The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin.

Abstract:

:The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual score, transepidermal water loss, chromametry and skin capacitance. Concurrent application of SLS/toluene induced stronger reactions than those caused by twice daily application of each irritant on its own. A protective effect of the protective cream was obtained against all treatment combinations and was significant for SLS/SLS (p < or = 0.01) and SLS/ toluene (p < or = 0.05). Our results indicate that the tandem repetitive irritation test has great potential in the evaluation of skin care products to prevent irritant contact dermatitis.

journal_name

Acta Derm Venereol

authors

Wigger-Alberti W,Spoo J,Schliemann-Willers S,Klotz A,Elsner P

doi

10.1080/00015550252948103

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

94-7

issue

2

eissn

0001-5555

issn

1651-2057

journal_volume

82

pub_type

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