Control of cell division by a retinoblastoma protein homolog in Chlamydomonas.

abstract：:Fgf-10-deficient mice (Fgf-10(-/-)) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in Fgf-10(-/-) mice. Strikingly, Fgf-10(-/-) fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for api...

journal_title：Genes & development

authors： Min H,Danilenko DM,Scully SA,Bolon B,Ring BD,Tarpley JE,DeRose M,Simonet WS

更新日期：1998-10-15 00:00:00

abstract：:Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin and the stages of progression of this tumor type are not well understood. We have developed a new model of lung adenocarcinoma in mice harboring a conditionally activatable allele of oncogenic K-ras. Here we show that the use of ...

journal_title：Genes & development

authors： Jackson EL,Willis N,Mercer K,Bronson RT,Crowley D,Montoya R,Jacks T,Tuveson DA

更新日期：2001-12-15 00:00:00

abstract：:In this issue of Genes & Development, Wierzbicki and colleagues (pp. 1825-1836) examine the current model of RNA-directed DNA methylation (RdDM) by determining genome-wide distributions of RNA polymerase V (Pol V) occupancy, siRNAs, and DNA methylation. Their data support the key role of base-pairing between Pol V tra...

journal_title：Genes & development

authors： Zhang H,Zhu JK

更新日期：2012-08-15 00:00:00

abstract：:Post-translational modifications of histones are significant regulators of replication, transcription, and DNA repair. Particularly, newly synthesized histone H4 in H3/H4 heterodimers becomes acetylated on N-terminal lysine residues prior to its incorporation into chromatin. Previous studies have established that the ...

journal_title：Genes & development

authors： Li Y,Zhang L,Liu T,Chai C,Fang Q,Wu H,Agudelo Garcia PA,Han Z,Zong S,Yu Y,Zhang X,Parthun MR,Chai J,Xu RM,Yang M

更新日期：2014-06-01 00:00:00

abstract：:Our understanding of eukaryotic transcriptional activation mechanisms has been hampered by an inability to identify the direct in vivo targets of activator proteins, primarily because of lack of appropriate experimental methods. To circumvent this problem, we have developed a fluorescence resonance energy transfer (FR...

journal_title：Genes & development

authors： Bhaumik SR,Raha T,Aiello DP,Green MR

更新日期：2004-02-01 00:00:00

abstract：:Cell growth and differentiation are usually antagonistic. Proteins of the basic helix-loop-helix (bHLH) family bind DNA and play important roles in the differentiation of specific cell types. Id proteins heterodimerize with bHLH transcription factors, blocking their activation of lineage-specific gene expression and t...

journal_title：Genes & development

authors： Iavarone A,Garg P,Lasorella A,Hsu J,Israel MA

更新日期：1994-06-01 00:00:00

abstract：:Hepatocyte nuclear factor 1 (HNF-1) is a transcriptional regulatory protein possibly involved in the activation of many liver-specifically expressed genes. HNF-1 mRNA is restricted to a small number of tissues, suggesting that the HNF-1 gene itself is regulated at the transcriptional level. We have isolated and charac...

journal_title：Genes & development

authors： Tian JM,Schibler U

更新日期：1991-12-01 00:00:00

abstract：:The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase (MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction. MuSK downstream signaling is largely undefined. Here we show that protein kinase CK2 interacts and colocalizes with MuSK at post-synaptic...

journal_title：Genes & development

authors： Cheusova T,Khan MA,Schubert SW,Gavin AC,Buchou T,Jacob G,Sticht H,Allende J,Boldyreff B,Brenner HR,Hashemolhosseini S

更新日期：2006-07-01 00:00:00

abstract：:Previous characterization of the Saccharomyces cerevisiae Spt4, Spt5, and Spt6 proteins suggested that these proteins act as transcription factors that modify chromatin structure. In this work, we report new genetic and biochemical studies of Spt4, Spt5, and Spt6 that reveal a role for these factors in transcription e...

journal_title：Genes & development

authors： Hartzog GA,Wada T,Handa H,Winston F

更新日期：1998-02-01 00:00:00

abstract：:The mechanisms by which homeoproteins bind selectively to target genes in vivo have long remained unresolved. Here we report that PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein by regulating its subnuclear localization and proximity to target genes. We demonstrate that the interaction of Msx1 with PIAS...

