Abstract:
BACKGROUND:It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies. METHODS AND RESULTS:Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, stable metabolite, macromolecular adduct, or measure of cellular damage. Because airborne exposures and these different biomarkers are time series that vary within and between persons in a population, they are all prone to measurement error effects when used as surrogates for true chemical exposures. It was shown that the attenuation bias in the estimated slope characterising a log exposure-log disease relation should decrease as the within- to between-person variance ratio of a given set of air or biomarker measurements decreases. To gauge the magnitudes of these variance ratios, a database of 12,077 repeated observations was constructed from 127 datasets, including air and biological measurements from either occupational or environmental settings. The within- and between-person variance components (in log scale, after controlling for fixed effects of time) and the corresponding variance ratios for each set of air and biomarker measurements were estimated. It was shown that estimated variance ratios of biomarkers decreased in the order short term (residence time < or =2 days) > intermediate term (2 days < residence time < or =2 months) > long term biomarkers (residence time >2 months). Overall, biomarkers had smaller variance ratios than air measurements, particularly in environmental settings. This suggests that a typical biomarker would provide a less biasing surrogate for exposure than would a typical air measurement. CONCLUSION:Epidemiologists are encouraged to consider the magnitudes of variance ratios, along with other factors related to practicality and cost, in choosing among candidate surrogate measures of exposure.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Lin YS,Kupper LL,Rappaport SMdoi
10.1136/oem.2004.013102subject
Has Abstractpub_date
2005-11-01 00:00:00pages
750-60issue
11eissn
1351-0711issn
1470-7926pii
62/11/750journal_volume
62pub_type
杂志文章abstract:BACKGROUND:For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample fr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.018754
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:Violence from care recipients and family members, including both verbal and physical abuse, is a serious occupational hazard for healthcare and social assistance workers. Most workplace violence studies in this sector focus on hospitals and other institutional settings. This study examined verbal abuse in a l...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105604
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To report the effects of bleach use at home on the frequency of infections in 9102 school-age children participating in the HITEA project. METHODS:Parents of pupils aged 6-12 years from schools in Barcelona province (Spain), Utrecht province (the Netherlands) and Eastern and Central Finland were administered...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102701
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2016-104168
更新日期:2017-06-01 00:00:00
abstract:AIMS:To assess the extent of indoor air problems in office environments in Finland. METHODS:Complaints and symptoms related to the indoor environment experienced by office workers were collected from 122 workplaces in 1996-99 by using the modified Indoor Air Questionnaire established by the Finnish Institute of Occupa...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-01-01 00:00:00
abstract:AIMS:To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulphuric acid mists at anodising plants, correlating the findings with duration of exposure and sulphuric acid concentrations in the air, and comparing them with a control group. METHODS:Fifty t...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/oem.60.6.395
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Use of cost-benefit analysis in occupational health increases insight into the intervention strategy that maximises the cost-benefit ratio. This study presents a methodological framework identifying the most important elements of a cost-benefit analysis for occupational health settings. One of the main aims ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2011.064709
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:Prevention of disability in the ageing workforce is essential for sustaining economic growth in Europe. In order to provide information on entry points for preventive measures, it is important to better understand sociodemographic, socioeconomic and work-related determinants of disability in older employees....
