Streptococcus pneumoniae polysaccharides conjugated to the outer membrane protein A from Klebsiella pneumoniae elicit protective antibodies.

abstract：:Lyme disease (LD) accounts for over 70% of tick-borne disease reported in the United States. The disease in humans is characterized by skin rash, arthritis, cardiac and neurological signs. Vaccination is the most efficient preventive measure that could be taken to reduce the incidence of the LD worldwide; however, at ...

journal_title：Vaccine

authors： Hassan WS,Giaretta PR,Rech R,Ollivault-Shiflett M,Esteve-Gasent MD

更新日期：2019-09-03 00:00:00

abstract：:A mass vaccination campaign against influenza A/H1N1 was launched in France in October 2009. Vaccination was offered free of charge to the entire population according to a pre-defined order of priority. Demographic data and data on vaccinations given were recorded in a dedicated database. We analysed vaccine uptake by...

journal_title：Vaccine

authors： Bone A,Guthmann JP,Nicolau J,Lévy-Bruhl D

更新日期：2010-11-29 00:00:00

abstract：:The recent introductions of highly pathogenic avian influenza (HPAI) H5N1 virus in wild birds and its subsequent spread throughout Asia, the Middle East, Africa and Europe has put a focus on the role of wild birds in the geographical spread of HPAI H5N1 virus. Large-scale surveillance programs are ongoing to determine...

journal_title：Vaccine

authors： Munster VJ,Fouchier RA

更新日期：2009-10-23 00:00:00

abstract：INTRODUCTION:Determining vaccine responsiveness is challenging in immune compromised individuals. The microbead array (MBA) assay is a rapid, inexpensive test for evaluating influenza vaccine immunogenicity. MBA performance was compared to hemagglutination inhibition assay (HAI) utilizing HIV seropositive vaccine recip...

journal_title：Vaccine

authors： Thorne A,Chowdhury F,Singer J,Keynan Y,Fowke KR,Cooper C,CIHR Canadian HIV Trials Network (CTN) Influenza Vaccine Research Group.

更新日期：2016-06-30 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of whole-cell and acellular pertussis vaccines administered to children singly or within diphtheria, tetanus and pertussis (DTP) vaccines. DATA SOURCES:We searched the Cochrane Library, MEDLINE, EMBASE, Biological Abstracts and Science Citation Index to December 2001. Specia...

journal_title：Vaccine

authors： Jefferson T,Rudin M,DiPietrantonj C

更新日期：2003-05-16 00:00:00

abstract：:Rotavirus vaccine was introduced in El Salvador in 2006 and is recommended to be given concomitantly with DTP-HepB-Haemophilus influenzae type b (pentavalent) vaccine at ages 2 months (upper age limit 15 weeks) and 4 months (upper age limit 8 months) of age. However, rotavirus vaccination coverage continues to lag beh...

journal_title：Vaccine

authors： Suarez-Castaneda E,Burnett E,Elas M,Baltrons R,Pezzoli L,Flannery B,Kleinbaum D,de Oliveira LH,Danovaro-Holliday MC

更新日期：2015-11-27 00:00:00

abstract：BACKGROUND:Pseudotuberculosis is an infection caused by the bacterial enteropathogen Yersinia pseudotuberculosis and is considered to be a significant problem in veterinary medicine. We previously found that intranasal administration of a recombinant Lactococcus lactis strain that secretes the low-calcium response V (L...

journal_title：Vaccine

authors： Daniel C,Titecat M,Poiret S,Cayet D,Boutillier D,Simonet M,Sirard JC,Lemaître N,Sebbane F

更新日期：2016-11-11 00:00:00

abstract：:The purpose of this study was to investigate the utility of various in vitro and in vivo methods to assess the stability of experimental vaccines containing tetanus toxoid (TT) within PLGA microspheres. In vitro, the breakdown of the encapsulating polymers into their acid components led to changes in the structure of ...

journal_title：Vaccine

authors： Sasiak AB,Bolgiano B,Crane DT,Hockley DJ,Corbel MJ,Sesardic D

更新日期：2000-11-22 00:00:00

abstract：:Native porcine zona pellucida (PZP) has been shown to be highly effective as an immunocontraceptive in white-tailed deer. However, the immunogenicity of PZP extracted from pig ovaries may vary from lot to lot and the extract has the potential of containing either viral or pathogenic material. Determination of the immu...

