Abstract:
:Human DAB2IP (for DAB2 interaction protein) is a novel member of the RasGTPase-activating protein family. It interacts directly with DAB2, which suppresses growth of many cancer types. We demonstrated that DAB2IP is often downregulated in human prostate cancer cell lines. The predicted DAB2IP protein (967 amino acids) shares 94.2% homology with the rat DIP1/2 protein. We mapped the promoter of DAB2IP and studied its regulation in normal and malignant prostate cancer cells. This gene is located at 9q33.1-q33.3 and spans approximately 96 kb with 15 exons and 14 introns. The DAB2IP promoter does not contain any typical TATA box-evidenced by the presence of various RNAs with differential transcription starting sites. We further demonstrated that normal prostatic epithelial cells have elevated DAB2IP mRNA compared with cancer cells, which correlates with increased DAB2IP promoter activity. These data indicate that transcriptional regulation of DAB2IP is responsible for the downregulation of DAB2IP expression in prostate cancer cells.
journal_name
Genomicsjournal_title
Genomicsauthors
Chen H,Pong RC,Wang Z,Hsieh JTdoi
10.1006/geno.2002.6739subject
Has Abstractpub_date
2002-04-01 00:00:00pages
573-81issue
4eissn
0888-7543issn
1089-8646pii
S088875430296739Xjournal_volume
79pub_type
杂志文章相关文献
GENOMICS文献大全abstract::We have isolated and examined the gene for the heart isoform of cytochrome c oxidase subunit VIIa (COX VIIa-H) in mouse, an isoform gene previously thought to be lacking in rodents. Interspecies amino acid comparisons indicate that mouse COX VIIa-H protein displays 82.5 and 70.9% identity with the bovine and human hea...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5279
更新日期:1998-05-01 00:00:00
abstract::DNA hybridization was used to isolate a 2.04-kb cDNA encoding carboxyl ester lipase (CEL) from a mouse lactating mammary gland, lambda gt10 cDNA library. The cDNA sequence translated into a protein of 599 amino acids, including 20 amino acids of a putative signal peptide. Comparison of the deduced amino acid sequence ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1221
更新日期:1995-09-01 00:00:00
abstract::We reported HIVID (high-throughput Viral Integration Detection), a novel experimental and computational method to detect the location of Hepatitis B Virus (HBV) integration breakpoints in Hepatocellular Carcinoma (HCC) genome. In this method, the fragments with HBV sequence were enriched by a set of HBV probes and the...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.07.002
更新日期:2013-10-01 00:00:00
abstract::The novel weakly inward rectifying potassium channel Kir7.1 is a low-conductance channel that is predominantly expressed in epithelial cells. Here we describe a partial genomic characterization and the chromosomal assignment of the human Kir7.1 gene (KCNJ13). Analysis of the genomic structure using a PCR-based approac...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5598
更新日期:1998-12-15 00:00:00
abstract::The intron-containing genes encoding rat and human ribosomal protein L19 (RPL19) have been cloned. The DNA sequences of the entire rat RPL19 gene and the 5' end of the human RPL19 gene have been determined. Sequence comparison of corresponding regions of the two genes reveals a striking interspecies homology in the 5'...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80036-l
更新日期:1995-01-20 00:00:00
abstract::Non-coding RNA (ncRNA) is a kind of RNA, produced by genomic transcription and does not encode protein, but can regulate the function of genes, thus widely regulating pathological and physiological processes. The dynamic balance of the reticular structure between them is needed to regulate the homeostasis, the abnorma...
