Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis.

abstract：:We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. La...

journal_title：Mechanisms of development

authors： Nataf V,Grapin-Botton A,Champeval D,Amemiya A,Yanagisawa M,Le Douarin NM

更新日期：1998-07-01 00:00:00

abstract：:To investigate the origin and nature of the signals responsible for specification of the dermatomal lineage, excised axial organs in 2-day-old chick embryos were replaced by grafts of the dorsal neural tube, or the ventral neural tube plus the notochord, or aggregates of cells engineered to produce Sonic hedgehog (Shh...

journal_title：Mechanisms of development

authors： Olivera-Martinez I,Thélu J,Teillet MA,Dhouailly D

更新日期：2001-02-01 00:00:00

abstract：:Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions ...

journal_title：Mechanisms of development

authors： Post LC,Ternet M,Hogan BL

更新日期：2000-11-01 00:00:00

abstract：:Avian neural crest cells migrate on precise pathways to their target areas where they form a wide variety of cellular derivatives, including neurons, glia, pigment cells and skeletal components. In one portion of their pathway, trunk neural crest cells navigate in the somitic mesoderm in a segmental fashion, invading ...

journal_title：Mechanisms of development

authors： Krull CE

更新日期：2001-07-01 00:00:00

abstract：:The induction of sensory organ placodes, in particular the lens placode, represents the paradigm for induction. We show that medaka Sox3 is expressed in the neuroectoderm and in the placodes of all sensory organs prior to placode formation and subsequently in placode-derived tissues. Ectopic Sox3 expression leads to e...

journal_title：Mechanisms of development

authors： Köster RW,Kühnlein RP,Wittbrodt J

更新日期：2000-07-01 00:00:00

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00

abstract：:The odd-skipped (odd) gene encodes a zinc finger protein that represses other segmentation genes in the early Drosophila embryo. Though odd is initially expressed in a striped pattern that reflects its function within the segmentation hierarchy, it is also expressed in a variety of patterns during later stages of embr...

journal_title：Mechanisms of development

authors： Ward EJ,Coulter DE

更新日期：2000-09-01 00:00:00

abstract：:In C. elegans development, unfavorable growth conditions lead a larva to an arrested and enduring form called a dauer. To elucidate components upstream of DAF-7/TGF-beta in this control pathway, we isolated a mutant that was defective in daf-7 promoter::gfp reporter expression and showed an arrested (dauer-constitutiv...

journal_title：Mechanisms of development

authors： Murakami M,Koga M,Ohshima Y

更新日期：2001-11-01 00:00:00

abstract：:The homeobox gene superfamily is highly conserved during evolution. These genes act as transcription factors during several important developmental processes through their 60 amino acid homeodomains that recognize and bind to the regulatory region of their target genes. We isolated a novel homeobox gene designated Tex...

journal_title：Mechanisms of development

authors： Lai YL,Li H,Chiang HS,Hsieh-Li HM

更新日期：2002-05-01 00:00:00

abstract：:We have sequenced and defined the expression during rat embryogenesis of the protocadherin fat, the murine homologue of a Drosophila tumour suppressor gene. As previously described for human fat, the sequence encodes a large protocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats contai...

journal_title：Mechanisms of development

authors： Ponassi M,Jacques TS,Ciani L,ffrench Constant C

更新日期：1999-02-01 00:00:00

abstract：:In the mammary gland Bcl-x is the most abundant cell survival factor from the Bcl-2 family. Since Bcl-x null mice die around day 12 of embryogenesis, the relevance of this protein in organ development and function is poorly understood. In erythroid cells bcl-x gene expression is controlled by cytokines and the transcr...

journal_title：Mechanisms of development

authors： Walton KD,Wagner KU,Rucker EB 3rd,Shillingford JM,Miyoshi K,Hennighausen L

更新日期：2001-12-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:We performed a systematic screen for mutations affecting the trajectory of axons visualized by immunohistochemical staining of Medaka embryos with anti-acetylated tubulin antibody. Among the mutations identified, yanagi (yan) and kazura (kaz) mutations caused specific defects in projection of the posterior lateral lin...

journal_title：Mechanisms of development

authors： Yasuoka A,Hirose Y,Yoda H,Aihara Y,Suwa H,Niwa K,Sasado T,Morinaga C,Deguchi T,Henrich T,Iwanami N,Kunimatsu S,Abe K,Kondoh H,Furutani-Seiki M

更新日期：2004-07-01 00:00:00

abstract：:The formation of mesoderm is an important developmental process of vertebrate embryos, which can be broken down into several steps; mesoderm induction, patterning, morphogenesis and differentiation. Although mesoderm formation in Xenopus has been intensively studied, much remains to be learned about the molecular even...

journal_title：Mechanisms of development

authors： Chen JA,Voigt J,Gilchrist M,Papalopulu N,Amaya E

更新日期：2005-03-01 00:00:00

abstract：:Using the epidermis-specific cytokeratin 14 promoter to deliver HGF exclusively from epidermal keratinocytes, we have examined the potential of hepatocyte growth factor (HGF) secreted from the normal environment to control morphogenesis. The transgenic mice displayed a significant increase of the number of melanocytes...

journal_title：Mechanisms of development

authors： Kunisada T,Yamazaki H,Hirobe T,Kamei S,Omoteno M,Tagaya H,Hemmi H,Koshimizu U,Nakamura T,Hayashi SI

更新日期：2000-06-01 00:00:00

abstract：:The Drosophila wing is a classical model for studying the generation of developmental patterns. Previous studies have suggested that vein primordia form at boundaries between discrete sectors of gene expression along the antero-posterior (A/P) axis in the larval wing imaginal disc. Observation that the vein marker rho...

