Air samples versus biomarkers for epidemiology.

Abstract:

BACKGROUND:It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies. METHODS AND RESULTS:Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, stable metabolite, macromolecular adduct, or measure of cellular damage. Because airborne exposures and these different biomarkers are time series that vary within and between persons in a population, they are all prone to measurement error effects when used as surrogates for true chemical exposures. It was shown that the attenuation bias in the estimated slope characterising a log exposure-log disease relation should decrease as the within- to between-person variance ratio of a given set of air or biomarker measurements decreases. To gauge the magnitudes of these variance ratios, a database of 12,077 repeated observations was constructed from 127 datasets, including air and biological measurements from either occupational or environmental settings. The within- and between-person variance components (in log scale, after controlling for fixed effects of time) and the corresponding variance ratios for each set of air and biomarker measurements were estimated. It was shown that estimated variance ratios of biomarkers decreased in the order short term (residence time < or =2 days) > intermediate term (2 days < residence time < or =2 months) > long term biomarkers (residence time >2 months). Overall, biomarkers had smaller variance ratios than air measurements, particularly in environmental settings. This suggests that a typical biomarker would provide a less biasing surrogate for exposure than would a typical air measurement. CONCLUSION:Epidemiologists are encouraged to consider the magnitudes of variance ratios, along with other factors related to practicality and cost, in choosing among candidate surrogate measures of exposure.

journal_name

Occup Environ Med

authors

Lin YS,Kupper LL,Rappaport SM

doi

10.1136/oem.2004.013102

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

750-60

issue

11

eissn

1351-0711

issn

1470-7926

pii

62/11/750

journal_volume

62

pub_type

杂志文章
  • Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women?

    abstract:BACKGROUND:For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample fr...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2004.018754

    authors: Pless-Mulloli T,Edwards R,Howel D,Wood R,Paepke O,Herrmann T

    更新日期:2005-12-01 00:00:00

  • Home care aides' experiences of verbal abuse: a survey of characteristics and risk factors.

    abstract:OBJECTIVE:Violence from care recipients and family members, including both verbal and physical abuse, is a serious occupational hazard for healthcare and social assistance workers. Most workplace violence studies in this sector focus on hospitals and other institutional settings. This study examined verbal abuse in a l...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2018-105604

    authors: Karlsson ND,Markkanen PK,Kriebel D,Gore RJ,Galligan CJ,Sama SR,Quinn MM

    更新日期:2019-07-01 00:00:00

  • Domestic use of bleach and infections in children: a multicentre cross-sectional study.

    abstract:OBJECTIVE:To report the effects of bleach use at home on the frequency of infections in 9102 school-age children participating in the HITEA project. METHODS:Parents of pupils aged 6-12 years from schools in Barcelona province (Spain), Utrecht province (the Netherlands) and Eastern and Central Finland were administered...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2014-102701

    authors: Casas L,Espinosa A,Borràs-Santos A,Jacobs J,Krop E,Heederik D,Nemery B,Pekkanen J,Hyvärinen A,Täubel M,Zock JP

    更新日期:2015-08-01 00:00:00

  • Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial.

    abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/oemed-2016-104168

    authors: Wong JYY,Bassig BA,Seow WJ,Hu W,Ji BT,Blair A,Silverman DT,Lan Q

    更新日期:2017-06-01 00:00:00

  • Assessment of indoor air problems at work with a questionnaire.

    abstract:AIMS:To assess the extent of indoor air problems in office environments in Finland. METHODS:Complaints and symptoms related to the indoor environment experienced by office workers were collected from 122 workplaces in 1996-99 by using the modified Indoor Air Questionnaire established by the Finnish Institute of Occupa...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Reijula K,Sundman-Digert C

    更新日期:2004-01-01 00:00:00

  • Clinical and histopathological changes of the nasal mucosa induced by occupational exposure to sulphuric acid mists.

    abstract:AIMS:To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulphuric acid mists at anodising plants, correlating the findings with duration of exposure and sulphuric acid concentrations in the air, and comparing them with a control group. METHODS:Fifty t...

