Abstract:
OBJECTIVES:We investigated the relationship between urinary metabolites of di(2-ethylhexyl) phthalate (DEHP) and reproductive hormones in workers of polyvinyl chloride (PVC) production plants. After exposure, most of the DEHP is rapidly metabolised to mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), which may be associated with reproductive hormone interruption and testicular toxicity. Some studies report that urinary concentrations of phthalate metabolites for plastics workers are significantly higher than for the general population. However, little is known about the disruption of reproductive hormones for DEHP exposure workers. METHODS:This cross-sectional study of 82 male workers measured the biomarkers for their reproductive hormones and their exposure to DEHP. Relationships between urinary concentrations of DEHP metabolites were estimated using multivariate linear regression and quartile analysis models. RESULTS:The geometric means of urinary creatinine-adjusted (μg/g-Cre) concentrations of MEHP, MEOHP and MEHHP during the post-shift period were 23.9, 66.9 and 84.6, respectively. In multiple regression models adjusted for potential confounders, there were significant positive associations between urinary concentrations of DEHP metabolites and estradiol (E2) (p<0.01), and in the ratio of E2 to testosterone (p<0.05). Moreover, quartile analysis showed significant positive relationships between the total urinary concentration of DEHP metabolites and E2 (ptrend=0.024), and in the ratio of E2 to testosterone (ptrend=0.031). CONCLUSIONS:Relationships between reproductive hormones and the total urinary concentration of DEHP metabolites in male PVC production workers were significantly positive. This indicated that aromatase activity had increased in male workers exposed to DEHP, which is consistent with animal studies.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Fong JP,Lee FJ,Lu IS,Uang SN,Lee CCdoi
10.1136/oemed-2014-102532subject
Has Abstractpub_date
2015-05-01 00:00:00pages
346-53issue
5eissn
1351-0711issn
1470-7926pii
oemed-2014-102532journal_volume
72pub_type
杂志文章abstract:AIMS:To investigate the concentration of urinary 8-hydroxydeoxyguanosine (8-OHdG) among electroplating workers in Taiwan. METHODS:Fifty workers were selected from five chromium (Cr) electroplating plants in central Taiwan. The 20 control subjects were office workers with no previous exposure to Cr. Urinary 8-OHdG conc...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.8.590
更新日期:2003-08-01 00:00:00
abstract::To improve interventions that aim to promote return to work (RTW) of workers with common mental disorders (CMD), insight into modifiable predictors of RTW is needed. This study tested the predictive value of self-efficacy change for RTW in addition to preintervention levels of self-efficacy. RTW self-efficacy was meas...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2016-104039
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of lumbar supports, education, and exercise in the prevention of back pain in industry. METHODS:A computerised search for controlled clinical trials was conducted. A criteria list was used to assess the methodological quality of the studies. The available evidence for the effectiv...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oem.54.12.841
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:To estimate the fraction of carpal tunnel syndrome (CTS) that is attributable to work in the total adult population of the island of Montreal. METHODS:The population consisted of 1.1 million people 20-64 years of age, with 73.2% of men and 60.6% of women employed. The rates of first surgery for CTS were comp...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.7.519
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:To investigate the association between preeclampsia and maternal exposure to ambient particulate matter (PM) with aerodynamic diameter less than 10 μm (PM10) and 2.5 μm (PM2.5) mass and sources. METHODS:Our analysis was based on a hospital cohort of pregnant women (N=3182) residing in Barcelona, Spain, duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101693
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:Apparent increases in human male reproductive disorders, including low sperm production, may have occurred because of increased chemical exposure. Various glycol ether-based solvents have pronounced adverse effects on sperm production and male fertility in laboratory animals. The authors investigated the eff...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.023952
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:Introduced in the UK in 2010, the fit note was designed to address the problem of long-term sickness absence. We explored (1) associations between demographic variables and fit note receipt, 'maybe fit' use and long-term conditions, (2) whether individuals with long-term conditions receive more fit notes and...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106035
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To investigate changes in digital circulation during and after exposure to hand transmitted vibration. By studying two frequencies and two magnitudes of vibration, to investigate the extent to which haemodynamic changes depend on the vibration frequency, the vibration acceleration, and the vibration velocity...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.8.566
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:Occupational exposure to agents in plastics and rubber manufacturing has been associated with elevated risk of certain cancers. We sought to evaluate cancer risk among workers employed in occupations and industries with these exposures as part of an ongoing surveillance programme in Ontario, Canada. METHODS:...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106581
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:To measure the levels of exposure to nitrogen trichloride (NCl3) in the atmosphere of indoor swimming pools and to examine how they relate to irritant and chronic respiratory symptoms, indices of pulmonary function, and bronchial hyperresponsiveness to methacholine in lifeguards working in the pools. METHOD...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.4.258
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVES:Studies concerning the association between shift work and drinking problems showed inconsistent results. We used data from a large occupational cohort to examine the association between shift work and different types of drinking behaviour. METHODS:A total of 93 121 non-abstinent workers from the Finnish Pub...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-107057
更新日期:2021-01-22 00:00:00
