Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli.

abstract：:Kinetic studies have been carried out to investigate the functional heterogeneity previously observed in populations of human marrow or peripheral blood cells separated by velocity sedimentation. The results obtained confirm the earlier results, in that slowly-sedimenting cells were found to stimulate both colony form...

journal_title：Blood

authors： Niho Y,Till JE,McCulloch EA

更新日期：1975-06-01 00:00:00

abstract：:To understand the regulatory mechanism of erythropoietin (EPO) receptor (EPOR) gene expression, the effect of EPO on the steady-state level of EPOR mRNA was examined using the human EPO-dependent cell line UT-7 as a model system. We found that the treatment of UT-7 cells with EPO resulted in a transient decrease of th...

journal_title：Blood

authors： Komatsu N,Kirito K,Kashii Y,Furukawa Y,Kikuchi J,Suwabe N,Yamamoto M,Miura Y

更新日期：1997-02-15 00:00:00

abstract：:Loxosceles is the most venomous spider in Brazil, and envenomation causes dermonecrosis and complement (C)-dependent intravascular hemolysis. The authors studied the mechanism of induction of C-induced hemolysis. Purified Loxosceles toxins rendered human erythrocytes susceptible to lysis by human C but did not have an...

journal_title：Blood

authors： Tambourgi DV,Morgan BP,de Andrade RM,Magnoli FC,van Den Berg CW

更新日期：2000-01-15 00:00:00

abstract：:Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V de...

journal_title：Blood

authors： Ghali DW,Panzer S,Fischer S,Argyriou-Tirita A,Haas OA,Kovar H,Gadner H,Panzer-Grümayer ER

更新日期：1995-05-15 00:00:00

abstract：:Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...

journal_title：Blood

authors： Becknell B,Hughes TL,Freud AG,Blaser BW,Yu J,Trotta R,Mao HC,Caligiuri de Jesús ML,Alghothani M,Benson DM Jr,Lehman A,Jarjoura D,Perrotti D,Bates MD,Caligiuri MA

更新日期：2007-03-15 00:00:00

abstract：:The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue mac...

journal_title：Blood

authors： Dale DC,Boxer L,Liles WC

更新日期：2008-08-15 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has a specific genetic rearrangement between the retinoic acid receptor (RAR)-alpha gene and the pml nuclear protein gene. All-trans retinoic acid (ATRA) induces granulocytic differentiation of APL-derived cells and is used to treat APL patients. However, ATRA interacts with normal c...

journal_title：Blood

authors： Makishima M,Umesono K,Shudo K,Naoe T,Kishi K,Honma Y

更新日期：1998-06-15 00:00:00

abstract：:CD34 is expressed on human hematopoietic stem and progenitor cells, and its clinical usefulness for the purification of stem cells has been well established. However, a similar pattern of expression for murine CD34 (mCD34) has not yet been determined. Two polyclonal anti-mCD34 antibodies that specifically recognize bo...

journal_title：Blood

authors： Krause DS,Ito T,Fackler MJ,Smith OM,Collector MI,Sharkis SJ,May WS

更新日期：1994-08-01 00:00:00

abstract：:Erythropoietin (EPO) is the hormone necessary for development of erythrocytes from immature erythroid cells. EPO activates Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family in the EPO-dependent murine erythroid HCD57 cells. Therefore, we tested if JNK activity supported prolif...

journal_title：Blood

authors： Jacobs-Helber SM,Sawyer ST

更新日期：2004-08-01 00:00:00

abstract：:Intracellular protein transport in endothelial cells is selectively inhibited by homocysteine, a thiol amino acid associated with both thrombosis and atherosclerosis. In a previous study, homocysteine decreased cell surface expression of the surface transmembrane glycoprotein thrombomodulin without decreasing secretio...

journal_title：Blood

authors： Lentz SR,Sadler JE

更新日期：1993-02-01 00:00:00

abstract：:In this issue of Blood, Pozzi et al demonstrate that removing an anionic cage promotes exposure of R169 thereby generating a protein C (PC) that is far more readily activated. ...