journal_title:Genomics
pub_type: 杂志文章,评审
doi:10.1016/j.ygeno.2019.10.006
更新日期:2020-03-01 00:00:00
abstract::Intercellular adhesion molecule-1 (ICAM-1, CD54) is a cell adhesion molecule that interacts with the leukocyte beta 2 integrins, LFA-1 and Mac-1. Murine inflammatory models are being utilized increasingly to define the role that ICAM-1 induction plays in the initiation of inflammation. We have isolated murine genomic ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(05)80132-6
更新日期:1992-12-01 00:00:00
abstract::Thirty-five new, unique, DNA probes have been isolated and each has been assigned to one of five regions on chromosome 22. The distribution of probes along the chromosome is what would be expected based on the estimated size of each region with the exception of the short arm (22p). RFLP analysis was performed using 13...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90190-p
更新日期:1991-08-01 00:00:00
abstract::DNA methylation is a major epigenetic modification of the genome that affects basic biological functions, such as gene expression and cell development. We used the human genome sequences and the DNA methylation data that are available in order to establish a map of the levels of GC and methylation in isochores. We als...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.09.006
更新日期:2010-01-01 00:00:00
abstract::Cardiac hypertrophy is an important risk factor for cardiac morbidity and mortality. To unravel the underlying pathogenic genetic pathways, we hybridized left ventricular RNA from Transverse Aortic Constriction mice at 48 h, 1 week, and 2, 3, and 8 weeks after surgery to microarrays containing a 15K fetal cDNA collect...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.04.012
更新日期:2006-10-01 00:00:00
abstract::A novel gene, TEGT (testis enhanced gene transcript), has been identified in humans. It does not belong to any known gene family of vertebrates. The deduced amino acid sequence of the gene and a bacterial protein of unknown function show low but significant homology and very similar hydrophobicity profiles. Two differ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1145
更新日期:1995-07-20 00:00:00
abstract::Human chromosome 20 is conserved as a single segment on distal mouse chromosome (Chr) 2. PPGB, protective protein for beta-galactosidase, maps to human chromosome 20q13.1, and from linkage analysis of two interspecific crosses incorporating the mouse reciprocal translocations, T(2;8)2Wa (T2Wa) and T(2;16)28H (T28H), w...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1373
更新日期:1994-07-01 00:00:00
abstract::A linkage analysis with 12 DNA markers from proximal 19q was performed in eight families with central core disease (CCO). Two-point analysis gave a peak lod score of Z = 4.95 at theta = 0.00 for the anonymous marker D19S190 and of Z = 2.53 at theta = 0.00 for the ryanodine receptor (RYR1) candidate gene. Multipoint li...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1302
更新日期:1993-07-01 00:00:00
abstract::Multiple inositol polyphosphate phosphatase is the only enzyme known to hydrolyze the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate. We have previously demonstrated that the chick homolog of multiple inositol polyphosphate phosphatase, designated HiPER1, has a role in growth plate chond...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5736
更新日期:1999-03-15 00:00:00
abstract::The nervous and immune systems share many functional and molecular similarities, including shared surface antigens, secretions of soluble factors, and cross-modulatory effects. We have identified previously a novel mRNA termed F5, which is expressed only in activated T lymphocytes and mature, postmitotic neurons. Tiss...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80137-b
更新日期:1995-01-01 00:00:00
abstract::We show a mute 9.1-kb gap in the human genome reference map, unraveled by RDA studies, to be a worldwide deletion/insertion polymorphism of stable type. The molecular and population data presented suggest its origin from a unique ancestral transposition event in chromosomal region 22q11.2, overlapping the IglambdaV ge...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.7014
更新日期:2002-12-01 00:00:00
abstract::Mapping of 33 anonymous DNA probes and 12 genes to the long arm of chromosome 16 was achieved by the use of 14 mouse/human hybrid cell lines and the fragile site FRA16B. Two of the hybrid cell lines contained overlapping interstitial deletions in bands q21 and q22.1. The localization of the 12 genes has been refined. ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90313-4
更新日期:1991-06-01 00:00:00
abstract::Given the vast amount of genomic data, alignment-free sequence comparison methods are required due to their low computational complexity. k-mer based methods can improve comparison accuracy by extracting an effective feature of the genome sequences. The aim of this paper is to extract k-mer intervals of a sequence as ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.11.001