journal_title：Vaccine

authors： Miller LA,Killian GJ

更新日期：2002-06-21 00:00:00

abstract：:The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we sh...

journal_title：Vaccine

authors： Premenko-Lanier M,Rota P,Rhodes G,Bellini W,McChesney M

更新日期：2004-01-26 00:00:00

abstract：:It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to t...

journal_title：Vaccine

authors： Do Y,Didierlaurent AM,Ryu S,Koh H,Park CG,Park S,Perlin DS,Powell BS,Steinman RM

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:Long-term immunosuppressive medications are being used more commonly for a variety of medical conditions, including immune-mediated diseases and organ transplantation. While these medications are often necessary, they are associated with an increased risk of serious infections. Vaccination may be a way to pr...

journal_title：Vaccine

authors： Agarwal N,Ollington K,Kaneshiro M,Frenck R,Melmed GY

更新日期：2012-02-14 00:00:00

abstract：:Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and vaccination is the primary tool for the disease control. Previously, we developed a more cost-effective PCV2 virus-like particle (VLP) vaccine by using ELPylation technology. In the present study, we compared the ELPylated VLP (ELP-VLP) P...

journal_title：Vaccine

authors： Li Y,Lin Y,Xin G,Zhou X,Lu H,Zhang X,Xia X,Sun H

更新日期：2020-05-13 00:00:00

abstract：:Streptococcus pneumoniae is one of the leading bacterial pathogens causing invasive disease and non-invasive infections at both extremes of life: in children younger than 5 years and in elderly persons of 65 years or more. Pneumococcal infections result in substantial morbidity and mortality among children under 5 yea...

journal_title：Vaccine

authors： Arguedas A,Soley C,Abdelnour A

更新日期：2011-09-14 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) is an important cause of diarrhea in children. EPEC adheres to the intestinal epithelium and causes attaching and effacing (A/E) lesions. Recombinant Mycobacterium smegmatis (Smeg) and Mycobacterium bovis BCG strains were constructed to express either BfpA or intimin. The entir...

journal_title：Vaccine

authors： Vasconcellos HL,Scaramuzzi K,Nascimento IP,Da Costa Ferreira JM Jr,Abe CM,Piazza RM,Kipnis A,Dias da Silva W

更新日期：2012-09-07 00:00:00

abstract：INTRODUCTION:HPV vaccine uptake is lowest among young adults. Little is known about the most effective way to decrease missed opportunities (MO) and increase uptake of the vaccine in this vulnerable population. OBJECTIVES:To determine the impact of a clinical intervention bundle on the rate of MO and uptake of the vac...

journal_title：Vaccine

authors： Deshmukh U,Oliveira CR,Griggs S,Coleman E,Avni-Singer L,Pathy S,Shapiro ED,Sheth SS

更新日期：2018-06-14 00:00:00

abstract：:Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass...

journal_title：Vaccine

authors： Thakur A,Ingvarsson PT,Schmidt ST,Rose F,Andersen P,Christensen D,Foged C

更新日期：2018-05-31 00:00:00

abstract：:After the publication of case reports of hepatitis B vaccinees with onset or relapse of multiple sclerosis (MS), followed by a media-driven scare campaign in France, the perception that hepatitis B vaccine causes MS has developed. This has led to a fall in the acceptance of hepatitis B vaccination particularly in Fren...

journal_title：Vaccine

authors： Monteyne P,André FE

更新日期：2000-04-03 00:00:00

abstract：:A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). In this study, CPMV-PARVO1 was inactivated by UV tre...

journal_title：Vaccine

authors： Langeveld JP,Brennan FR,Martínez-Torrecuadrada JL,Jones TD,Boshuizen RS,Vela C,Casal JI,Kamstrup S,Dalsgaard K,Meloen RH,Bendig MM,Hamilton WD

更新日期：2001-06-14 00:00:00

abstract：:Dengue is one of the most important mosquito-borne viral disease causing dengue fever and/or dengue shock syndrome/haemorrhagic fever. In some reports, the non-structural protein 1 (NS1) has been identified as a promising antigen for the development of vaccines against dengue virus (DENV). Apparently, it can elicit a ...