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-100924
更新日期:2013-03-01 00:00:00
abstract:AIM:To explore attitudes to influenza immunisation and rates of uptake among staff working in acute hospitals in the UK. METHOD:A cross-sectional survey of 11,670 healthcare workers in six UK hospitals was carried out using a postal questionnaire. RESULTS:Among 6302 responders (54% of those mailed), 19% had taken up ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.023564
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:Vibration white finger (VWF), also known as "occupational Raynaud's phenomenon", is marked by arterial hyperresponsiveness and vasoconstriction during cold stimulation. The impact of tobacco use, and by extension stopping smoking, on the long term course of the disease has been inconclusively characterised. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.5.341
更新日期:2000-05-01 00:00:00
abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.882
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach c...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2016-103597
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:There is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case-control study of French AREVA NC P...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104575
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks, and (c) organisational ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.2.73
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:This study estimated the prevalence of spirometry-defined airflow obstruction and coal workers' pneumoconiosis (CWP) among never-smoking coal miners participating in the National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP). METHODS:Data were from ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106213
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To investigate the relation between fluctuations in personal exposure to nitrogen dioxide (NO(2)) in school children and changes in outdoor NO(2) concentrations. METHODS:114 Asthmatic school children aged 7-12 years were recruited from the Southampton area. Weekly average personal exposures to NO(2) were me...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.7.472
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:Previous research has produced conflicting evidence on the relative merits of advancing and delaying shift systems. The current study assessed the effects of the direction of shift rotation within 8 hour systems, upon a range of measures including sleep, on shift alertness, physical health, and psychological...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.10.678
更新日期:2000-10-01 00:00:00
abstract::Crystalline silica is a widely used industrial material that is readily available worldwide, and is one of the most common types of particulate mineral pollutants. It has been classified as a group 1 human carcinogen of the respiratory system; however, whether it is linked to gastric cancer remains uncertain. We condu...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/oemed-2016-103552
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To study the effect on the incidence of cancer of exposure to chemicals handled in the leather tanning industry. MATERIALS AND METHODS:A case-control study was performed within a cohort of 2487 workers employed for at least six months during the period 1900-89 in three Swedish leather tanneries. 68 cancer ca...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.7.463
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of lumbar supports, education, and exercise in the prevention of back pain in industry. METHODS:A computerised search for controlled clinical trials was conducted. A criteria list was used to assess the methodological quality of the studies. The available evidence for the effectiv...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oem.54.12.841
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:The main objective was to study the acute vascular effects in the hands of normal healthy subjects of a complex vibration spectrum similar to that generated by many industrial hand held tools. The effects of repeated bouts of vibrations and alterations in the intensity of vibration were also studied. METHOD...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.10.663
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:Professional judgment is necessary to assess occupational exposure in population-based case-control studies; however, the assessments lack transparency and are time-consuming to perform. To improve transparency and efficiency, we systematically applied decision rules to questionnaire responses to assess dies...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100524
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The pathogenesis of cataract is influenced by a number of factors including oxidative stress. Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors. It is important for detoxification of xenobiotics in order to protect tissues from oxidative damage...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.022343
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:To examine the efficacy of a participatory ergonomics intervention in preventing musculoskeletal disorders among kitchen workers. Participatory ergonomics is commonly recommended to reduce musculoskeletal disorders, but evidence for its effectiveness is sparse. METHODS:A cluster randomised controlled trial ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/oem.2007.034579
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:To obtain knowledge about the use and distribution of hazardous chemicals in Danish industry. This knowledge is used to regulate the occupational environment and prevent hazardous exposure. METHODS:A national survey on the use of chemicals was carried out in 1989 in a stratified sample of 1448 Danish busine...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.7.454
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106794
更新日期:2021-01-12 00:00:00
abstract::Mortality data have been updated for a further 12 years for a cohort of workers in the reinforced plastics and composites industry with exposures to styrene monomer and other chemicals. The cohort consisted of 15,826 male and female employees who were exposed to styrene for at least six months between 1948 and 1977 at...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.6.386
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVES:Most of the evidence on agreement between self- and proxy-reported occupational data comes from interview-based studies. The authors aimed to examine agreement between women's reports of their partner's occupation and their partner's own description using questionnaire-based data collected as a part of the p...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2009.052506
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To estimate excess mortality during heat waves and cold spells, and to identify vulnerable population groups by age and cause of death. METHODS:Daily mortality in Moscow, Russia from all non-accidental, cardiovascular and respiratory causes between January 2000 and February 2006 was analysed. Mortality and ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2007.033944
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:Job exposure matrices (JEMs) can be constructed from expert-rated assessments, direct measurement and self-reports. This paper describes the construction of a general population JEM based on self-reported physical exposures, its ability to create homogeneous exposure groups (HEG) and the use of different exp...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105287
更新日期:2019-06-01 00:00:00