Abstract:
BACKGROUND:GnRH agonists constitute a well-documented treatment for premenstrual syndrome (PMS). However, the hypo-estrogenic state induced by the treatment renders it less suitable for long-term clinical use. The aim of the current study was to investigate the efficacy of a low dose GnRH agonist with respect to its ability to relieve premenstrual symptoms and maintain regular ovulatory cycles. METHODS:The effect of a low dose GnRH agonist (buserelin) on luteal phase symptomatology was evaluated in 27 women with severe premenstrual syndrome. The design was doubleblind, placebo-controlled and cross-over. Patients were randomized to either GnRH-agonist intranasally in a dosage of 100 microg once daily for two months or placebo for two months before the cross-over was made. The primary outcome measure consisted of daily symptom ratings for mood and physical symptoms made by the patients throughout the study. Adverse events and hormone concentrations were assessed at visits every second week. RESULTS:Premenstrual irritability and depression were significantly relieved by low dose GnRH agonist. Positive symptoms such as friendliness and cheerfulness were also improved during the premenstrual week. Likewise physical symptoms of swelling and headache displayed a significant improvement during buserelin treatment, whereas breast tenderness scores were unaffected by the treatment. The low dose GnRH agonist treatment regimen induced anovulation in as much as 56% of patients, but these subjects were significantly older than those women who maintained ovulatory cycles throughout the study. CONCLUSION:GnRH treatment significantly reduced premenstrual depression and irritability. However, low dose GnRH therapy is prone to induce anovulation, particularly with increasing age.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Sundström I,Nyberg S,Bixo M,Hammarbäck S,Bäckström Tsubject
Has Abstractpub_date
1999-11-01 00:00:00pages
891-9issue
10eissn
0001-6349issn
1600-0412journal_volume
78pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The objectives of this paper were to assess the prevalence of different viral infections in relation to late abortions, stillbirths, and congenital malformations in sera from Russian pregnant women and recurrent aborters in order to establish basic knowledge for future pregnancy care. METHODS:Patients were ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2001.801110.x
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVES:Low birthweight of the offspring has been associated with increased risk of early death and ischemic heart disease in the mother. However, other measurements of fetal growth than the basic birthweight are more accurate. We investigated the relation between the standardized birthweight by gestational age and ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01355.x
更新日期:2012-04-01 00:00:00
abstract::Peripheral plasma levels of medroxyprogesterone acetate (MPA) were determined by radioimmunoassay in 5 women after oral administration of 5 and 10 mg medroxyprogesterone acetate daily. Peak levels of MPA in plasma were recorded within 1 - 3 hours of taking the tablet, which indicates a rapid absorption from the gastro...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409154654
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:To evaluate if calcium supplementation during pregnancy could have any influence on primary dentition measured as the reduction of dental caries of the child. DESIGN:Individual randomized controlled trial. SETTING:One hospital in Rosario, Argentina. POPULATION:Random sample of 195 12-year-old children fro...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.3109/00016349.2010.518228
更新日期:2010-11-01 00:00:00
abstract::Information bias occurs when any information used in a study is either measured or recorded inaccurately. This paper describes some of the most common types of information bias, using examples from obstetrics and gynecology, and describes how information bias may affect results of observational studies. Non-differenti...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/aogs.13330
更新日期:2018-04-01 00:00:00
abstract::A model of prospective counselling and intervention after prenatal diagnosis of fetal malformation is presented. 13 patients/couples with severe malformations were fully counselled, 3 patients/couples interviewed post-termination. Objectives of the counselling strategy were to support patient autonomy, facilitate mour...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348909028667
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:Early mother-infant relationships in preterm populations were evaluated in the context of a systematic review of the literature. DESIGN AND SETTING:A systematic search of three electronic databases (PsychINFO, PubMed and Cochrane Library) was undertaken. Three studies of maternal attachment, 18 studies of mo...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0412.2011.01304.x
更新日期:2012-02-01 00:00:00
abstract::Using the registration of all pregnant women living within a particular geographical district of Copenhagen the risk of spontaneous abortion has been calculated by means of a decremental method. A total of 3,042 pregnancies were registered and the total risk of spontaneous abortion was calculated at 10 per cent. In 43...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348009154629
更新日期:1980-01-01 00:00:00
abstract::The experience using pre-treatment with GnRH-agonists in an IVF-program are reported. 55 patients having a 'poor response', premature LH surge, or follicular luteinization in previous treatment cycles were treated for a total of 68 cycles. Therapy with GnRH agonists was initiated in the midluteal phase, and given by s...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109007884
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Clinical studies show that analysis of the fetal electrocardiographic (FECG) ST waveform at term gives important information on the myocardial response to intrapartum asphyxia. However, it is not known whether the preterm fetus responds in a similar fashion. The objective of the present study was to evaluate...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00594.x
更新日期:2005-02-01 00:00:00
abstract::Persistently elevated levels of serum human chorionic gonadotropin (hCG) in women call for a tumor investigation, if pregnancy can be ruled out. We present a case of increased hCG concentrations for 1 1/2 years. Radiolabelled antibody directed against the hCG molecule indicated the source of production to be a chorioc...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348909020999
更新日期:1989-01-01 00:00:00
abstract::The incidence of birth has been determined for each hour of the day for all births in Norway in 1968-1977 of fetuses of 16 weeks of gestation or older, with resident mothers. The 24-hour incidence variations of births (A) with spontaneous onset and parturition, (B) with spontaneous onset, but delivery intervention, (C...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309155754