journal_title：Vaccine

authors： Costa SM,Freire MS,Alves AM

更新日期：2006-05-22 00:00:00

abstract：:The 9-valent Human Papillomavirus (HPV) vaccine, 9vHPV, was licensed in the U.S. in December, 2014. We assessed healthcare provider (HCP) awareness of the newly approved vaccine and identified questions HCPs have about the vaccine. As part of a larger study, we used semi-structured interviews to ask 22 pediatric HCPs ...

journal_title：Vaccine

authors： Kasting ML,Wilson S,Dixon BE,Downs SM,Kulkarni A,Zimet GD

更新日期：2016-03-08 00:00:00

abstract：:According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp12...

journal_title：Vaccine

authors： Metlas R,Veljković V

更新日期：1995-03-01 00:00:00

abstract：:Human botulism is commonly associated with botulinum neurotoxin (BoNT) serotypes A, B, E and F. This suggests that the greatest need is for a tetravalent vaccine that provides protection against all four of these serotypes. In current study, we investigated the feasibility of generating several tetravalent vaccines th...

journal_title：Vaccine

authors： Yu YZ,Guo JP,An HJ,Zhang SM,Wang S,Yu WY,Sun ZW

更新日期：2013-05-07 00:00:00

abstract：:A study of the serological and epidemiological effects of primary immunization with current live attenuated measles vaccine (Hu191) among 503 children aged 6-15 months, was conducted in Jingzhou, Hubei province, China from 1991 to 1998. The results showed that the positive conversion rate of measles IgG was 91.65%, ge...

journal_title：Vaccine

authors： Youwang Y,Ping W,Feng C

更新日期：2001-02-28 00:00:00

abstract：:We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...

journal_title：Vaccine

authors： Mendelson I,Gat O,Aloni-Grinstein R,Altboum Z,Inbar I,Kronman C,Bar-Haim E,Cohen S,Velan B,Shafferman A

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:The recent emergence of avian influenza strains has fuelled concern about pandemic preparedness since vaccines targeting these viruses are often poorly immunogenic. Weak antibody responses to vaccines have been seen across multiple platforms including plant-made VLPs. To better understand these differences...

journal_title：Vaccine

authors： Hendin HE,Pillet S,Lara AN,Wu CY,Charland N,Landry N,Ward BJ

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Health-care personnel (HCP) are at risk for exposure to and possible transmission of vaccine-preventable diseases. Receiving recommended vaccines is an essential prevention practice for HCP to protect themselves and their patients. The tetanus, diphtheria and acellular pertussis vaccine (Tdap) was recommende...

journal_title：Vaccine

authors： Lu PJ,Graitcer SB,O'Halloran A,Liang JL

更新日期：2014-01-23 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animal species. The FMDV capsid is highly acid labile and viral particles lose their immunogenicity when they disassemble at mildly acidic pHs. The viral capsid of FMDV serotype O is more sensitive th...

journal_title：Vaccine

authors： Xie Y,Li H,Qi X,Ma Y,Yang B,Zhang S,Chang H,Yin X,Li Z

更新日期：2019-03-28 00:00:00

abstract：BACKGROUND:Although global progress in measles control has been realized, achieving elimination has proven difficult in many regions of the world. China has adopted a goal of measles elimination but recent outbreaks predominantly affecting children <8 months who are ineligible for vaccination and incompletely protected...

journal_title：Vaccine

authors： Janusz CB,Wagner AL,Masters NB,Ding Y,Zhang Y,Hutton DW,Boulton ML

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Although the mortality from diarrheal diseases has been decreasing dramatically in Iran, it still represents an important proportion of disease burden in children <5 years old. Rotavirus vaccines are among the most effective strategies against diarrheal diseases in specific epidemiological conditions. This s...

journal_title：Vaccine

authors： Javanbakht M,Moradi-Lakeh M,Yaghoubi M,Esteghamati A,Mansour Ghanaie R,Mahmoudi S,Shamshiri AR,Zahraei SM,Baxter L,Shakerian S,Chaudhri I,Fleming JA,Munier A,Baradaran HR

更新日期：2015-05-07 00:00:00