journal_title：Blood

authors： Maurer MC

更新日期：2012-07-19 00:00:00

abstract：:We tested the hypothesis that the antibody response to human factor IX in mice is controlled by genetic factors, especially histocompatibility antigens. Seven inbred mouse strains were immunized against human factor IX by adenoviral gene transfer or serial injections of human factor IX protein. A/J mice had the highes...

journal_title：Blood

authors： Lozier JN,Tayebi N,Zhang P

更新日期：2005-02-01 00:00:00

abstract：:The deregulated Bcr/Abl tyrosine kinase is responsible for the development of Philadelphia (Ph)-positive leukemia in humans. To investigate the significance of the C-terminal Abl actin-binding domain within Bcr/Abl p190 in the development of leukemia/lymphoma in vivo, mutant p190 DNA constructs were used to generate t...

journal_title：Blood

authors： Heisterkamp N,Voncken JW,Senadheera D,Gonzalez-Gomez I,Reichert A,Haataja L,Reinikainen A,Pattengale PK,Groffen J

更新日期：2000-09-15 00:00:00

abstract：:The development of novel technologies for high-throughput DNA sequencing is having a major impact on our ability to measure and define normal and pathologic variation in humans. This review discusses advances in DNA sequencing that have been applied to benign hematologic disorders, including those affecting the red bl...

journal_title：Blood

authors： Sankaran VG,Gallagher PG

更新日期：2013-11-21 00:00:00

abstract：:We demonstrated that Flk-1(+) cells derived from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and mural cells (MCs) to suffice as vascular progenitor cells (VPCs). In the present study, we investigated the importance of the stage of ES cell differentiation on effective participat...

journal_title：Blood

authors： Yurugi-Kobayashi T,Itoh H,Yamashita J,Yamahara K,Hirai H,Kobayashi T,Ogawa M,Nishikawa S,Nishikawa S,Nakao K

更新日期：2003-04-01 00:00:00

abstract：:The spatial distribution of subpopulations of hemopoietic progenitor cells following syngeneic transplantation was investigated at the single-cell level. The location of infused hemopoietic progenitor cells within the femoral bone marrow of nonablated recipients was determined by 5-(and-6)-carboxyfluorescein diacetate...

journal_title：Blood

authors： Nilsson SK,Johnston HM,Coverdale JA

更新日期：2001-04-15 00:00:00

abstract：:Drug-dependent antibodies (DDAbs) that cause acute thrombocytopenia upon drug exposure are nonreactive in the absence of the drug but bind tightly to a platelet membrane glycoprotein, usually α(IIb)/β3 integrin (GPIIb/IIIa) when the drug is present. How a drug promotes binding of antibody to its target is unknown and ...

journal_title：Blood

authors： Bougie DW,Peterson J,Rasmussen M,Aster RH

更新日期：2015-10-29 00:00:00

abstract：:The status of the T cell receptor beta and gamma genes in natural killer (NK) cells was investigated in two patients with a marked expansion of CD2+, CD3- NK cells. Both genes were found to be in the germline state. The T alpha and complete T beta gene transcripts were not detected, but a 1.0-kilobase T beta gene tran...

journal_title：Blood

authors： Chan WC,Dahl C,Waldmann T,Link S,Mawle A,Nicholson J,Bach FH,Bongiovanni K,McCue PA,Winton EF

更新日期：1988-01-01 00:00:00

abstract：:Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein encoded by the same gene that codes for uteroferrin, a placental iron transport protein. In human peripheral mononuclear cells, TRAP expression is inhibited by both hemin (ferric protoporphyrin IX) and protoporphyrin IX. Nuclear run-on assays con...

journal_title：Blood

authors： Reddy SV,Alcantara O,Roodman GD,Boldt DH

更新日期：1996-09-15 00:00:00

abstract：:The role of glycosylated recombinant human granulocyte colony-stimulating factor (G-CSF) in the induction treatment of older adults with acute myeloid leukemia (AML) is still uncertain. In this trial, a total of 722 patients with newly diagnosed AML, median age 68 years, were randomized into 4 treatment arms: (A) no G...