journal_title：Genes & development

authors： Lee H,Quinn JC,Prasanth KV,Swiss VA,Economides KD,Camacho MM,Spector DL,Abate-Shen C

更新日期：2006-04-01 00:00:00

abstract：:The daughterless (da) gene is known to have separate maternal and zygotic functions: Maternally supplied daughterless activity is required for proper sex determination and dosage compensation in female embryos, whereas loss of zygotically supplied da+ activity causes embryonic lethality in both male and female embryos...

journal_title：Genes & development

authors： Caudy M,Grell EH,Dambly-Chaudière C,Ghysen A,Jan LY,Jan YN

更新日期：1988-07-01 00:00:00

abstract：:Proximal-distal outgrowth of the vertebrate limb bud is regulated by the apical ectodermal ridge (AER), which forms at an invariant position along the dorsal-ventral (D/V) axis of the embryo. We have studied the genetic and cellular events that regulate AER formation in the mouse. In contrast to implications from prev...

journal_title：Genes & development

authors： Kimmel RA,Turnbull DH,Blanquet V,Wurst W,Loomis CA,Joyner AL

更新日期：2000-06-01 00:00:00

abstract：:SET8 (also known as PR-SET7) is a histone H4-Lys-20-specific methyltransferase that is implicated in cell-cycle-dependent transcriptional silencing and mitotic regulation in metazoans. Herein we report the crystal structure of human SET8 (hSET8) bound to a histone H4 peptide bearing Lys-20 and the product cofactor S-a...

journal_title：Genes & development

authors： Couture JF,Collazo E,Brunzelle JS,Trievel RC

更新日期：2005-06-15 00:00:00

abstract：:The embryonic lethal abnormal visual system (ELAV) is a gene-specific regulator of alternative pre-mRNA processing in neurons of Drosophila. Here we define a functional in vivo binding site for ELAV in neurons through the development of a reporter gene system in transgenic animals in combination with in vitro binding ...

journal_title：Genes & development

authors： Soller M,White K

更新日期：2003-10-15 00:00:00

abstract：:The ability to initiate organs throughout the lifecycle is a unique feature of plant development that is executed by groups of stem cells called meristems. The balance between stem cell proliferation and organ initiation is carefully regulated and ensures that organs can be initiated in regular geometric patterns. To ...

journal_title：Genes & development

authors： Taguchi-Shiobara F,Yuan Z,Hake S,Jackson D

更新日期：2001-10-15 00:00:00

abstract：:All multisubunit DNA-dependent RNA polymerases (RNAP) are zinc metalloenzymes, and at least two zinc atoms are present per enzyme molecule. RNAP residues involved in zinc binding and the functional role of zinc ions in the transcription mechanism or RNAP structure are unknown. Here, we locate four cysteine residues in...

journal_title：Genes & development

authors： Markov D,Naryshkina T,Mustaev A,Severinov K

更新日期：1999-09-15 00:00:00

abstract：:The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions. Using amino acid sequence information derived ...

journal_title：Genes & development

authors： Waterman ML,Fischer WH,Jones KA

更新日期：1991-04-01 00:00:00

abstract：:DNA repair associated with DNA replication is important for the conservation of genomic sequence information, whereas reconstitution of chromatin after replication sustains epigenetic information. We have isolated and characterized mutations in the BRU1 gene of Arabidopsis that suggest a novel link between these under...

journal_title：Genes & development

authors： Takeda S,Tadele Z,Hofmann I,Probst AV,Angelis KJ,Kaya H,Araki T,Mengiste T,Mittelsten Scheid O,Shibahara K,Scheel D,Paszkowski J

更新日期：2004-04-01 00:00:00

abstract：:Transcription factor IIA has been shown to interact with the TATA-binding protein and to act early during preinitiation complex formation. The human factor is composed of three subunits (alpha, beta, gamma). A human cDNA clone encoding the largest subunit of TFIIA (alpha) was isolated. The recombinant alpha polypeptid...

journal_title：Genes & development

authors： Ma D,Watanabe H,Mermelstein F,Admon A,Oguri K,Sun X,Wada T,Imai T,Shiroya T,Reinberg D

