Pre-operative oral erythromycin reduces residual gastric volume and acidity.

Abstract:

:We investigated whether low-dose erythromycin (200 mg) given as an oral premedicant altered the residual gastric volume and its acidity in fasted patients at induction of anaesthesia in a single-blinded study. Sixty patients were allocated randomly to receive either an erythromycin tablet (200 mg) or nothing with 10 ml water 3 h before induction of anaesthesia, and another 60 patients 1 h before induction of anaesthesia. Oral erythromycin significantly reduced residual gastric volume when it was given approximately 3 h (P<0.05; 95% CI for median difference: 0.1-17 ml) or 1 h (P<0.0005; 95% CI for median difference: 6-24 ml) before induction of anaesthesia. Erythromycin significantly reduced gastric acidity when it was given 1 h before induction of anaesthesia (P<0.02; 95% CI for median pH difference: 0.1-1.7). In contrast, when given 3 h before induction of anaesthesia, erythromycin did not significantly alter acidity.

journal_name

Br J Anaesth

authors

Asai T,Murao K,Shingu K

doi

10.1093/bja/85.6.861

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

861-4

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)36789-2

journal_volume

85

pub_type

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