Hydrocortisone treatment of early SIRS in acute experimental pancreatitis.

Abstract:

:This work studied the effects of hydrocortisone treatment in experimental acute pancreatitis on cytokines, phospholipase A2, and breakdown products of arachidonic acid and survival. Edematous and necrotizing pancreatitis were induced in Wistar rats by cerulein hyperstimulation and retrograde intraductal infusion of sodium taurocholate, respectively. Hydrocortisone (10 mg/kg) was administered intravenously 10 minutes after induction of acute pancreatitis. Serum was assayed for phospholipase A2; interleukin (IL) 1beta, IL-6, IL-10, thromboxane B2; Prostaglandin E2; and leukotriene B4 at five different time points. A significant release of inflammatory mediators was seen only in the severe model. Hydrocortisone powerfully suppressed arachidonic acid breakdown products and only mildly attenuated the systemic increase of phospholipase A2 and pro- and antiinflammatory cytokines. The mortality rate after 72 hr in the severe model was 86%. Hydrocortisone treatment reduced mortality to 13% (P = 0.001; Fisher's exact test). Hydrocortisone seems to be effective in the treatment of the early systemic inflammatory response syndrome associated with severe acute pancreatitis.

journal_name

Dig Dis Sci

authors

Gloor B,Uhl W,Tcholakov O,Roggo A,Muller CA,Worni M,Büchler MW

doi

10.1023/a:1011902729392

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

2154-61

issue

10

eissn

0163-2116

issn

1573-2568

journal_volume

46

pub_type

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