Abstract：
:In order to explore the mechanisms of inflammatory skin disorders, we established two methods of expanding skin-derived lymphocytes, one using high levels of interleukin (IL)-2 and IL-4 (method A) and the other using low levels of cytokines and anti-CD3/CD28 microbeads (method B). Both methods provide advantages for functional studies. With either of these two, we could obtain more than 10(7) cells/ from a 3 mm skin biopsy in 21 days from 23 out of 26 biopsies of various skin diseases. The relevance of these cells was confirmed by shifted T-cell receptor beta chain variable region (TCR-Vbeta) repertoire and antigen-dependent proliferation in antigen-driven skin disorders. The propagation of skin-resident lymphocytes, seen especially in method A, seems to be mediated by a functional defect of regulatory T cells residing in skin sequentially expanding under the conditions of our methods.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Hashizume H,Hansen A,Poulsen LK,Thomsen AR,Takigawa M,Thestrup-Pedersen Kdoi
10.2340/00015555-0927subject
Has Abstractpub_date
2010-09-01 00:00:00pages
468-73issue
5eissn
0001-5555issn
1651-2057journal_volume
90pub_type
杂志文章,多中心研究abstract：:A 36-year-old Japanese woman with an extraskeletal osteochondroma in the left thumb is reported. A roentgenogram showed a calcified tumor, located at the distal portion of the left distal phalanx, which mimicked the fourth phalangeal bone. The pathogenesis might in this case be hamartomatous. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555572287288
更新日期：1992-08-01 00:00:00
abstract：:is missing (Quiz). ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3566
更新日期：2020-08-17 00:00:00
abstract：:Dermal cells maintained in cultured human skin explants for up to 10 weeks were studied by electron microscopy. Common findings in the cell organelles were: 1) altered nuclear shapes and numerous nuclear bodies; 2) reduced rough endoplasmic reticulum; 3) a prominent Golgi complex; and 4) an increasing number of free r...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Serum IgE concentrations were determined by the paper radioimmunosorbent test in 56 patients with psoriasis and 50 normal controls, and by the paper enzyme-immunosorbent test in 32 of these patients and 50 controls. Elevated IgE levels were found in 26 (46%) of 56 patients with psoriasis and in 1 normal control (2%). ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The association between itch and suicidal ideation has not been explored previously in the general population. The aim of the present study is to analyse the association between itch and suicidal ideation in adolescents, and to compare the findings with an expected association between pain and suicidal ideation in the...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1251
更新日期：2012-09-01 00:00:00
abstract：:The expression of blood-group antigens was studied on human epidermal cultures used as allografts in 13 non-immunosuppressed patients treated for leg ulcers. The study was carried out using monoclonal antibodies to A and B antigens by an indirect immunofluorescence technique. Blood-group antigens are weakly expressed ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The forearm skin of 10 Caucasians and 10 American Negroes was inoculated with Candida albicans and the severity of the ensuing dermatitis as well as the population of Candida and other aerobes in the inoculum site have been assessed. Negroid skin proved to be less susceptible to irritation, even though it harboured a ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:A case of incontinentia pigmenti achromians syndrome with associated abnormalities occurring in a 21-year-old woman is reported. Since birth she has had whorling macular, hypopigmented areas on the skin of the lateral, anterior, and posterior aspects of the trunk. Histopathological picture: the melanocytes in the depi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:A skin biopsy is one of the most frequently performed procedures in the dermatology outpatient clinic, but doctors often do not consider the cognitive impact of the biopsy procedure. Based on "terror management theory," we reasoned that a skin biopsy increases patient compliance by unconsciously stimulating mortality ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0849
更新日期：2010-05-01 00:00:00
abstract：:Itch is known to be associated with psychological factors in adults, but has not been explored among adolescents. A cross-sectional, questionnaire-based population study involving adolescents born mostly in 1986 was carried out in 2004. A total of 4744 individuals were invited and the participation rate was 80%. The H...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0554
更新日期：2009-01-01 00:00:00
abstract：:Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors. We compared 5-S-CD and eumelanin-related metabolites regarding the correlation of their production in melanoma and excretion in urine, versus the weight of B16 mouse melanoma. It ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort st...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3607
更新日期：2020-10-20 00:00:00
abstract：:The ultrastructural localization of copper and zinc superoxide dismutase (Cu,Zn-SOD) and manganese superoxide dismutase (Mn-SOD) was investigated in normal human skin by the post-embedding immunogold staining method. Epidermal keratinocytes were positive for both Cu,Zn-SOD and Mn-SOD. The Cu,Zn-SOD was predominantly l...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555734145
更新日期：1993-02-01 00:00:00