更新日期：1993-11-01 00:00:00

abstract：:Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that regulate homophili...

journal_title：Genes & development

authors： Halbleib JM,Nelson WJ

更新日期：2006-12-01 00:00:00

abstract：:How dividing mammalian cells overcome blocks to DNA replication by DNA damage, depleted nucleotide pools, or template-bound proteins is unclear. Here, we show that the response to blocked replication requires BRCA2, a suppressor of human breast cancer. By using two-dimensional gel electrophoresis, we demonstrate that ...

journal_title：Genes & development

authors： Lomonosov M,Anand S,Sangrithi M,Davies R,Venkitaraman AR

更新日期：2003-12-15 00:00:00

abstract：:Expression of the gene encoding atrial natriuretic factor (ANF) during mouse cardiac embryogenesis was studied using in situ hybridization to histologic sections. ANF mRNA was first detected in a subpopulation of myocardial cells at day 8 of embryogenesis. During day 9, abundant hybridization of the ANF probe to the a...

journal_title：Genes & development

authors： Zeller R,Bloch KD,Williams BS,Arceci RJ,Seidman CE

更新日期：1987-09-01 00:00:00

abstract：:The oncoprotein MDM2 binds to the activation domain of the tumor suppressor p53 and inhibits its ability to stimulate transcription. This same region of p53 is able to bind several basal transcription factors that appear to be important for the transactivation function of p53. It has therefore been suggested that MDM2...

journal_title：Genes & development

authors： Thut CJ,Goodrich JA,Tjian R

更新日期：1997-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) infects humans and causes a wide range of clinical manifestations, from acute hepatitis to hepatocellular carcinoma (HCC). The HBV genome contains multiple promoters with gene expression regulated predominantly by the cellular transcription initiation machinery. Accordingly, the HBV-encoded pX,...

journal_title：Genes & development

authors： Haviv I,Matza Y,Shaul Y

更新日期：1998-04-15 00:00:00

abstract：:Structural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of ...

journal_title：Genes & development

authors： Jiménez G,González-Reyes A,Casanova J

更新日期：2002-04-15 00:00:00

abstract：:Centromeres are maintained epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which directs kinetochore assembly and hence centromere function. To identify factors that promote assembly of CENP-A chromatin, we affinity-selected solubilized fission yeast CENP-ACnp1 chromatin. All ...

journal_title：Genes & development

authors： Singh PP,Shukla M,White SA,Lafos M,Tong P,Auchynnikava T,Spanos C,Rappsilber J,Pidoux AL,Allshire RC

更新日期：2020-02-01 00:00:00

abstract：:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such re...

journal_title：Genes & development

authors： Drexel T,Mahofsky K,Latham R,Zimmer M,Cochella L

更新日期：2016-09-15 00:00:00

abstract：:The yeast HO gene is transcribed transiently during G1 as cells undergo START. START-specific HO activation requires two proteins, SWI4 and SWI6, which act via a motif (CACGA4) repeated up to 10 times within the URS2 region of the HO promoter. We identified a DNA-binding activity containing SWI4 and SWI6 that recogniz...

journal_title：Genes & development

authors： Taba MR,Muroff I,Lydall D,Tebb G,Nasmyth K

更新日期：1991-11-01 00:00:00

abstract：:The 134-bp enhancer region of the pancreatic elastase I gene is sufficient to direct pancreatic acinar cell-specific transcription in transgenic mice and in transfected cells in culture. Ten-base-pair scanner mutations in three separate enhancer domains that inactivate enhancer function in transfected pancreatic cells...

journal_title：Genes & development

authors： Swift GH,Kruse F,MacDonald RJ,Hammer RE

更新日期：1989-05-01 00:00:00

abstract：:Thousands of eukaryotic protein-coding genes are noncanonically spliced to produce circular RNAs. Bioinformatics has indicated that long introns generally flank exons that circularize in Drosophila, but the underlying mechanisms by which these circular RNAs are generated are largely unknown. Here, using extensive muta...

journal_title：Genes & development

authors： Kramer MC,Liang D,Tatomer DC,Gold B,March ZM,Cherry S,Wilusz JE

更新日期：2015-10-15 00:00:00