Clinical effects of topiramate against secondarily generalized tonic--clonic seizures.

abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

journal_title：Epilepsy research

authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

更新日期：2002-09-01 00:00:00

abstract：INTRODUCTION:Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. METHODS:Eighty chi...

journal_title：Epilepsy research

authors： Isler C,Kucukyuruk B,Ozkara C,Gunduz A,Is M,Tanriverdi T,Comunoglu N,Oz B,Uzan M

更新日期：2017-10-01 00:00:00

abstract：:The compound 5-(4-chlorophenyl)-2,4-dihydro-4-ethyl-3H-1,2,4-triazol-3-one (MDL 27,192) was evaluated in a variety of rodent models to assess its anticonvulsant profile and its potential neuroprotective activity. MDL 27,192 demonstrated anticonvulsant activity in a wide range of epilepsy models that are genetically-ba...

journal_title：Epilepsy research

authors： Kehne JH,Kane JM,Chaney SF,Hurst G,McCloskey TC,Petty MA,Senyah Y,Wolf HH,Zobrist R,White HS

更新日期：1997-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the risk of intrauterine growth delay in the offspring of epileptic mothers and to quantify the risks of intrauterine exposure to antiepileptic drugs (AEDs). Data concerning 870 newborns, prospectively collected in Canada, Japan and Italy, using the same study design, were ...

journal_title：Epilepsy research

authors： Battino D,Kaneko S,Andermann E,Avanzini G,Canevini MP,Canger R,Croci D,Fumarola C,Guidolin L,Mamoli D,Molteni F,Pardi G,Vignoli A,Fukushima Y,Kan R,Takeda A,Nakane Y,Ogawa Y,Dansky L,Oguni M,Lopez-Ciendas I,Sher

更新日期：1999-08-01 00:00:00

abstract：:Hippocampal Deep Brain Stimulation (DBS) is proposed as an experimental treatment for refractory epilepsy, but the optimal stimulation parameters are undetermined. High frequency hippocampal DBS at 130Hz is effective in both animals and patients with epilepsy. Low frequency stimulation (approximately 5Hz) is assumed t...

journal_title：Epilepsy research

authors： Wyckhuys T,Raedt R,Vonck K,Wadman W,Boon P

更新日期：2010-02-01 00:00:00

abstract：AIM:Vitamin D (Vit D) has been considered as a neurosteroid and has a pivotal role in neuroprotection including epilepsy. Vit D regulator acts via a Vit D receptor (VDR). WAG/Rij rats have a genetically epileptic model of absence epilepsy with comorbidity of depression. The aim of the present study was to investigate t...

journal_title：Epilepsy research

authors： Aygun H,Ayyildiz M,Agar E

更新日期：2019-11-01 00:00:00

abstract：:Increased excitatory amino acid transmission and decreased GABAergic inhibitory responses seem to be important mechanisms in the genesis of convulsions, where reactive oxygen species (ROS) have recently been suggested to play a critical role. Therefore, administration of antioxidants may be potentially beneficial for ...

journal_title：Epilepsy research

authors： Ribeiro MC,de Avila DS,Schneider CY,Hermes FS,Furian AF,Oliveira MS,Rubin MA,Lehmann M,Krieglstein J,Mello CF

更新日期：2005-08-01 00:00:00

abstract：:We planned this study to investigate the frequency of epilepsy in paralytic polio survivors. We analyzed the clinical data of 91 paralytic polio survivors. Patients who had been diagnosed with epilepsy were examined by electroencephalography and brain magnetic resonance imaging. 11 of the 91 patients had epilepsy (12%...

journal_title：Epilepsy research

authors： Demir CF,Berilgen MS,Mungen B,Bulut S

更新日期：2012-01-01 00:00:00

abstract：:This study was planned so as to evaluate whether magnetic field exposure has any significant effect on the pentylenetetrazol (PTZ)-induced seizures. Mice were exposed to 50 Hz, 2 G (0.2 mT) magnetic field in glass cages for 1 h. Sham exposure was produced by turning off the current while the animals were in the same e...

journal_title：Epilepsy research

authors： Keskil IS,Keskil ZA,Canseven AG,Seyhan N

更新日期：2001-04-01 00:00:00

abstract：:In order to assess the chloride channel gene CLCN2 as a candidate susceptibility gene for childhood absence epilepsy, parametric and non-parametric linkage analysis was performed in 65 nuclear pedigrees. This provided suggestive evidence for linkage with heterogeneity: NPL score=2.3, p<0.009; HLOD=1.5, alpha=0.44. Mut...