journal_title：Mechanisms of development

authors： Crozatier M,Glise B,Khemici V,Vincent A

更新日期：2003-05-01 00:00:00

abstract：:High expression of the B1 Sox genes, Sox2 and Sox3, is associated with the development of definitive neural primordia, the neural plates, in early stage embryos. However, in the caudal lateral epiblast (CLE) where axial stem cells reside, Sox2 and Sox3 are expressed at low levels, together with Brachyury. Because axia...

journal_title：Mechanisms of development

authors： Yoshida M,Uchikawa M,Rizzoti K,Lovell-Badge R,Takemoto T,Kondoh H

更新日期：2014-05-01 00:00:00

abstract：:The gastrointestinal tract is subdivided into regions with different roles in digestion and absorption. How this patterning is established is unknown. We now report that the pancreatic-duodenal homeobox 1 gene (pdx1) is also expressed in cells of the distal stomach. Positive cells include subpopulations of the three m...

journal_title：Mechanisms of development

authors： Larsson LI,Madsen OD,Serup P,Jonsson J,Edlund H

更新日期：1996-12-01 00:00:00

abstract：:Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, we used zebrafish, which lack lung tissue, to investigate the role of CFTR in ca...

journal_title：Mechanisms of development

authors： Liu Y,Lin Z,Liu M,Liao H,Chen Y,Zhang X,Chan HC,Zhou B,Rao L,Sun H

更新日期：2020-09-01 00:00:00

abstract：:Ovotestis development in B6-XY(POS) mice provides a rare opportunity to study the interaction of the testis- and ovary-determining pathways in the same tissue. We studied expression of several markers of mouse fetal testis (SRY, SOX9) or ovary (FOXL2, Rspo1) development in B6-XY(POS) ovotestes by immunofluorescence, u...

journal_title：Mechanisms of development

authors： Wilhelm D,Washburn LL,Truong V,Fellous M,Eicher EM,Koopman P

更新日期：2009-05-01 00:00:00

abstract：:A key role for phosphorylation of Smad2 by TGFβ superfamily ligands in the axial patterning of early embryos is well established. The regulation and role of Smad2 signaling in post-neurula embryonic patterning, however, is less well understood. While a variety of TGFβ superfamily ligands are implicated in various stag...

journal_title：Mechanisms of development

authors： Ho DM,Yeo CY,Whitman M

更新日期：2010-09-01 00:00:00

abstract：:We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is exp...

journal_title：Mechanisms of development

authors： Sumanas S,Ekker SC

更新日期：2001-05-01 00:00:00

abstract：:We analyse the role of the empty spiracles (ems) gene in embryonic brain and ventral nerve cord development. ems is differentially expressed in the neurectoderm of the anterior head versus the trunk region of early embryos. A distal enhancer region drives expression in the deutocerebral brain anlage and a proximal enh...

journal_title：Mechanisms of development

authors： Hartmann B,Hirth F,Walldorf U,Reichert H

更新日期：2000-02-01 00:00:00

abstract：:Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the...

journal_title：Mechanisms of development

authors： Moreno TA,Bronner-Fraser M

更新日期：2002-11-01 00:00:00

abstract：:We present the first time/space analysis using in situ hybridization for PTTG and prc1 genes during development of the mouse telencephalon. During the stages E11.5-E13.5 PTTG and prc1 are expressed in most tissues of the embryo. Within the telencephalon, PTTG and prc1 are found exclusively inside of the ventricular zo...

journal_title：Mechanisms of development

authors： Tarabykin V,Britanova O,Fradkov A,Voss A,Katz LS,Lukyanov S,Gruss P

更新日期：2000-04-01 00:00:00

abstract：:Hsp47 is a heat-shock protein which interacts with newly synthesize procollagen chains in the endoplasmic reticulum (ER) of collagen-secreting cells and is thought to assist in procollagen triple helix assembly and subsequent transport to the cis-Golgi. This is supported by studies which have reported that genes encod...

journal_title：Mechanisms of development

authors： Lele Z,Krone PH

更新日期：1997-01-01 00:00:00

abstract：:We have isolated and characterized two complete cDNA clones, Zfz8a and Zfz8b, which encode zebrafish Frizzled (Fz) homologues. The predicted protein sequences, spanning 579 and 576 amino acid residues for ZFz8a and ZFz8b, respectively, were highly homologous (78%) to each other and contained an extracellular cysteine-...

journal_title：Mechanisms of development

authors： Kim SH,Park HC,Yeo SY,Hong SK,Choi JW,Kim CH,Weinstein BM,Huh TL

更新日期：1998-11-01 00:00:00

abstract：:Unfertilized eggs of Oryzias latipes were artificially inseminated and incubated at 26+/-1 degrees C. Careful observation of the process of embryonic development by light microscopy allowed division of the process into 39 stages based on diagnostic features of the developing embryos. The principal diagnostic features ...

journal_title：Mechanisms of development

authors： Iwamatsu T

更新日期：2004-07-01 00:00:00

abstract：:Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...

journal_title：Mechanisms of development

authors： Ghersi G,Salamone M,Dolo V,Levi G,Vittorelli ML

更新日期：1993-04-01 00:00:00

abstract：:We examined the roles of Notch signaling and fibroblast growth factors (FGFs) in the gliogenesis of mouse mesencephalic neural crest cells. The present study demonstrated that Notch activation or FGF treatment promotes the differentiation of glia expressing glial fibrillary acidic protein. Notch activation or FGF2 exp...

journal_title：Mechanisms of development

authors： Ijuin K,Nakanishi K,Ito K

更新日期：2008-05-01 00:00:00