Abstract:
OBJECTIVES:Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. METHODS:Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement. RESULTS:Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens. CONCLUSION:These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Villeneuve S,Cyr D,Lynge E,Orsi L,Sabroe S,Merletti F,Gorini G,Morales-Suarez-Varela M,Ahrens W,Baumgardt-Elms C,Kaerlev L,Eriksson M,Hardell L,Févotte J,Guénel Pdoi
10.1136/oem.2009.052175subject
Has Abstractpub_date
2010-12-01 00:00:00pages
837-44issue
12eissn
1351-0711issn
1470-7926pii
oem.2009.052175journal_volume
67pub_type
杂志文章,多中心研究abstract:OBJECTIVES:Introduced in the UK in 2010, the fit note was designed to address the problem of long-term sickness absence. We explored (1) associations between demographic variables and fit note receipt, 'maybe fit' use and long-term conditions, (2) whether individuals with long-term conditions receive more fit notes and...
journal_title:Occupational and environmental medicine
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journal_title:Occupational and environmental medicine
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journal_title:Occupational and environmental medicine
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pub_type: 杂志文章,meta分析,评审
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journal_title:Occupational and environmental medicine
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更新日期:2007-03-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:2003-09-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To investigate allegations of an excess risk of leukaemia among children living near the Solway Firth coast of Dumfries and Galloway Health Board area in Scotland, UK. METHODS:Incident cases of childhood leukaemia (International Classification of Diseases, 10th revision, C91-C95, patients aged 0-14 years) fo...
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更新日期:2007-01-01 00:00:00
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更新日期:2007-10-01 00:00:00
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doi:10.1136/oem.60.7.475
更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Occupational and environmental medicine
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更新日期:2014-02-01 00:00:00
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更新日期:1995-11-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.4.267
更新日期:1994-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.012492
更新日期:2005-04-01 00:00:00
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