Increased tissue concentrations of arachidonic acid in umbilical artery and placenta in fetal growth retardation.

Abstract:

OBJECTIVE:To compare the fatty acid phospholipid composition of the umbilical artery and the placenta in cases of fetal growth retardation (FGR) and of normal growth, as well as in symmetric and asymmetric FGR. DESIGN:Case-control study. SETTING:University hospital. POPULATION:Thirty-nine FGR cases (12 asymmetric, 27 symmetric) and 78 cases with normal growth. MAIN OUTCOME MEASURES:Thin layer gas-liquid capillary chromatography of phospholipid fatty acids in umbilical artery and placental cotyledons. Newborns were classified as FGR if their weight was under the 10th percentile for our center. FGR was defined as symmetric if the ponderal index was >2.32, and as asymmetric if it was <2.32. RESULTS:In FGR, arachidonic acid was significantly increased both in placenta (24.05%+/-2.78 vs 22.46%+/-2.93) and in umbilical artery (16.76%+/-2.40 vs 15.58%+/-3.67). Indeed this increase was significantly higher in asymmetric than in symmetric FGR (25.70+/-2.32 vs 23.32+/-2.68 in placenta and 18.06+/-1.46 vs 16.14 +/-2.53 in umbilical artery). On the other hand, in the placenta there were a number of differences in the metabolic ratios analyzed when comparing symmetric and asymmetric FGR, indicating a lower DHA availability and a higher n-6 fatty acid elongation and desaturation in asymmetric FGR. CONCLUSION:FGR is characterized by an increase in arachidonic acid both in the placenta and umbilical artery phospolipids, probably reflecting a different mobilization from tissue stores. It is speculated that the different arterial composition could be partially responsible for the increased cardiovascular risk of FGR in adulthood. On the other hand the metabolic status of the placenta concerning polyunsaturated fatty acids was very different in symmetric and asymmetric FGR, suggesting a different pathogenesis.

authors

Matorras R,López De Larrucea A,Sanjurjo P,Ignacio Ruiz J,Echevarría Y,Nieto A,Perteagudo L,Aldamiz-Echevarria JL

doi

10.1034/j.1600-0412.2001.080009807.x

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

807-12

issue

9

eissn

0001-6349

issn

1600-0412

pii

aog800905

journal_volume

80

pub_type

杂志文章
  • Incidence and risk factors of venous thromboembolism during postpartum period: a population-based cohort-study.

    abstract:INTRODUCTION:The awareness of the incidence and timing of postpartum venous thromboembolic events guides the use of thromboprophylaxis. Our aims were to assess the incidence and mortality of venous thromboembolic events and identify its associated risk factors during different postpartum periods. MATERIAL AND METHODS:...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13137

    authors: Galambosi PJ,Gissler M,Kaaja RJ,Ulander VM

    更新日期:2017-07-01 00:00:00

  • Epigenetics and assisted reproductive technologies.

    abstract::Epigenetic modification controls gene activity without changes in the DNA sequence. The genome undergoes several phases of epigenetic programming during gametogenesis and early embryo development, coinciding with assisted reproductive technologies (ART) treatments. Imprinting disorders have been associated with ART te...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aogs.12799

    authors: Pinborg A,Loft A,Romundstad LB,Wennerholm UB,Söderström-Anttila V,Bergh C,Aittomäki K

    更新日期:2016-01-01 00:00:00

  • Does the intake of nuts and seeds alter the appearance of menarche?

    abstract:BACKGROUND:The nutritional state reportedly influences the age of menarche. In this work we investigated the potential relationship between the intake of various types of foods and the age of menarche, irrespective of body weight. METHODS:An overall 777 schoolgirls of ages between 8 and 16 years from Benalmádena (Mála...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349509024409

    authors: Soriguer FJ,González-Romero S,Esteva I,García-Arnés JA,Tinahones F,Ruiz de Adana MS,Olveira G,Mancha I,Vazques F

    更新日期:1995-07-01 00:00:00

  • Serum anti-Müllerian hormone in subfertile women.

    abstract:INTRODUCTION:The correlation between ovarian reserve and infertility remains unclear. Albeit poorly predictive of pregnancy success in in vitro fertilization cycles, serum anti-Müllerian hormone (AMH) has been acknowledged as a surrogate measure of ovarian reserve and is commonly evaluated in women seeking pregnancy. D...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12761

    authors: Somigliana E,Lattuada D,Colciaghi B,Filippi F,La Vecchia I,Tirelli A,Baffero GM,Paffoni A,Persico N,Bolis G,Fedele L

    更新日期:2015-12-01 00:00:00

  • Maternal risk factors for postterm pregnancy and cesarean delivery following labor induction.

