Abstract:
AIMS:To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulphuric acid mists at anodising plants, correlating the findings with duration of exposure and sulphuric acid concentrations in the air, and comparing them with a control group. METHODS:Fifty two workers from five plants underwent a clinical evaluation (standard questionnaire, clinical, and ear, nose, and throat examination including nasal endoscopy). For the histopathological study, 20 of the 52 subjects (study group) were randomly selected, as well as 11 unexposed subjects (control group), matched by sex, age, and smoking habits. Nasal biopsy specimens were obtained from the anterior septum mucosa and the anterior curvature of the middle turbinate in each individual. A total of 56 nasal mucosa specimens (37 in the study group and 19 in the control group) were evaluated with regard to normal respiratory epithelium or metaplastic epithelium, atypia or dysplasia, and alterations of the lamina propria. RESULTS:The histopathological study revealed squamous metaplasia in 29 (79%) and atypia in 13 (35%) of the 37 study group samples. No association was found between exposure duration and the clinical and histopathological variables, but a significant association was found between sulphuric acid concentrations higher than 200 micro g/m(3) and pale mucosal patches and ulcerations in the exposed subjects. Logistic regression analysis showed that the exposed subjects had a fivefold risk of developing atypia compared with the unexposed subjects. CONCLUSIONS:Workers exposed to sulphuric acid mists presented with a high incidence of nasal symptoms, and macroscopic and microscopic changes of the nasal mucosa, including squamous atypia and dysplasia. The risk for these histopthological lesions increased with higher sulphuric acid concentrations in the air, revealing an exposure-response relation.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Grasel SS,Alves VA,da Silva CS,Cruz OL,Almeida ER,de Oliveira Edoi
10.1136/oem.60.6.395subject
Has Abstractpub_date
2003-06-01 00:00:00pages
395-402issue
6eissn
1351-0711issn
1470-7926journal_volume
60pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:CONTEXT:More than 400,000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure. OBJECTIVE:We conducted a meta-analysis examining the relationship between protracted low-dose ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/oem.2009.054684
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:There is limited research concerning how small companies in particular, respond to health and safety messages. AIMS:To understand individuals' knowledge and beliefs about chemical risks and to compare these with those of experts. METHODS:The use of chromic acid in particular, and also other chemicals assoc...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.10.689
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine whether self-reported occupational exposure to cleaning/disinfecting agents in hospital workers is accurate, in comparison to expert assessment, taken to be the gold standard. METHODS:In the Epidemiological Study of the Genetics and Environment of Asthma (EGEA), partici...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.061671
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Numerous studies have reported that day-to-day changes in particulate air pollution are associated with day-to-day changes in deaths. Recently, several reports have indicated that the software used to control for season and weather in some of these studies had deficiencies. AIMS:To investigate the use of th...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2003.008250
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To determine site-specific cancer incidence among women spinning-weaving and dyeing-finishing workers in the largest flax textile factory in Lithuania. METHOD:The cancer incidence of a cohort of 3447 women workers from a flax textile factory was investigated for the period 1978-2002. All subjects were employ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2009.048058
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:The main objective of this study was to investigate exposure-response relations between adverse musculoskeletal outcomes and ergonomic exposure variables. METHODS:A cross sectional analytical study was conducted in 11 factories from seven sectors of manufacturing industry in South Africa. Exposure to workpl...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.1.46
更新日期:1995-01-01 00:00:00
abstract::Mortality data have been updated for a further 12 years for a cohort of workers in the reinforced plastics and composites industry with exposures to styrene monomer and other chemicals. The cohort consisted of 15,826 male and female employees who were exposed to styrene for at least six months between 1948 and 1977 at...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.6.386
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Between 2001 and 2010, six research groups conducted coordinated multiyear, prospective studies of carpal tunnel syndrome (CTS) incidence in US workers from various industries and collected detailed subject-level exposure information with follow-up symptom, physical examination, electrophysiological measures...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101365
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:Recently, diesel motor exhaust (DME) has been classified as a known human carcinogen. We used data from epidemiological studies of diesel exposures to perform a quantitative risk assessment to calculate DME exposure levels, expressed as elemental carbon (EC), corresponding to acceptable risk (AR) and maximum...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2016-103977
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:This study estimated the prevalence of spirometry-defined airflow obstruction and coal workers' pneumoconiosis (CWP) among never-smoking coal miners participating in the National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP). METHODS:Data were from ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106213
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between protease exposure and respiratory disease in a cohort of detergent enzyme manufacturers. METHODS:Case-referent analysis of a cohort of employees working in a European detergent factory between 1989 and 2002. Cases with new lower or upper respiratory disease were ascertain...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.043851
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2016-104168
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:To investigate whether an increased risk of cardiovascular disease might be caused by increased arrhythmogeneity and by unfavourable changes in autonomic cardiac control the changes in the occurrence of premature complexes (PVCs) and in heart rate variability (HRV) were studied in subjects who started to wor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.10.678