abstract::Complex and dynamic physiologic processes underlie the exposure-response relations that occupational and environmental epidemiologists study. Simple summary measures of exposure such as the average, cumulative exposure, or duration of exposure, can be applied suitably in exposure-response analyses in many instances. H...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.030031
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:It was hypothesised that inflammation plays a dominant part in the respiratory effects of exposure to wood dust. The purpose of this study was to relate the nasal inflammatory responses of workers exposed to meranti wood dust to (a) levels of exposure, (b) respiratory symptoms and (c) respiratory function. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.5.338
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Previous studies of the risk of heart disease after shift work reached different estimates and review authors disagree about the validity of some of the studies. A cross sectional study showed that shift workers had a higher prevalence of nearly every unfavourable work environment factor investigated. Confli...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.026716
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:The Stand Back study evaluated the feasibility and effects of a multicomponent intervention targeting reduced prolonged sitting and pain self-management in desk workers with chronic low back pain (LBP). METHODS:This randomised controlled trial recruited 27 individuals with chronic LBP, Oswestry Disability In...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2017-104732
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leukaemia because of chronic exposure to several potential carcinogens. METHODS:The Italian SETIL study (Study on the aetio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101604
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Systematic assessments of the effectiveness of interventions to prevent work related eye injuries are needed. AIM:To investigate the long term effectiveness of a multicomponent prevention campaign. METHODS:The campaign (conducted in collaboration with the local Employers' Association and Trade Unions) targ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.019570
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To investigate allegations of an excess risk of leukaemia among children living near the Solway Firth coast of Dumfries and Galloway Health Board area in Scotland, UK. METHODS:Incident cases of childhood leukaemia (International Classification of Diseases, 10th revision, C91-C95, patients aged 0-14 years) fo...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.028829
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Standardised mortality ratios (SMRs) play an important role in the epidemiological literature, particularly in evaluations of occupational hazards. While some authors have argued that comparisons of SMRs should be avoided, many investigators find such analyses appealing particularly when data are sparse. For...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-100792
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Two main theoretical models have been used to assess the impact of psychosocial work factors on blood pressure (BP): the demand-control model (DC) and the effort-reward imbalance (ERI) model. Little is known about their independent and combined effect. OBJECTIVE:To examine the independent and combined effec...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101416
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To investigate the effectiveness of a counselling and education programme on work ability and work disability pension for employees in the construction industry. METHODS:Employees with a high disability risk of 38% or more in the following four years were included. Employees in the intervention group were e...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章
doi:10.1136/oem.2006.029678
更新日期:2007-12-01 00:00:00
abstract::Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical features and increased urinary mercury concentrations was found...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.4.267
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVES:To investigate the relation between shift work and death from ischaemic heart disease (IHD). METHODS:A nested case-control approach was used. The cohort comprised male manual workers who joined an industrial company aged 50 years or under between 1 January 1950 and 31 December 1992 and worked there for at l...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.6.367
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2016-104168
更新日期:2017-06-01 00:00:00
abstract:AIMS:This study examines the impact of work-related psychosocial and mechanical exposure on the development of low back pain (LBP) in the general working population. METHODS:A randomly drawn cohort from the general population in Norway aged 18-66 years was followed up for 3 years (n=12 550, response rate at baseline=6...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101116
更新日期:2013-05-01 00:00:00
abstract:AIM:To determine the prevalence of chronic fatigue syndrome (CFS)-like caseness in the working population. METHODS:Using data from the prospective Maastricht Cohort Study on Fatigue at Work, the prevalence and incidence of CFS-like cases (employees meeting research criteria for CFS) were determined among 5499 employee...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.008912
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106794
更新日期:2021-01-12 00:00:00
abstract:OBJECTIVE:To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents and Stoddard solvent during the period from 1 month before conception through the first trimester. METHODS:The study population included mothers...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100536
更新日期:2012-09-01 00:00:00
abstract::Lymphohaematopoeitic cancer mortality was examined among 4417 workers at a chemical plant by cumulative and peak benzene exposure. There was little evidence of increasing risk with increasing cumulative exposure for all leukaemias or acute non-lymphocytic leukaemias (ANL), or the other lymphohaematopoeitic cancers wit...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.9.676
更新日期:2003-09-01 00:00:00
abstract:AIMS:To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulphuric acid mists at anodising plants, correlating the findings with duration of exposure and sulphuric acid concentrations in the air, and comparing them with a control group. METHODS:Fifty t...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/oem.60.6.395
更新日期:2003-06-01 00:00:00