Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross.

Abstract:

:The melanocortin-4 receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this association further, we analysed the segregation of this missense mutation in relation to variation in fatness traits using a Wild Boar x Large White intercross. The Wild Boar and Large White founders were homozygous for different MC4R alleles. The MC4R was assigned to the expected region on pig chromosome 1. The statistical evaluation did not reveal any indication of a significant effect on fatness related traits in this pedigree.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Park HB,Carlborg O,Marklund S,Andersson L

doi

10.1046/j.1365-2052.2002.00824.x

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

155-7

issue

2

eissn

0268-9146

issn

1365-2052

pii

824

journal_volume

33

pub_type

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