更新日期:2019-12-01 00:00:00
abstract::The inherited cancer syndrome multiple endocrine neoplasia type 2A (MEN2A) has recently been mapped to chromosome 10. We have typed 29 families with this disorder with DNA markers from the pericentromeric region of chromosome 10. Two markers, RBP3 and MCK2, were tightly linked to the MEN2A gene at recombination fracti...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90046-3
更新日期:1989-08-01 00:00:00
abstract::Physical activity enhances muscle mitochondrial gene expression, while inactivity and mitochondrial dysfunction are both risk factors for developing diabetes. Defective activation of the transcriptional coactivator PGC-1alpha may contribute to the gene expression pattern observed in diabetic and insulin-resistant skel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2005.09.007
更新日期:2006-01-01 00:00:00
abstract::Interspecific somatic cell hybrids containing single human chromosomes are valuable reagents for localization of cloned genes and DNA fragments to specific chromosomes, for the development of chromosome-specific libraries, and for generation of hybrid cell lines containing subchromosomal regions. A CHO somatic cell hy...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90122-u
更新日期:1991-09-01 00:00:00
abstract::Thirteen moderately to highly informative microsatellite DNA polymorphisms based on (dC-dA)n.(dG-dT)n repeats were mapped to segments of human chromosome 5 using both linkage analysis and a panel of somatic cell hybrids which contained rearranged chromosomes. The markers were distributed throughout most of the length ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90077-r
更新日期:1991-11-01 00:00:00
abstract::The gene encoding human carboxyl ester lipase (CEL), including 1628 bp of the 5'-flanking region, has been isolated and characterized from two overlapping lambda phage clones. The gene spans 9832 bp and contains 11 exons interrupted by 10 introns. The exons range in size from 88 to 204 bp, except for the last exon, wh...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90134-e
更新日期:1992-07-01 00:00:00
abstract::We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1075
更新日期:1994-01-15 00:00:00
abstract::The recessive male sterility and histoincompatibility (mshi) mutation in the mouse generates pleiotropic effects on histocompatibility and male reproduction, while female mutants appear to be reproductively normal. We have mapped the mshi mutation to mouse Chromosome (Chr) 10 by analysis of 126 progeny from an intrasp...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4475
更新日期:1997-01-01 00:00:00
abstract::The ADH7 gene encoding human Class IV (sigma) alcohol dehydrogenase (ADH) was cloned from a Caucasian genomic DNA library and characterized. It has nine exons and eight introns that span about 22 kb, and its intron insertion is identical to that of the other ADH genes (ADH1 to ADH5). The nucleotide sequences of the ex...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0040
更新日期:1996-01-15 00:00:00
abstract::Perilipin 1 (PLIN1) protein, also known as lipid droplet-associated protein, is encoded by the PLIN1 gene and is able to anchor itself to the membranes of lipid droplets. The phosphorylation of PLIN1 is critical for the mobilization of fat in adipose tissue and plays an important role in regulating lipolysis and lipid...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.01.012
更新日期:2020-05-01 00:00:00
abstract::Two murine homologs of the Drosophila Krüppel gene, a member of the gap class of developmental control genes that encode a protein with zinc fingers, were mapped to mouse chromosomes 8 and 11 by using somatic cell hybrids and an interspecific backcross. Surprisingly, both genes were closely linked to two previously ma...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90033-q
更新日期:1990-11-01 00:00:00
abstract::Fluorescence in situ hybridization was used to establish the order of, and to estimate genomic distances among, members of the carcinoembryonic antigen (CEA) and pregnancy-specific glycoprotein (PSG) subgroups on chromosome 19. Fluorescence in situ hybridization to metaphase chromosomes localized the PSG subgroup telo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90308-f
更新日期:1992-04-01 00:00:00
abstract::Immunoblotting of isoelectric focusing gels of plasma and direct genomic DNA sequencing have been used to characterize a mutation in apolipoprotein A-I associated with the familial amyloidotic polyneuropathy originally described by Van Allen in an Iowa kindred. An arginine for glycine substitution in apolipoprotein A-...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90288-6
更新日期:1990-10-01 00:00:00