Abstract:
:Salt-sensitive persons have lower plasma renin activity than salt-resistant persons and their plasma renin activity increases less with a low sodium diet or volume depletion, compared to salt-resistant individuals. However, the time course of the renin response to acute volume contraction has not been studied in humans. Therefore, we designed an acute study in salt-sensitive and salt-resistant normotensive volunteers, in which we examined the renin response to isotonic volume contraction. Twenty-four previously characterized salt-resistant (n = 13) and salt-sensitive (n = 11) persons were placed on a high salt diet containing 280 mmol NaCl/day for 3 days. After an overnight stay, volume depletion (total, 300 mmol Na) was induced by furosemide infusion. Free water deficits were replaced by 5% isotonic glucose infusion. Blood was obtained for electrolytes, plasma renin activity, and plasma aldosterone concentration. Blood pressure (BP) and heart rate were monitored during the experiment. Intravascular volume depletion resulted in a progressive increase in plasma renin activity that was both steeper and higher in salt-resistant than in the salt-sensitive subjects (P < .001). There was a slight increase in BP in response to volume contraction in both groups. Although heart rate did not change in salt-sensitive persons, it increased significantly (P < .001) in the salt-resistant group. These findings point to an intrinsic difference in the regulation of renin release between salt-sensitive and salt-resistant subjects that may account for the different BP responses to changes in dietary sodium intake.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Schorr U,Schultz C,Sharma AMdoi
10.1016/s0895-7061(01)02226-9subject
Has Abstractpub_date
2002-01-01 00:00:00pages
48-52issue
1 Pt 1eissn
0895-7061issn
1941-7225pii
S0895706101022269journal_volume
15pub_type
临床试验,杂志文章abstract:BACKGROUND:Subclinical cardiac damage has recently emerged as a potential predictor of adverse renal outcome. We therefore retrospectively evaluated the effect of left-ventricular hypertrophy (LVH), diagnosed electrocardiographically, on the renal outcome of hypertensive patients managed in primary care. METHODS:From ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hps100
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abstract::The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(97)00484-6
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.04.023
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa093
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aort...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpt082
更新日期:2013-09-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1016/s0895-7061(03)01032-x
更新日期:2003-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(01)02220-8
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(03)01030-6
更新日期:2003-10-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.333
更新日期:2009-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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更新日期:2000-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ajh/hpu209
更新日期:2015-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(97)00159-3
更新日期:1997-09-01 00:00:00
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(96)00048-9
更新日期:1997-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2010.52
更新日期:2010-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1016/s0895-7061(98)00003-x
更新日期:1998-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00042-9
更新日期:1998-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type:
doi:10.1093/ajh/hpz125
更新日期:2019-11-15 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/4.10.534s
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1016/0895-7061(96)87761-2
更新日期:1996-10-01 00:00:00
abstract::The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/3.1.62
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