Abstract：
:It has previously been shown that mucosal nitric oxide synthase (NOS) is involved in acid-induced duodenal mucosal alkaline secretion. The primary aim of the present study was to elucidate which isoform of NOS is responsible in rats. Immunohistochemistry showed that inducible NOS (iNOS) was constitutively expressed in villous epithelial cells. Exposing the duodenal mucosa to 10 mM HCl resulted in an increased duodenal mucosal alkaline secretion. This response was totally inhibited by intraluminal administration of a selective inhibitor of iNOS (L-N6-1-iminoethyl-lysine). One hour after the acid exposure, western blot technique showed a marked increase in mucosal iNOS expression. A second acid exposure resulted in a further stimulation of alkaline secretion. These data suggest that exposure of the duodenal mucosa to HCI initiates an increased mucosal alkaline secretion, via NO synthesis mediated by iNOS located in the epithelial cells of the villi. In addition, luminal acid stimulates expression of iNOS.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Holm M,Powell T,Casselbrant A,Johansson B,Fändriks Ldoi
10.1023/a:1010674109111subject
Has Abstractpub_date
2001-08-01 00:00:00pages
1765-71issue
8eissn
0163-2116issn
1573-2568journal_volume
46pub_type
杂志文章abstract：:While transilluminating guinea pig gastric wall, we noticed foci of irregular compression of submucosal veins and arteries, featuring parallel bands across arteries, with complete cessation of blood flow, mucosal pallor, and shrinkage of the area. Other features demonstrated that this was not due to artifactual pressu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296065
更新日期：1993-07-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02065551
更新日期：1995-06-01 00:00:00
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journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-006-9272-4
更新日期：2007-04-01 00:00:00
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doi：10.1007/s10620-014-3343-8
更新日期：2015-02-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1024788428692
更新日期：2003-08-01 00:00:00
abstract：:The motor function of the gallbladder after partial distal gastrectomy for gastric carcinoma (Billroth-I reconstruction) and its relationship to the motor function of the stomach was investigated using a double-isotope method. In this method, [99mTc]N-54-pyridoxyl-5-methyltryptophan ([99mTc]PMT) was utilized as a trac...
journal_title：Digestive diseases and sciences
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doi：10.1007/BF02064968
更新日期：1995-04-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1985-11-01 00:00:00
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doi：10.1007/s10620-012-2232-2
更新日期：2012-08-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1998-10-01 00:00:00
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更新日期：1979-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088138
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND AND AIMS:The Chronic Hepatitis Cohort Study (CHeCS) is a longitudinal observational study of risks and benefits of treatments and care in patients with chronic hepatitis B (HBV) and C (HCV) infection from four US health systems. We hypothesized that comparative effectiveness methods-including a centralized d...
journal_title：Digestive diseases and sciences
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更新日期：2014-12-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295657
更新日期：1982-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018826917657
更新日期：1998-06-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2239-8
更新日期：2012-11-01 00:00:00
