Abstract:
:Target controlled infusion (TCI) pumps function using a programme based on a pharmacokinetic/pharmacodynamic model. We compared the Marsh and Schnider models to find out which better correlates with the clinically observed effect of propofol as assessed by the Observer Assessment of Alertness/Sedation (OAAS) score and the Bispectral index. We assessed the sedation score and Bispectral index score in 40 un-premedicated patients undergoing surgical procedures under spinal anaesthesia with propofol sedation to a target concentration of 2 microg.ml(-1). Half of the patients received TCI propofol driven by the Schnider model in effect site control, the other half were sedated with TCI propofol driven by the Marsh model in plasma control. We calculated the effect site concentration predicted by both models for all the patients. Changes in the sedation score and Bispectral index correlated better with the Marsh than with the Schnider effect site prediction in both study groups.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Barakat AR,Sutcliffe N,Schwab Mdoi
10.1111/j.1365-2044.2007.05059.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
661-6issue
7eissn
0003-2409issn
1365-2044pii
ANA5059journal_volume
62pub_type
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