    abstract:OBJECTIVE:To investigate risk factors associated with postterm pregnancy and cesarean delivery following labor induction. DESIGN:Population-based cohort study. SETTING:Sweden. POPULATION:From the Swedish Medical Birth Register, a total of 1,176,131 singletons births from gestational week 37 and onwards, between 1992...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349.2010.500009

    authors: Roos N,Sahlin L,Ekman-Ordeberg G,Kieler H,Stephansson O

    更新日期:2010-08-01 00:00:00

  • Relapsing thymic carcinoma during pregnancy.

    abstract::A 23 year old woman, who was known to be in remission from thymic carcinoma, presented in her first trimester. She had previously been treated with radiation and chemotherapy. Her pregnancy was complicated by fever and contractions at 30 weeks and ended with the birth of a live preterm male infant. Subsequent investig...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349209021082

    authors: Peleg D,Zabari A,Shalev E

    更新日期:1992-07-01 00:00:00

  • Gonadal steroids, gonadotropins and endometrial histology in postmenopausal women with malignant ovarian tumors.

    abstract::The concentrations of FSH, LH, 17-beta-estradiol (E2), estrone (E1) and progesterone (P) were measured in peripheral and ovarian vein sera obtained at preoperative pelvic angiography from 5 postmenopausal women with malignant ovarian tumors. In 5 others the concentrations of E2, P and testosterone (T) were also measur...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348609155172

    authors: Jeppsson S,Karlsson S,Kullander S

    更新日期:1986-01-01 00:00:00

  • Histopathological prognostic factors of adult granulosa cell tumors of the ovary.

    abstract:BACKGROUND:The prognostic factors of adult granulosa cell tumor (AGCT) have not been well defined. METHODS:In 27 AGCT patients, we examined clinical stage, microscopic patterns, mitotic index (MI), and lymph-vascular space invasion (LVSI) to determine whether these factors were related to disease-free survival (DFS) o...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.2001.801120.x

    authors: Fujimoto T,Sakuragi N,Okuyama K,Fujino T,Yamashita K,Yamashiro S,Shimizu M,Fujimoto S

    更新日期:2001-11-01 00:00:00

  • Treatment of premenstrual syndrome with gonadotropin-releasing hormone agonist in a low dose regimen.

    abstract:BACKGROUND:GnRH agonists constitute a well-documented treatment for premenstrual syndrome (PMS). However, the hypo-estrogenic state induced by the treatment renders it less suitable for long-term clinical use. The aim of the current study was to investigate the efficacy of a low dose GnRH agonist with respect to its ab...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sundström I,Nyberg S,Bixo M,Hammarbäck S,Bäckström T

    更新日期:1999-11-01 00:00:00

  • Treatment of vaginal recurrence in endometrial cancer. A review.

    abstract:BACKGROUND:We have reviewed the literature concerning vaginal recurrence in endometrial cancer with emphasis on prognostics and therapeutic results. Compared to the overall outcome of recurrences (11-17 per cent survive more than 3-19 years) the survival rate of strictly vaginal recurrence appears significantly higher ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.3109/00016349609033275

    authors: Møller LA,Engelholm SA

    更新日期:1996-01-01 00:00:00

  • Induction of labor. A double-blind randomized controlled study of prostaglandin E2 vaginal suppositories compared with intranasal oxytocin and with sequential treatment.

    abstract::In a double-blind randomized controlled study of 300 women, 150 primiparas and 150 multiparas, induction of labor by means of vaginal suppositories containing 3 mg prostaglandin E2 (PGE2) was compared with the conventional method of intranasal oxytocin and with a combined method of 3 mg PGE2 vaginal suppositories alte...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00016348509154710

    authors: Andreasson B,Bock JE,Larsen J

    更新日期:1985-01-01 00:00:00

  • Effect of urinary trypsin inhibitor on potassium currents: fetus modulates membrane excitability by production of UTI.

    abstract:BACKGROUND:Amniotic fluid contains a significant level of urinary trypsin inhibitor (UTI). Previously, we reported that UTI inhibits calcium influx of myometrium and it is effective in preventing uterine contraction. This study examined the effects of UTI upon potassium channels, which is important for membrane excitab...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2004.00268.x

    authors: Takeuchi K,Fukuda A,Kanayama N

    更新日期:2004-01-01 00:00:00

  • Intrapartum predictors of maternal levator ani injury.

    abstract:INTRODUCTION:Damage to the pelvic floor during vaginal childbirth is common, and may take the form of levator avulsion or irreversible overdistension of the levator hiatus (microtrauma). Such trauma is a major risk factor for pelvic organ prolapse later in life. In this study we aimed to identify intrapartum risk facto...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aogs.13103

    authors: Caudwell-Hall J,Kamisan Atan I,Martin A,Guzman Rojas R,Langer S,Shek K,Dietz HP

