当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY期刊下所有文献 > Developmental aspects of psychostimulant treatment in children and adolescents with attention-deficit/hyperactivity disorder.

Developmental aspects of psychostimulant treatment in children and adolescents with attention-deficit/hyperactivity disorder.

Abstract：

OBJECTIVES:To examine the relationship between age and short-term clinical response to psychostimulant treatment in youths with attention-deficit/hyperactivity disorder (ADHD) and to examine whether weight-corrected doses of optimized psychostimulant therapy varied as a function of patient age. METHOD:One hundred seventy-seven patients were treated with either methylphenidate (MPH) or Adderall (ADL). Sixty-six youths received ADL and 111 patients were treated with MPH. All youths were evaluated at baseline and after receiving a week of treatment at each blinded, randomized dose level (placebo, 5, 10, or 15 mg). A "best dose" for each patient was assigned before the medication blind was broken. Behavioral ratings by both teachers and parents were examined for dose and medication effects. RESULTS:The medications had similar efficacy in children and teenagers. Older youths, however, benefited from a smaller weight-adjusted dose of medication than did the younger children. Similar efficacy was observed between the medications. CONCLUSIONS:These data suggest that psychostimulants are equally effective in treating children and adolescents with ADHD. Adolescents with ADHD may not necessarily require more medication than younger children to achieve a similar therapeutic response.

journal_name

J Am Acad Child Adolesc Psychiatry

journal_title

Journal of the American Academy of Child and Adolescent Psychiatry

authors

Findling RL,Short EJ,Manos MJ

doi

10.1097/00004583-200112000-00015

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1441-7

issue

12

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)60844-3

journal_volume

40

pub_type

临床试验,杂志文章,随机对照试验

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