Abstract:
OBJECTIVES:To examine the relationship between protease exposure and respiratory disease in a cohort of detergent enzyme manufacturers. METHODS:Case-referent analysis of a cohort of employees working in a European detergent factory between 1989 and 2002. Cases with new lower or upper respiratory disease were ascertained by examination of occupational health records and matched to referents on date of first employment. Personal exposures to airborne detergent protease were estimated, using a job exposure matrix, from >12,000 measurements taken in the factory during the period of study. RESULTS:We found clear, monotonic relationships between estimated protease exposure and both lower and upper respiratory disease. After control for age, sex and smoking, the odds ratio of lower respiratory disease was significantly elevated (1.98, 95% CI 1.04 to 3.79) in those employees working in jobs in the highest quartile of protease exposure (geometric mean 7.9 ng x m(-3)). For employees with upper respiratory disease, the risk was significantly elevated at a lower level of estimated protease exposure (geometric mean 2.3 ng x m(-3)). CONCLUSIONS:These findings provide strong evidence of an association between detergent enzyme exposure and the development of respiratory disease in an occupational setting. Using the routinely collected information on specific sensitisation and the close attention to workplace exposures that are characteristic of this industry, it should be possible to derive meaningful occupational exposure standards for most detergent enzymes.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Brant A,Upchurch S,van Tongeren M,Zekveld C,Helm J,Barnes F,Newman Taylor AJ,Cullinan Pdoi
10.1136/oem.2008.043851subject
Has Abstractpub_date
2009-11-01 00:00:00pages
754-8issue
11eissn
1351-0711issn
1470-7926pii
oem.2008.043851journal_volume
66pub_type
杂志文章abstract:OBJECTIVES:The aim of the present case-referent study was to investigate the incidence of myocardial infarction among male professional drivers, taking the type of vehicles and area of residence into account. METHODS:The study base comprised all men aged 30-74 in five counties in middle Sweden during 1976-81 or 1976-8...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00
abstract:OBJECTIVES:Previous studies into occupational risk factors for non-Hodgkin's lymphoma (NHL) in New Zealand have indicated that farmers and meat workers are at increased risk for these neoplasms. A new nationwide case-control study was conducted to assess whether previously observed associations persist and to identify ...
journal_title:Occupational and environmental medicine
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更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To report the effects of bleach use at home on the frequency of infections in 9102 school-age children participating in the HITEA project. METHODS:Parents of pupils aged 6-12 years from schools in Barcelona province (Spain), Utrecht province (the Netherlands) and Eastern and Central Finland were administered...
journal_title:Occupational and environmental medicine
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doi:10.1136/oemed-2014-102701
更新日期:2015-08-01 00:00:00
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journal_title:Occupational and environmental medicine
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abstract:OBJECTIVES:A previous study of the short term effects of air pollution in London from April 1987 to March 1992 found associations between all cause mortality and black smoke and ozone, but no clear evidence of specificity for cardiorespiratory deaths. London data from 1992 to 1994 were analysed to examine the consisten...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.4.237
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abstract:BACKGROUND AND OBJECTIVES:Although past studies of workplace exposures have contributed greatly to our understanding of carcinogens, significant knowledge gaps still exist with regard to the actual extent of exposure among current workers, with no routinely collected population-based data being available in most countr...
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doi:10.1136/oemed-2013-101651
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To investigate the relation with a case-control study between symptomatic osteochondrosis or spondylosis of the lumbar spine and cumulative occupational exposure to lifting or carrying and to working postures with extreme forward bending. METHODS:From two practices and four clinics were recruited 229 male p...
journal_title:Occupational and environmental medicine
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doi:10.1136/oem.58.11.735
更新日期:2001-11-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.058016
更新日期:2011-06-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.3.202
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:To identify determinants of sickness absence in hospital physicians. METHODS:The Poisson regression analyses of short (1--3 days) and long (>3 days) recorded spells of sickness absence relating to potential determinants of sickness absence were based on a 2 year follow up period and cohorts of 447 (251 male...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
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更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:Sick building syndrome (SBS) is described as a group of symptoms attributed to the physical environment of specific buildings. Isolating particular environmental features responsible for the symptoms has proved difficult. This study explores the role and significance of the physical and psychosocial work env...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.022889
更新日期:2006-04-01 00:00:00
abstract::A survey was carried out on respiratory symptoms and skin prick test response to common allergens (atopy), storage mites, and occupational allergens among 226 bakers and pastry makers from 105 small businesses in northern Italy. Atopy was present in 54 workers (23.4%); 40 workers (17.7%) were skin positive to at least...
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doi:10.1136/oem.51.8.548
更新日期:1994-08-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2009.052175
更新日期:2010-12-01 00:00:00
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doi:10.1136/oemed-2011-100524
更新日期:2012-10-01 00:00:00
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doi:10.1136/oem.2004.018614
更新日期:2006-03-01 00:00:00
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doi:10.1136/oemed-2017-104575
更新日期:2018-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:The fit note, introduced in England, Wales and Scotland in 2010, was designed to change radically the sickness certification process from advising individuals on their inability to work to advising them on what they could do if work could be adapted. Our review aimed to evaluate the following: (1) Is the 'ma...
journal_title:Occupational and environmental medicine
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doi:10.1136/oemed-2017-104730
更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/oem.51.2.95
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doi:10.1136/oemed-2019-105801
更新日期:2019-09-01 00:00:00
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doi:10.1136/oemed-2017-104459
更新日期:2018-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101116
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The mortality experience of 4702 (4413 men and 289 women) civilian workers in a US Coast Guard shipyard was evaluated. METHODS:All workers employed at the shipyard between 1 January 1950 and 31 December 1964 were included in the study and were followed through 31 December 2001 for vital status. Detailed shi...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.029652
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:Few studies have assessed the effects of policies aimed to reduce traffic-related air pollution. The aims of this study were to evaluate the impact, in terms of air quality and health effects, of two low-emission zones established in Rome in the period 2001-2005 and to assess the impact by socioeconomic posi...
journal_title:Occupational and environmental medicine
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doi:10.1136/oem.2010.063750
更新日期:2012-02-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.12.836
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVES:To describe the small area system developed in Finland. To illustrate the use of the system with analyses of incidence of lung cancer around an asbestos mine. To compare the performance of different spatial statistical models when applied to sparse data. METHODS:In the small area system, cancer and populati...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.5.315
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Two main theoretical models have been used to assess the impact of psychosocial work factors on blood pressure (BP): the demand-control model (DC) and the effort-reward imbalance (ERI) model. Little is known about their independent and combined effect. OBJECTIVE:To examine the independent and combined effec...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101416
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To examine the association between occupational lifting during pregnancy and preterm birth. The risk of preterm birth was estimated for total burden lifted per day and number of medium and heavy loads lifted per day. METHODS:In a study population of 62 803 pregnant women enrolled to the Danish National Birt...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101173
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Previous analyses of cataract in radiation-exposed populations have assessed relative risk; radiogenic excess additive risk (EAR), arguably of more public health importance, has not been estimated. Previous analysis of a large prospective cohort of US radiologic technologists (USRT) quantified excess relativ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-105902
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of enzyme sensitisation in the detergent industry. METHODS:A cross sectional study was conducted in a detergent factory. Sensitisation to enzymes was examined by skin prick and radioallergosorbent (RAST) tests. 76 Workers were tested; 40 in manufacturing, packing, and maintenance, a...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.2.121
更新日期:2000-02-01 00:00:00