Abstract:
OBJECTIVES:To review and summarise the epidemiological evidence on the carcinogenicity of occupational exposure to inorganic lead. METHODS:Case-control and cohort studies were reviewed and combined for meta-analysis. Fixed and random effect methods were used to estimate the summary effects. RESULTS:The combined results show a significant excess risk of overall cancer, stomach cancer, lung cancer, and bladder cancer, with relative risk ratios (RRs) and 95% confidence intervals (95% CIs) in the meta-analysis of 1.11 (1.05-1.17), 1.33 (1.18-1.49), 1.29 (1.10-1.50), and 1.41 (1.16-1.71) respectively. The RR (95% CI) for kidney cancer was also high, but did not reach significance (1.19 (0.96-1.48)). A separate analysis of studies of heavily exposed workers provided slightly increased RRs for cancers of the stomach (1.50) and lung (1.42). CONCLUSIONS:The findings from the workers with heavy exposure to lead provided some evidence to support the hypothesis of an association between stomach and lung cancer and exposure to lead. The main limitation of the present analysis is that the excess risks do not take account of potential confounders, because little information was available for other occupational exposures, smoking, and dietary habits. To some extent, the risk of lung cancer might be explained by confounders such as tobacco smoking and exposure to other occupational carcinogens. The excess risk of stomach cancer may also be explained, at least in part, by non-occupational factors. For bladder and kidney cancers, the excess risks are only suggestive of a true effect because of possible publication bias.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Fu H,Boffetta Pdoi
10.1136/oem.52.2.73subject
Has Abstractpub_date
1995-02-01 00:00:00pages
73-81issue
2eissn
1351-0711issn
1470-7926journal_volume
52pub_type
杂志文章,meta分析abstract:OBJECTIVES:Dental instruments such as the right angle or straight handpiece, air turbine, and ultrasonic scaler have the ability to produce dental aerosols containing water, saliva, microorganisms, blood, tooth particles, lubricating oil, and restorative materials. The purpose of this study was to find out whether pers...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.2.125
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Between 2001 and 2010, six research groups conducted coordinated multiyear, prospective studies of carpal tunnel syndrome (CTS) incidence in US workers from various industries and collected detailed subject-level exposure information with follow-up symptom, physical examination, electrophysiological measures...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101365
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:To investigate changes in digital circulation during and after exposure to hand transmitted vibration. By studying two frequencies and two magnitudes of vibration, to investigate the extent to which haemodynamic changes depend on the vibration frequency, the vibration acceleration, and the vibration velocity...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.8.566
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:This study assessed the efficacy of preventive measures in a graphite electrode plant aimed at reducing occupational exposure to polycyclic aromatic hydrocarbons (PAHs). METHODS:Electrode workers (n = 146) answered a questionnaire and provided an end of shift urine sample. Urinary 1-hydroxypyrene (1-hpur), a...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.6.401
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:While large cotton industry plants producing for the foreign market have undergone improvements of occupational hygiene lately, working conditions in power looms producing mainly for the local market are still poor. The respiratory health in workers of power looms has not been studied so far. METHODS:In a cros...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-102902
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To describe the relation with age of risk of reported injury after a fall among women at work in two countries, the United Kingdom and Sweden, with particular emphasis on fractures, and to interpret these data. METHODS:Rates of accidents compiled under the national reporting regulations of each country duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.11.785
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:To examine the association of immune cell number and function with occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). METHODS:A cross sectional medical survey. The exposed participants were employed at two chemical plants between 1951 and 1972 in the manufactur...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.11.742
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVES:To describe workers with low back symptoms, to identify risk factors and to assess the occupational consequences separately in men and women. METHODS:A descriptive study was conducted between 1 October 1996 and 31 December 1996 in a sample of workers selected at random from all types of small companies in t...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.10.696
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVES:To examine the relation between exposure to acid anhydrides and the risk of developing immediate skin prick test responses to acid anhydride human serum albumin (AA-HSA) conjugates or work related respiratory symptoms; to assess whether these relations are modified by atopy or smoking. METHODS:A cohort of 5...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.10.684
更新日期:1998-10-01 00:00:00
abstract:INTRODUCTION:Analyses of secular trends in work-related fatal injury in New Zealand have previously only considered the total working population, potentially hiding trends for important subgroups of workers. This paper examines trends in work-related fatalities in worker subgroups between 2005 and 2014 to indicate wher...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106812
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVES:To investigate the association between occupational exposure to disinfectants/antiseptics used for hand hygiene and asthma control in nurses. METHODS:In 2014, we invited female nurses with asthma drawn from the Nurses' Health Study II to complete two supplemental questionnaires on their occupation and asthm...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104740
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:To update mortality for 34 560 employees from diverse operating segments of a Canadian petroleum company; and to investigate potential relations with occupational factors. METHODS:Employees from 1964-83 were linked to the Canadian mortality data base to provide 11 years additional follow up. There were 6760...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.9.595
