Effects of surgical stress and nitrous oxide anaesthesia on peri-operative plasma levels of total homocysteine. A randomised, controlled study in general surgery.

Abstract:

:Previous studies of patients have shown that anaesthesia with nitrous oxide (N2O) increases the plasma levels of total homocysteine. In a randomised, controlled trial we measured the plasma total homocysteine levels in patients undergoing general surgery before and after anaesthesia with and without N2O. Plasma total homocysteine levels were measured before anaesthesia and 1, 3-5 and 24 h after incision in 24 patients randomly allocated to anaesthesia with N2O (n = 12) and without N2O (n = 12). Total homocysteine levels significantly decreased from 10.4 +/- 2.7 to 8.2 +/- 2.9 micromol x l(-1) in the non-N2O group 24 h after incision (p < 0.02), while they tended to increase slightly in the N2O group from 10.5 +/- 4.5 to 10.9 +/- 4.3 micromol x l(-1) (p > 0.05). Our randomised controlled study indicates that total homocysteine decreases after general surgery in patients in whom anaesthesia is maintained without N2O, but not in patients in whom anaesthesia is maintained with N2O.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Foschi D,Rizzi A,Zighetti ML,Bissi M,Corsi F,Trabucchi E,Mezzetti M,Cattaneo M

doi

10.1046/j.1365-2044.2001.01374-2.x

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

676-9

issue

7

eissn

0003-2409

issn

1365-2044

pii

ana1374-2

journal_volume

56

pub_type

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