Abstract:
:The melanocortin-4 receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this association further, we analysed the segregation of this missense mutation in relation to variation in fatness traits using a Wild Boar x Large White intercross. The Wild Boar and Large White founders were homozygous for different MC4R alleles. The MC4R was assigned to the expected region on pig chromosome 1. The statistical evaluation did not reveal any indication of a significant effect on fatness related traits in this pedigree.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Park HB,Carlborg O,Marklund S,Andersson Ldoi
10.1046/j.1365-2052.2002.00824.xsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
155-7issue
2eissn
0268-9146issn
1365-2052pii
824journal_volume
33pub_type
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