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:To explore the use of 99technetiumm-hexamethyl propylene amine oxime single photon computed tomography (HMPAO-SPECT) of the brain as a means of detecting nervous tissue damage in divers and to determine if there is any correlation between brain image and a diver's history of diving or decompression illness (...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.4.247
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Assessment of exposure assessment to metal working fluids (MWF) has almost exclusively focused on inhalation exposure. AIMS:To assess levels of, and factors affecting, dermal and inhalation exposure to semi-synthetic MWF, and to identify suitable dermal exposure grouping schemes among metal workers for an e...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.015396
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Limited evidence suggests the association between severity of acute occupational pesticide poisoning and depressive symptoms in farmers. The aim of this study was to investigate the association between occupational pesticide exposure and depressive symptoms among male farmers in South Korea. METHODS:A natio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101005
更新日期:2013-05-01 00:00:00
abstract::Sex ratios in the offspring of those affected by dioxins or dioxin-like compounds have been reported from Seveso, Italy and Yucheng, Taiwan. The sex ratio of live births in Yusho, Japan after a similar accidental massive exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) in 1968 are...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.8.540
更新日期:2001-08-01 00:00:00
abstract::Dermal uptake of chemicals at the workplace may contribute considerably to the total internal exposure and so needs to be regulated. At present only qualitative warning signs--the "skin notations"--are available as instruments. An attempt was made to develop a quantitative dermal occupational exposure limit (DOEL) com...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.55.12.795
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:To investigate the occurrence of work related respiratory symptoms and to assess the effect of atopy in a group of trainee bakers. METHODS:A prospective study of work related respiratory symptoms among 125 trainee bakers who were investigated with a questionnaire plus skin prick test with wheat flour and al...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.1.58
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To report the effects of bleach use at home on the frequency of infections in 9102 school-age children participating in the HITEA project. METHODS:Parents of pupils aged 6-12 years from schools in Barcelona province (Spain), Utrecht province (the Netherlands) and Eastern and Central Finland were administered...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102701
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To estimate the fraction of carpal tunnel syndrome (CTS) that is attributable to work in the total adult population of the island of Montreal. METHODS:The population consisted of 1.1 million people 20-64 years of age, with 73.2% of men and 60.6% of women employed. The rates of first surgery for CTS were comp...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.7.519
更新日期:1997-07-01 00:00:00
abstract::This paper systematically reviews the scientific literature on the effects of individual and work-related factors on the Work Ability Index (WAI). Studies on work ability published from 1985 to 2006 were identified through a structured search in PubMed, and Web of Science. Studies were included if the WAI was used as ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2008.039883
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies. METHODS AND RESULTS:Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, s...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.013102
更新日期:2005-11-01 00:00:00
abstract::To improve interventions that aim to promote return to work (RTW) of workers with common mental disorders (CMD), insight into modifiable predictors of RTW is needed. This study tested the predictive value of self-efficacy change for RTW in addition to preintervention levels of self-efficacy. RTW self-efficacy was meas...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2016-104039
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:The current study examines and compares the relationship between both macroeconomic and industry-specific business cycle indicators, and work-related injuries among construction workers in Denmark using emergency department (ED) injury data and also officially reported injuries to the Danish Working Environm...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102290
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:To understand the variations of selenium (Se) concentration relative to changes in occupational exposure to coal dust, taking into account age and changes in smoking habits in miners surveyed twice, in 1990 and 1994. To better understand the relation of Se concentration with glutathione peroxidase activities...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.4.239
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To investigate the differences between measurements of personal exposure to particulate air pollution and static area measurements in a group of people working close to traffic and to determine whether such differences might obscure any threshold for health effects in epidemiological studies. METHODS:Persona...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.12.790
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:It remains unclear over whether it is possible to develop an epidemic forecasting model for transmission of dengue fever in Queensland, Australia. OBJECTIVES:To examine the potential impact of El Niño/Southern Oscillation on the transmission of dengue fever in Queensland, Australia and explore the possibili...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.044966
更新日期:2010-05-01 00:00:00
abstract::The International Agency for Research on Cancer has classified occupational exposure as a painter as 'carcinogenic to humans', largely based on increased risks of bladder and lung cancer. A meta-analysis, including more than 2900 incident cases or deaths from bladder cancer among painters reported in 41 cohort (n=2), ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2009.051565
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Few studies have assessed the effects of policies aimed to reduce traffic-related air pollution. The aims of this study were to evaluate the impact, in terms of air quality and health effects, of two low-emission zones established in Rome in the period 2001-2005 and to assess the impact by socioeconomic posi...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.063750
更新日期:2012-02-01 00:00:00
abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.882
更新日期:2003-11-01 00:00:00