    journal_title:Occupational and environmental medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/oem.60.6.395

    authors: Grasel SS,Alves VA,da Silva CS,Cruz OL,Almeida ER,de Oliveira E

    更新日期:2003-06-01 00:00:00

  • Cost-benefit analysis in occupational health: a comparison of intervention scenarios for occupational asthma and rhinitis among bakery workers.

    abstract:OBJECTIVES:Use of cost-benefit analysis in occupational health increases insight into the intervention strategy that maximises the cost-benefit ratio. This study presents a methodological framework identifying the most important elements of a cost-benefit analysis for occupational health settings. One of the main aims ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2011.064709

    authors: Meijster T,van Duuren-Stuurman B,Heederik D,Houba R,Koningsveld E,Warren N,Tielemans E

    更新日期:2011-10-01 00:00:00

  • Socioeconomic position, psychosocial work environment and disability in an ageing workforce: a longitudinal analysis of SHARE data from 11 European countries.

    abstract:OBJECTIVES:Prevention of disability in the ageing workforce is essential for sustaining economic growth in Europe. In order to provide information on entry points for preventive measures, it is important to better understand sociodemographic, socioeconomic and work-related determinants of disability in older employees....

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2012-100924

    authors: Reinhardt JD,Wahrendorf M,Siegrist J

    更新日期:2013-03-01 00:00:00

  • Influenza immunisation: attitudes and beliefs of UK healthcare workers.

    abstract:AIM:To explore attitudes to influenza immunisation and rates of uptake among staff working in acute hospitals in the UK. METHOD:A cross-sectional survey of 11,670 healthcare workers in six UK hospitals was carried out using a postal questionnaire. RESULTS:Among 6302 responders (54% of those mailed), 19% had taken up ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2005.023564

    authors: Smedley J,Poole J,Waclawski E,Stevens A,Harrison J,Watson J,Hayward A,Coggon D

    更新日期:2007-04-01 00:00:00

  • Vibration exposure, smoking, and vascular dysfunction.

    abstract:OBJECTIVES:Vibration white finger (VWF), also known as "occupational Raynaud's phenomenon", is marked by arterial hyperresponsiveness and vasoconstriction during cold stimulation. The impact of tobacco use, and by extension stopping smoking, on the long term course of the disease has been inconclusively characterised. ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.57.5.341

    authors: Cherniack M,Clive J,Seidner A

    更新日期:2000-05-01 00:00:00

  • Primary osteoarthritis and occupations: a national cross sectional survey of 10 412 symptomatic patients.

    abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.60.11.882

    authors: Rossignol M,Leclerc A,Hilliquin P,Allaert FA,Rozenberg S,Valat JP,Avouac B,Coste P,Savarieau B,Fautrel B

    更新日期:2003-11-01 00:00:00

  • Night shift work and stomach cancer risk in the MCC-Spain study.

    abstract:OBJECTIVES:Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach c...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2016-103597

    authors: Gyarmati G,Turner MC,Castaño-Vinyals G,Espinosa A,Papantoniou K,Alguacil J,Costas L,Pérez-Gómez B,Martin Sanchez V,Ardanaz E,Moreno V,Gómez-Acebo I,Fernández-Tardon G,Villanueva Ballester V,Capelo R,Chirlaque MD,Santibáñe

    更新日期:2016-08-01 00:00:00

  • Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case-control study.

    abstract:OBJECTIVES:There is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case-control study of French AREVA NC P...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2017-104575

    authors: Zhivin S,Guseva Canu I,Davesne E,Blanchardon E,Garsi JP,Samson E,Niogret C,Zablotska LB,Laurier D

    更新日期:2018-04-01 00:00:00

  • Dutch monitor on stress and physical load: risk factors, consequences, and preventive action.

    abstract:OBJECTIVES:Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks, and (c) organisational ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.55.2.73

    authors: Houtman IL,Goudswaard A,Dhondt S,van der Grinten MP,Hildebrandt VH,van der Poel EG

    更新日期:1998-02-01 00:00:00

  • Prevalence of spirometry-defined airflow obstruction in never-smoking working US coal miners by pneumoconiosis status.

