Abstract：
:Selective DNA pooling is an advanced methodology for linkage mapping of quantitative trait loci (QTL) in farm animals. The principle is based on densitometric estimates of marker allele frequency in pooled DNA samples of phenotypically extreme individuals from half-sib, backcross and F(2) experimental designs in farm animals. This methodology provides a rapid and efficient analysis of a large number of individuals with short tandem repeat markers that are essential to detect QTL through the genome - wide searching approach. Several strategies involving whole genome scanning with a high statistical power have been developed for systematic search to detect the quantitative traits loci and linked loci of complex traits. In recent studies, greater success has been achieved in mapping several QTLs in Israel-Holstein cattle using selective DNA pooling. This paper outlines the currently emerged novel strategies of linkage mapping to identify QTL based on selective DNA pooling with more emphasis on its theoretical pre-requisite to detect linked QTLs, applications, a general theory for experimental half-sib designs, the power of statistics and its feasibility to identify genetic markers linked QTL in dairy cattle. The study reveals that the application of selective DNA pooling in dairy cattle can be best exploited in the genome-wide detection of linked loci with small and large QTL effects and applied to a moderately sized half-sib family of about 500 animals.
journal_name
J Appl Genetjournal_title
Journal of applied geneticsauthors
Pareek CS,Pareek RS,Walawski Ksubject
Has Abstractpub_date
2002-01-01 00:00:00pages
309-18issue
3eissn
1234-1983issn
2190-3883pii
104journal_volume
43pub_type
杂志文章,评审abstract：:Treacher Collins syndrome (TCS) is associated with an abnormal differentiation of the first and second pharyngeal arches during fetal development. This causes mostly craniofacial deformities, which require numerous corrective surgeries. TCS is an autosomal dominant disorder and it occurs in the general population at a...
journal_title：Journal of applied genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/s13353-017-0420-7
更新日期：2018-02-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/BF03195222
更新日期：2007-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/BF03194627
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/s13353-014-0226-9
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：Journal of applied genetics
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doi：
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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