    更新日期:2017-04-01 00:00:00

  • The comparison of vessels in elective and spontaneous abortion decidua in first trimester pregnancies: importance of vascular changes in early pregnancy losses.

    abstract:BACKGROUND:To determine whether adequate trophoblastic migration and maternal placental perfusion occurs in cases of early pregnancy loss, we compared vessels in elective abortion decidua with those in spontaneous abortion decidua. METHODS:Elective abortion decidua at 5-11 weeks (n = 40) were compared with spontaneous...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340500501731

    authors: Gun BD,Numanoglu G,Ozdamar SO

    更新日期:2006-01-01 00:00:00

  • Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol.

    abstract::To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Gestrinone bound to endometrial receptors for estrogen, pro...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348609157380

    authors: Tamaya T,Fujimoto J,Watanabe Y,Arahori K,Okada H

    更新日期:1986-01-01 00:00:00

  • Inter- and intra-observer agreement of non-reassuring cardiotocography analysis and subsequent clinical management.

    abstract:OBJECTIVE:To quantify inter- and intra-observer agreement of non-reassuring intrapartum cardiotocography (CTG) patterns and subsequent clinical management. DESIGN:Methodological study. SETTING:University Medical Center. POPULATION:CTG patterns of 79 women beyond 37 weeks of gestation with a singleton fetus in vertex...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12371

    authors: Rhöse S,Heinis AM,Vandenbussche F,van Drongelen J,van Dillen J

    更新日期:2014-06-01 00:00:00

  • Placenta previa: its relationship with race and the country of origin among Asian women.

    abstract:OBJECTIVES:To examine the association between placenta previa with maternal race and its variations by country of origin among Asian women. STUDY DESIGN:Retrospective cohort study. METHODS:We analyzed data from a population-based retrospective cohort study of 16,751,627 pregnancies in the US. The data were derived fr...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340802071037

    authors: Yang Q,Wu Wen S,Caughey S,Krewski D,Sun L,Walker MC

    更新日期:2008-01-01 00:00:00

  • External cephalic version: a safe procedure? A systematic review of version-related risks.

    abstract:BACKGROUND:The Term Breech Trial has considerably increased the number of cesareans. External cephalic version (ECV) might be an effective method of lowering the rate of cesareans; its efficacy has been well established. However, although in the absence of anesthesia the risks are thought to be low, most studies have u...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.0001-6349.2004.00347.x

    authors: Collaris RJ,Oei SG

    更新日期:2004-06-01 00:00:00

  • Live birth after robotic-assisted live donor uterus transplantation.

    abstract:INTRODUCTION:The proof-of-concept of uterus transplantation, as a treatment for absolute uterine factor infertility, came with the first live birth after uterus transplantation, which took place in Sweden in 2014. This was after a live donor procedure, with laparotomy in both donor and recipient. In our second, ongoing...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13853

    authors: Brännström M,Dahm-Kähler P,Kvarnström N,Akouri R,Rova K,Olausson M,Groth K,Ekberg J,Enskog A,Sheikhi M,Mölne J,Bokström H

    更新日期:2020-09-01 00:00:00

  • Differential expression of T-helper cytokines in the peritoneal fluid of women with normal ovarian cycle compared with women with chronic anovulation.

    abstract:BACKGROUND:Estrogen and progesterone immunoregulate the genital environment by expression of cytokines and growth factors. OBJECTIVE:To investigate the pattern of expression of T-helper cytokines during the ovarian cycle compared with women with chronic anovulation resistant to clomiphene citrate. HYPOTHESIS:Expressi...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.2003.00045.x

    authors: Omu AE,Al-Azemi MK,Makhseed M,Al-Oattan F,Ismail AA,Al-Tahir S,Al-Busiri N

    更新日期:2003-07-01 00:00:00

  • Expectant management of ectopic pregnancy in the presence of ovarian hyperstimulation syndrome.

    abstract::Cases of coexisting ovarian hyperstimulation and ectopic pregnancy are rare, and pose a difficult diagnostic problem. The routine attempts at laparoscopic diagnosis and treatment of these pregnancies may prove to be hazardous. Such cases may be better managed nonsurgically either by methotrexate or, in selected cases,...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349509009951

    authors: Yaron Y,Lessing JB,Peyser MR

    更新日期:1995-01-01 00:00:00

  • Iron prophylaxis in menorrhagia.

    abstract::Heavy menstrual bleedings frequently lead to iron deficiency. Iron supplementation is usually given to cover the increased losses. In the present study one tablet containing 100 mg of iron (Duroferon R, Durules R) was given daily for 10 days in connection with the menstrual period in 15 women with menorrhagia. The tab...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Arvidsson B,Ekenved G,Rybo G,Sölvell L

    更新日期:1981-01-01 00:00:00

  • Women receiving massive transfusion due to postpartum hemorrhage: A comparison over time between two nationwide cohort studies.

    abstract:INTRODUCTION:Incidence of massive transfusion after birth was high in the Netherlands between 2004 and 2006 compared with other high-income countries. This study investigated incidence, causes, management and outcome of women receiving massive transfusion due to postpartum hemorrhage in the Netherlands in more recent y...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13542

    authors: Ramler PI,van den Akker T,Henriquez DDCA,Zwart JJ,van Roosmalen J,van Lith JMM,van der Bom JG,TeMpOH-1 study group.