journal_title：Blood

authors： Amadori S,Suciu S,Jehn U,Stasi R,Thomas X,Marie JP,Muus P,Lefrère F,Berneman Z,Fillet G,Denzlinger C,Willemze R,Leoni P,Leone G,Casini M,Ricciuti F,Vignetti M,Beeldens F,Mandelli F,De Witte T,EORTC\/GIMEMA Leukemi

更新日期：2005-07-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) elevates H- and L-ferritin subunit synthesis in both human hepatoma cells (HepG2) and primary human umbilical vein endothelial cells. Ferritin induction is greater than the increase in total HepG2 protein synthesis in response to IL-1. IL-6 causes a moderate increase in L-subunit synthesis...

journal_title：Blood

authors： Rogers JT

更新日期：1996-03-15 00:00:00

abstract：:The last 2 years have seen much excitement in the field of genetics with the identification of a formerly unappreciated level of "structural variation" within the normal human genome. Genetic structural variants include deletions, duplications, and inversions in addition to the recently discovered, copy number variant...

journal_title：Blood

authors： Mullally A,Ritz J

更新日期：2007-02-15 00:00:00

abstract：:The effect of lipopolysaccharide (LPS) on endothelial cells is a key component of the inflammatory response seen in Gram-negative sepsis. LPS does not cause death of cultured human endothelial cells. However, when the expression of new proteins is inhibited by cycloheximide, microvascular endothelial cells in culture ...

journal_title：Blood

authors： Hu X,Yee E,Harlan JM,Wong F,Karsan A

更新日期：1998-10-15 00:00:00

abstract：:Intravital microscopy was used to monitor leukocyte traffic across rat mesenteric postcapillary venules induced by the inactive terminal complement (C) complex (iTCC) topically applied to ileal mesentery. Leukocytes started rolling within 15 minutes from the administration of iTCC, and by 1 hour they adhered almost co...

journal_title：Blood

authors： Dobrina A,Pausa M,Fischetti F,Bulla R,Vecile E,Ferrero E,Mantovani A,Tedesco F

更新日期：2002-01-01 00:00:00

abstract：:The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation...

journal_title：Blood

authors： Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

更新日期：2012-05-03 00:00:00

abstract：:Two fractions of human prothrombin can be isolated from single donor plasma by the technique of heparin-agarose chromatography in (sodium) citrate buffer, pH 7.5, as previously reported for pooled plasma. The two fractions, designated H-II1 and H-II2, are found in a ratio of approximately 4:1. Both forms comigrate in ...

journal_title：Blood

authors： Bajaj SP,Rapaport SI,Prodonos C,Russell WA

更新日期：1981-11-01 00:00:00

abstract：:The therapeutic potential of hematopoietic stem cell (HSC) gene therapy can be fully exploited only by reaching efficient gene transfer into HSCs without compromising their biologic properties. Although HSCs can be transduced by HIV-derived lentiviral vectors (LVs) in short ex vivo culture, they display low permissivi...

journal_title：Blood

authors： Santoni de Sio FR,Cascio P,Zingale A,Gasparini M,Naldini L

更新日期：2006-06-01 00:00:00

abstract：:The balanced manifestation of effector functions and the generation of long-living memory cells is a hallmark of efficient CD8(+) T-cell response. Accumulating data pinpoint CD4(+) CD25(high) regulatory T (Treg) cells as a key factor for the inefficiency of CD8(+) T-cell responses in viral persistence. Little is known...

journal_title：Blood

authors： Nikolova M,Lelievre JD,Carriere M,Bensussan A,Lévy Y

更新日期：2009-05-07 00:00:00

abstract：:Surprisingly little is known about the interaction of human blood mononuclear cells with viruses. Here, we show that monocytes are the predominant cell type infected when peripheral blood mononuclear cells are exposed to viruses ex vivo. Remarkably, infection with vesicular stomatitis virus, vaccinia virus, and a vari...

journal_title：Blood

authors： Hou W,Gibbs JS,Lu X,Brooke CB,Roy D,Modlin RL,Bennink JR,Yewdell JW

更新日期：2012-03-29 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the β-globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cells. Using zinc-finger nucleases (ZFNs) designed to flank the sickle mu...

journal_title：Blood

authors： Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A

更新日期：2015-04-23 00:00:00