Abstract:
AIM:The aim of this case-control study was to investigate both the distribution of MCP-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes. METHOD:Between September 1997-January 2005, 20 patients with HPS (group 1) were compared with a group of cirrhotic patients (group 2, n = 19) as well as unrelated healthy controls (group 3, n = 59) in respect to MCP1, eNOS, tPA and PAI-1 gene polymorphism frequency distribution. RESULTS:MCP1-2518G allele carriage in patients with HPS was higher than in controls (P = 0.01). In non-HPS cirrhotic patients, eNOS Glu298Asp, Asp gene carriers and frequency of Asp alleles were detected to be considerably higher than in patients with HPS and healthy controls (P < 0.05). CONCLUSION:HPS is more common in patients with MCP-1 2518G gene carriage; conversely it is less frequent in patients with high frequency of eNOS 298Asp allele and eNOS 298Asp carriage.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Tumgor G,Berdeli A,Arikan C,Levent E,Aydogdu Sdoi
10.1007/s10620-007-0002-3subject
Has Abstractpub_date
2008-05-01 00:00:00pages
1345-51issue
5eissn
0163-2116issn
1573-2568journal_volume
53pub_type
杂志文章abstract::Previous studies have shown that duodenal motility patterns differ in preterm and term infants, but antral motor activities were not compared. Using a validated, low-compliance, continuous-perfusion, neonatal manometric system, antral and duodenal motility was studied in 19 preterm and nine term infants. Antral motili...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308336
更新日期:1992-01-01 00:00:00
abstract::Forty-nine Japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-A, non-B hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a sim...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01307512
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:According to the Japanese Esophageal Society (JES) guidelines, risk factors for lymph node (LN) metastasis in the muscularis mucosa (MM)/submucosa to a depth of up to 200 μm (SM1) in cases of esophageal squamous cell carcinomas (ESCCs) include the presence of lymphatic invasion (ly), venous invasion (v), inf...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5029-0
更新日期:2018-06-01 00:00:00
abstract::Extraintestinal symptoms are often found in patients with irritable bowel syndrome (IBS). Recent studies suggest that IBS is associated with bronchial hyperresponsiveness. But it is still arguable that the bronchial hyperresponsiveness is associated with IBS patients. The purpose of this study is to investigate the po...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2916-y
更新日期:2005-09-01 00:00:00
abstract::We have previously reported impressive results in using a gonadotropin-releasing hormone analog, leuprolide acetate (Lupron), in the treatment of moderate to severe symptoms (especially abdominal pain and nausea) in patients with functional bowel disease (FBD). Pain is the hallmark of patients with FBD, and there is n...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1023/a:1018888631286
更新日期:1998-06-01 00:00:00
abstract::Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297143
更新日期:1991-07-01 00:00:00
abstract::This manuscript is a secondary analysis of a large multicenter randomized controlled trial. The primary study is Cross RK et al., A Randomized Controlled Trial of TELEmedicine for patients with Inflammatory Bowel Disease (TELE-IBD). Am J Gastroenterol, 2019 Mar. ...
journal_title:Digestive diseases and sciences
pub_type: 已发布勘误
doi:10.1007/s10620-019-05953-4
更新日期:2020-02-01 00:00:00
abstract::Work-up of a 62-year-old black male, with a complaint of low back pain for three months, revealed a mass in the porta hepatis, narrowing of the common hepatic duct, and dilated intrahepatic bile ducts. A 3 X 4-cm tumor in the common hepatic duct was excised and biliary continuity restored by hepaticojejunostomy. The e...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296145
更新日期:1987-07-01 00:00:00
abstract::Using conventional statistical analysis and multiple regression analysis, we investigated the viral and host factors that influence the response to recombinant interferon-alpha 2a therapy in patients with chronic hepatitis C. A total of 36 patients was randomly assigned to three administration schedules, 12 patients i...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02093793
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2510-z
更新日期:2013-05-01 00:00:00
abstract::The double pylorus is a fistulous communication between the gastric antrum and duodenal bulb. In most instances, it is believed to be a complication of peptic ulcer disease. In prior reports, the longest follow-up has been only 5 years. We report four cases of double pylorus, three of which have been followed medicall...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296254
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVES:To evaluate rate, recurrence, and predictors of gastrointestinal bleeding (GIB) and impact of endoscopy in left ventricular assist device (LVAD) patients. METHODS:This is a cohort study of all patients who received the current-generation continuous-flow HeartMate II LVAD from 2005 to 2013 at our institution...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3743-4
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Enhanced cell expression of MAdCAM-1 is critical in tissue recruitment of lymphocytes in response to stimuli expressing the α4β7 integrin. MAdCAM-1 is well characterized in gut mucosa with emerging evidence of hepatic expression. AIMS:(i) Compare quantitative/semi-quantitatively MAdCAM-1 expression in relat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2755-1
更新日期:2013-09-01 00:00:00
abstract::Hyperglycemia slows gastric emptying and increases the intensity of perception of gastric distension during fasting and small intestinal nutrient stimulation. In order to examine the possibility that abnormalities of gastric electrical rhythm may be associated with the effects of hyperglycemia, the gastric electrical ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/a:1018851227051