journal_title：Epilepsy research

authors： Everett K,Chioza B,Aicardi J,Aschauer H,Brouwer O,Callenbach P,Covanis A,Dooley J,Dulac O,Durner M,Eeg-Olofsson O,Feucht M,Friis M,Guerrini R,Heils A,Kjeldsen M,Nabbout R,Sander T,Wirrell E,McKeigue P,Robinson R,

更新日期：2007-07-01 00:00:00

abstract：:Multiple sclerosis (MS) patients are at higher risk for epilepsy. Epilepsy was frequent among our MS patients (6.55%). Progressive MS forms were associated with higher incidence of epilepsy (p=0.021). Partial motor seizures were observed in five patients (62.5%) and generalized tonic-clonic in three (37.5%). Electroen...

journal_title：Epilepsy research

authors： Martínez-Juárez IE,López-Meza E,González-Aragón Mdel C,Ramírez-Bermúdez J,Corona T

更新日期：2009-04-01 00:00:00

abstract：OBJECT:The use of T2 relaxometry was investigated to detect non-sclerotic epileptogenic abnormality of the hippocampus in presurgical evaluation of temporal lobe epilepsy (TLE). METHODS:This prospective study included 30 patients who underwent hippocampectomy as part of surgical treatment of refractory TLE. Ten patien...

journal_title：Epilepsy research

authors： Sato S,Iwasaki M,Suzuki H,Mugikura S,Jin K,Tominaga T,Takase K,Takahashi S,Nakasato N

更新日期：2016-10-01 00:00:00

abstract：:Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges (SWD) in the WAG/Rij rat model for absence epilepsy. Since following a single dose of vigabatrin GABA concentrations are known to be increased...

journal_title：Epilepsy research

authors： Perescis MFJ,van Luijtelaar G,van Rijn CM

更新日期：2020-09-01 00:00:00

abstract：:Four patients with complex partial seizure disorder whose positron emission tomography (PET) scans show sustained hyperperfusion of the epileptiform focus 12-24 h after a seizure episode are presented. Three of these patients underwent same day Fluorine-18 (18F) deoxyglucose (FDG) PET scans, which showed hypometabolis...

journal_title：Epilepsy research

authors： Tatlidil R

更新日期：2000-12-01 00:00:00

abstract：SUMMARY:Metabotropic glutamate receptors (mGluR) may represent a perspective target for anticonvulsant therapy but spectrum of their anticonvulsant effects is not sufficiently known. Our study was aimed at comparison of anticonvulsant actions of antagonists of mGluR1 and mGluR5 subtypes in immature rats. Seven-, 12-, 1...

journal_title：Epilepsy research

authors： Mares P

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Antiepileptic drugs (AEDs) may have adverse effects on bone metabolism and bone mineral density (BMD). The aim of this study is to determine the changes of bone metabolism and BMD in epilepsy patients who are undergoing levetiracetam (LEV) monotherapy. METHODS:Drug-naïve, sixty-one patients with recent onset e...

journal_title：Epilepsy research

authors： Koo DL,Joo EY,Kim D,Hong SB

更新日期：2013-03-01 00:00:00

abstract：:Special issues are related to AED testing in several populations. Pharmacokinetics, pharmacodynamics and underlying neurochemistry and developing systems require specific testing in appropriate infants with refractory seizures. EEG monitoring is an essential part of seizure definition and recognition, making it a nece...

journal_title：Epilepsy research

authors： Pellock J

更新日期：2006-01-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) has been modeled in mice using pilocarpine induction, with variable results depending on specific strains. To allow efficient xenotransplantation for the purpose of optimizing potential cell-based therapy of human TLE, we have determined the optimal dosing strategy to produce spontaneous r...

journal_title：Epilepsy research

authors： Leung A,Ahn S,Savvidis G,Kim Y,Iskandar D,Luna MJ,Kim KS,Cunningham M,Chung S

更新日期：2015-01-01 00:00:00

abstract：:Stroke is an important cause of symptomatic epilepsy especially in the elderly. Seizures in the setting of stroke will furthermore worsen the prognosis of stroke. Studies show that the frequency of seizures in stroke ranges between 2.3% and 14%. Typically early seizures are defined as those that occur within 14 days o...