    abstract:INTRODUCTION:This study estimated the prevalence of spirometry-defined airflow obstruction and coal workers' pneumoconiosis (CWP) among never-smoking coal miners participating in the National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP). METHODS:Data were from ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2019-106213

    authors: Kurth L,Laney AS,Blackley DJ,Halldin CN

    更新日期:2020-04-01 00:00:00

  • Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air.

    abstract:OBJECTIVES:To investigate the relation between fluctuations in personal exposure to nitrogen dioxide (NO(2)) in school children and changes in outdoor NO(2) concentrations. METHODS:114 Asthmatic school children aged 7-12 years were recruited from the Southampton area. Weekly average personal exposures to NO(2) were me...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.57.7.472

    authors: Linaker CH,Chauhan AJ,Inskip HM,Holgate ST,Coggon D

    更新日期:2000-07-01 00:00:00

  • Effects of direction of rotation in continuous and discontinuous 8 hour shift systems.

    abstract:OBJECTIVES:Previous research has produced conflicting evidence on the relative merits of advancing and delaying shift systems. The current study assessed the effects of the direction of shift rotation within 8 hour systems, upon a range of measures including sleep, on shift alertness, physical health, and psychological...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.57.10.678

    authors: Tucker P,Smith L,Macdonald I,Folkard S

    更新日期:2000-10-01 00:00:00

  • Occupational exposure to crystalline silica and gastric cancer: a systematic review and meta-analysis.

    abstract::Crystalline silica is a widely used industrial material that is readily available worldwide, and is one of the most common types of particulate mineral pollutants. It has been classified as a group 1 human carcinogen of the respiratory system; however, whether it is linked to gastric cancer remains uncertain. We condu...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/oemed-2016-103552

    authors: Lee W,Ahn YS,Lee S,Song BM,Hong S,Yoon JH

    更新日期:2016-11-01 00:00:00

  • Cancer incidence and specific occupational exposures in the Swedish leather tanning industry: a cohort based case-control study.

    abstract:OBJECTIVE:To study the effect on the incidence of cancer of exposure to chemicals handled in the leather tanning industry. MATERIALS AND METHODS:A case-control study was performed within a cohort of 2487 workers employed for at least six months during the period 1900-89 in three Swedish leather tanneries. 68 cancer ca...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.53.7.463

    authors: Mikoczy Z,Schütz A,Strömberg U,Hagmar L

    更新日期:1996-07-01 00:00:00

  • A systematic review of controlled clinical trials on the prevention of back pain in industry.

    abstract:OBJECTIVE:To assess the effectiveness of lumbar supports, education, and exercise in the prevention of back pain in industry. METHODS:A computerised search for controlled clinical trials was conducted. A criteria list was used to assess the methodological quality of the studies. The available evidence for the effectiv...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析

    doi:10.1136/oem.54.12.841

    authors: van Poppel MN,Koes BW,Smid T,Bouter LM

    更新日期:1997-12-01 00:00:00

  • Acute effects of vibration on peripheral blood flow in healthy subjects.

    abstract:OBJECTIVES:The main objective was to study the acute vascular effects in the hands of normal healthy subjects of a complex vibration spectrum similar to that generated by many industrial hand held tools. The effects of repeated bouts of vibrations and alterations in the intensity of vibration were also studied. METHOD...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.53.10.663

    authors: Egan CE,Espie BH,McGrann S,McKenna KM,Allen JA

    更新日期:1996-10-01 00:00:00

  • Comparison of two expert-based assessments of diesel exhaust exposure in a case-control study: programmable decision rules versus expert review of individual jobs.

    abstract:OBJECTIVES:Professional judgment is necessary to assess occupational exposure in population-based case-control studies; however, the assessments lack transparency and are time-consuming to perform. To improve transparency and efficiency, we systematically applied decision rules to questionnaire responses to assess dies...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2011-100524

    authors: Pronk A,Stewart PA,Coble JB,Katki HA,Wheeler DC,Colt JS,Baris D,Schwenn M,Karagas MR,Johnson A,Waddell R,Verrill C,Cherala S,Silverman DT,Friesen MC