    更新日期:2019-06-01 00:00:00

  • Exposure to secondhand smoke and associated factors among non-smoking pregnant women with smoking husbands in Sichuan province, China.

    abstract:BACKGROUND:Secondhand smoke (SHS) exposure harms pregnant women and the fetus. China has the world's largest number of smokers and a high male smoking prevalence rate. OBJECTIVE:To compare exposure to SHS among rural and urban Chinese non-smoking pregnant women with smoking husbands, and analyze factors associated wit...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016341003713851

    authors: Yang L,Tong EK,Mao Z,Hu TW

    更新日期:2010-01-01 00:00:00

  • Antenatal diagnosis of placenta accreta leads to reduced blood loss.

    abstract:OBJECTIVE:Placenta accreta is one of the most devastating pregnancy complications. We sought to compare outcomes between women with placenta accreta when diagnosed antenatally or intrapartum, and to define predictors of the antenatal diagnosis. DESIGN:Retrospective case-control study. SETTING:University teaching hosp...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2011.01147.x

    authors: Tikkanen M,Paavonen J,Loukovaara M,Stefanovic V

    更新日期:2011-10-01 00:00:00

  • Hormonal counterregulation and subjective symptoms during induced hypoglycemia in insulin-dependent diabetes mellitus patients during and after pregnancy.

    abstract:BACKGROUND:The objective was to elicit whether hormonal responses to and subjective symptoms of hypoglycemia are modified during pregnancy in patients with insulin-dependent diabetes mellitus. METHODS:In ten type I diabetic women, hyperinsulinemic hypoglycemic clamps, with target arterial blood glucose content of 2.2 ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.1998.770609.x

    authors: Björklund A,Adamson U,Andréasson K,Carlström K,Hennen G,Igout A,Lins PE,Westgren M

    更新日期:1998-07-01 00:00:00

  • Meconium stained amniotic fluid is associated with maternal infectious morbidity in pre term delivery.

    abstract::The purpose of the study was to determine if intra partum meconium stained amniotic fluid (MSAF) is associated with infectious morbidity in women with pre term delivery. The study group was composed of 89 women with pre term delivery and MSAF. The control group comprised 89 women with pre term delivery and clear amnio...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349309058159

    authors: Markovitch O,Mazor M,Shoham-Vardi I,Chaim W,Leiberman JR,Glezerman M

    更新日期:1993-10-01 00:00:00

  • Induction of labor and cerebral palsy: a population-based study in Norway.

    abstract:OBJECTIVE:To investigate the association between labor induction and later development of cerebral palsy (CP). DESIGN:Registry-based cohort study. SETTING:Perinatal data on all children born in Norway 1996-1998 were obtained from the Medical Birth Registry of Norway (MBRN). Neurodevelopmental data were collected from...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2010.01022.x

    authors: Elkamil AI,Andersen GL,Salvesen KÅ,Skranes J,Irgens LM,Vik T

    更新日期:2011-01-01 00:00:00

  • Maternal and fetal outcome after severe anemia in pregnancy in rural Ghana.

    abstract:BACKGROUND:Anemia in pregnancy contributes to poor outcome for mother and child in low-income countries. This study analyzes adverse maternal and fetal outcome after severe anemia in pregnancy in rural Ghana. METHODS:A cohort study in two (sub)district hospitals, including 157 pregnant women exposed to severe anemia (...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340500334794

    authors: Geelhoed D,Agadzi F,Visser L,Ablordeppey E,Asare K,O'Rourke P,Van Leeuwen JS,Van Roosmalen J

    更新日期:2006-01-01 00:00:00

  • Treatment with hachimijiogan, a non-ergot Chinese herbal medicine, in two hyperprolactinemic infertile women.

    abstract::Two hyperprolactinemic infertile women, one with and one without a pituitary adenoma, who were resistant to bromocriptine treatment, were treated orally with Hachimijiogan, a Chinese herbal medicine. This treatment reduced the serum prolactin level, resulting in a normal ovulatory cycle and pregnancy, without side eff...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348909021028

    authors: Usuki S,Kubota S,Usuki Y

    更新日期:1989-01-01 00:00:00