Omeprazole for prophylaxis of acid aspiration in elective surgery.

Abstract:

:The aim of the study was to determine whether a single oral dose of omeprazole 40 mg is effective in increasing the pH of gastric residue above 2.5 at the time of anaesthetic induction in adult patients scheduled for elective gynaecological surgery. The patients were allocated to receive either chlorazepate dipotassium 25 mg alone or omeprazole 40 mg and chlorazepate dipotassium 25 mg on the night before surgery. Gastric volume and pH were measured after induction of anaesthesia. Patients who received omeprazole had a higher mean pH than control patients (p less than 0.001). The pH was less than 3.5 in 50% of patients in the control group, but in only 4.5% of those who received omeprazole (p less than 0.01). Mean (SEM) volume of gastric fluid was 15.2 (2.7) ml in the control group and 9.2 (1.8) ml in the omeprazole group, but the results were not statistically significant. A single dose of 40 mg omeprazole significantly decreased the number of patients at risk of aspiration pneumonitis.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Ng Wingtin L,Glomaud D,Hardy F,Phil S

doi

10.1111/j.1365-2044.1990.tb14327.x

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

436-8

issue

6

eissn

0003-2409

issn

1365-2044

journal_volume

45

pub_type

临床试验,杂志文章,随机对照试验
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  • Plasma morphine levels produced by continuous infusion in children.

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    pub_type: 临床试验,杂志文章,随机对照试验

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  • An unusual cause of neonatal respiratory distress. RDS in a neonate with a neuro-enteric cyst.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1981.tb08817.x

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  • The alkalinisation of bupivacaine for intercostal nerve blockade.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    doi:10.1111/j.1365-2044.1991.tb09596.x

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    doi:10.1111/j.1365-2044.1995.tb06142.x

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    更新日期:1995-09-01 00:00:00

  • Systemic side-effects of extradural steroids.

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