    更新日期:2012-10-01 00:00:00

  • Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk.

    abstract:BACKGROUND:The pathogenesis of cataract is influenced by a number of factors including oxidative stress. Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors. It is important for detoxification of xenobiotics in order to protect tissues from oxidative damage...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2005.022343

    authors: Saadat M,Farvardin-Jahromi M

    更新日期:2006-07-01 00:00:00

  • A randomised controlled trial on whether a participatory ergonomics intervention could prevent musculoskeletal disorders.

    abstract:OBJECTIVES:To examine the efficacy of a participatory ergonomics intervention in preventing musculoskeletal disorders among kitchen workers. Participatory ergonomics is commonly recommended to reduce musculoskeletal disorders, but evidence for its effectiveness is sparse. METHODS:A cluster randomised controlled trial ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/oem.2007.034579

    authors: Haukka E,Leino-Arjas P,Viikari-Juntura E,Takala EP,Malmivaara A,Hopsu L,Mutanen P,Ketola R,Virtanen T,Pehkonen I,Holtari-Leino M,Nykänen J,Stenholm S,Nykyri E,Riihimäki H

    更新日期:2008-12-01 00:00:00

  • National survey on the use of chemicals in the working environment: estimated exposure events.

    abstract:OBJECTIVES:To obtain knowledge about the use and distribution of hazardous chemicals in Danish industry. This knowledge is used to regulate the occupational environment and prevent hazardous exposure. METHODS:A national survey on the use of chemicals was carried out in 1989 in a stratified sample of 1448 Danish busine...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.52.7.454

    authors: Brandorff NP,Flyvholm MA,Beck ID,Skov T,Bach E

    更新日期:1995-07-01 00:00:00

  • Manager-oriented intervention to reduce absence among pregnant employees in the healthcare and daycare sector: a cluster randomised trial.

    abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2020-106794

    authors: Begtrup LM,Malmros P,Brauer C,Soegaard Toettenborg S,Flachs EM,Hammer PEC,Bonde JP

    更新日期:2021-01-12 00:00:00

  • An updated cohort mortality study of workers exposed to styrene in the reinforced plastics and composites industry.

    abstract::Mortality data have been updated for a further 12 years for a cohort of workers in the reinforced plastics and composites industry with exposures to styrene monomer and other chemicals. The cohort consisted of 15,826 male and female employees who were exposed to styrene for at least six months between 1948 and 1977 at...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.51.6.386

    authors: Wong O,Trent LS,Whorton MD

    更新日期:1994-06-01 00:00:00

  • Reconstructing past occupational exposures: how reliable are women's reports of their partner's occupation?

    abstract:OBJECTIVES:Most of the evidence on agreement between self- and proxy-reported occupational data comes from interview-based studies. The authors aimed to examine agreement between women's reports of their partner's occupation and their partner's own description using questionnaire-based data collected as a part of the p...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2009.052506

    authors: Tagiyeva N,Semple S,Devereux G,Sherriff A,Henderson J,Elias P,Ayres JG

    更新日期:2011-06-01 00:00:00

  • Excess mortality during heat waves and cold spells in Moscow, Russia.

    abstract:OBJECTIVES:To estimate excess mortality during heat waves and cold spells, and to identify vulnerable population groups by age and cause of death. METHODS:Daily mortality in Moscow, Russia from all non-accidental, cardiovascular and respiratory causes between January 2000 and February 2006 was analysed. Mortality and ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2007.033944

    authors: Revich B,Shaposhnikov D

    更新日期:2008-10-01 00:00:00

  • The CONSTANCES job exposure matrix based on self-reported exposure to physical risk factors: development and evaluation.

    abstract:OBJECTIVES:Job exposure matrices (JEMs) can be constructed from expert-rated assessments, direct measurement and self-reports. This paper describes the construction of a general population JEM based on self-reported physical exposures, its ability to create homogeneous exposure groups (HEG) and the use of different exp...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2018-105287

    authors: Evanoff BA,Yung M,Buckner-Petty S,Andersen JH,Roquelaure Y,Descatha A,Dale AM

    更新日期:2019-06-01 00:00:00