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:A randomized multicenter study was conducted in the Stockholm-Örebro areas in Sweden to evaluate how treatment aiming at normoglycemia affects fetal growth, pregnancy and neonatal outcome in pregnant women with severe hyperglycemia. MATERIAL AND METHODS:Pregnant women with hyperglycemia defined as fasting...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/aogs.12717
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:Accurate estimates and reliable classification of maternal deaths are imperative steps in the chain of actions targeted at reducing avoidable maternal mortality. The aims of this study were to estimate the maternal mortality ratio (MMR) in 10 Italian regions covering 77% of total national births and to ide...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13415
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To revise, validate and test for reliability an anal sphincter rupture questionnaire in relation to construct, content and face validity. SETTING AND BACKGROUND: Since 1996 women with anal sphincter rupture (ASR) at one of the public university hospitals in Copenhagen, Denmark have been offered pelvic floor m...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802443814
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Approximately 85% of vaginal deliveries are accompanied by perineal trauma. The objective of this trial was to compare the incidence of perineal trauma after primary delivery of either the anterior or posterior shoulder during vaginal delivery. MATERIAL AND METHODS:This was a randomized single-blinded tri...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.12914
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The effect of physical training on bone mineral density (BMD) in women with endometriosis treated with gonadotropin-releasing hormone (GnRH) analogs was studied. METHODS:Nineteen Caucasian premenopausal women aged 23-38 years were included in the study. The subjects were all treated with 21.6 mg goserelin d...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.0001-6349.2005.00558.x
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:The accuracy of ultrasound in the diagnosis of congenital malformations has been the subject of many studies. Most of these are hospital-based studies over a limited period of years presenting high detection rates and also relatively high incidence of major malformations. We present here a large population-b...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600676474
更新日期:2006-01-01 00:00:00
abstract::With advancing age, the postural balance function deteriorates as a consequence of decreased functional capacity. Deteriorating balance is a risk factor for bone fractures due to increased risks of falls. It has been suggested that the loss of estrogen, which occurs in relation to the menopause, may be associated with...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701207575
更新日期:2007-01-01 00:00:00
abstract::In recent years, accurate preoperative diagnosis has been increasingly emphasized as an important therapeutic aspect of urinary incontinence in women. Forty patients suffering from recurrent stress incontinence underwent a dura-sling operation, i.e. loop surgery. The mean period od incontinence complaints prior to sec...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349009021039
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE: To determine the influence of type 1 diabetes mellitus (T1DM) on the first trimester serum markers of fetal aneuploidy; pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free β-hCG) and to evaluate the influence of glycemic control on these parameters in th...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01212.x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Preterm infants are at 8 times higher risk than term infants for pre- and perinatal brain damage, resulting in cerebral palsy. In this paper we have analysed the influence of prenatal and birth-related risk factors on cerebral palsy in preterm infants. METHODS:In a register-based study, 175 preterm singleto...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.3109/00016349709024363
更新日期:1997-10-01 00:00:00
abstract::Congenital granular cell myoblastoma of the newborn is a rare tumor. The combination of polyhydramnios caused by obstruction of the infant's mouth by this tumor is extremely rare, and this is the first published report of such a condition. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609157400
更新日期:1986-01-01 00:00:00
abstract::In 706 midtrimester amniocenteses, 180 (25.5%) samples yielded blood-stained amniotic fluid (macroscopically and microscopically), 152 (21.5%) contained maternal blood, 28 (3.9%) fetal blood and 8 samples contained both maternal and fetal blood. In the 180 cases of bloody midtrimester amniocentesis, the abortion rate ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348209156950
更新日期:1982-01-01 00:00:00
abstract::The purpose of the present study was to establish the occurrence of infertility in Finnish women aged 30, 35 and 40 years. The study is based on an interview by questionnaire carried out on women participating in screening for cancer by Pap smear. The participation rate is generally about 60%. A total of 4,879 women w...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609157030
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Previous studies have shown conflicting results as to whether unsuccessful medically assisted reproduction is a risk factor for depression among women. This study therefore investigated if women with no live birth after assisted reproductive technology (ART) treatment had a higher risk of unipolar depressi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12705
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Adverse obstetric outcome in fetuses that are smaller than expected at second trimester routine ultrasound examination. AIM:To assess the obstetric outcome when the interval between the estimated date of delivery by last menstrual period and the estimated date of delivery by second trimester ultrasound exce...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2002.810908.x
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Uterine artery embolization (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been growing concern over the risk of unintended embolization of the utero-ovarian circulation, leading to reduction of ovarian blood supply wit...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析
doi:10.1111/aogs.13698
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Women with endometriosis have reduced health-related quality of life (HRQoL). However, comparisons to the general population and other patient groups are lacking. MATERIAL AND METHODS:The present cross-sectional questionnaire study included 157 women with endometriosis, 156 women from the general populati...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13427
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:There is little evidence to guide the timing of delivery of women with early-onset severe preeclampsia. We hypothesize that immediate delivery is not inferior for neonatal outcome but reduces maternal complications compared with temporizing management. MATERIAL AND METHODS:This Dutch multicenter open-labe...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13976
更新日期:2021-01-01 00:00:00