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:This study assessed the efficacy of preventive measures in a graphite electrode plant aimed at reducing occupational exposure to polycyclic aromatic hydrocarbons (PAHs). METHODS:Electrode workers (n = 146) answered a questionnaire and provided an end of shift urine sample. Urinary 1-hydroxypyrene (1-hpur), a...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.6.401
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:There is an ongoing debate regarding environmental health risks of exposures to dust and microbial agents from livestock farming in the Netherlands. The aims of the study were (1) to investigate associations between indicators of air pollution from livestock farms and asthma, allergic rhinitis and chronic ob...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101485
更新日期:2014-02-01 00:00:00
abstract:AIMS:To correlate the prevalence of respiratory tract symptoms and diseases with dust and fibre exposure in the soft tissue industry in Germany. METHODS:Ambient monitoring was performed for inhalable, respirable dust and fibres in seven soft tissue producing factories. In 441 workers (72 controls, 90 moderate, 279 hig...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.12.830
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of cigarette smoking cessation and examine the association between cessation and various factors among workers in a nationally representative sample of US adults. METHODS:Data were derived from the 2010 National Health Interview Survey. Prevalence rates were calculated for intere...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101852
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:To describe the relation with age of risk of reported injury after a fall among women at work in two countries, the United Kingdom and Sweden, with particular emphasis on fractures, and to interpret these data. METHODS:Rates of accidents compiled under the national reporting regulations of each country duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.11.785
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:Standardised mortality ratios (SMRs) play an important role in the epidemiological literature, particularly in evaluations of occupational hazards. While some authors have argued that comparisons of SMRs should be avoided, many investigators find such analyses appealing particularly when data are sparse. For...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-100792
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To investigate associations between cancer incidence and exposure to coal tar pitch volatiles, asbestos, pot emissions (fluorides, sulphur dioxide), heat stress, and magnetic fields in workers from a Norwegian aluminium smelter that operated from 1914 to 1975. METHODS:Cancer incidence between 1953 and 1991 w...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.4.250
更新日期:1995-04-01 00:00:00
abstract:AIMS:To examine whether asthma induced by exposure to aluminium potroom emissions (potroom asthma) is associated with inflammatory changes in the airways. METHODS:Bronchial biopsy specimens from 20 asthmatic workers (8 non-smokers and 12 smokers), 15 healthy workers (8 non-smokers and 7 smokers), and 10 non-exposed co...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2003.011627
更新日期:2004-09-01 00:00:00
abstract::Fluorocarbons are widely used in industry, and manifestations of inhalation toxicity include polymer fume fever, reactive airways dysfunction, and bronchospasm. Only seven cases of alveolitis occurring acutely after inhalation have been reported. This paper presents four cases of toxic pneumonitis due to direct inhala...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.015784
更新日期:2005-06-01 00:00:00
abstract:AIMS:To investigate work related and individual factors as predictors for incident neck pain among office employees working with video display units (VDUs). METHODS:Employees in three administrative units of a medium sized city in Finland (n = 515) received mailed questionnaires in the baseline survey in 1998 and in t...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.7.475
更新日期:2003-07-01 00:00:00
abstract:AIMS:To assess the impact of newly introduced point-of-sale glass bottle recycling on indoor air quality and employee health. METHODS:Airborne exposures and both chronic and acute respiratory and somatic symptoms were surveyed among 226 employees at 36 randomly selected liquor stores with bottle recycling and in-house...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.009753
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:To examine the association between occupational lifting during pregnancy and preterm birth. The risk of preterm birth was estimated for total burden lifted per day and number of medium and heavy loads lifted per day. METHODS:In a study population of 62 803 pregnant women enrolled to the Danish National Birt...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101173
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To estimate the fraction of carpal tunnel syndrome (CTS) that is attributable to work in the total adult population of the island of Montreal. METHODS:The population consisted of 1.1 million people 20-64 years of age, with 73.2% of men and 60.6% of women employed. The rates of first surgery for CTS were comp...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.7.519
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:To assess occupational exposure to inorganic germanium (Ge) in workers from a producing plant, and to assess the health of these workers, with a special focus on respiratory, kidney, and liver functions. METHODS:Cross sectional study of 75 workers exposed to Ge and 79 matched referents. Exposure was charact...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.4.242
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To find whether continuous ceramic filaments (CCFs) and silicon carbide whiskers (SiCWs), which are used in many industries as reinforcing materials in advanced ceramic composites, are carcinogenic in the intrapleural inoculation assay. METHODS:Samples of SiCWs, CCF, International Union Against Cancer crocid...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.12.813
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS:Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classificat...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oemed-2018-105131
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To confirm or refute the hypothesis that organic farmers have higher sperm concentrations than traditional farmers. METHODS:Traditional and organic farmers were selected randomly from central registers, and 171 traditional farmers and 85 organic farmers delivered one semen sample before the start of the spr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.2.139
更新日期:1999-02-01 00:00:00