupivacaine. This study was performed to determine any differential effects of two lipid-soluble opioids upon regression of sensory anesthesia during coadministration with epidur...

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ferrante FM,Fanciullo GJ,Grichnik KP,Vaisman J,Sacks GM,Concepcion MA

    更新日期:1993-12-01 00:00:00

  • Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation.

    abstract:IMPLICATIONS:This case describes the impact of argatroban and off-pump coronary revascularization on hemostasis as assessed by conventional hemostatic measures and Thrombelastography in a patient with heparin-induced thrombocytopenia. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kieta DR,McCammon AT,Holman WL,Nielsen VG

    更新日期:2003-04-01 00:00:00

  • Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates.

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    authors: Skrobik Y,Ahern S,Leblanc M,Marquis F,Awissi DK,Kavanagh BP

    更新日期:2010-08-01 00:00:00

  • The Science of Local Anesthesia: Basic Research, Clinical Application, and Future Directions.

    abstract::Local anesthetics have been used clinically for more than a century, but new insights into their mechanisms of action and their interaction with biological systems continue to surprise researchers and clinicians alike. Next to their classic action on voltage-gated sodium channels, local anesthetics interact with calci...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Lirk P,Hollmann MW,Strichartz G

    更新日期:2018-04-01 00:00:00

  • Transcutaneous monitoring of carbon dioxide tension after cardiothoracic surgery in infants and children.

    abstract:UNLABELLED:In this prospective investigation, we evaluated the efficacy and accuracy of transcutaneous monitoring of CO2 (TC-CO2) in infants and children after cardiothoracic surgery. Cardiothoracic surgery patients whose ETCO2 and arterial CO2 values did not correlate (gradient > or = 5 mm Hg) during the first postope...

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  • A simple technique to reduce epistaxis and nasopharyngeal trauma during nasotracheal intubation in a child with factor IX deficiency having dental restoration.

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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


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    更新日期:2004-10-01 00:00:00

  • Intraoperative patient-controlled analgesia: an alternative to physician administration during outpatient monitored anesthesia care.

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  • Effects of Obesity and Leptin Deficiency on Morphine Pharmacokinetics in a Mouse Model.

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    更新日期:2016-12-01 00:00:00

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    更新日期:2008-10-01 00:00:00

  • Initial Preference for Labor Without Neuraxial Analgesia and Actual Use: Results from a National Survey in France.

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    authors: Kpéa L,Bonnet MP,Le Ray C,Prunet C,Ducloy-Bouthors AS,Blondel B

    更新日期:2015-09-01 00:00:00

  • Analysis of 1478 Cases of Hypospadias Repair: The Incidence of Requiring Repeated Anesthetic Exposure as Well as Exploration of the Involvement of Trainees on Case Duration.

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    authors: Xu L,Huang Y,Yu X,Yue J,Yang N,Zuo P

    更新日期:2007-12-01 00:00:00

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    authors: Rothstein P,Arthur GR,Feldman HS,Kopf GS,Covino BG

    更新日期:1986-06-01 00:00:00

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    更新日期:2014-06-01 00:00:00

  • Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence.

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  • Activity changes in rat raphe magnus neurons at different concentrations of fentanyl in vitro.

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    pub_type: 杂志文章


    authors: Ohta Y,Alojado ME,Kemmotsu O

    更新日期:1995-05-01 00:00:00

  • Intraoperative management of patients with carcinoid heart disease having valvular surgery: a review of one hundred consecutive cases.

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  • The relationship among carbon dioxide pneumoperitoneum, vasopressin release, and hemodynamic changes.

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  • Toxicity of chloroprocaine and sodium bisulfite on human neuroblastoma cells.

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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Seravalli E,Lear E

    更新日期:1987-10-01 00:00:00

  • Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.

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    pub_type: 杂志文章


    authors: Shnayderman D,Laster MJ,Eger EI 2nd,Oh I,Zhang Y,Jinks SL,Antognini JF,Raines DE

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  • Exposure to sevoflurane and nitrous oxide during four different methods of anesthetic induction.

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    pub_type: 杂志文章


    authors: Hoerauf KH,Wallner T,Akça O,Taslimi R,Sessler DI

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  • Effects of end-tidal gas monitoring and flow rates on hemodynamic stability and recovery profiles.

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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2002-11-01 00:00:00

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    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wajima Z,Yoshikawa T,Ogura A,Imanaga K,Shiga T,Inoue T,Ogawa R

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    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Heavner JE

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  • Sevoflurane, but not propofol, significantly prolongs the Q-T interval.

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2000-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2000-12-01 00:00:00