journal_title：Epilepsy research

authors： Menon B,Shorvon SD

更新日期：2009-11-01 00:00:00

abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

journal_title：Epilepsy research

authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

更新日期：1990-07-01 00:00:00

abstract：:Valproate (VPA) and vigabatrin (gamma-vinyl GABA, GVG) are two novel antiepileptic drugs with a presumed GABAergic mechanism of action. However, for VPA, this aspect has been extensively debated. The aim of the present study was to investigate whether treatment of cultured neurons with clinically relevant concentratio...

journal_title：Epilepsy research

authors： Gram L,Larsson OM,Johnsen AH,Schousboe A

更新日期：1988-03-01 00:00:00

abstract：:The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequen...

journal_title：Epilepsy research

authors： Busolin G,Malacrida S,Bisulli F,Striano P,Di Bonaventura C,Egeo G,Pasini E,Cianci V,Ferlazzo E,Bianchi A,Coppola G,Elia M,Mecarelli O,Gobbi G,Casellato S,Marchini M,Binelli S,Freri E,Granata T,Posar A,Parmeggiani

更新日期：2011-03-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

journal_title：Epilepsy research

authors： Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

更新日期：1992-10-01 00:00:00

abstract：SUMMARY:Stereotactic radiofrequency amygdalohippocampectomy (AHE) has been reintroduced as an alternative treatment of mesial temporal lobe epilepsy. The aim of this study was to describe MRI changes after stereotactic AHE and to correlate the hippocampal and amygdalar volumes reduction with the clinical seizure outcom...

journal_title：Epilepsy research

authors： Malikova H,Vojtech Z,Liscak R,Prochazka T,Vymazal J,Vladyka V,Keller J,Kalina M

更新日期：2009-02-01 00:00:00

abstract：:The distribution and kinetics of specific binding sites for gamma-hydroxybutyrate (GHB), a naturally occurring compound known to produce absence-like seizures, was studied in the brains of Wistar rats with spontaneous, bilaterally synchronous spike wave discharges (SWDs), a model of petit mal epilepsy, and non-epilept...

journal_title：Epilepsy research

authors： Snead OC 3rd,Hechler V,Vergnes M,Marescaux C,Maitre M

更新日期：1990-11-01 00:00:00

abstract：:The behavioral and EEG concomitants of kindling produced by daily electrical stimulation of the inferior colliculus have been recorded in three series of Wistar rats: (1) non epileptic controls (NE), (2) rats susceptible to audiogenic seizures (AS), (3) acoustically susceptible rats with prior kindling of audiogenic s...

journal_title：Epilepsy research

authors： Hirsch E,Maton B,Vergnes M,Depaulis A,Marescaux C

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:Caffeine is a non-selective antagonist of A1 and A2A adenosine receptors (ARs). In this regard, nitric oxide (NO) is partly involved in the central effects of caffeine. In this study, we examined the effect of acute caffeine administration on pentylenetetrazole (PTZ)-induced seizure threshold by focusing on A1R...

journal_title：Epilepsy research

authors： Esmaili Z,Heydari A

更新日期：2019-01-01 00:00:00

abstract：:Interruption of neurogenesis and/or neuronal migration produces brain dysplasia modifying susceptibility to epileptic seizures in adulthood. The course of neurogenesis has a strictly defined time-table. Consequently, the developmental stage at which the interruption occurs determines what functional subsystem potentia...

journal_title：Epilepsy research

authors： Setkowicz Z,Janicka D,Kowalczyk A,Turlej A,Janeczko K

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Little is known, so far, about the cerebral structural abnormalities in drug-naïve patients with childhood absence epilepsy (CAE). We aimed to investigate regional grey matter (GM) volume differences using voxel-based morphometry (VBM) in patients and closely matched healthy control subjects. METHODS:Twenty...

journal_title：Epilepsy research

authors： Wang G,Dai ZY,Song W,Wang S,Shi H,Pan P,Chen F,Xu Y,Zhong J

更新日期：2016-08-01 00:00:00

abstract：:The present study aimed at investigating to what extent the regulation of excitability in cortical networks, as indicated by surface-negative slow cortical potentials (SCPs), is impaired in epileptic patients and to what extent training of SCP self-regulation by means of biofeedback and instrumental learning procedure...

journal_title：Epilepsy research

authors： Rockstroh B,Elbert T,Birbaumer N,Wolf P,Düchting-Röth A,Reker M,Daum I,Lutzenberger W,Dichgans J

更新日期：1993-01-01 00:00:00