abstract：:32 women complaining of diffuse alopecia were assessed by a psychiatrist, and daily hair loss and root counts were measured and compared with control women. Seven of the 32 women had severe marital difficulties, and 2 of these were overtly depressed. In these 7 women, daily hair loss and telogen counts did not differ ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation o...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2235
更新日期：2016-03-01 00:00:00
abstract：:The incidence of refractory atopic dermatitis has increased in teenagers and young adults. The purpose of this study was to control the skin symptoms of such patients in daily life. Seventy patients repeatedly took a 10-min 42 degrees C acidic hot-spring bath twice daily. The skin symptoms were improved in 76% of case...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：10.2340/0001555577452454
更新日期：1997-11-01 00:00:00
abstract：:The venoarteriolar vasoconstriction reflex plays a major role in the prevention of leg oedema in the upright position in man. We studied the venoarteriolar vasoconstriction reflex with laser Doppler flowmetry in young (21 subjects, age 17-27) and very old (20 subjects, age 75-100) healthy volunteers. In the group of y...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574194196
更新日期：1994-05-01 00:00:00
abstract：:A case of juvenile xanthogranuloma in a female newborn infant is reported. Red-brown, flat, well-demarcated lesions were present at birth on her scalp, face and trunk. During the following year of observation the eruptions regressed slowly and spontaneously. Light and electron microscopy revealed histiocytes and Touto...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Eosinophilic pustular folliculitis is an inflammatory skin disease characterized by pruritic follicular papulopustules. It is usually resistant to topical and/or systemic corticosteroids, but it responds well to systemic indomethacin. We report here two patients with classical-type disease who were treated with system...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0759
更新日期：2010-01-01 00:00:00
abstract：:Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-3025
更新日期：2019-01-01 00:00:00
abstract：:The treatment and relapse rate of genital warts are significant problems. The aim of this observational study was to assess the efficacy of holmium laser treatment of genital warts. A total of 1500 outpatients with genital human papillomavirus-induced lesions presenting from August 2002 to June 2005 were treated with ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0354
更新日期：2008-01-01 00:00:00
abstract：:Tobacco smoke and UV radiation are extrinsic risk factors for accelerated skin ageing. In this study the effects of smoking on wrinkling and ageing were assessed in males living in Northern Finland, where cumulative sun exposure is low. Smoking habits, age and facial wrinkling were estimated from facial photographs of...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550410014969
更新日期：2004-01-01 00:00:00
abstract：:Etretinate 0.5 mg/kg body weight combined with 0.1% triamcinolone acetonide and 5% salicylic acid in an O/W cream gave more than 70% improvement in 62% of 75 patients. Of this satisfactorily improved group, at least 41% were still in the same condition after 3 years on a maintenance dose of, on average, 0.3 mg/kg body...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The releasability of arachidonic acid-derived inflammatory mediators (eicosanoids) from peripheral blood leukocytes has been tested in patients with atopic eczema and healthy, non-atopic controls. Spontaneous and stimulated release of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and leukotriene C4 (LTC4) has been me...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Twenty-one patients with Behçet's disease were typed for HLA antigens. The controls were 50 subjects randomly chosen from a local population and 24 apparently healthy subjects of the same ethnic groupings as those of the patients. The study revealed significant differences in the frequencies of various antigens in the...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Multicentric reticulohistiocytosis is a rare systemic disease of unknown aetiology characterized by erosive arthritis and cutaneous lesions consisting of multiple reddish-brown papules and nodules, mainly involving the face and distal upper extremities. It has been suggested that skin eruptions in multicentric reticul...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0961
更新日期：2011-03-01 00:00:00
abstract：:Atopic dermatitis is a multifactorial disorder probably caused by environmental factors in combination with susceptibility genes. The clinical similarity between atopic dermatitis and the eczema manifestation in patients with Wiskott-Aldrich syndrome made the previously identified WAS gene in chromosome sub-band Xpl 1...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155501317140043
更新日期：2001-10-01 00:00:00
abstract：:Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has p...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2315
更新日期：2016-06-15 00:00:00
abstract：:Itching is the most frequent symptom in dermatology. Little is known about its occurrence and its characteristics in the general population. Instruments specifically designed to measure itch are scarce. The aim of this pilot study was to develop and validate an instrument measuring prevalence and characteristics of ch...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0641
更新日期：2009-01-01 00:00:00
abstract：:Papillon-Lefèvre syndrome is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and aggressive periodontitis. The aim of the study was to identify underlying cathepsin C mutations in 39 subjects with Papillon-Lefèvre syndrome and to explore any phenotypic associations. Genotyping and mutation...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550510011619
更新日期：2006-01-01 00:00:00