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Previous studies have shown vitamin D status to be associated with disease activity in patients with inflammatory bowel disease (IBD), but its influence on the clinical course of IBD has not been established. AIMS:We aimed to analyze whether the serum 25-hydroxyvitamin D3 [25(OH)D] status is associated with...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06207-4
更新日期:2020-03-26 00:00:00
abstract:BACKGROUND AND AIM:Population-based endoscopic studies of esophageal eosinophilia and eosinophilic esophagitis are limited in the world. This study was aiming to describe features of esophageal eosinophilia and eosinophilic esophagitis in a representative sample of the adult in Shanghai, China. METHODS:As part of a la...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3512-9
更新日期:2015-06-01 00:00:00
abstract::The original version of the article unfortunately contained tagging error in first and family name of authors Ariella Bar-Gil Shitrit and Ami Ben Ya'acov. This has been corrected with this erratum. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10620-018-5084-6
更新日期:2018-09-01 00:00:00
abstract::We conducted this study to evaluate the impact of the expression of peroxisome proliferator-activated receptor delta on angiogenesis in tissue samples of colorectal cancer. We examined 52 samples of primary human colorectal carcinomas and matched normal adjacent tissues to evaluate the expression of peroxisome prolife...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0465-x
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Gastric emptying scintigraphy (GES) of solids is typically used to evaluate for gastroparesis. AIMS:The purpose of this study was to determine the value of simultaneously measuring gastric emptying of liquids and solids for assessing patients for delayed gastric emptying. METHODS:A total of 596 patients at...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1635-9
更新日期:2011-04-01 00:00:00
abstract::We prospectively assessed the relationship between nodular gastritis and Helicobacter pylori infection. Of 1409 adults who underwent endoscopy for persistent dyspepsia between June 2004 and August 2005, 41 (2.9%) patients were diagnosed with nodular gastritis (11 [27%] men and 30 [73%] women). The mean age was 45.9 ye...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9281-3
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:There is a large Barrett's esophagus patient population undergoing endoscopic surveillance. Methods to stratify patients into higher and lower risk groups may enable more varied surveillance intervals for patients with non-dysplastic Barrett's esophagus that could optimize use of endoscopy resources. OBJECT...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06483-0
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3886-3
更新日期:2016-02-01 00:00:00
abstract::Macro-creatine-kinases are isoenzymes of creatinine-kinases (CK). They have been classified in two types: type 1 (CK bound to an immunoglobulin) and type 2 (an oligomeric mitochondrial CK). CK type 1 has been found in patients with ulcerative colitis (UC) but not in Crohn's disease (CD). However, there are no studies ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9888-z
更新日期:2008-02-01 00:00:00
abstract::The early rebound in serum HCV RNA during HCV dynamic studies with high-dose interferon may be due to de novo infection with interferon escape quasispecies. We simultaneously measured serum alanine aminotransferase (ALT) and HCV RNA at rapid intervals in chronic HCV liver disease patients during interferon therapy alo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1021798701772
更新日期:2003-01-01 00:00:00
abstract::Azithromycin (Zithromax), an erythromycin derivative that belongs to a subgroup of the macrolides known as azolides, has generally been considered to be a very safe medication. Hepatic side effects are uncommon but may include jaundice, fever, and right upper quadrant pain. Herein we describe a patient who developed a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1020170807742
更新日期:2002-10-01 00:00:00
abstract::Epidemiological studies have demonstrated a variety of potential environmental factors that may alter susceptibility to chronic pancreatitis (CP) through oxidative/xenobiotic stress; however, a direct causal and mechanistic role has not been established. We aimed (1) to determine the prevalence of functional genetic p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2790-7
更新日期:2005-07-01 00:00:00
abstract::Although systemic steroids remain as the gold standard for the treatment of acute moderate to severe active ulcerative colitis (UC), 15-57% of patients do not achieve clinical remission. We sought to identify clinical, biological, or radiologic predictive factors of response to steroid treatment in acute UC attacks. T...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9103-7
更新日期:2006-08-01 00:00:00
abstract::A comparative study of three different high-dose regimens of interferon-alpha-2b (IFN) was conducted in patients with chronic hepatitis C to determine which was better at obtaining a sustained remission. A total of 126 patients were assigned randomly to one of three groups: group A was given 10 million international u...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF01316789
更新日期:1993-04-01 00:00:00
abstract::In a retrospective study, 50 patients with obvious necrotizing pancreatitis (NP) were allocated in four groups according to the morphological aspects of the necrosis. Appearance of ascite (N1), extrapancreatic spread of necrosis towards neighboring organs (N2), a large amount of necrosis (N3), and infected necrosis (N...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018890221620
更新日期:1997-08-01 00:00:00
abstract::To evaluate the influence of chronic alcoholism on clinical features of chronic pancreatitis in Japan, pain evolution, pancreatic insufficiency, and long-term prognosis were studied by comparing chronic alcoholic pancreatitis (N = 88) with idiopathic pancreatitis (N = 67). The 155 patients with known course of the dis...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536151
更新日期:1989-01-01 00:00:00