Abstract:
OBJECTIVE:Neuroimaging studies have identified distinct neural correlates of obsessive-compulsive disorder (OCD) symptom dimensions in adult subjects and may be related to functional abnormalities in different cortico-striatal-thalamic neural systems underlying cognition and affective processing. Similar symptom dimensions are apparent in childhood and adolescence, but their functional neural correlates remain to be elucidated. METHOD:Pediatric subjects with OCD (n = 18) and matched controls (n = 18), ages 10 to 17 years, were recruited for two functional magnetic resonance imaging experiments. They were scanned while viewing alternating blocks of symptom provocation (contamination-related or symmetry-related) and neutral pictures and imagining scenarios related to the content of each picture type. RESULTS:The subjects with OCD demonstrated reduced activity in the right insula, putamen, thalamus, dorsolateral prefrontal cortex, and left orbitofrontal cortex (contamination experiment) and in the right thalamus and right insula (symmetry experiment). Higher scores on OCD symptom-related measures (contamination and total severity) were significantly predictive of reduced neural activity in the right dorsolateral prefrontal cortex during the contamination experiment. CONCLUSIONS:Our findings indicate reduced activity in neural regions underlying emotional processing, cognitive processing, and motor performance in pediatric subjects with OCD compared with the controls. These between-group differences are present during both contamination and symmetry provocation experiments and during symptom provocation as well as viewing neutral pictures. The direction of activity is in contrast to adult findings in the insula and in components of cortico-striatal-thalamic neural systems. Our findings suggest developmental effects on neural systems underlying symptom dimensions in pediatric OCD.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Gilbert AR,Akkal D,Almeida JRC,Mataix-Cols D,Kalas C,Devlin B,Birmaher B,Phillips MLdoi
10.1097/CHI.0b013e3181b2163csubject
Has Abstractpub_date
2009-09-01 00:00:00pages
936-944issue
9eissn
0890-8567issn
1527-5418pii
S0890-8567(09)60149-0journal_volume
48pub_type
杂志文章abstract::Variability in the trajectory of clinical symptoms in the early emerging presentation of young children with autism spectrum disorder (ASD) exists within an individual child over time and between different children at any point in time and across time. Georgiades et al.1 recently coined the term "chronogeneity" to ind...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2018.06.021
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:The course of obsessive-compulsive disorder (OCD) in childhood and adolescence was analyzed. METHOD:Twenty-three (88%) of 26 children and adolescents with OCD, all referred to a county child psychiatric clinic as inpatients or outpatients, were longitudinally evaluated every 6 months for obsessive-compulsive...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199511000-00009
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abstract::This study reviewed 158 consecutive admissions to an inpatient adolescent psychiatric service for factors that determine length of hospitalization. Variables associated with length of stay included diagnostic category and the treatment variables of number and type of psychotropic medications prescribed. Patients with ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199111000-00019
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199607000-00016
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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doi:10.1097/00004583-199311000-00008
更新日期:1993-11-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199307000-00003
更新日期:1993-07-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199209000-00004
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abstract::Children's reactions to parental quarrels were investigated in a general population sample of children between 9 and 12 years old. One hundred and thirty-nine families participated in the study. Approximately half the children were living in disharmonious families and half were in harmonious families. Mothers and chil...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-198903000-00006
更新日期:1989-03-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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doi:10.1097/00004583-200011000-00019
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To examine the influence of development and gender on the pharmacokinetics of desipramine (DMI) in the pediatric population. METHOD:DMI pharmacokinetic parameters were calculated from 407 routinely drawn, dose- and weight-normalized serum concentrations in 173 youths receiving DMI (90 children, 83 adolescent...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199901000-00023
更新日期:1999-01-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/chi.0b013e31802d0b3d
更新日期:2007-03-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1097/00004583-200106000-00007
更新日期:2001-06-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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doi:10.1097/00004583-200001000-00019
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00004583-200201000-00013
更新日期:2002-01-01 00:00:00
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doi:10.1016/j.jaac.2019.12.005
更新日期:2020-10-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199003000-00008
更新日期:1990-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200302000-00014
更新日期:2003-02-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1992-11-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2016.09.490
更新日期:2016-12-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2019.01.021
更新日期:2019-11-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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更新日期:2004-05-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1097/00004583-199708000-00018
更新日期:1997-08-01 00:00:00
abstract::Interpersonal psychotherapy (IPT) is a brief treatment developed and tested specifically for depressed adults. This paper describes a modification for use with depressed adolescents (IPT-A) that will be tested in a controlled clinical trial. A description of IPT, its efficacy in adults, a rationale for developing IPT-...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199107000-00018
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:This article describes the results of a pilot study that evaluated the effectiveness of the Early Intervention Foster Care (EIFC) program in the period immediately following a child's placement in a new foster home. METHOD:Data were collected from an EIFC group, a regular foster care group, and a community c...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200011000-00009
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:The cost-effectiveness of three active interventions for major depression in adolescents was compared after 36 weeks of treatment in the Treatment of Adolescents with Depression Study. METHOD:Outpatients aged 12 to 18 years with a primary diagnosis of major depression participated in a randomized controlled ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/CHI.0b013e3181a2b319
更新日期:2009-07-01 00:00:00