Occupational exposure assessment in case-control studies: opportunities for improvement.

Abstract:

:Community based case-control studies are an efficient means to study disease aetiologies, and may be the only practical means to investigate rare diseases. However, exposure assessment remains problematic. We review the literature on the validity and reliability of common case-control exposure assessment methods: occupational histories, job-exposure matrices (JEMs), self reported exposures, and expert assessments. Given the variable quality of current exposure assessment techniques, we suggest methods to improve assessments, including the incorporation of hygiene measurements: using data from administrative exposure databases; using results of studies identifying determinants of exposure to develop questionnaires; and where reasonable given latency and biological half life considerations, directly measuring exposures of study subjects.

journal_name

Occup Environ Med

authors

Teschke K,Olshan AF,Daniels JL,De Roos AJ,Parks CG,Schulz M,Vaughan TL

doi

10.1136/oem.59.9.575

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

575-93; discussion 594

issue

9

eissn

1351-0711

issn

1470-7926

journal_volume

59

pub_type

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